Multicenter study of intravenous busulfan, cyclophosphamide, and etoposide (i.v. Bu/Cy/E) as conditioning regimen for autologous stem cell transplantation in patients ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-11

AUTHORS

J G Kim, S K Sohn, Y S Chae, D H Yang, J-J Lee, H-J Kim, H J Shin, J S Jung, W S Kim, D H Kim, C Suh, S J Kim, H-S Eom, S H Bae

ABSTRACT

The current study aimed to evaluate the efficacy and toxicity of a combination of intravenous busulfan, cyclophosphamide and etoposide (i.v. Bu/Cy/E) as a conditioning regimen prior to autologous hematopoietic stem cell transplantation in patients with non-Hodgkin's lymphoma (NHL). Sixty-four patients with relapsed/refractory (n=36) or high-risk (n=28) lymphoma were enrolled. The high-dose chemotherapy consisted of i.v. Bu (0.8 mg kg(-1) i.v. q 6 h from day -7 to day -5), Cy (50 mg kg(-1) i.v. on day -3 and day -2) and E (400 mg m(-2) i.v. on day -5 and day -4). The median age was 43 (range 18-65) years, and 39 patients were male. Diffuse large B-cell lymphoma (40.6%) was the most common histological subtype. All evaluable patients achieved an engraftment of neutrophils (median, day 12) and platelets (median, day 13). Hepatic veno-occlusive disease was observed in four patients (three mild, one moderate grade), and two patients (3.1%) died from treatment-related complications. At a median follow-up of 16.4 months, 15 patients (23.4%) exhibited a relapse or progression, while 13 patients (20.3%) had died of disease. The estimated 3-year overall and progression-free survival for all patients was 72.1 and 70.1%, respectively. In conclusion, the conditioning regimen of i.v. Bu/Cy/E was well tolerated and seemed to be effective in patients with aggressive NHL. More... »

PAGES

919

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705841

DOI

http://dx.doi.org/10.1038/sj.bmt.1705841

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041304996

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17846602


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705841'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705841'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705841'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705841'


 

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312 schema:name Division of Hematology and Oncology, Department of Internal Medicine, Korea University Medical Center, Seoul, Korea
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314 https://www.grid.ac/institutes/grid.411597.f schema:alternateName Chonnam National University Hospital
315 schema:name Department of Hematology/Oncology, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea
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317 https://www.grid.ac/institutes/grid.412072.2 schema:alternateName Daegu Catholic University Medical Center
318 schema:name Department of Oncology/Hematology, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, Daegu, Korea
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320 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
321 schema:name Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
322 rdf:type schema:Organization
 




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