Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-10

AUTHORS

E D Batts, H M Lazarus

ABSTRACT

Transplantation-associated thrombotic microangiopathy (TA-TMA) is an infrequent but devastating syndrome that occurs in allogeneic hematopoietic stem cell transplant recipients, and is associated with a variety of transplantation-related factors, including conditioning regimens, immunosuppressive agents, GVHD and opportunistic infections. Progress in managing this condition has been hampered by lack of a consensus definition and poor understanding of the pathophysiology of the disorder. Two different groups recently have proposed consensus definitions, yet they fail to distinguish the primary syndrome from the secondary causes, such as a variety of infections, medication exposure or other conditions. Increasing evidence suggests that TA-TMA is a multifactorial disorder that is distinct from thrombotic thrombocytopenic purpura (TTP), and likely represents the final common pathway of a number of endothelial cell insults. TA-TMA responds poorly to conventional treatment for TTP, including plasma exchange, but newer agents, including daclizumab and defibrotide show promise. In addition, other agents known to modify endothelial responses to injury, including statins, prostacyclin analogues, endothelin-receptor antagonists and free radical scavengers, may lead to improved outcomes for patients affected by this disorder. More... »

PAGES

709

References to SciGraph publications

  • 1989-02. Cyclosporine toxicity on cultured rat microvascular endothelial cells in KIDNEY INTERNATIONAL
  • 2000-01. A case of hemolytic uremic syndrome improved with nitric oxide in BONE MARROW TRANSPLANTATION
  • 2001-10. Oral eicosapentaenoic acid for complications of bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2001-10. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura in NATURE
  • 1997-05. Endothelial cell markers in bone marrow transplant recipients with and without acute graft-versus-host disease in BONE MARROW TRANSPLANTATION
  • 2002-12. Transplantation-associated thrombotic microangiopathy: twenty-two years later in BONE MARROW TRANSPLANTATION
  • 1998-06. Thrombotic microangiopathy of hyperacute onset after autologous peripheral blood stem cell transplantation in malignant lymphoma in BONE MARROW TRANSPLANTATION
  • 1998-04. Diagnostic value of hemostatic parameters in bone marrow transplant-associated thrombotic microangiopathy in BONE MARROW TRANSPLANTATION
  • 2004-06. Thrombotic microangiopathy after allogeneic bone marrow transplantation: a pathologic abnormality associated with diverse clinical syndromes in BONE MARROW TRANSPLANTATION
  • 2000-11. Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities in BONE MARROW TRANSPLANTATION
  • 2004-01. Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention in BONE MARROW TRANSPLANTATION
  • 2005-12. Transplant-associated microangiopathy (TAM) in recipients of allogeneic hematopoietic stem cell transplants in BONE MARROW TRANSPLANTATION
  • 2003-03. Endothelial damage caused by cytomegalovirus and human herpesvirus-6 in BONE MARROW TRANSPLANTATION
  • 2006-09. Replacement of calcineurin inhibitors with daclizumab in patients with transplantation-associated microangiopathy or renal insufficiency associated with graft-versus-host disease in BONE MARROW TRANSPLANTATION
  • 1998-03. Endothelial dysfunction after bone marrow transplantation: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications in ANNALS OF HEMATOLOGY
  • 2006-02. Decrease in circulating endothelial cell adhesion molecule and thrombomodulin levels during oral iloprost treatment in rheumatoid arthritis patients: preliminary results in RHEUMATOLOGY INTERNATIONAL
  • 2001-07. Treatment of severe steroid refractory acute graft-versus-host disease with infliximab, a chimeric human/mouse antiTNFα antibody in BONE MARROW TRANSPLANTATION
  • 1999-10. Thrombotic microangiopathy associated with reactivation of human herpesvirus-6 following high-dose chemotherapy with autologous bone marrow transplantation in young children in BONE MARROW TRANSPLANTATION
  • 1998-08. Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis in BONE MARROW TRANSPLANTATION
  • 1998-02. Hemolytic uremic syndrome after allogeneic or autologous hematopoietic stem cell transplantation for childhood malignancies in BONE MARROW TRANSPLANTATION
  • 2000-11. Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2006-06. Combination antithymocyte globulin and soluble TNFα inhibitor (etanercept) +/− mycophenolate mofetil for treatment of steroid refractory acute graft-versus-host disease in BONE MARROW TRANSPLANTATION
  • 2001-03. Thrombotic thrombocytopenic purpura-like syndromes following bone marrow transplantation: an analysis of associated conditions and clinical outcomes in BONE MARROW TRANSPLANTATION
  • 2002-03. Defibrotide as a promising treatment for thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2001. Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy. in HAEMATOLOGICA
  • 2002-06. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome following allogeneic bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 1999-07. Severe thrombotic microangiopathy: an infrequent complication of bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2005-11. Significance of elevation in cell-derived microparticles after allogeneic stem cell transplantation: transient elevation of platelet-drived microparticles in TMA/TTP in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705758

    DOI

    http://dx.doi.org/10.1038/sj.bmt.1705758

    DIMENSIONS

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    PUBMED

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