Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-07

AUTHORS

Y-J Huh, J-M Kim, H Kim, H Song, H So, S Y Lee, S B Kwon, H J Kim, H-H Kim, S H Lee, Y Choi, S-C Chung, D-w Jeong, B-M Min

ABSTRACT

This study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the gamma-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-kappaB and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis. More... »

PAGES

4401793

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793

DOI

http://dx.doi.org/10.1038/sj.cdd.4401793

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010740531

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16224490


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Active Transport, Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Buthionine Sulfoximine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamate-Cysteine Ligase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Disulfide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoclasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RANK Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Activator of Nuclear Factor-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "IBEC, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huh", 
        "givenName": "Y-J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "IBEC, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "J-M", 
        "id": "sg:person.01074310055.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074310055.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "IBEC, Seoul National University College of Dentistry, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "H", 
        "id": "sg:person.0625354540.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625354540.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Advanced Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.37172.30", 
          "name": [
            "Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "H", 
        "id": "sg:person.01106304407.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106304407.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wonkwang University", 
          "id": "https://www.grid.ac/institutes/grid.410899.d", 
          "name": [
            "Vestibulorcochlear Research Center, Wonkwang University School of Medicine, Chonbuk, Ik-San 570-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "So", 
        "givenName": "H", 
        "id": "sg:person.01031373704.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031373704.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ewha Womans University", 
          "id": "https://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Woman's University, Seoul 120-750, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "S Y", 
        "id": "sg:person.0607223000.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607223000.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ewha Womans University", 
          "id": "https://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Woman's University, Seoul 120-750, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "S B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Cell and Developmental Biology, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "H J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Cell and Developmental Biology, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "H-H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Abramson Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "S H", 
        "id": "sg:person.0701715163.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701715163.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Abramson Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Y", 
        "id": "sg:person.010624305154.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010624305154.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Oral Medicine and Oral Diagnosis, Seoul National University College of Dentistry, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "S-C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "D-w", 
        "id": "sg:person.0733074237.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733074237.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "IBEC, Seoul National University College of Dentistry, Seoul 110-749, Korea", 
            "BK21 HLS, Seoul National University, Seoul 110-749, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Min", 
        "givenName": "B-M", 
        "id": "sg:person.01175405760.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175405760.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0891-5849(96)00109-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003464017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(96)00501-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005475452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(01)00751-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009129636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.61.suppl_2.ii13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009869883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.6.2729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010379181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650110515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012952154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650110515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012952154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m001004200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015056769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000047804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016874296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(01)00480-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018930552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019910253", 
          "https://doi.org/10.1038/nature01658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019910253", 
          "https://doi.org/10.1038/nature01658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020696340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200808200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021819181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00516.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022285845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208284200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023070761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023538865", 
          "https://doi.org/10.1038/nrg1122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023538865", 
          "https://doi.org/10.1038/nrg1122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-2728(96)00111-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024574458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1197-1285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027864426", 
          "https://doi.org/10.1038/nm1197-1285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1997.9997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028365424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030263854", 
          "https://doi.org/10.1038/nm1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030263854", 
          "https://doi.org/10.1038/nm1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203631200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034008082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039290480", 
          "https://doi.org/10.1007/s002239900538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)02628-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045847272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(03)00035-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050734949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(03)00035-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050734949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/8756-3282(96)00177-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051397099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1355616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062477289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci18859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.20.3.0367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.4.6647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.13.10.1169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074482890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/70.4.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074526491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074947254", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075041880", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.10.7.8635688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082887854"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-07", 
    "datePublishedReg": "2006-07-01", 
    "description": "This study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the gamma-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-kappaB and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.cdd.4401793", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors", 
    "pagination": "4401793", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "332b3340d896fb4c65e79b901f1872ded89c87c05a604e0910c62cd0606bc0aa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16224490"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9437445"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cdd.4401793"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010740531"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cdd.4401793", 
      "https://app.dimensions.ai/details/publication/pub.1010740531"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29197_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/4401793"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      89 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cdd.4401793 schema:about N04d49e7179cd4655906a7e6bd8ba8c9e
2 N137d54cb2c334228b3e5f04a43e43aa1
3 N152a4e9ff1cf4b318eda965cb00affad
4 N214c4877ba3e451a8e4f1edf838a590d
5 N26e655ce558b4002ad0f3177d1f326e0
6 N2a1ebfe6f4914e17b808a7eec6579360
7 N2a91da75318d428fad6755d7d1a2af86
8 N31957d84c1cb4011ac78925a094a1dce
9 N3b2efb8163254bdf86c47d89e903dfe7
10 N43bc14b496324dd6b8166bc615c6b299
11 N44625a5301ef49b1b8037aba9fc59b6b
12 N574fb020b14b43ada2c25dc8040f3ce9
13 N5f4f9f546c3b4559a4dce8038ba00791
14 N5fd05b09ff294f46b6a82ccb88a4a177
15 N65a25bf427084df2bda61196f4a95f08
16 N67fe0cded1384763838b74d0fdbcf0e9
17 N6b47b5ed0c6843b28c94b738d04fad7d
18 N76e29639e16f40e596c70a68238d5d30
19 N89f91c3c8d884347ac7109d7d1b91122
20 N8ce4e9b277f34849987aceaa7be68337
21 N96f0e27e9e5c4e36a2a79267ed0eb544
22 N9bb3104fb6f547aa8062e27353c97db7
23 Na17e8171453848fe8e2c7dcf0891da21
24 Nb0086442be87452bb74bb90b1d43b311
25 Ncccd6ee54f4b4c928ed69a87721cae45
26 Ne55b561507b941fe8fc43e0e5978e7a7
27 Nf8ce75802b4e424c8f424cecc1d346f3
28 anzsrc-for:11
29 anzsrc-for:1103
30 schema:author N04442bea02024404931e29aea057b54a
31 schema:citation sg:pub.10.1007/s002239900538
32 sg:pub.10.1038/nature01658
33 sg:pub.10.1038/nm1054
34 sg:pub.10.1038/nm1197-1285
35 sg:pub.10.1038/nrg1122
36 https://app.dimensions.ai/details/publication/pub.1074947254
37 https://app.dimensions.ai/details/publication/pub.1075041880
38 https://doi.org/10.1002/jbmr.5650110515
39 https://doi.org/10.1006/abbi.1997.9997
40 https://doi.org/10.1006/bbrc.1997.7812
41 https://doi.org/10.1016/0891-5849(96)00109-8
42 https://doi.org/10.1016/8756-3282(96)00177-9
43 https://doi.org/10.1016/s0005-2728(96)00111-9
44 https://doi.org/10.1016/s0014-5793(02)02628-5
45 https://doi.org/10.1016/s0026-0495(03)00035-0
46 https://doi.org/10.1016/s0891-5849(01)00480-4
47 https://doi.org/10.1016/s0891-5849(01)00751-1
48 https://doi.org/10.1016/s0891-5849(96)00501-1
49 https://doi.org/10.1074/jbc.m001004200
50 https://doi.org/10.1074/jbc.m200808200
51 https://doi.org/10.1074/jbc.m203631200
52 https://doi.org/10.1074/jbc.m208284200
53 https://doi.org/10.1093/ajcn/70.4.557
54 https://doi.org/10.1096/fasebj.10.7.8635688
55 https://doi.org/10.1096/fasebj.13.10.1169
56 https://doi.org/10.1126/science.1355616
57 https://doi.org/10.1136/ard.61.suppl_2.ii13
58 https://doi.org/10.1152/ajpcell.00516.2003
59 https://doi.org/10.1159/000047804
60 https://doi.org/10.1172/jci18859
61 https://doi.org/10.1210/edrv.20.3.0367
62 https://doi.org/10.1210/endo.140.4.6647
63 https://doi.org/10.4049/jimmunol.168.6.2729
64 schema:datePublished 2006-07
65 schema:datePublishedReg 2006-07-01
66 schema:description This study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the gamma-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-kappaB and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N15cb8b7bd0f4419c9be8d6d4ddd8a630
71 Ne2c98fd8537642caafc46d9d489b845a
72 sg:journal.1112551
73 schema:name Regulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors
74 schema:pagination 4401793
75 schema:productId N9e3ff5822ee14322884bde58984e140f
76 Na89169b3563a4167991c9b9671a50235
77 Na8b8ae7f77bc4cedb7453e9169c35aa6
78 Nb177f47f131c4ea785aeacd3a0795219
79 Nb3fb0692564743f998c0f808791e4932
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010740531
81 https://doi.org/10.1038/sj.cdd.4401793
82 schema:sdDatePublished 2019-04-11T11:53
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N16772acb48c54b26aafdb1baabaf5c40
85 schema:url http://www.nature.com/articles/4401793
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N04442bea02024404931e29aea057b54a rdf:first Nf0434c71c04144f797ce63193b70705d
90 rdf:rest N0865366d239e4776856d5ea832f982bb
91 N04d49e7179cd4655906a7e6bd8ba8c9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Glutamate-Cysteine Ligase
93 rdf:type schema:DefinedTerm
94 N07c97b52e1a94e549370356ca2faa99f rdf:first sg:person.0733074237.10
95 rdf:rest Nb194fd8d475d467095b85210b81f47b0
96 N0865366d239e4776856d5ea832f982bb rdf:first sg:person.01074310055.75
97 rdf:rest Nb5e6dd11b8914eb68620d65bc727f505
98 N137d54cb2c334228b3e5f04a43e43aa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Oxidation-Reduction
100 rdf:type schema:DefinedTerm
101 N152a4e9ff1cf4b318eda965cb00affad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Buthionine Sulfoximine
103 rdf:type schema:DefinedTerm
104 N15cb8b7bd0f4419c9be8d6d4ddd8a630 schema:issueNumber 7
105 rdf:type schema:PublicationIssue
106 N16772acb48c54b26aafdb1baabaf5c40 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N1ad3e8511f63465c8213e781635aa4d4 rdf:first sg:person.01031373704.90
109 rdf:rest Nbde67c115c1542abae9282d90bba7e79
110 N214c4877ba3e451a8e4f1edf838a590d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Glutathione Disulfide
112 rdf:type schema:DefinedTerm
113 N26e655ce558b4002ad0f3177d1f326e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Transcription Factor AP-1
115 rdf:type schema:DefinedTerm
116 N2a1ebfe6f4914e17b808a7eec6579360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name RANK Ligand
118 rdf:type schema:DefinedTerm
119 N2a91da75318d428fad6755d7d1a2af86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Active Transport, Cell Nucleus
121 rdf:type schema:DefinedTerm
122 N2ea82fc7704a4f53933b94e4fb2d959a schema:affiliation https://www.grid.ac/institutes/grid.255649.9
123 schema:familyName Kwon
124 schema:givenName S B
125 rdf:type schema:Person
126 N31957d84c1cb4011ac78925a094a1dce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cell Survival
128 rdf:type schema:DefinedTerm
129 N38136a7ef5304936a0d991bc037ad60c rdf:first N5ef279b90f68448fbdab61432c02bab1
130 rdf:rest Nd4ed9b343fac4614bff27358e6d33f88
131 N3b2efb8163254bdf86c47d89e903dfe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Line
133 rdf:type schema:DefinedTerm
134 N43bc14b496324dd6b8166bc615c6b299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Microscopy, Confocal
136 rdf:type schema:DefinedTerm
137 N44625a5301ef49b1b8037aba9fc59b6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Nucleus
139 rdf:type schema:DefinedTerm
140 N4914605d60b54a34b3b14341d2b815ad rdf:first N2ea82fc7704a4f53933b94e4fb2d959a
141 rdf:rest N38136a7ef5304936a0d991bc037ad60c
142 N574fb020b14b43ada2c25dc8040f3ce9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Animals
144 rdf:type schema:DefinedTerm
145 N5ef279b90f68448fbdab61432c02bab1 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
146 schema:familyName Kim
147 schema:givenName H J
148 rdf:type schema:Person
149 N5f4f9f546c3b4559a4dce8038ba00791 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Carrier Proteins
151 rdf:type schema:DefinedTerm
152 N5fd05b09ff294f46b6a82ccb88a4a177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Transcription Factors
154 rdf:type schema:DefinedTerm
155 N606235ed460a4e85baab6e5e6b247c83 rdf:first sg:person.010624305154.23
156 rdf:rest N8f3286dbd67d4c3f81953428430ba901
157 N65a25bf427084df2bda61196f4a95f08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Receptor Activator of Nuclear Factor-kappa B
159 rdf:type schema:DefinedTerm
160 N67fe0cded1384763838b74d0fdbcf0e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Mice, Inbred C57BL
162 rdf:type schema:DefinedTerm
163 N6b47b5ed0c6843b28c94b738d04fad7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Reverse Transcriptase Polymerase Chain Reaction
165 rdf:type schema:DefinedTerm
166 N76e29639e16f40e596c70a68238d5d30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Female
168 rdf:type schema:DefinedTerm
169 N7d5518d6a84d472b9627ff5528659943 rdf:first sg:person.0701715163.81
170 rdf:rest N606235ed460a4e85baab6e5e6b247c83
171 N89f91c3c8d884347ac7109d7d1b91122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Osteoclasts
173 rdf:type schema:DefinedTerm
174 N8ce4e9b277f34849987aceaa7be68337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Osteoblasts
176 rdf:type schema:DefinedTerm
177 N8f3286dbd67d4c3f81953428430ba901 rdf:first Nc191958a497a4856b56beb95d83be434
178 rdf:rest N07c97b52e1a94e549370356ca2faa99f
179 N96f0e27e9e5c4e36a2a79267ed0eb544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Membrane Glycoproteins
181 rdf:type schema:DefinedTerm
182 N9bb3104fb6f547aa8062e27353c97db7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Glutathione
184 rdf:type schema:DefinedTerm
185 N9e3ff5822ee14322884bde58984e140f schema:name nlm_unique_id
186 schema:value 9437445
187 rdf:type schema:PropertyValue
188 Na17e8171453848fe8e2c7dcf0891da21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Differentiation
190 rdf:type schema:DefinedTerm
191 Na89169b3563a4167991c9b9671a50235 schema:name pubmed_id
192 schema:value 16224490
193 rdf:type schema:PropertyValue
194 Na8b8ae7f77bc4cedb7453e9169c35aa6 schema:name readcube_id
195 schema:value 332b3340d896fb4c65e79b901f1872ded89c87c05a604e0910c62cd0606bc0aa
196 rdf:type schema:PropertyValue
197 Nb0086442be87452bb74bb90b1d43b311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name NF-kappa B
199 rdf:type schema:DefinedTerm
200 Nb177f47f131c4ea785aeacd3a0795219 schema:name doi
201 schema:value 10.1038/sj.cdd.4401793
202 rdf:type schema:PropertyValue
203 Nb194fd8d475d467095b85210b81f47b0 rdf:first sg:person.01175405760.11
204 rdf:rest rdf:nil
205 Nb3fb0692564743f998c0f808791e4932 schema:name dimensions_id
206 schema:value pub.1010740531
207 rdf:type schema:PropertyValue
208 Nb5e6dd11b8914eb68620d65bc727f505 rdf:first sg:person.0625354540.07
209 rdf:rest Ne8db6dcbca524283ba8a0da7dc82f67f
210 Nbde67c115c1542abae9282d90bba7e79 rdf:first sg:person.0607223000.23
211 rdf:rest N4914605d60b54a34b3b14341d2b815ad
212 Nc191958a497a4856b56beb95d83be434 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
213 schema:familyName Chung
214 schema:givenName S-C
215 rdf:type schema:Person
216 Ncccd6ee54f4b4c928ed69a87721cae45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Cell Proliferation
218 rdf:type schema:DefinedTerm
219 Nd4ed9b343fac4614bff27358e6d33f88 rdf:first Nf5ba9af2d4244414910e7e2366ee602f
220 rdf:rest N7d5518d6a84d472b9627ff5528659943
221 Ne2c98fd8537642caafc46d9d489b845a schema:volumeNumber 13
222 rdf:type schema:PublicationVolume
223 Ne55b561507b941fe8fc43e0e5978e7a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Immunoblotting
225 rdf:type schema:DefinedTerm
226 Ne8db6dcbca524283ba8a0da7dc82f67f rdf:first sg:person.01106304407.14
227 rdf:rest N1ad3e8511f63465c8213e781635aa4d4
228 Nf0434c71c04144f797ce63193b70705d schema:affiliation https://www.grid.ac/institutes/grid.31501.36
229 schema:familyName Huh
230 schema:givenName Y-J
231 rdf:type schema:Person
232 Nf5ba9af2d4244414910e7e2366ee602f schema:affiliation https://www.grid.ac/institutes/grid.31501.36
233 schema:familyName Kim
234 schema:givenName H-H
235 rdf:type schema:Person
236 Nf8ce75802b4e424c8f424cecc1d346f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Mice
238 rdf:type schema:DefinedTerm
239 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
240 schema:name Medical and Health Sciences
241 rdf:type schema:DefinedTerm
242 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
243 schema:name Clinical Sciences
244 rdf:type schema:DefinedTerm
245 sg:journal.1112551 schema:issn 1350-9047
246 1476-5403
247 schema:name Cell Death & Differentiation
248 rdf:type schema:Periodical
249 sg:person.01031373704.90 schema:affiliation https://www.grid.ac/institutes/grid.410899.d
250 schema:familyName So
251 schema:givenName H
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031373704.90
253 rdf:type schema:Person
254 sg:person.010624305154.23 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
255 schema:familyName Choi
256 schema:givenName Y
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010624305154.23
258 rdf:type schema:Person
259 sg:person.01074310055.75 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
260 schema:familyName Kim
261 schema:givenName J-M
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074310055.75
263 rdf:type schema:Person
264 sg:person.01106304407.14 schema:affiliation https://www.grid.ac/institutes/grid.37172.30
265 schema:familyName Song
266 schema:givenName H
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106304407.14
268 rdf:type schema:Person
269 sg:person.01175405760.11 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
270 schema:familyName Min
271 schema:givenName B-M
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175405760.11
273 rdf:type schema:Person
274 sg:person.0607223000.23 schema:affiliation https://www.grid.ac/institutes/grid.255649.9
275 schema:familyName Lee
276 schema:givenName S Y
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607223000.23
278 rdf:type schema:Person
279 sg:person.0625354540.07 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
280 schema:familyName Kim
281 schema:givenName H
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625354540.07
283 rdf:type schema:Person
284 sg:person.0701715163.81 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
285 schema:familyName Lee
286 schema:givenName S H
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701715163.81
288 rdf:type schema:Person
289 sg:person.0733074237.10 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
290 schema:familyName Jeong
291 schema:givenName D-w
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733074237.10
293 rdf:type schema:Person
294 sg:pub.10.1007/s002239900538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039290480
295 https://doi.org/10.1007/s002239900538
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nature01658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019910253
298 https://doi.org/10.1038/nature01658
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nm1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030263854
301 https://doi.org/10.1038/nm1054
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nm1197-1285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027864426
304 https://doi.org/10.1038/nm1197-1285
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nrg1122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023538865
307 https://doi.org/10.1038/nrg1122
308 rdf:type schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1074947254 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1075041880 schema:CreativeWork
311 https://doi.org/10.1002/jbmr.5650110515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012952154
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1006/abbi.1997.9997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028365424
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1006/bbrc.1997.7812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020696340
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/0891-5849(96)00109-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003464017
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/8756-3282(96)00177-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051397099
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0005-2728(96)00111-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024574458
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0014-5793(02)02628-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045847272
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0026-0495(03)00035-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050734949
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0891-5849(01)00480-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018930552
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0891-5849(01)00751-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009129636
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0891-5849(96)00501-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005475452
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/jbc.m001004200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015056769
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1074/jbc.m200808200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021819181
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1074/jbc.m203631200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034008082
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1074/jbc.m208284200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023070761
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/ajcn/70.4.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074526491
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1096/fasebj.10.7.8635688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082887854
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1096/fasebj.13.10.1169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074482890
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1126/science.1355616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477289
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1136/ard.61.suppl_2.ii13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009869883
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1152/ajpcell.00516.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022285845
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1159/000047804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016874296
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1172/jci18859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416370
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1210/edrv.20.3.0367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238469
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1210/endo.140.4.6647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283017
360 rdf:type schema:CreativeWork
361 https://doi.org/10.4049/jimmunol.168.6.2729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010379181
362 rdf:type schema:CreativeWork
363 https://www.grid.ac/institutes/grid.255649.9 schema:alternateName Ewha Womans University
364 schema:name Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Woman's University, Seoul 120-750, Korea
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
367 schema:name Department of Pathology and Laboratory Medicine, Abramson Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
370 schema:name BK21 HLS, Seoul National University, Seoul 110-749, Korea
371 Department of Cell and Developmental Biology, Seoul National University College of Dentistry, Seoul 110-749, Korea
372 Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, Seoul National University College of Dentistry, Seoul 110-749, Korea
373 Department of Oral Medicine and Oral Diagnosis, Seoul National University College of Dentistry, Seoul 110-749, Korea
374 IBEC, Seoul National University College of Dentistry, Seoul 110-749, Korea
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.37172.30 schema:alternateName Korea Advanced Institute of Science and Technology
377 schema:name Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.410899.d schema:alternateName Wonkwang University
380 schema:name Vestibulorcochlear Research Center, Wonkwang University School of Medicine, Chonbuk, Ik-San 570-749, Korea
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...