Ontology type: schema:ScholarlyArticle Open Access: True
2002-06
AUTHORSWenyin Shi, Christian Teschendorf, Nicholas Muzyczka, Dietmar W Siemann
ABSTRACTA variety of approaches has demonstrated that interfering with tumor-induced angiogenesis may be an effective strategy in cancer therapy. However, it is likely that to be most effective such strategies will require extended suppression of the angiogenic process. Gene therapy offers a possible approach to achieve sustained release of a therapeutically potent transferred gene product. In the present study the angiogenesis inhibitor endostatin was expressed through a recombinant adeno-associated viral (rAAV) vector and shown to be biologically active in vitro and in vivo. Intramuscular injection of rAAV-HuEndo (1 x 10(9) i.u.) led to a sustained serum endostatin level of approximately 35-40 ng/mL. This endostatin level was sufficient to inhibit tumor cell-induced angiogenesis and to suppress both the initiation and subsequent growth of a human colorectal cancer model. More... »
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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700463'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700463'
This table displays all metadata directly associated to this object as RDF triples.
335 TRIPLES
21 PREDICATES
100 URIs
45 LITERALS
33 BLANK NODES