Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-12

AUTHORS

Akira Ito, Fumiko Matsuoka, Hiroyuki Honda, Takeshi Kobayashi

ABSTRACT

Heat shock proteins (HSPs) are recognized as significant participants in immune reactions. We previously reported that expression of HSP70 in response to hyperthermia, produced using our original magnetite cationic liposomes (MCLs), induces antitumor immunity. In the present study, we examine whether the antitumor immunity induced by hyperthermia is enhanced by hsp70 gene transfer. A human hsp70 gene mediated by cationic liposomes was injected into a B16 melanoma nodule in C57BL/6 mice in situ. At 24 hours after the injection of the hsp70 gene, MCLs were injected into melanoma nodules in C57BL/6 mice, which were subjected to an alternating magnetic field for 30 minutes. The temperature at the tumor reached 43 degrees C and was maintained by controlling the magnetic field intensity. The combined treatment strongly arrested tumor growth over a 30-day period, and complete regression of tumors was observed in 30% (3/10) of mice. Systemic antitumor immunity was induced in the cured mice. This study demonstrates that this novel therapeutic strategy combining the use of hsp70 gene therapy and hyperthermia using MCLs may be applicable to patients with advanced malignancies. More... »

PAGES

7700648

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700648

DOI

http://dx.doi.org/10.1038/sj.cgt.7700648

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046709912

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14712318


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electromagnetic Fields", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ferrosoferric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HSP70 Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperthermia, Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liposomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Particle Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464-8603, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Akira", 
        "id": "sg:person.01037221040.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037221040.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464-8603, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuoka", 
        "givenName": "Fumiko", 
        "id": "sg:person.01266432206.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266432206.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464-8603, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honda", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.016617716011.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016617716011.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464-8603, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Takeshi", 
        "id": "sg:person.012466626631.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012466626631.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199803)28:03<1016::aid-immu1016>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000178089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-001-0233-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588042", 
          "https://doi.org/10.1007/s00262-001-0233-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00188611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005765189", 
          "https://doi.org/10.1007/bf00188611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200304000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005880414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200304000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005880414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1996.tb03129.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006842994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1996.tb03129.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006842994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.55.070186.005443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010277610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19861015)58:8<1589::aid-cncr2820580802>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010423219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01438.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012364209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01438.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012364209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80570-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013017941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.19.7146-7159.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015271744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019030063", 
          "https://doi.org/10.1038/sj.cgt.7700395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019030063", 
          "https://doi.org/10.1038/sj.cgt.7700395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020066916", 
          "https://doi.org/10.1038/sj.cgt.7700357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020066916", 
          "https://doi.org/10.1038/sj.cgt.7700357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-003-0416-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024393994", 
          "https://doi.org/10.1007/s00262-003-0416-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.12.040194.005015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024846748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1997.tb00429.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025554129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1997.tb00429.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025554129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3191/thermalmedicine.10.168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027179936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.11.805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027717875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028349667", 
          "https://doi.org/10.1038/74697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028349667", 
          "https://doi.org/10.1038/74697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02656739709023550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028707476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/10.5.609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030395240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.4.1391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030566171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02656730110108785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033660043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02656730210146926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036705752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/12.11.1539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037326964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039009108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb03283.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039912197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb03283.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039912197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00586.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044462998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00586.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044462998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197210)30:4<885::aid-cncr2820300404>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044828751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(99)01558-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049431794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02656739309061478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052656084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5335.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062558154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/0007-1285-55-656-579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064554050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1379/1466-1268(2000)005<0425:hpbapn>2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067173723", 
          "https://doi.org/10.1379/1466-1268(2000)005<0425:hpbapn>2.0.co;2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.16.6.1153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074494543", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074601062", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075053399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-002-0335-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075240185", 
          "https://doi.org/10.1007/s00262-002-0335-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077265631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-75875-1_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077325959", 
          "https://doi.org/10.1007/978-3-642-75875-1_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077793647", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078459049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078782475", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082693295", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-12", 
    "datePublishedReg": "2003-12-01", 
    "description": "Heat shock proteins (HSPs) are recognized as significant participants in immune reactions. We previously reported that expression of HSP70 in response to hyperthermia, produced using our original magnetite cationic liposomes (MCLs), induces antitumor immunity. In the present study, we examine whether the antitumor immunity induced by hyperthermia is enhanced by hsp70 gene transfer. A human hsp70 gene mediated by cationic liposomes was injected into a B16 melanoma nodule in C57BL/6 mice in situ. At 24 hours after the injection of the hsp70 gene, MCLs were injected into melanoma nodules in C57BL/6 mice, which were subjected to an alternating magnetic field for 30 minutes. The temperature at the tumor reached 43 degrees C and was maintained by controlling the magnetic field intensity. The combined treatment strongly arrested tumor growth over a 30-day period, and complete regression of tumors was observed in 30% (3/10) of mice. Systemic antitumor immunity was induced in the cured mice. This study demonstrates that this novel therapeutic strategy combining the use of hsp70 gene therapy and hyperthermia using MCLs may be applicable to patients with advanced malignancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.cgt.7700648", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5809082", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112008", 
        "issn": [
          "0929-1903", 
          "1476-5500"
        ], 
        "name": "Cancer Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles", 
    "pagination": "7700648", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "de81fb9dfecfff1d6b4c31923c5d5a229e73bebef8b29ec0769cfe426a72d25e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14712318"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9432230"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cgt.7700648"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046709912"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cgt.7700648", 
      "https://app.dimensions.ai/details/publication/pub.1046709912"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87079_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/7700648"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700648'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700648'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700648'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700648'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      93 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cgt.7700648 schema:about N24ee62ecab774f8b9a2610c5fc2c4a64
2 N27584105a50b42848457ec8ae8fd659a
3 N3233ecce4465402fad6770becb19f6d5
4 N4fd16b9f56324aafa921e2f0666ffda2
5 N525a5c7011304c3aa156a7b06ac3b34b
6 N5f78f8ffda3e4ff9961c122965909cec
7 N7fc270952b40467987e0a32984f8c64e
8 N9a0f376a176f4131b6054f863eb67dfe
9 Nb0c13b39f1564e93aa3c9e6eabb50883
10 Nc002d3757f85465d997d34ff0ac5b41c
11 Ncbddd1b8242541249c29eee0e6653737
12 Ncbf6a35d947d41f0aae20f5b1f197b23
13 Nd37481805c454db8945990b21d41d3e6
14 Nd9680c962e8b4645ac4edcd1f8916126
15 Nd9afdf8d505a43de928881764e659142
16 Nde9e5d30b65a46b0b0a76656d68cca8f
17 Nea75ea79696b4db6b0828cf52ed38c2e
18 Nf4a121b7a4ed4eda84a7a9e1eddf46bf
19 Nf84ce0b5be244cd5abccd4e49bda665d
20 Nfb42bb2ab2544792ad6f0888202de62e
21 anzsrc-for:11
22 anzsrc-for:1107
23 schema:author Nfcac85464cb74fea8fee5f4710fd5db9
24 schema:citation sg:pub.10.1007/978-3-642-75875-1_7
25 sg:pub.10.1007/bf00188611
26 sg:pub.10.1007/s00262-001-0233-7
27 sg:pub.10.1007/s00262-002-0335-x
28 sg:pub.10.1007/s00262-003-0416-5
29 sg:pub.10.1038/74697
30 sg:pub.10.1038/sj.cgt.7700357
31 sg:pub.10.1038/sj.cgt.7700395
32 sg:pub.10.1379/1466-1268(2000)005<0425:hpbapn>2.0.co;2
33 https://app.dimensions.ai/details/publication/pub.1074494543
34 https://app.dimensions.ai/details/publication/pub.1074601062
35 https://app.dimensions.ai/details/publication/pub.1075053399
36 https://app.dimensions.ai/details/publication/pub.1077265631
37 https://app.dimensions.ai/details/publication/pub.1077793647
38 https://app.dimensions.ai/details/publication/pub.1078459049
39 https://app.dimensions.ai/details/publication/pub.1078782475
40 https://app.dimensions.ai/details/publication/pub.1082693295
41 https://doi.org/10.1002/(sici)1521-4141(199803)28:03<1016::aid-immu1016>3.0.co;2-g
42 https://doi.org/10.1002/1097-0142(197210)30:4<885::aid-cncr2820300404>3.0.co;2-g
43 https://doi.org/10.1002/1097-0142(19861015)58:8<1589::aid-cncr2820580802>3.0.co;2-b
44 https://doi.org/10.1016/s0167-5699(99)01558-3
45 https://doi.org/10.1016/s1074-7613(00)80570-1
46 https://doi.org/10.1080/02656730110108785
47 https://doi.org/10.1080/02656730210146926
48 https://doi.org/10.1084/jem.178.4.1391
49 https://doi.org/10.1093/annonc/mdf280
50 https://doi.org/10.1093/intimm/10.5.609
51 https://doi.org/10.1093/intimm/12.11.1539
52 https://doi.org/10.1093/jnci/94.11.805
53 https://doi.org/10.1097/00008390-200304000-00004
54 https://doi.org/10.1111/j.1349-7006.1996.tb03129.x
55 https://doi.org/10.1111/j.1349-7006.1997.tb00429.x
56 https://doi.org/10.1111/j.1349-7006.1998.tb00586.x
57 https://doi.org/10.1111/j.1349-7006.1998.tb03283.x
58 https://doi.org/10.1111/j.1349-7006.2003.tb01438.x
59 https://doi.org/10.1126/science.278.5335.117
60 https://doi.org/10.1128/mcb.20.19.7146-7159.2000
61 https://doi.org/10.1146/annurev.bi.55.070186.005443
62 https://doi.org/10.1146/annurev.iy.12.040194.005015
63 https://doi.org/10.1259/0007-1285-55-656-579
64 https://doi.org/10.3109/02656739309061478
65 https://doi.org/10.3109/02656739709023550
66 https://doi.org/10.3191/thermalmedicine.10.168
67 https://doi.org/10.3892/ijo.16.6.1153
68 schema:datePublished 2003-12
69 schema:datePublishedReg 2003-12-01
70 schema:description Heat shock proteins (HSPs) are recognized as significant participants in immune reactions. We previously reported that expression of HSP70 in response to hyperthermia, produced using our original magnetite cationic liposomes (MCLs), induces antitumor immunity. In the present study, we examine whether the antitumor immunity induced by hyperthermia is enhanced by hsp70 gene transfer. A human hsp70 gene mediated by cationic liposomes was injected into a B16 melanoma nodule in C57BL/6 mice in situ. At 24 hours after the injection of the hsp70 gene, MCLs were injected into melanoma nodules in C57BL/6 mice, which were subjected to an alternating magnetic field for 30 minutes. The temperature at the tumor reached 43 degrees C and was maintained by controlling the magnetic field intensity. The combined treatment strongly arrested tumor growth over a 30-day period, and complete regression of tumors was observed in 30% (3/10) of mice. Systemic antitumor immunity was induced in the cured mice. This study demonstrates that this novel therapeutic strategy combining the use of hsp70 gene therapy and hyperthermia using MCLs may be applicable to patients with advanced malignancies.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N3c5b656f730f427cb61abef0d167279d
75 N72b1904330234431968f6fb032cae946
76 sg:journal.1112008
77 schema:name Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles
78 schema:pagination 7700648
79 schema:productId N1d8c2bbc2ec94676af24a7122aca264b
80 N625750d7c7ca49689771ed02d5232ead
81 N6a45b52c1a3d4c56b829530251a4cd73
82 N8135a43478014fd684b0835754382bc6
83 Nf29efdf3b79845a5809ceb7be3684f47
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046709912
85 https://doi.org/10.1038/sj.cgt.7700648
86 schema:sdDatePublished 2019-04-11T12:21
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Ne5c9788a041746e9ae694def4c13af94
89 schema:url http://www.nature.com/articles/7700648
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N1d8c2bbc2ec94676af24a7122aca264b schema:name readcube_id
94 schema:value de81fb9dfecfff1d6b4c31923c5d5a229e73bebef8b29ec0769cfe426a72d25e
95 rdf:type schema:PropertyValue
96 N24ee62ecab774f8b9a2610c5fc2c4a64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Treatment Outcome
98 rdf:type schema:DefinedTerm
99 N27584105a50b42848457ec8ae8fd659a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Combined Modality Therapy
101 rdf:type schema:DefinedTerm
102 N3233ecce4465402fad6770becb19f6d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Gene Transfer Techniques
104 rdf:type schema:DefinedTerm
105 N3c5b656f730f427cb61abef0d167279d schema:issueNumber 12
106 rdf:type schema:PublicationIssue
107 N4fd16b9f56324aafa921e2f0666ffda2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cell Division
109 rdf:type schema:DefinedTerm
110 N525a5c7011304c3aa156a7b06ac3b34b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Ferrosoferric Oxide
112 rdf:type schema:DefinedTerm
113 N5f78f8ffda3e4ff9961c122965909cec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Melanoma
115 rdf:type schema:DefinedTerm
116 N6187f4e82d0c49358b55b34cf48d37a6 rdf:first sg:person.01266432206.86
117 rdf:rest Nd5d5d6ef9cd542ee9863065bd0c5f87c
118 N625750d7c7ca49689771ed02d5232ead schema:name nlm_unique_id
119 schema:value 9432230
120 rdf:type schema:PropertyValue
121 N6a45b52c1a3d4c56b829530251a4cd73 schema:name pubmed_id
122 schema:value 14712318
123 rdf:type schema:PropertyValue
124 N72b1904330234431968f6fb032cae946 schema:volumeNumber 10
125 rdf:type schema:PublicationVolume
126 N7fc270952b40467987e0a32984f8c64e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 N8135a43478014fd684b0835754382bc6 schema:name doi
130 schema:value 10.1038/sj.cgt.7700648
131 rdf:type schema:PropertyValue
132 N9a0f376a176f4131b6054f863eb67dfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Liposomes
134 rdf:type schema:DefinedTerm
135 Nb0c13b39f1564e93aa3c9e6eabb50883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Nanotechnology
137 rdf:type schema:DefinedTerm
138 Nc002d3757f85465d997d34ff0ac5b41c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Particle Size
140 rdf:type schema:DefinedTerm
141 Ncbddd1b8242541249c29eee0e6653737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hyperthermia, Induced
143 rdf:type schema:DefinedTerm
144 Ncbf6a35d947d41f0aae20f5b1f197b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Iron
146 rdf:type schema:DefinedTerm
147 Nd37481805c454db8945990b21d41d3e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Neoplasms, Experimental
149 rdf:type schema:DefinedTerm
150 Nd5d5d6ef9cd542ee9863065bd0c5f87c rdf:first sg:person.016617716011.29
151 rdf:rest Ne20fcec6f1d149a7b6d6241baefe2e95
152 Nd9680c962e8b4645ac4edcd1f8916126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Skin Neoplasms
154 rdf:type schema:DefinedTerm
155 Nd9afdf8d505a43de928881764e659142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice
157 rdf:type schema:DefinedTerm
158 Nde9e5d30b65a46b0b0a76656d68cca8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Genetic Therapy
160 rdf:type schema:DefinedTerm
161 Ne20fcec6f1d149a7b6d6241baefe2e95 rdf:first sg:person.012466626631.65
162 rdf:rest rdf:nil
163 Ne5c9788a041746e9ae694def4c13af94 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nea75ea79696b4db6b0828cf52ed38c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Oxides
167 rdf:type schema:DefinedTerm
168 Nf29efdf3b79845a5809ceb7be3684f47 schema:name dimensions_id
169 schema:value pub.1046709912
170 rdf:type schema:PropertyValue
171 Nf4a121b7a4ed4eda84a7a9e1eddf46bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Electromagnetic Fields
173 rdf:type schema:DefinedTerm
174 Nf84ce0b5be244cd5abccd4e49bda665d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name HSP70 Heat-Shock Proteins
176 rdf:type schema:DefinedTerm
177 Nfb42bb2ab2544792ad6f0888202de62e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mice, Inbred C57BL
179 rdf:type schema:DefinedTerm
180 Nfcac85464cb74fea8fee5f4710fd5db9 rdf:first sg:person.01037221040.28
181 rdf:rest N6187f4e82d0c49358b55b34cf48d37a6
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
186 schema:name Immunology
187 rdf:type schema:DefinedTerm
188 sg:grant.5809082 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cgt.7700648
189 rdf:type schema:MonetaryGrant
190 sg:journal.1112008 schema:issn 0929-1903
191 1476-5500
192 schema:name Cancer Gene Therapy
193 rdf:type schema:Periodical
194 sg:person.01037221040.28 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
195 schema:familyName Ito
196 schema:givenName Akira
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037221040.28
198 rdf:type schema:Person
199 sg:person.012466626631.65 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
200 schema:familyName Kobayashi
201 schema:givenName Takeshi
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012466626631.65
203 rdf:type schema:Person
204 sg:person.01266432206.86 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
205 schema:familyName Matsuoka
206 schema:givenName Fumiko
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266432206.86
208 rdf:type schema:Person
209 sg:person.016617716011.29 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
210 schema:familyName Honda
211 schema:givenName Hiroyuki
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016617716011.29
213 rdf:type schema:Person
214 sg:pub.10.1007/978-3-642-75875-1_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077325959
215 https://doi.org/10.1007/978-3-642-75875-1_7
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf00188611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005765189
218 https://doi.org/10.1007/bf00188611
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s00262-001-0233-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002588042
221 https://doi.org/10.1007/s00262-001-0233-7
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s00262-002-0335-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075240185
224 https://doi.org/10.1007/s00262-002-0335-x
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s00262-003-0416-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024393994
227 https://doi.org/10.1007/s00262-003-0416-5
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/74697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028349667
230 https://doi.org/10.1038/74697
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.cgt.7700357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020066916
233 https://doi.org/10.1038/sj.cgt.7700357
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.cgt.7700395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019030063
236 https://doi.org/10.1038/sj.cgt.7700395
237 rdf:type schema:CreativeWork
238 sg:pub.10.1379/1466-1268(2000)005<0425:hpbapn>2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067173723
239 https://doi.org/10.1379/1466-1268(2000)005<0425:hpbapn>2.0.co;2
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1074494543 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1074601062 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1075053399 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1077265631 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1077793647 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1078459049 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1078782475 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1082693295 schema:CreativeWork
249 https://doi.org/10.1002/(sici)1521-4141(199803)28:03<1016::aid-immu1016>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1000178089
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/1097-0142(197210)30:4<885::aid-cncr2820300404>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1044828751
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/1097-0142(19861015)58:8<1589::aid-cncr2820580802>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1010423219
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0167-5699(99)01558-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049431794
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s1074-7613(00)80570-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013017941
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1080/02656730110108785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033660043
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1080/02656730210146926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036705752
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1084/jem.178.4.1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030566171
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/annonc/mdf280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039009108
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/intimm/10.5.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030395240
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/intimm/12.11.1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037326964
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/jnci/94.11.805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027717875
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00008390-200304000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005880414
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1349-7006.1996.tb03129.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006842994
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1349-7006.1997.tb00429.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025554129
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1349-7006.1998.tb00586.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044462998
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1349-7006.1998.tb03283.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039912197
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1349-7006.2003.tb01438.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012364209
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1126/science.278.5335.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558154
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1128/mcb.20.19.7146-7159.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015271744
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1146/annurev.bi.55.070186.005443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010277610
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1146/annurev.iy.12.040194.005015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024846748
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1259/0007-1285-55-656-579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064554050
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3109/02656739309061478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052656084
296 rdf:type schema:CreativeWork
297 https://doi.org/10.3109/02656739709023550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028707476
298 rdf:type schema:CreativeWork
299 https://doi.org/10.3191/thermalmedicine.10.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027179936
300 rdf:type schema:CreativeWork
301 https://doi.org/10.3892/ijo.16.6.1153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511350
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
304 schema:name Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464-8603, Japan
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...