Adeno-associated virus–mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-06

AUTHORS

Wenyin Shi, Christian Teschendorf, Nicholas Muzyczka, Dietmar W Siemann

ABSTRACT

A variety of approaches has demonstrated that interfering with tumor-induced angiogenesis may be an effective strategy in cancer therapy. However, it is likely that to be most effective such strategies will require extended suppression of the angiogenic process. Gene therapy offers a possible approach to achieve sustained release of a therapeutically potent transferred gene product. In the present study the angiogenesis inhibitor endostatin was expressed through a recombinant adeno-associated viral (rAAV) vector and shown to be biologically active in vitro and in vivo. Intramuscular injection of rAAV-HuEndo (1 x 10(9) i.u.) led to a sustained serum endostatin level of approximately 35-40 ng/mL. This endostatin level was sufficient to inhibit tumor cell-induced angiogenesis and to suppress both the initiation and subsequent growth of a human colorectal cancer model. More... »

PAGES

513

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700463

    DOI

    http://dx.doi.org/10.1038/sj.cgt.7700463

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036125774

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12032662


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