Murine interferon-α1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-α/β therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-05

AUTHORS

Carmela Rozera, Monica Mecchia, Ion Gresser, Marie-Therese Bandu, Enrico Proietti, Massimo Venditti, Paola Sestili, Stefano Maria Santini, Stefano Fais, Filippo Belardelli, Maria Ferrantini

ABSTRACT

The highly metastatic ESb tumor is totally resistant to murine interferon-alpha/beta (IFN-alpha/beta) therapy, regardless of the number of cells injected or the route of inoculation. In contrast, as we show herein, mouse IFN-alpha1-transduced ESb tumor cells were inhibited markedly when injected subcutaneously into immunocompetent mice. IFN-producing ESb tumor rejection was mediated by the immune system, because these tumor cells grew normally in immunosuppressed mice. Tumor regression was accompanied by extensive necrosis and cellular infiltrates in the tumor area. These results further support the use of IFN-alpha in cytokine gene therapy of cancer and suggest the advantage of using gene transfer rather than cytokine administration to enhance an antitumor immune response. More... »

PAGES

7700051

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cgt.7700051

DOI

http://dx.doi.org/10.1038/sj.cgt.7700051

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015592565

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10359210


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Multiple", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred DBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retroviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rozera", 
        "givenName": "Carmela", 
        "id": "sg:person.01275762455.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275762455.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mecchia", 
        "givenName": "Monica", 
        "id": "sg:person.0610341056.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610341056.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Laboratoire d'Oncologie Virale, Centre National de la Recherche Scientifique, Villejuif, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gresser", 
        "givenName": "Ion", 
        "id": "sg:person.0654172020.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654172020.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Laboratoire d'Oncologie Virale, Centre National de la Recherche Scientifique, Villejuif, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bandu", 
        "givenName": "Marie-Therese", 
        "id": "sg:person.015162661207.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162661207.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Proietti", 
        "givenName": "Enrico", 
        "id": "sg:person.01114351175.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114351175.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venditti", 
        "givenName": "Massimo", 
        "id": "sg:person.01316703443.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316703443.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sestili", 
        "givenName": "Paola", 
        "id": "sg:person.01106771544.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106771544.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santini", 
        "givenName": "Stefano Maria", 
        "id": "sg:person.0717377226.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717377226.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fais", 
        "givenName": "Stefano", 
        "id": "sg:person.014715171620.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014715171620.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belardelli", 
        "givenName": "Filippo", 
        "id": "sg:person.077031223.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077031223.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, Istituto Superiore di Sanit\u00e0, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrantini", 
        "givenName": "Maria", 
        "id": "sg:person.01272007632.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272007632.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ijc.2910230215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000124646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910310518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001212339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(88)90101-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014058196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00132985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019069761", 
          "https://doi.org/10.1007/bf00132985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00132985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019069761", 
          "https://doi.org/10.1007/bf00132985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.1.355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028626169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01756594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029044528", 
          "https://doi.org/10.1007/bf01756594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01756594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029044528", 
          "https://doi.org/10.1007/bf01756594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910600216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038623347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357909609012162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045788599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5270.1947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553452"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-05", 
    "datePublishedReg": "1999-05-01", 
    "description": "The highly metastatic ESb tumor is totally resistant to murine interferon-alpha/beta (IFN-alpha/beta) therapy, regardless of the number of cells injected or the route of inoculation. In contrast, as we show herein, mouse IFN-alpha1-transduced ESb tumor cells were inhibited markedly when injected subcutaneously into immunocompetent mice. IFN-producing ESb tumor rejection was mediated by the immune system, because these tumor cells grew normally in immunosuppressed mice. Tumor regression was accompanied by extensive necrosis and cellular infiltrates in the tumor area. These results further support the use of IFN-alpha in cytokine gene therapy of cancer and suggest the advantage of using gene transfer rather than cytokine administration to enhance an antitumor immune response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.cgt.7700051", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1112008", 
        "issn": [
          "0929-1903", 
          "1476-5500"
        ], 
        "name": "Cancer Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Murine interferon-\u03b11 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-\u03b1/\u03b2 therapy", 
    "pagination": "7700051", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4a4a83dd22b7026c3ad65b5ce5a94007f755094a62997d89ca16af2d52aee45e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10359210"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9432230"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cgt.7700051"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015592565"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cgt.7700051", 
      "https://app.dimensions.ai/details/publication/pub.1015592565"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53981_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/7700051"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700051'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700051'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700051'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700051'


 

This table displays all metadata directly associated to this object as RDF triples.

219 TRIPLES      21 PREDICATES      50 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cgt.7700051 schema:about N249e1a347fa444e1bcc14c164a627126
2 N2e0e60bfff9e47149c739c30718ac75d
3 N36eaeff7cd254f55847ba4496ccc1ec7
4 N5cd76f3e140c4205b3b48dbe2060827c
5 N6286635c2bce48c1899fe65cced41ff8
6 N7a61f43b2e744ccab4e97ae1fceeabb4
7 N8a432fc580b4411392ecf543fb0f97ac
8 N8cac32e92de34a8ab5baf00ae4fa0ba1
9 Naa178e75331e4a22854b212425e75538
10 Nb3dce35b8d944971b21fd437a3accd96
11 Ne1d29a82acac434eb6d2af025c2c8134
12 Nf9448db202ee4641a4c192a38235e626
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N28a0f731458347d5a36606dccdf871e0
16 schema:citation sg:pub.10.1007/bf00132985
17 sg:pub.10.1007/bf01756594
18 https://doi.org/10.1002/ijc.2910230215
19 https://doi.org/10.1002/ijc.2910310518
20 https://doi.org/10.1002/ijc.2910600216
21 https://doi.org/10.1016/0042-6822(88)90101-8
22 https://doi.org/10.1084/jem.178.1.355
23 https://doi.org/10.1126/science.272.5270.1947
24 https://doi.org/10.3109/07357909609012162
25 schema:datePublished 1999-05
26 schema:datePublishedReg 1999-05-01
27 schema:description The highly metastatic ESb tumor is totally resistant to murine interferon-alpha/beta (IFN-alpha/beta) therapy, regardless of the number of cells injected or the route of inoculation. In contrast, as we show herein, mouse IFN-alpha1-transduced ESb tumor cells were inhibited markedly when injected subcutaneously into immunocompetent mice. IFN-producing ESb tumor rejection was mediated by the immune system, because these tumor cells grew normally in immunosuppressed mice. Tumor regression was accompanied by extensive necrosis and cellular infiltrates in the tumor area. These results further support the use of IFN-alpha in cytokine gene therapy of cancer and suggest the advantage of using gene transfer rather than cytokine administration to enhance an antitumor immune response.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N0e3acf4711974e5586abc66623653f3d
32 Nc9969707131347b19bdc505d8a7626d3
33 sg:journal.1112008
34 schema:name Murine interferon-α1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-α/β therapy
35 schema:pagination 7700051
36 schema:productId N06d8451a1d1e416e8f56074c83078283
37 N810d156deb58458790609535d66c9bc9
38 N855b41855f13434c8285b7d9994dddaa
39 Nb17daeacf0b64b0ca1bdcdef02dfc707
40 Nf890e7f60b9f4dc0b9096d75ce61107e
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015592565
42 https://doi.org/10.1038/sj.cgt.7700051
43 schema:sdDatePublished 2019-04-11T12:11
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher Nfbf4fb73b7454cc69d8593ca4694b1a3
46 schema:url http://www.nature.com/articles/7700051
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N06d8451a1d1e416e8f56074c83078283 schema:name doi
51 schema:value 10.1038/sj.cgt.7700051
52 rdf:type schema:PropertyValue
53 N0e3acf4711974e5586abc66623653f3d schema:issueNumber 3
54 rdf:type schema:PublicationIssue
55 N20d1174861b74807af2bc1d56e3a7a68 rdf:first sg:person.01114351175.02
56 rdf:rest Nb9b84a32a1f24b5aaadfee34c5769333
57 N249e1a347fa444e1bcc14c164a627126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Time Factors
59 rdf:type schema:DefinedTerm
60 N28a0f731458347d5a36606dccdf871e0 rdf:first sg:person.01275762455.15
61 rdf:rest N7cfc4006bce44e09bfeefcd2c7f76dfd
62 N2e0e60bfff9e47149c739c30718ac75d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Mice, Inbred DBA
64 rdf:type schema:DefinedTerm
65 N31387166516b486e90be7902e7302e65 rdf:first sg:person.077031223.43
66 rdf:rest N94bebbb7918b416bbcb60432406c265d
67 N36eaeff7cd254f55847ba4496ccc1ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Male
69 rdf:type schema:DefinedTerm
70 N4e10501ad3ad4efc85f2fcdcfd480b9f rdf:first sg:person.014715171620.77
71 rdf:rest N31387166516b486e90be7902e7302e65
72 N53eda39eb321442ebc03bc440160cf34 rdf:first sg:person.015162661207.93
73 rdf:rest N20d1174861b74807af2bc1d56e3a7a68
74 N5cd76f3e140c4205b3b48dbe2060827c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Retroviridae
76 rdf:type schema:DefinedTerm
77 N6286635c2bce48c1899fe65cced41ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Interferon-alpha
79 rdf:type schema:DefinedTerm
80 N7a61f43b2e744ccab4e97ae1fceeabb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Neoplasms, Experimental
82 rdf:type schema:DefinedTerm
83 N7cfc4006bce44e09bfeefcd2c7f76dfd rdf:first sg:person.0610341056.89
84 rdf:rest Nb611aab5986e429e8a0e2bb6576bbc88
85 N810d156deb58458790609535d66c9bc9 schema:name nlm_unique_id
86 schema:value 9432230
87 rdf:type schema:PropertyValue
88 N855b41855f13434c8285b7d9994dddaa schema:name dimensions_id
89 schema:value pub.1015592565
90 rdf:type schema:PropertyValue
91 N8a432fc580b4411392ecf543fb0f97ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Gene Transfer Techniques
93 rdf:type schema:DefinedTerm
94 N8cac32e92de34a8ab5baf00ae4fa0ba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Drug Resistance, Multiple
96 rdf:type schema:DefinedTerm
97 N94bebbb7918b416bbcb60432406c265d rdf:first sg:person.01272007632.86
98 rdf:rest rdf:nil
99 Naa178e75331e4a22854b212425e75538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 Nb17daeacf0b64b0ca1bdcdef02dfc707 schema:name pubmed_id
103 schema:value 10359210
104 rdf:type schema:PropertyValue
105 Nb3dce35b8d944971b21fd437a3accd96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Interferon-beta
107 rdf:type schema:DefinedTerm
108 Nb611aab5986e429e8a0e2bb6576bbc88 rdf:first sg:person.0654172020.39
109 rdf:rest N53eda39eb321442ebc03bc440160cf34
110 Nb9b84a32a1f24b5aaadfee34c5769333 rdf:first sg:person.01316703443.55
111 rdf:rest Nc427c3dd18094edab68a1d84ed78ac02
112 Nc427c3dd18094edab68a1d84ed78ac02 rdf:first sg:person.01106771544.39
113 rdf:rest Ne94aa2e50f6b474cb4c1fe56bc4bdf77
114 Nc9969707131347b19bdc505d8a7626d3 schema:volumeNumber 6
115 rdf:type schema:PublicationVolume
116 Ne1d29a82acac434eb6d2af025c2c8134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Mice
118 rdf:type schema:DefinedTerm
119 Ne94aa2e50f6b474cb4c1fe56bc4bdf77 rdf:first sg:person.0717377226.36
120 rdf:rest N4e10501ad3ad4efc85f2fcdcfd480b9f
121 Nf890e7f60b9f4dc0b9096d75ce61107e schema:name readcube_id
122 schema:value 4a4a83dd22b7026c3ad65b5ce5a94007f755094a62997d89ca16af2d52aee45e
123 rdf:type schema:PropertyValue
124 Nf9448db202ee4641a4c192a38235e626 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Tumor Cells, Cultured
126 rdf:type schema:DefinedTerm
127 Nfbf4fb73b7454cc69d8593ca4694b1a3 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
133 schema:name Immunology
134 rdf:type schema:DefinedTerm
135 sg:journal.1112008 schema:issn 0929-1903
136 1476-5500
137 schema:name Cancer Gene Therapy
138 rdf:type schema:Periodical
139 sg:person.01106771544.39 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
140 schema:familyName Sestili
141 schema:givenName Paola
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106771544.39
143 rdf:type schema:Person
144 sg:person.01114351175.02 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
145 schema:familyName Proietti
146 schema:givenName Enrico
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114351175.02
148 rdf:type schema:Person
149 sg:person.01272007632.86 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
150 schema:familyName Ferrantini
151 schema:givenName Maria
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272007632.86
153 rdf:type schema:Person
154 sg:person.01275762455.15 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
155 schema:familyName Rozera
156 schema:givenName Carmela
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275762455.15
158 rdf:type schema:Person
159 sg:person.01316703443.55 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
160 schema:familyName Venditti
161 schema:givenName Massimo
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316703443.55
163 rdf:type schema:Person
164 sg:person.014715171620.77 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
165 schema:familyName Fais
166 schema:givenName Stefano
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014715171620.77
168 rdf:type schema:Person
169 sg:person.015162661207.93 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
170 schema:familyName Bandu
171 schema:givenName Marie-Therese
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162661207.93
173 rdf:type schema:Person
174 sg:person.0610341056.89 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
175 schema:familyName Mecchia
176 schema:givenName Monica
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610341056.89
178 rdf:type schema:Person
179 sg:person.0654172020.39 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
180 schema:familyName Gresser
181 schema:givenName Ion
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654172020.39
183 rdf:type schema:Person
184 sg:person.0717377226.36 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
185 schema:familyName Santini
186 schema:givenName Stefano Maria
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717377226.36
188 rdf:type schema:Person
189 sg:person.077031223.43 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
190 schema:familyName Belardelli
191 schema:givenName Filippo
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077031223.43
193 rdf:type schema:Person
194 sg:pub.10.1007/bf00132985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019069761
195 https://doi.org/10.1007/bf00132985
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/bf01756594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029044528
198 https://doi.org/10.1007/bf01756594
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/ijc.2910230215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000124646
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/ijc.2910310518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001212339
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/ijc.2910600216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038623347
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0042-6822(88)90101-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014058196
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1084/jem.178.1.355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028626169
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1126/science.272.5270.1947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553452
211 rdf:type schema:CreativeWork
212 https://doi.org/10.3109/07357909609012162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045788599
213 rdf:type schema:CreativeWork
214 https://www.grid.ac/institutes/grid.416651.1 schema:alternateName Istituto Superiore di Sanità
215 schema:name Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy
216 rdf:type schema:Organization
217 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
218 schema:name Laboratoire d'Oncologie Virale, Centre National de la Recherche Scientifique, Villejuif, Paris, France
219 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...