Egr-1 inhibits apoptosis during the UV response: correlation of cell survival with Egr-1 phosphorylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-01

AUTHORS

Ruo-Pan Huang, Yan Fan, Ian deBelle, Zhengyu Ni, Wynette Matheny, Eileen D Adamson

ABSTRACT

UV irradiation of normal or immortalized cells induces a rapid increase in the expression of several transcription factors and is thought to serve a protective function. The human fibrosarcoma cell line, HT1080 clone H4, expresses almost undetectable levels of Egr-1 and does not respond to UV-C irradiation by the induction of Egr-1. The H4 cells are hypersensitive to UV which induces apoptosis and reduces clonogenicity. The introduction of exogenous Egr-1 into H4 (H4E9 and H4E4 cell-lines) confers protection from UV damage as measured by a number of assays. In both NIH3T3 (with inducible Egr-1) and H4E9 (constitutive Egr-1) cells, UV irradiation gave enhanced transactivation of Egr-1 reporters that correlated with phosphorylated Egr-1. Studies using inhibitors indicated that protein kinase-C and tyrosine kinases are involved in the anti-apoptotic effects of Egr-1 after UV damage. This is the first description of a biological effect of phosphorylated Egr-1. More... »

PAGES

4400322

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.cdd.4400322

DOI

http://dx.doi.org/10.1038/sj.cdd.4400322

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044892511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10200450


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