Local inflammation and devascularization — in vivo mechanisms of the “bystander effect” in VPC-mediated HSV-Tk/GCV gene therapy for human malignant ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-11

AUTHORS

Frank W Floeth, Nick Shand, Hans Bojar, Hans B Prisack, Jörg Felsberg, Eva Neuen-Jacob, Albrecht Aulich, Klaus J Burger, Wolfgang J Bock, Friedrich Weber

ABSTRACT

Somatic gene therapy with the herpes simplex virus type I thymidine kinase gene/ganciclovir (HSV-Tk/GCV) system and murine retroviral vector producer cells (VPCs) was introduced as a new adjuvant treatment modality to treat tumor bulk and to prevent tumor recurrence in patients harboring malignant glioma. The single-center experience after treatment of 27 patients undergoing tumor resection followed by intracerebral VPC injection for HSV-Tk suicide gene therapy will be presented focused on findings of systematic and close MRI follow-up and a few histological specimens. The data indicate that hemorrhagic necrosis due to endothelial cell transfection mediated vessel necrosis and that local inflammatory immune response occurs frequently after gene therapy. These phenomena seem to be specific because none of the patients of a control group showed any similar features. The prognosis (time to progression, survival) of the patients with "bystander effects" after gene therapy was better, but compared to those patients without bystander effects, they were also privileged by a favorable constellation of prognostic factors. Therefore, the appearance of these neuroradiologic features cannot serve as an indicator for treatment effectiveness and outcome. More... »

PAGES

843

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700382

DOI

http://dx.doi.org/10.1038/sj.cgt.7700382

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017468951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11773974


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