Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

J Mann, F Oakley, F Akiboye, A Elsharkawy, A W Thorne, D A Mann

ABSTRACT

Myofibroblasts are critical cellular elements of wound healing generated at sites of injury by transdifferentiation of resident cells. A paradigm for this process is conversion of hepatic stellate cells (HSC) into hepatic myofibroblasts. Treatment of HSC with DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-azadC) blocked transdifferentiation. 5-azadC also prevented loss of IkappaBalpha and PPARgamma expression that occurs during transdifferentiation to allow acquisition of proinflammatory and profibrogenic characteristics. ChIP analysis revealed IkappaBalpha promoter is associated with transcriptionally repressed chromatin that converts to an active state with 5-azadC treatment. The methyl-CpG-binding protein MeCP2 which promotes repressed chromatin structure is selectively detected in myofibroblasts of diseased liver. siRNA knockdown of MeCP2 elevated IkappaBalpha promoter activity, mRNA and protein expression in myofibroblasts. MeCP2 interacts with IkappaBalpha promoter via a methyl-CpG-dependent mechanism and recruitment into a CBF1 corepression complex. We conclude that MeCP2 and DNA methylation exert epigenetic control over hepatic wound healing and fibrogenesis. More... »

PAGES

4401979

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4401979

DOI

http://dx.doi.org/10.1038/sj.cdd.4401979

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031115443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16763620


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Azacitidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Decitabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "I-kappa B Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Cirrhosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methyl-CpG-Binding Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-KappaB Inhibitor alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wound Healing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "J", 
        "id": "sg:person.0636317123.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636317123.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oakley", 
        "givenName": "F", 
        "id": "sg:person.01330224315.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330224315.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiboye", 
        "givenName": "F", 
        "id": "sg:person.01030120767.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030120767.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elsharkawy", 
        "givenName": "A", 
        "id": "sg:person.0615371546.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615371546.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Portsmouth", 
          "id": "https://www.grid.ac/institutes/grid.4701.2", 
          "name": [
            "Institute of Biomedical and Biomolecular Sciences, School of Biological Sciences, University of Portsmouth, Portsmouth PO12DT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thorne", 
        "givenName": "A W", 
        "id": "sg:person.01066624377.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066624377.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "D A", 
        "id": "sg:person.01361723223.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361723223.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.gde.2004.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000503641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.med.55.091902.103810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001722150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.042127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001965393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301472", 
          "https://doi.org/10.1038/13810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301472", 
          "https://doi.org/10.1038/13810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2000.9322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002803179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2005.02.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004459050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20040335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004768215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20040335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004768215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m105747200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006420339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1090842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008417146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011719650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.lab.0000101911.53973.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012461921", 
          "https://doi.org/10.1097/01.lab.0000101911.53973.90"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62476-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014360777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015302967", 
          "https://doi.org/10.1038/ng1089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015302967", 
          "https://doi.org/10.1038/ng1089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.242566899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016434991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016473487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021284694", 
          "https://doi.org/10.1038/ng1491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021284694", 
          "https://doi.org/10.1038/ng1491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62291-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021452684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1067-1927.2005.130102.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022068725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.11.4727-4741.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024064243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.50.6.891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025009161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211051200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026254230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1086446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029496741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031680428", 
          "https://doi.org/10.1038/ng1068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031680428", 
          "https://doi.org/10.1038/ng1068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00276-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032443958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00276-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032443958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11883-005-0010-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037480237", 
          "https://doi.org/10.1007/s11883-005-0010-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-003-0565-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038739112", 
          "https://doi.org/10.1007/s00384-003-0565-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m410078200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040001404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00383.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043170130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(97)70105-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047862288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049720312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107582200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051248080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000082799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051693971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0890075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056728341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0890075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056728341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2001-17552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057410337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2001-17554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057410339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.041802ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067190393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074265122", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074493714", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-02", 
    "datePublishedReg": "2007-02-01", 
    "description": "Myofibroblasts are critical cellular elements of wound healing generated at sites of injury by transdifferentiation of resident cells. A paradigm for this process is conversion of hepatic stellate cells (HSC) into hepatic myofibroblasts. Treatment of HSC with DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-azadC) blocked transdifferentiation. 5-azadC also prevented loss of IkappaBalpha and PPARgamma expression that occurs during transdifferentiation to allow acquisition of proinflammatory and profibrogenic characteristics. ChIP analysis revealed IkappaBalpha promoter is associated with transcriptionally repressed chromatin that converts to an active state with 5-azadC treatment. The methyl-CpG-binding protein MeCP2 which promotes repressed chromatin structure is selectively detected in myofibroblasts of diseased liver. siRNA knockdown of MeCP2 elevated IkappaBalpha promoter activity, mRNA and protein expression in myofibroblasts. MeCP2 interacts with IkappaBalpha promoter via a methyl-CpG-dependent mechanism and recruitment into a CBF1 corepression complex. We conclude that MeCP2 and DNA methylation exert epigenetic control over hepatic wound healing and fibrogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.cdd.4401979", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2764772", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3633065", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis", 
    "pagination": "4401979", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "943aff10613be38077790b0bddc31864fed7408bae71f48b91ab8f61e5d0e4f7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16763620"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9437445"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cdd.4401979"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031115443"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cdd.4401979", 
      "https://app.dimensions.ai/details/publication/pub.1031115443"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53978_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/4401979"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401979'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401979'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401979'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401979'


 

This table displays all metadata directly associated to this object as RDF triples.

337 TRIPLES      21 PREDICATES      92 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cdd.4401979 schema:about N04536c6ba11e4946ab1a79c9251f5aa9
2 N0459d3f1e71248f195979c938dbff66e
3 N0b4addad502a478ab94c558e35c07566
4 N0d13e118b38840cf8b344ec72c11c044
5 N20bd7d3f53cc46a0b6c1735e36bff62c
6 N2a09ca30614d4f17a72b1a41351ff532
7 N458e5f756b594d01a2fec2d5a8fcd653
8 N5a5935eb4ea74211978e597653bbef42
9 N6458bbb2c7c04b369b3f93f93b4bfe63
10 N6e933939c96146a7aaf3ebf306b36b2b
11 N7f39e42c513b4ce6a617dbdc90c37f73
12 N8830996484e74823a7959f37152bfecf
13 N91ed990898be48e2bec7931236ed7dd4
14 N99ea53a8c21a4fd9a5add60872eec354
15 N9a23b78ac13c4e618f3ba0368800052a
16 N9ac89fc1aae84b6a9b6a53b9c5653db4
17 N9cec656271f54c8cbc9126e3acbcf7b8
18 Naa750ac5e2cd4d798c44821e41091242
19 Nb4f55eaeef104b09b9ed764706384a89
20 Nb9483b6e6a654759a41a43725e62ee68
21 Nc3d7f09817744c459306b658c599b4b7
22 Nc94841581cec4c80be67ec611f78f40b
23 Nd858e500e4cb4c608f2e2f43ec1d91ea
24 Ndf159fd22d8a4cf3b6d77a615a946531
25 Nf6c72a4a32e648ff85dd96e30ce17cec
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author Nd086bab4468d4e4ba431de5e962404a7
29 schema:citation sg:pub.10.1007/s00384-003-0565-1
30 sg:pub.10.1007/s11883-005-0010-8
31 sg:pub.10.1038/13810
32 sg:pub.10.1038/ng1068
33 sg:pub.10.1038/ng1089
34 sg:pub.10.1038/ng1491
35 sg:pub.10.1097/01.lab.0000101911.53973.90
36 https://app.dimensions.ai/details/publication/pub.1074265122
37 https://app.dimensions.ai/details/publication/pub.1074493714
38 https://doi.org/10.1016/j.gde.2004.07.007
39 https://doi.org/10.1016/j.gde.2005.01.005
40 https://doi.org/10.1016/j.jhep.2005.02.035
41 https://doi.org/10.1016/s0002-9440(10)62291-2
42 https://doi.org/10.1016/s0002-9440(10)62476-5
43 https://doi.org/10.1016/s0016-5085(97)70105-7
44 https://doi.org/10.1016/s1097-2765(03)00276-4
45 https://doi.org/10.1042/cs0890075
46 https://doi.org/10.1042/cs20040335
47 https://doi.org/10.1053/j.gastro.2004.10.003
48 https://doi.org/10.1053/jhep.2000.9322
49 https://doi.org/10.1055/s-2001-17552
50 https://doi.org/10.1055/s-2001-17554
51 https://doi.org/10.1073/pnas.242566899
52 https://doi.org/10.1074/jbc.m105747200
53 https://doi.org/10.1074/jbc.m107582200
54 https://doi.org/10.1074/jbc.m211051200
55 https://doi.org/10.1074/jbc.m410078200
56 https://doi.org/10.1111/j.1067-1927.2005.130102.x
57 https://doi.org/10.1126/science.1086446
58 https://doi.org/10.1126/science.1090842
59 https://doi.org/10.1128/mcb.25.11.4727-4741.2005
60 https://doi.org/10.1136/gut.2004.042127
61 https://doi.org/10.1136/gut.50.6.891
62 https://doi.org/10.1146/annurev.med.55.091902.103810
63 https://doi.org/10.1152/ajplung.00383.2004
64 https://doi.org/10.1159/000082799
65 https://doi.org/10.1172/jci116753
66 https://doi.org/10.1387/ijdb.041802ad
67 schema:datePublished 2007-02
68 schema:datePublishedReg 2007-02-01
69 schema:description Myofibroblasts are critical cellular elements of wound healing generated at sites of injury by transdifferentiation of resident cells. A paradigm for this process is conversion of hepatic stellate cells (HSC) into hepatic myofibroblasts. Treatment of HSC with DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-azadC) blocked transdifferentiation. 5-azadC also prevented loss of IkappaBalpha and PPARgamma expression that occurs during transdifferentiation to allow acquisition of proinflammatory and profibrogenic characteristics. ChIP analysis revealed IkappaBalpha promoter is associated with transcriptionally repressed chromatin that converts to an active state with 5-azadC treatment. The methyl-CpG-binding protein MeCP2 which promotes repressed chromatin structure is selectively detected in myofibroblasts of diseased liver. siRNA knockdown of MeCP2 elevated IkappaBalpha promoter activity, mRNA and protein expression in myofibroblasts. MeCP2 interacts with IkappaBalpha promoter via a methyl-CpG-dependent mechanism and recruitment into a CBF1 corepression complex. We conclude that MeCP2 and DNA methylation exert epigenetic control over hepatic wound healing and fibrogenesis.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N1ccb642c00ed4028bdc607f843f5ab75
74 N619c8e6101d643de822f9a6960877730
75 sg:journal.1112551
76 schema:name Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
77 schema:pagination 4401979
78 schema:productId N05eb65b489fd42ed944134702f0fdd29
79 N09717974717246c683b1d02d14eef98b
80 N65781ddc30404955913857f8f4c23476
81 N76b68324cdd44487971eaa25bd632262
82 Nab0bab6ed4104421b014b9e7a434ae3a
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031115443
84 https://doi.org/10.1038/sj.cdd.4401979
85 schema:sdDatePublished 2019-04-11T12:11
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N3a29cbbd1b5248d3be89e79d9b392780
88 schema:url http://www.nature.com/articles/4401979
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N04536c6ba11e4946ab1a79c9251f5aa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Liver Cirrhosis
94 rdf:type schema:DefinedTerm
95 N0459d3f1e71248f195979c938dbff66e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Mice
97 rdf:type schema:DefinedTerm
98 N05eb65b489fd42ed944134702f0fdd29 schema:name nlm_unique_id
99 schema:value 9437445
100 rdf:type schema:PropertyValue
101 N09717974717246c683b1d02d14eef98b schema:name readcube_id
102 schema:value 943aff10613be38077790b0bddc31864fed7408bae71f48b91ab8f61e5d0e4f7
103 rdf:type schema:PropertyValue
104 N0b4addad502a478ab94c558e35c07566 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Liver
106 rdf:type schema:DefinedTerm
107 N0d13e118b38840cf8b344ec72c11c044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name I-kappa B Proteins
109 rdf:type schema:DefinedTerm
110 N1ccb642c00ed4028bdc607f843f5ab75 schema:volumeNumber 14
111 rdf:type schema:PublicationVolume
112 N20bd7d3f53cc46a0b6c1735e36bff62c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Fibroblasts
114 rdf:type schema:DefinedTerm
115 N2a09ca30614d4f17a72b1a41351ff532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name RNA, Messenger
117 rdf:type schema:DefinedTerm
118 N387dd17be81548b49ec6217325e2901d schema:name Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
119 rdf:type schema:Organization
120 N3a29cbbd1b5248d3be89e79d9b392780 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N458e5f756b594d01a2fec2d5a8fcd653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Azacitidine
124 rdf:type schema:DefinedTerm
125 N4e9b48f54c044732a00383bacb03d064 schema:name Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
126 rdf:type schema:Organization
127 N53a101cf981e46c589d4ec9d3904f0ae rdf:first sg:person.01361723223.86
128 rdf:rest rdf:nil
129 N5a5935eb4ea74211978e597653bbef42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Decitabine
131 rdf:type schema:DefinedTerm
132 N5d91e0c86c654876a502a3c621a9e377 schema:name Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
133 rdf:type schema:Organization
134 N619c8e6101d643de822f9a6960877730 schema:issueNumber 2
135 rdf:type schema:PublicationIssue
136 N63c75d3652ef462eb96e7a82efa06822 rdf:first sg:person.01066624377.88
137 rdf:rest N53a101cf981e46c589d4ec9d3904f0ae
138 N6458bbb2c7c04b369b3f93f93b4bfe63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Models, Genetic
140 rdf:type schema:DefinedTerm
141 N65781ddc30404955913857f8f4c23476 schema:name doi
142 schema:value 10.1038/sj.cdd.4401979
143 rdf:type schema:PropertyValue
144 N67b47afbcb79455bb4e43eb4ec75d8d4 rdf:first sg:person.01330224315.54
145 rdf:rest N7ee2c9df5c02412a895c6611ced477d5
146 N6e933939c96146a7aaf3ebf306b36b2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Promoter Regions, Genetic
148 rdf:type schema:DefinedTerm
149 N76b68324cdd44487971eaa25bd632262 schema:name pubmed_id
150 schema:value 16763620
151 rdf:type schema:PropertyValue
152 N78b8702e90e64c20acb5bd7229c3f948 rdf:first sg:person.0615371546.52
153 rdf:rest N63c75d3652ef462eb96e7a82efa06822
154 N7ee2c9df5c02412a895c6611ced477d5 rdf:first sg:person.01030120767.49
155 rdf:rest N78b8702e90e64c20acb5bd7229c3f948
156 N7f39e42c513b4ce6a617dbdc90c37f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name DNA Methylation
158 rdf:type schema:DefinedTerm
159 N8830996484e74823a7959f37152bfecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Epigenesis, Genetic
161 rdf:type schema:DefinedTerm
162 N8c8bbcdef9a740cfbbbfa98a0ec17f87 schema:name Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
163 rdf:type schema:Organization
164 N91ed990898be48e2bec7931236ed7dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Rats, Sprague-Dawley
166 rdf:type schema:DefinedTerm
167 N949c277e581041a7a5cb8cf6191a291e schema:name Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
168 rdf:type schema:Organization
169 N99ea53a8c21a4fd9a5add60872eec354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cell Differentiation
171 rdf:type schema:DefinedTerm
172 N9a23b78ac13c4e618f3ba0368800052a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Rats
174 rdf:type schema:DefinedTerm
175 N9ac89fc1aae84b6a9b6a53b9c5653db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Hepatocytes
177 rdf:type schema:DefinedTerm
178 N9cec656271f54c8cbc9126e3acbcf7b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Naa750ac5e2cd4d798c44821e41091242 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name CpG Islands
183 rdf:type schema:DefinedTerm
184 Nab0bab6ed4104421b014b9e7a434ae3a schema:name dimensions_id
185 schema:value pub.1031115443
186 rdf:type schema:PropertyValue
187 Nb4f55eaeef104b09b9ed764706384a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Animals
189 rdf:type schema:DefinedTerm
190 Nb9483b6e6a654759a41a43725e62ee68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name NF-KappaB Inhibitor alpha
192 rdf:type schema:DefinedTerm
193 Nc3d7f09817744c459306b658c599b4b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Transcription, Genetic
195 rdf:type schema:DefinedTerm
196 Nc94841581cec4c80be67ec611f78f40b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Methyl-CpG-Binding Protein 2
198 rdf:type schema:DefinedTerm
199 Nd086bab4468d4e4ba431de5e962404a7 rdf:first sg:person.0636317123.31
200 rdf:rest N67b47afbcb79455bb4e43eb4ec75d8d4
201 Nd858e500e4cb4c608f2e2f43ec1d91ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Repressor Proteins
203 rdf:type schema:DefinedTerm
204 Ndf159fd22d8a4cf3b6d77a615a946531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Male
206 rdf:type schema:DefinedTerm
207 Nf6c72a4a32e648ff85dd96e30ce17cec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Wound Healing
209 rdf:type schema:DefinedTerm
210 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
211 schema:name Biological Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
214 schema:name Biochemistry and Cell Biology
215 rdf:type schema:DefinedTerm
216 sg:grant.2764772 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cdd.4401979
217 rdf:type schema:MonetaryGrant
218 sg:grant.3633065 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cdd.4401979
219 rdf:type schema:MonetaryGrant
220 sg:journal.1112551 schema:issn 1350-9047
221 1476-5403
222 schema:name Cell Death & Differentiation
223 rdf:type schema:Periodical
224 sg:person.01030120767.49 schema:affiliation N8c8bbcdef9a740cfbbbfa98a0ec17f87
225 schema:familyName Akiboye
226 schema:givenName F
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030120767.49
228 rdf:type schema:Person
229 sg:person.01066624377.88 schema:affiliation https://www.grid.ac/institutes/grid.4701.2
230 schema:familyName Thorne
231 schema:givenName A W
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066624377.88
233 rdf:type schema:Person
234 sg:person.01330224315.54 schema:affiliation N5d91e0c86c654876a502a3c621a9e377
235 schema:familyName Oakley
236 schema:givenName F
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330224315.54
238 rdf:type schema:Person
239 sg:person.01361723223.86 schema:affiliation N4e9b48f54c044732a00383bacb03d064
240 schema:familyName Mann
241 schema:givenName D A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361723223.86
243 rdf:type schema:Person
244 sg:person.0615371546.52 schema:affiliation N949c277e581041a7a5cb8cf6191a291e
245 schema:familyName Elsharkawy
246 schema:givenName A
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615371546.52
248 rdf:type schema:Person
249 sg:person.0636317123.31 schema:affiliation N387dd17be81548b49ec6217325e2901d
250 schema:familyName Mann
251 schema:givenName J
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636317123.31
253 rdf:type schema:Person
254 sg:pub.10.1007/s00384-003-0565-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038739112
255 https://doi.org/10.1007/s00384-003-0565-1
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s11883-005-0010-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037480237
258 https://doi.org/10.1007/s11883-005-0010-8
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/13810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301472
261 https://doi.org/10.1038/13810
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/ng1068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031680428
264 https://doi.org/10.1038/ng1068
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/ng1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015302967
267 https://doi.org/10.1038/ng1089
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/ng1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021284694
270 https://doi.org/10.1038/ng1491
271 rdf:type schema:CreativeWork
272 sg:pub.10.1097/01.lab.0000101911.53973.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012461921
273 https://doi.org/10.1097/01.lab.0000101911.53973.90
274 rdf:type schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1074265122 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1074493714 schema:CreativeWork
277 https://doi.org/10.1016/j.gde.2004.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000503641
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.gde.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016473487
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.jhep.2005.02.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004459050
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0002-9440(10)62291-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021452684
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0002-9440(10)62476-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014360777
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0016-5085(97)70105-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047862288
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s1097-2765(03)00276-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032443958
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1042/cs0890075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056728341
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1042/cs20040335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004768215
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1053/j.gastro.2004.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011719650
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1053/jhep.2000.9322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002803179
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1055/s-2001-17552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057410337
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1055/s-2001-17554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057410339
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.242566899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016434991
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m105747200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006420339
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m107582200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051248080
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1074/jbc.m211051200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026254230
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.m410078200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040001404
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1111/j.1067-1927.2005.130102.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022068725
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.1086446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029496741
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1126/science.1090842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008417146
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1128/mcb.25.11.4727-4741.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024064243
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1136/gut.2004.042127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965393
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1136/gut.50.6.891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025009161
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1146/annurev.med.55.091902.103810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001722150
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1152/ajplung.00383.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043170130
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1159/000082799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051693971
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1172/jci116753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049720312
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1387/ijdb.041802ad schema:sameAs https://app.dimensions.ai/details/publication/pub.1067190393
334 rdf:type schema:CreativeWork
335 https://www.grid.ac/institutes/grid.4701.2 schema:alternateName University of Portsmouth
336 schema:name Institute of Biomedical and Biomolecular Sciences, School of Biological Sciences, University of Portsmouth, Portsmouth PO12DT, UK
337 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...