Bag1 is a regulator and marker of neuronal differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-04

AUTHORS

P Kermer, M Krajewska, J M Zapata, S Takayama, J Mai, S Krajewski, J C Reed

ABSTRACT

Bag 1 acts as a co-chaperone for Hsp70/Hsc70. We report here that stable over-expression of Bag1 in immortalized neuronal CSM14.1 cells prevents death following serum deprivation. Bag1 over-expression slowed the proliferative rate of CSM14.1 cells, resulted in increased levels of phospo-MAP kinases and accelerated neuronal differentiation. Immunocytochemistry revealed mostly nuclear localization of Bag1 protein in these cells. However, during differentiation in vitro, Bag1 protein shifted from predominantly nuclear to mostly cytosolic in CSM14.1 cells. To explore in vivo parallels of these findings, we investigated Bag1 expression in the developing mouse nervous system using immunohistochemical methods. Early in brain development, Bag1 was found in nuclei of neuronal precursor cells, whereas cytosolic Bag1 staining was observed mainly after completion of neuronal precursor migration and differentiation. Taken together, these findings raise the possibility that the Bag1 protein is expressed early in neurogenesis in vivo and is capable of modulating neuronal cell survival and differentiation at least in part from a nuclear location. More... »

PAGES

4400972

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4400972

DOI

http://dx.doi.org/10.1038/sj.cdd.4400972

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014924525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11965493


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nervous System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kermer", 
        "givenName": "P", 
        "id": "sg:person.01320733504.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320733504.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krajewska", 
        "givenName": "M", 
        "id": "sg:person.01316271421.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316271421.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zapata", 
        "givenName": "J M", 
        "id": "sg:person.0604455527.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604455527.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takayama", 
        "givenName": "S", 
        "id": "sg:person.010116560357.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010116560357.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
          "id": "https://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA", 
            "Heinrich-Heine Universit\u00e4t D\u00fcsseldorf, Department of Neuroanatomy, Moorenstrasse 5, D-40001 D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mai", 
        "givenName": "J", 
        "id": "sg:person.014000463242.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014000463242.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krajewski", 
        "givenName": "S", 
        "id": "sg:person.015060247134.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015060247134.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reed", 
        "givenName": "J C", 
        "id": "sg:person.010716130457.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010716130457.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb1001-e237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005299981", 
          "https://doi.org/10.1038/ncb1001-e237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1001-e237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005299981", 
          "https://doi.org/10.1038/ncb1001-e237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(99)00284-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006155237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1997.69052075.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006409677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.23.14620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010770087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011289401", 
          "https://doi.org/10.1038/sj.onc.1201147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011289401", 
          "https://doi.org/10.1038/sj.onc.1201147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2000.tb00256.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012856092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.10.2736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015024311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00054.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015817991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.9.3953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016510619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.10.5752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016521672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.25.11465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018881175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(98)01392-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020649212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(90)90308-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022548329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.14.7063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025561662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.2.781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031268505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.16.4887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032337260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.19.11660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034040819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036560370", 
          "https://doi.org/10.1038/35060068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036560370", 
          "https://doi.org/10.1038/35060068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.10.4533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036900664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90410-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041229717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(99)02266-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041297181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.3.1083-1088.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041309407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.27.16985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044050524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(97)80060-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045744716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026409808732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046177154", 
          "https://doi.org/10.1023/a:1026409808732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-4310(99)01599-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048745640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.11.5.9925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/rp.56.1.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064333652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074650569", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074785708", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-10-06364.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082374965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082599016", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb01009.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083009714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083296839", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-04", 
    "datePublishedReg": "2002-04-01", 
    "description": "Bag 1 acts as a co-chaperone for Hsp70/Hsc70. We report here that stable over-expression of Bag1 in immortalized neuronal CSM14.1 cells prevents death following serum deprivation. Bag1 over-expression slowed the proliferative rate of CSM14.1 cells, resulted in increased levels of phospo-MAP kinases and accelerated neuronal differentiation. Immunocytochemistry revealed mostly nuclear localization of Bag1 protein in these cells. However, during differentiation in vitro, Bag1 protein shifted from predominantly nuclear to mostly cytosolic in CSM14.1 cells. To explore in vivo parallels of these findings, we investigated Bag1 expression in the developing mouse nervous system using immunohistochemical methods. Early in brain development, Bag1 was found in nuclei of neuronal precursor cells, whereas cytosolic Bag1 staining was observed mainly after completion of neuronal precursor migration and differentiation. Taken together, these findings raise the possibility that the Bag1 protein is expressed early in neurogenesis in vivo and is capable of modulating neuronal cell survival and differentiation at least in part from a nuclear location.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.cdd.4400972", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2558618", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2446587", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2472321", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Bag1 is a regulator and marker of neuronal differentiation", 
    "pagination": "4400972", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "471b2a2f75a57e4e9e20e21e09a83059c515f2ebf64697d46146f0dc27107d73"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11965493"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9437445"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.cdd.4400972"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014924525"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.cdd.4400972", 
      "https://app.dimensions.ai/details/publication/pub.1014924525"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118342_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/4400972"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400972'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400972'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400972'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400972'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.cdd.4400972 schema:about N001c2515cbe94595a5398c3f3d62ef3d
2 N3d2b474b86844cd3aa36e33af8ea8489
3 N3e3ae63fa12d438697c2824aa28a4127
4 N58b726c05e5a44fab02d8b9505cb32b1
5 N5d5ddc0bc66f45f68041ea3855e8bf10
6 N8f0e528f0e414c2ba10c521394d828b1
7 Nbace378d807446f9b4e47757fb0719d1
8 Ncb271fe8dde5460eab8684c445d7bee3
9 Nce261e4fc6d04dfdb03ccf3a93183567
10 Ndd61f2fcd90a4ad8b19ba83e87eac2e1
11 Nf9787edae55a4844829b71221499b955
12 Nfa6136ca65874f12a9dbf6a3fecc0246
13 Nfc746b5187974fe7b057fcbff2404924
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author N444a1cf295264af9bb781f9808c2aeab
17 schema:citation sg:pub.10.1023/a:1026409808732
18 sg:pub.10.1038/35060068
19 sg:pub.10.1038/ncb1001-e237
20 sg:pub.10.1038/sj.onc.1201147
21 https://app.dimensions.ai/details/publication/pub.1074650569
22 https://app.dimensions.ai/details/publication/pub.1074785708
23 https://app.dimensions.ai/details/publication/pub.1082599016
24 https://app.dimensions.ai/details/publication/pub.1083296839
25 https://doi.org/10.1002/j.1460-2075.1996.tb01009.x
26 https://doi.org/10.1016/0092-8674(95)90410-7
27 https://doi.org/10.1016/0896-6273(90)90308-3
28 https://doi.org/10.1016/s0006-8993(99)02266-0
29 https://doi.org/10.1016/s0166-2236(98)01392-7
30 https://doi.org/10.1016/s0925-4773(99)00284-1
31 https://doi.org/10.1016/s0955-0674(97)80060-9
32 https://doi.org/10.1016/s1357-4310(99)01599-3
33 https://doi.org/10.1046/j.1471-4159.1997.69052075.x
34 https://doi.org/10.1046/j.1471-4159.2001.00054.x
35 https://doi.org/10.1073/pnas.90.10.4533
36 https://doi.org/10.1073/pnas.92.25.11465
37 https://doi.org/10.1073/pnas.93.14.7063
38 https://doi.org/10.1073/pnas.93.9.3953
39 https://doi.org/10.1073/pnas.96.10.5752
40 https://doi.org/10.1074/jbc.273.19.11660
41 https://doi.org/10.1074/jbc.273.23.14620
42 https://doi.org/10.1074/jbc.273.27.16985
43 https://doi.org/10.1074/jbc.274.2.781
44 https://doi.org/10.1093/emboj/16.16.4887
45 https://doi.org/10.1093/emboj/17.10.2736
46 https://doi.org/10.1111/j.1750-3639.2000.tb00256.x
47 https://doi.org/10.1128/mcb.20.3.1083-1088.2000
48 https://doi.org/10.1210/mend.11.5.9925
49 https://doi.org/10.1210/rp.56.1.127
50 https://doi.org/10.1523/jneurosci.15-10-06364.1995
51 schema:datePublished 2002-04
52 schema:datePublishedReg 2002-04-01
53 schema:description Bag 1 acts as a co-chaperone for Hsp70/Hsc70. We report here that stable over-expression of Bag1 in immortalized neuronal CSM14.1 cells prevents death following serum deprivation. Bag1 over-expression slowed the proliferative rate of CSM14.1 cells, resulted in increased levels of phospo-MAP kinases and accelerated neuronal differentiation. Immunocytochemistry revealed mostly nuclear localization of Bag1 protein in these cells. However, during differentiation in vitro, Bag1 protein shifted from predominantly nuclear to mostly cytosolic in CSM14.1 cells. To explore in vivo parallels of these findings, we investigated Bag1 expression in the developing mouse nervous system using immunohistochemical methods. Early in brain development, Bag1 was found in nuclei of neuronal precursor cells, whereas cytosolic Bag1 staining was observed mainly after completion of neuronal precursor migration and differentiation. Taken together, these findings raise the possibility that the Bag1 protein is expressed early in neurogenesis in vivo and is capable of modulating neuronal cell survival and differentiation at least in part from a nuclear location.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N3efe2f9a98d44d8e92612a5d4a55b15c
58 Ne70b8bd6257e406aa0f45a5f4255eb60
59 sg:journal.1112551
60 schema:name Bag1 is a regulator and marker of neuronal differentiation
61 schema:pagination 4400972
62 schema:productId N0ce703154e9c4792ae3b1dde29706ba2
63 N129ca0a83e7249b187042febe0e38553
64 N138162ec983344758383882122425bca
65 N1b273e6716254ada97c89d870b972177
66 N1f721b36cb704ff0b0f4be4eeb43b9e0
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014924525
68 https://doi.org/10.1038/sj.cdd.4400972
69 schema:sdDatePublished 2019-04-11T12:06
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N7eba42d21f5a4c26b76faba80132da01
72 schema:url http://www.nature.com/articles/4400972
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N001c2515cbe94595a5398c3f3d62ef3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Animals
78 rdf:type schema:DefinedTerm
79 N0ce703154e9c4792ae3b1dde29706ba2 schema:name doi
80 schema:value 10.1038/sj.cdd.4400972
81 rdf:type schema:PropertyValue
82 N129ca0a83e7249b187042febe0e38553 schema:name dimensions_id
83 schema:value pub.1014924525
84 rdf:type schema:PropertyValue
85 N138162ec983344758383882122425bca schema:name readcube_id
86 schema:value 471b2a2f75a57e4e9e20e21e09a83059c515f2ebf64697d46146f0dc27107d73
87 rdf:type schema:PropertyValue
88 N1b273e6716254ada97c89d870b972177 schema:name nlm_unique_id
89 schema:value 9437445
90 rdf:type schema:PropertyValue
91 N1f721b36cb704ff0b0f4be4eeb43b9e0 schema:name pubmed_id
92 schema:value 11965493
93 rdf:type schema:PropertyValue
94 N3d2b474b86844cd3aa36e33af8ea8489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Biomarkers
96 rdf:type schema:DefinedTerm
97 N3e3ae63fa12d438697c2824aa28a4127 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cell Death
99 rdf:type schema:DefinedTerm
100 N3efe2f9a98d44d8e92612a5d4a55b15c schema:issueNumber 4
101 rdf:type schema:PublicationIssue
102 N4445ed79e5f54756b731f80bfd5ceaaf rdf:first sg:person.010116560357.66
103 rdf:rest N7d80e75fc837430ba05289062ea9a65f
104 N444a1cf295264af9bb781f9808c2aeab rdf:first sg:person.01320733504.88
105 rdf:rest Ne61f09ce7339445cbf94b41406dd769e
106 N50fcdecae4b247deb3511d0315b0c33c rdf:first sg:person.015060247134.41
107 rdf:rest Ne3f874a12837484099b971bf21d9a20b
108 N58b726c05e5a44fab02d8b9505cb32b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Neurons
110 rdf:type schema:DefinedTerm
111 N5d5ddc0bc66f45f68041ea3855e8bf10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name DNA-Binding Proteins
113 rdf:type schema:DefinedTerm
114 N7d80e75fc837430ba05289062ea9a65f rdf:first sg:person.014000463242.09
115 rdf:rest N50fcdecae4b247deb3511d0315b0c33c
116 N7eba42d21f5a4c26b76faba80132da01 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N83e44d97fe974faca19e9044d02bcf45 rdf:first sg:person.0604455527.45
119 rdf:rest N4445ed79e5f54756b731f80bfd5ceaaf
120 N8f0e528f0e414c2ba10c521394d828b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Transcription Factors
122 rdf:type schema:DefinedTerm
123 Nbace378d807446f9b4e47757fb0719d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name MAP Kinase Signaling System
125 rdf:type schema:DefinedTerm
126 Ncb271fe8dde5460eab8684c445d7bee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mice
128 rdf:type schema:DefinedTerm
129 Nce261e4fc6d04dfdb03ccf3a93183567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Line
131 rdf:type schema:DefinedTerm
132 Ndd61f2fcd90a4ad8b19ba83e87eac2e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Membrane Proteins
134 rdf:type schema:DefinedTerm
135 Ne3f874a12837484099b971bf21d9a20b rdf:first sg:person.010716130457.66
136 rdf:rest rdf:nil
137 Ne61f09ce7339445cbf94b41406dd769e rdf:first sg:person.01316271421.35
138 rdf:rest N83e44d97fe974faca19e9044d02bcf45
139 Ne70b8bd6257e406aa0f45a5f4255eb60 schema:volumeNumber 9
140 rdf:type schema:PublicationVolume
141 Nf9787edae55a4844829b71221499b955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Differentiation
143 rdf:type schema:DefinedTerm
144 Nfa6136ca65874f12a9dbf6a3fecc0246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Nervous System
146 rdf:type schema:DefinedTerm
147 Nfc746b5187974fe7b057fcbff2404924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Culture Media
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
154 schema:name Neurosciences
155 rdf:type schema:DefinedTerm
156 sg:grant.2446587 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cdd.4400972
157 rdf:type schema:MonetaryGrant
158 sg:grant.2472321 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cdd.4400972
159 rdf:type schema:MonetaryGrant
160 sg:grant.2558618 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.cdd.4400972
161 rdf:type schema:MonetaryGrant
162 sg:journal.1112551 schema:issn 1350-9047
163 1476-5403
164 schema:name Cell Death & Differentiation
165 rdf:type schema:Periodical
166 sg:person.010116560357.66 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
167 schema:familyName Takayama
168 schema:givenName S
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010116560357.66
170 rdf:type schema:Person
171 sg:person.010716130457.66 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
172 schema:familyName Reed
173 schema:givenName J C
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010716130457.66
175 rdf:type schema:Person
176 sg:person.01316271421.35 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
177 schema:familyName Krajewska
178 schema:givenName M
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316271421.35
180 rdf:type schema:Person
181 sg:person.01320733504.88 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
182 schema:familyName Kermer
183 schema:givenName P
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320733504.88
185 rdf:type schema:Person
186 sg:person.014000463242.09 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
187 schema:familyName Mai
188 schema:givenName J
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014000463242.09
190 rdf:type schema:Person
191 sg:person.015060247134.41 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
192 schema:familyName Krajewski
193 schema:givenName S
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015060247134.41
195 rdf:type schema:Person
196 sg:person.0604455527.45 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
197 schema:familyName Zapata
198 schema:givenName J M
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604455527.45
200 rdf:type schema:Person
201 sg:pub.10.1023/a:1026409808732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046177154
202 https://doi.org/10.1023/a:1026409808732
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/35060068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036560370
205 https://doi.org/10.1038/35060068
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ncb1001-e237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005299981
208 https://doi.org/10.1038/ncb1001-e237
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/sj.onc.1201147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011289401
211 https://doi.org/10.1038/sj.onc.1201147
212 rdf:type schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1074650569 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1074785708 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1082599016 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1083296839 schema:CreativeWork
217 https://doi.org/10.1002/j.1460-2075.1996.tb01009.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1083009714
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0092-8674(95)90410-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041229717
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0896-6273(90)90308-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022548329
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0006-8993(99)02266-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041297181
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0166-2236(98)01392-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020649212
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0925-4773(99)00284-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006155237
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0955-0674(97)80060-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045744716
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1357-4310(99)01599-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048745640
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1046/j.1471-4159.1997.69052075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006409677
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1046/j.1471-4159.2001.00054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015817991
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.90.10.4533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036900664
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.92.25.11465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018881175
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1073/pnas.93.14.7063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025561662
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.93.9.3953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016510619
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1073/pnas.96.10.5752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016521672
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.273.19.11660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034040819
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.273.23.14620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010770087
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.273.27.16985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044050524
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1074/jbc.274.2.781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031268505
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/emboj/16.16.4887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032337260
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/emboj/17.10.2736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015024311
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1750-3639.2000.tb00256.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012856092
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/mcb.20.3.1083-1088.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041309407
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1210/mend.11.5.9925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331458
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1210/rp.56.1.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064333652
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1523/jneurosci.15-10-06364.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082374965
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.411327.2 schema:alternateName Heinrich Heine University Düsseldorf
270 schema:name Heinrich-Heine Universität Düsseldorf, Department of Neuroanatomy, Moorenstrasse 5, D-40001 Düsseldorf, Germany
271 The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
274 schema:name The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, California, CA 92037, USA
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...