Ontology type: schema:ScholarlyArticle Open Access: True
1998-05
AUTHORSAndrea Tasinato, Dale E Bredesen, James JL Wang, Nuria Assa-Munt, Sabina Sperandio, Shahrooz Rabizadeh, Xin Ye
ABSTRACTCells depend on specific stimuli, such as trophic factors, for survival and in the absence of such stimuli, undergo apoptosis. How do cells initiate apoptosis in response to the withdrawal of trophic factors or other dependent stimuli? Recent studies of apoptosis induction by neurotrophin withdrawal argue for a novel form of pro-apoptotic signal transduction - 'negative signal transduction' - in which the absence of ligand-receptor interaction induces cell death. We have found that the prototype for this form of signaling - the common neurotrophin receptor, p75NTR - creates a state of cellular dependence (or addiction) on neurotrophins, and that this effect requires an 'addiction/dependence domain' (ADD) in the intracytoplasmic region of p75NTR. We have recently found other receptors that include dependence domains, arguing that dependence receptors, and their associated dependence domains, may be involved in a rather general mechanism to create cellular states of dependence on trophic factors, cytokines, adhesion, electrical activity and other dependent stimuli. More... »
PAGES365
http://scigraph.springernature.com/pub.10.1038/sj.cdd.4400378
DOIhttp://dx.doi.org/10.1038/sj.cdd.4400378
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10200485
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