Heat-inducible TNF-α gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-09

AUTHORS

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

ABSTRACT

Heat-induced therapeutic gene expression is highly desired for gene therapy to minimize side effects. Furthermore, if the gene expression is triggered by heat stress, combined therapeutic effects of hyperthermia and gene therapy may be possible. We combined TNF-alpha gene therapy driven by the stress-inducible promoter, gadd 153, with hyperthermia using magnetite cationic liposomes (MCLs). In nude mice, MCLs induced cell death throughout much of the tumor area on heating under an alternating magnetic field. This heat stress also resulted in a 3-fold increase in TNF-alpha gene expression driven by the gadd 153 promoter as compared with that of nonheated tumor. TNF-alpha gene expression was also observed in the peripheral area where the hyperthermic effect was not enough to cause cell death. The combined treatment strongly arrested tumor growth in nude mice over a 30-day period, suggesting potential for cancer treatment. More... »

PAGES

7700357

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700357

DOI

http://dx.doi.org/10.1038/sj.cgt.7700357

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020066916

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11593333


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