Ontology type: schema:ScholarlyArticle Open Access: True
2006-07
AUTHORSY-J Huh, J-M Kim, H Kim, H Song, H So, S Y Lee, S B Kwon, H J Kim, H-H Kim, S H Lee, Y Choi, S-C Chung, D-w Jeong, B-M Min
ABSTRACTThis study sought to characterize the reduced glutathione (GSH)/oxidized GSSG ratio during osteoclast differentiation and determine whether changes in the intracellular redox status regulate its differentiation through a RANKL-dependent signaling pathway. A progressive decrease of the GSH/GSSG ratio was observed during osteoclast differentiation, and the phenomenon was dependent on a decrease in total glutathione via downregulation of expression of the gamma-glutamylcysteinyl synthetase modifier gene. Glutathione depletion by L-buthionine-(S,R)-sulfoximine (BSO) was found to inhibit osteoclastogenesis by blocking nuclear import of NF-kappaB and AP-1 in RANKL-propagated signaling and bone pit formation by increasing BSO concentrations in mature osteoclasts. Furthermore, intraperitoneal injection of BSO in mice resulted in an increase in bone density and a decrease of the number of osteoclasts in bone. Conversely, glutathione repletion with either N-acetylcysteine or GSH enhanced osteoclastogenesis. These findings indicate that redox status decreases during osteoclast differentiation and that this modification directly regulates RANKL-induced osteoclastogenesis. More... »
PAGES4401793
http://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793
DOIhttp://dx.doi.org/10.1038/sj.cdd.4401793
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16224490
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"type": "PropertyValue",
"value": [
"9437445"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.cdd.4401793"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1010740531"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.cdd.4401793",
"https://app.dimensions.ai/details/publication/pub.1010740531"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:53",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29197_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/4401793"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401793'
This table displays all metadata directly associated to this object as RDF triples.
381 TRIPLES
21 PREDICATES
89 URIs
48 LITERALS
36 BLANK NODES