Safety of vaccinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-09

AUTHORS

A Y H Leung, H C H Chow, J S Y Kwok, C K H Lui, V C C Cheng, K-Y Yuen, A K W Lie, R Liang

ABSTRACT

Reactivation of varicella zoster virus (VZV), clinically manifested as herpes zoster (HZ) is a common complication after hematopoietic stem cell transplantation (HSCT). The optimum prophylaxis for this disease has not been defined. In this study, we examined the effects of vaccinating donors with a live-attenuated vaccine with particular reference to their immune responses and the outcome of HSCT patients. Forty prospective HLA-matched sibling donors were vaccinated before HSCT. There were humoral immune responses in both sero-positive (P<0.01) and sero-negative (P=0.058) donors. Cellular immune response was assayed in 26 donors. Significant correlation was observed between cellular immune responses as enumerated by thymidine incorporation and interferon γ secretion (P<0.001) and the latter was used in subsequent analyses. Significant response was observed in sero-negative (6/26) and a group of sero-positive (13/26) donors while 7/26 sero-positive donors showed no response. Thirty-four HSCT were performed. These patients have a lower, albeit insignificant, risk of HZ compared with historical controls and only 3/34 patients developed single dermatomal HZ at 6, 9 and 28 months after HSCT. No patients developed VZV-related mortality. Vaccinating donors with live-attenuated VZV vaccine was safe, but whether it confers a significant protection to the patients would require further study. More... »

PAGES

661-665

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705673

DOI

http://dx.doi.org/10.1038/sj.bmt.1705673

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041149133

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17417658


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickenpox Vaccine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Herpes Zoster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Safety", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Siblings", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Donors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leung", 
        "givenName": "A Y H", 
        "id": "sg:person.011121156664.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121156664.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chow", 
        "givenName": "H C H", 
        "id": "sg:person.010004444262.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010004444262.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwok", 
        "givenName": "J S Y", 
        "id": "sg:person.013166240242.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013166240242.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lui", 
        "givenName": "C K H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "V C C", 
        "id": "sg:person.010741026134.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010741026134.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuen", 
        "givenName": "K-Y", 
        "id": "sg:person.011623652602.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623652602.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lie", 
        "givenName": "A K W", 
        "id": "sg:person.014425311664.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014425311664.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China", 
          "id": "http://www.grid.ac/institutes/grid.194645.b", 
          "name": [
            "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liang", 
        "givenName": "R", 
        "id": "sg:person.07707430152.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07707430152.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1702190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037720825", 
          "https://doi.org/10.1038/sj.bmt.1702190"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-09", 
    "datePublishedReg": "2007-04-09", 
    "description": "Reactivation of varicella zoster virus (VZV), clinically manifested as herpes zoster (HZ) is a common complication after hematopoietic stem cell transplantation (HSCT). The optimum prophylaxis for this disease has not been defined. In this study, we examined the effects of vaccinating donors with a live-attenuated vaccine with particular reference to their immune responses and the outcome of HSCT patients. Forty prospective HLA-matched sibling donors were vaccinated before HSCT. There were humoral immune responses in both sero-positive (P<0.01) and sero-negative (P=0.058) donors. Cellular immune response was assayed in 26 donors. Significant correlation was observed between cellular immune responses as enumerated by thymidine incorporation and interferon \u03b3 secretion (P<0.001) and the latter was used in subsequent analyses. Significant response was observed in sero-negative (6/26) and a group of sero-positive (13/26) donors while 7/26 sero-positive donors showed no response. Thirty-four HSCT were performed. These patients have a lower, albeit insignificant, risk of HZ compared with historical controls and only 3/34 patients developed single dermatomal HZ at 6, 9 and 28 months after HSCT. No patients developed VZV-related mortality. Vaccinating donors with live-attenuated VZV vaccine was safe, but whether it confers a significant protection to the patients would require further study.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.bmt.1705673", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "keywords": [
      "hematopoietic stem cell transplantation", 
      "varicella-zoster virus", 
      "sero-positive donors", 
      "stem cell transplantation", 
      "cellular immune responses", 
      "herpes zoster", 
      "immune response", 
      "cell transplantation", 
      "risk of HZ", 
      "interferon \u03b3 secretion", 
      "dermatomal herpes zoster", 
      "varicella zoster vaccine", 
      "humoral immune response", 
      "optimum prophylaxis", 
      "prospective HLA", 
      "\u03b3 secretion", 
      "zoster vaccine", 
      "HSCT patients", 
      "sibling donors", 
      "common complication", 
      "VZV vaccine", 
      "zoster virus", 
      "historical controls", 
      "patients", 
      "significant protection", 
      "thymidine incorporation", 
      "vaccine", 
      "Further studies", 
      "transplantation", 
      "significant correlation", 
      "donors", 
      "significant response", 
      "response", 
      "zoster", 
      "prophylaxis", 
      "complications", 
      "HLA", 
      "mortality", 
      "vaccinating", 
      "disease", 
      "secretion", 
      "months", 
      "outcomes", 
      "virus", 
      "risk", 
      "study", 
      "reactivation", 
      "safety", 
      "subsequent analysis", 
      "group", 
      "particular reference", 
      "control", 
      "correlation", 
      "effect", 
      "protection", 
      "insignificant", 
      "analysis", 
      "incorporation", 
      "reference"
    ], 
    "name": "Safety of vaccinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation", 
    "pagination": "661-665", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041149133"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1705673"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17417658"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1705673", 
      "https://app.dimensions.ai/details/publication/pub.1041149133"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_438.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.bmt.1705673"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705673'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705673'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705673'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705673'


 

This table displays all metadata directly associated to this object as RDF triples.

236 TRIPLES      21 PREDICATES      100 URIs      91 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1705673 schema:about N0b837d67346f453a80c27187b1a20a27
2 N132126ca4dfb4978b10d368e6f6f2124
3 N18004f57c21d425db02c0301abff1dfa
4 N2784ca2f524646c78cf7b7b152d8a71c
5 N3232e8a209884d17b9d58ac98dd97da8
6 N3fd14d53d3e14c65bd268dbec007e37e
7 N49391aeb1e1c4fba89462001d4bb4d6b
8 N4fae4a645a0b4e4c966dadf9ccd73ab4
9 N674db35c538646afb215765e20edb2a9
10 N6fdd38eb838e42d8b81c89d02f58ec6e
11 N8e40ef4cf7704570a5236ec730f64e0b
12 Nb220a66cbcd84976962b94ae3e0ed945
13 Nbe2c46b554ca4b0e8f93bfbdeb99e18e
14 Nd5252552311149259c658d5ee3635cc0
15 Ne2001555495d415ab98e67efc8051e66
16 anzsrc-for:11
17 anzsrc-for:1107
18 schema:author N38bd887cd7164dc592cf96db7610a234
19 schema:citation sg:pub.10.1038/sj.bmt.1702190
20 schema:datePublished 2007-04-09
21 schema:datePublishedReg 2007-04-09
22 schema:description Reactivation of varicella zoster virus (VZV), clinically manifested as herpes zoster (HZ) is a common complication after hematopoietic stem cell transplantation (HSCT). The optimum prophylaxis for this disease has not been defined. In this study, we examined the effects of vaccinating donors with a live-attenuated vaccine with particular reference to their immune responses and the outcome of HSCT patients. Forty prospective HLA-matched sibling donors were vaccinated before HSCT. There were humoral immune responses in both sero-positive (P<0.01) and sero-negative (P=0.058) donors. Cellular immune response was assayed in 26 donors. Significant correlation was observed between cellular immune responses as enumerated by thymidine incorporation and interferon γ secretion (P<0.001) and the latter was used in subsequent analyses. Significant response was observed in sero-negative (6/26) and a group of sero-positive (13/26) donors while 7/26 sero-positive donors showed no response. Thirty-four HSCT were performed. These patients have a lower, albeit insignificant, risk of HZ compared with historical controls and only 3/34 patients developed single dermatomal HZ at 6, 9 and 28 months after HSCT. No patients developed VZV-related mortality. Vaccinating donors with live-attenuated VZV vaccine was safe, but whether it confers a significant protection to the patients would require further study.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N7189f94edc1b4956a8364658f57aa7e1
26 N7f85ca25319b4ae7a44887f226f39949
27 sg:journal.1096890
28 schema:keywords Further studies
29 HLA
30 HSCT patients
31 VZV vaccine
32 analysis
33 cell transplantation
34 cellular immune responses
35 common complication
36 complications
37 control
38 correlation
39 dermatomal herpes zoster
40 disease
41 donors
42 effect
43 group
44 hematopoietic stem cell transplantation
45 herpes zoster
46 historical controls
47 humoral immune response
48 immune response
49 incorporation
50 insignificant
51 interferon γ secretion
52 months
53 mortality
54 optimum prophylaxis
55 outcomes
56 particular reference
57 patients
58 prophylaxis
59 prospective HLA
60 protection
61 reactivation
62 reference
63 response
64 risk
65 risk of HZ
66 safety
67 secretion
68 sero-positive donors
69 sibling donors
70 significant correlation
71 significant protection
72 significant response
73 stem cell transplantation
74 study
75 subsequent analysis
76 thymidine incorporation
77 transplantation
78 vaccinating
79 vaccine
80 varicella zoster vaccine
81 varicella-zoster virus
82 virus
83 zoster
84 zoster vaccine
85 zoster virus
86 γ secretion
87 schema:name Safety of vaccinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation
88 schema:pagination 661-665
89 schema:productId N198626e5110d434b8321033ca673f10d
90 N5d76f707f696422f8be134faab49541f
91 N8069efb1d53d498aa167304e1c1c28a6
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041149133
93 https://doi.org/10.1038/sj.bmt.1705673
94 schema:sdDatePublished 2022-11-24T20:52
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N4b0fd18581024a72b90439846fef1e39
97 schema:url https://doi.org/10.1038/sj.bmt.1705673
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0b837d67346f453a80c27187b1a20a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Transplantation, Homologous
103 rdf:type schema:DefinedTerm
104 N132126ca4dfb4978b10d368e6f6f2124 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Adult
106 rdf:type schema:DefinedTerm
107 N18004f57c21d425db02c0301abff1dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Male
109 rdf:type schema:DefinedTerm
110 N198626e5110d434b8321033ca673f10d schema:name doi
111 schema:value 10.1038/sj.bmt.1705673
112 rdf:type schema:PropertyValue
113 N1d1799f7418e496dbb1e18e5775cbe52 rdf:first sg:person.010004444262.39
114 rdf:rest N8ee4d6ecd193475983b6ee647120841d
115 N227afc9140fe440da6cbdce5c86f19be schema:affiliation grid-institutes:grid.194645.b
116 schema:familyName Lui
117 schema:givenName C K H
118 rdf:type schema:Person
119 N234d504f288c4473bebbb1254526656c rdf:first sg:person.07707430152.30
120 rdf:rest rdf:nil
121 N2784ca2f524646c78cf7b7b152d8a71c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Leukemia
123 rdf:type schema:DefinedTerm
124 N30396b97106c47788a0038d425d74c99 rdf:first N227afc9140fe440da6cbdce5c86f19be
125 rdf:rest N45754031490d42919cde7a93e05aa203
126 N3232e8a209884d17b9d58ac98dd97da8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Female
128 rdf:type schema:DefinedTerm
129 N38bd887cd7164dc592cf96db7610a234 rdf:first sg:person.011121156664.42
130 rdf:rest N1d1799f7418e496dbb1e18e5775cbe52
131 N3fd14d53d3e14c65bd268dbec007e37e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Chickenpox Vaccine
133 rdf:type schema:DefinedTerm
134 N45754031490d42919cde7a93e05aa203 rdf:first sg:person.010741026134.27
135 rdf:rest Nf25bf6be50ee48bda484267dde800007
136 N46edd6a6052142c1b0965f62c37291f6 rdf:first sg:person.014425311664.90
137 rdf:rest N234d504f288c4473bebbb1254526656c
138 N49391aeb1e1c4fba89462001d4bb4d6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Hematopoietic Stem Cell Transplantation
140 rdf:type schema:DefinedTerm
141 N4b0fd18581024a72b90439846fef1e39 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N4fae4a645a0b4e4c966dadf9ccd73ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Tissue Donors
145 rdf:type schema:DefinedTerm
146 N5d76f707f696422f8be134faab49541f schema:name dimensions_id
147 schema:value pub.1041149133
148 rdf:type schema:PropertyValue
149 N674db35c538646afb215765e20edb2a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Herpes Zoster
151 rdf:type schema:DefinedTerm
152 N6fdd38eb838e42d8b81c89d02f58ec6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 N7189f94edc1b4956a8364658f57aa7e1 schema:volumeNumber 39
156 rdf:type schema:PublicationVolume
157 N7f85ca25319b4ae7a44887f226f39949 schema:issueNumber 11
158 rdf:type schema:PublicationIssue
159 N8069efb1d53d498aa167304e1c1c28a6 schema:name pubmed_id
160 schema:value 17417658
161 rdf:type schema:PropertyValue
162 N8e40ef4cf7704570a5236ec730f64e0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adolescent
164 rdf:type schema:DefinedTerm
165 N8ee4d6ecd193475983b6ee647120841d rdf:first sg:person.013166240242.92
166 rdf:rest N30396b97106c47788a0038d425d74c99
167 Nb220a66cbcd84976962b94ae3e0ed945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Treatment Outcome
169 rdf:type schema:DefinedTerm
170 Nbe2c46b554ca4b0e8f93bfbdeb99e18e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Safety
172 rdf:type schema:DefinedTerm
173 Nd5252552311149259c658d5ee3635cc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Siblings
175 rdf:type schema:DefinedTerm
176 Ne2001555495d415ab98e67efc8051e66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Middle Aged
178 rdf:type schema:DefinedTerm
179 Nf25bf6be50ee48bda484267dde800007 rdf:first sg:person.011623652602.78
180 rdf:rest N46edd6a6052142c1b0965f62c37291f6
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
185 schema:name Immunology
186 rdf:type schema:DefinedTerm
187 sg:journal.1096890 schema:issn 0268-3369
188 1476-5365
189 schema:name Bone Marrow Transplantation
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.010004444262.39 schema:affiliation grid-institutes:grid.194645.b
193 schema:familyName Chow
194 schema:givenName H C H
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010004444262.39
196 rdf:type schema:Person
197 sg:person.010741026134.27 schema:affiliation grid-institutes:grid.194645.b
198 schema:familyName Cheng
199 schema:givenName V C C
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010741026134.27
201 rdf:type schema:Person
202 sg:person.011121156664.42 schema:affiliation grid-institutes:grid.194645.b
203 schema:familyName Leung
204 schema:givenName A Y H
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121156664.42
206 rdf:type schema:Person
207 sg:person.011623652602.78 schema:affiliation grid-institutes:grid.194645.b
208 schema:familyName Yuen
209 schema:givenName K-Y
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623652602.78
211 rdf:type schema:Person
212 sg:person.013166240242.92 schema:affiliation grid-institutes:grid.194645.b
213 schema:familyName Kwok
214 schema:givenName J S Y
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013166240242.92
216 rdf:type schema:Person
217 sg:person.014425311664.90 schema:affiliation grid-institutes:grid.194645.b
218 schema:familyName Lie
219 schema:givenName A K W
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014425311664.90
221 rdf:type schema:Person
222 sg:person.07707430152.30 schema:affiliation grid-institutes:grid.194645.b
223 schema:familyName Liang
224 schema:givenName R
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07707430152.30
226 rdf:type schema:Person
227 sg:pub.10.1038/sj.bmt.1702190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037720825
228 https://doi.org/10.1038/sj.bmt.1702190
229 rdf:type schema:CreativeWork
230 grid-institutes:grid.194645.b schema:alternateName Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
231 Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
232 Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
233 schema:name Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
234 Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
235 Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
236 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...