The role of the tumor suppressor p53 in spermatogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-08

AUTHORS

Tim L Beumer, Hermien L Roepers-Gajadien, Iris S Gademan, Paul PW van Buul, Gabriel Gil-Gomez, Derek H Rutgers, Dirk G de Rooij

ABSTRACT

The p53 protein appeared to be involved in both spermatogonial cell proliferation and radiation response. During normal spermatogenesis in the mouse, spermatogonia do not express p53, as analyzed by immunohistochemistry. However, after a dose of 4 Gy of X-rays, a distinct p53 staining was present in spermatogonia, suggesting that, in contrast to other reports, p53 does have a role in spermatogonia. To determine the possible role of p53 in spermatogonia, histological analysis was performed in testes of both p53 knock out C57BL/6 and FvB mice. The results indicate that p53 is an important factor in normal spermatogonial cell production as well as in the regulation of apoptosis after DNA damage. First, p53 knock out mouse testes contained about 50% higher numbers of A1 spermatogonia, indicating that the production of differentiating type spermatogonia by the undifferentiated spermatogonia is enhanced in these mice. Second, 10 days after a dose of 5 Gy of X-rays, in the p53 knock out testes, increased numbers of giant sized spermatogonial stem cells were found, indicating disturbance of the apoptotic process in these cells. Third, in the p53 knock out testis, the differentiating A2-B spermatogonia are more radioresistant compared to their wild-type controls, indicating that p53 is partly indispensable in the removal of lethally irradiated differentiating type spermatogonia. In accordance with our immunohistochemical data, Western analysis showed that levels of p53 are increased in total adult testis lysates after irradiation. These data show that p53 is important in the regulation of cell production during normal spermatogenesis either by regulation of cell proliferation or, more likely, by regulating the apoptotic process in spermatogonia. Furthermore, after irradiation, p53 is important in the removal of lethally damaged spermatogonia. More... »

PAGES

4400396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4400396

DOI

http://dx.doi.org/10.1038/sj.cdd.4400396

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028299035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10200522


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158 schema:name MGC-Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratory, Leiden University, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
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160 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
161 schema:name Department of Radiotherapy, Academic Hospital Utrecht, Heidelberglaan 100 Utrecht, The Netherlands
162 rdf:type schema:Organization
 




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