Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-05

AUTHORS

J Milia, F Teyssier, F Dalenc, I Ader, C Delmas, A Pradines, I Lajoie-Mazenc, R Baron, J Bonnet, E Cohen-Jonathan, G Favre, C Toulas

ABSTRACT

Our previous results demonstrated that expressing the GTPase ras homolog gene family, member B (RhoB) in radiosensitive NIH3T3 cells increases their survival following 2 Gy irradiation (SF2). We have first demonstrated here that RhoB expression inhibits radiation-induced mitotic cell death. RhoB is present in both a farnesylated and a geranylgeranylated form in vivo. By expressing RhoB mutants encoding for farnesylated (RhoB-F cells), geranylgeranylated or the CAAX deleted form of RhoB, we have then shown that only RhoB-F expression was able to increase the SF2 value by reducing the sensitivity of these cells to radiation-induced mitotic cell death. Moreover, RhoB-F cells showed an increased G2 arrest and an inhibition of centrosome overduplication following irradiation mediated by the Rho-kinase, strongly suggesting that RhoB-F may control centrosome overduplication during the G2 arrest after irradiation. Overall, our results for the first time clearly implicate farnesylated RhoB as a crucial protein in mediating cellular resistance to radiation-induced nonapoptotic cell death. More... »

PAGES

492

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4401586

DOI

http://dx.doi.org/10.1038/sj.cdd.4401586

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045151903

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15776002


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