Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-02

AUTHORS

L Coultas, M Pellegrini, J E Visvader, G J Lindeman, L Chen, J M Adams, D C S Huang, A Strasser

ABSTRACT

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-GL. It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-GL, Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development. More... »

PAGES

185-192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4401204

DOI

http://dx.doi.org/10.1038/sj.cdd.4401204

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008047640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12700646


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