Ontology type: schema:ScholarlyArticle Open Access: True
2007-06
AUTHORST Vu, G Carrum, G Hutton, H E Heslop, M K Brenner, R Kamble
ABSTRACTImmunosuppressive monoclonal antibodies directed to immune system cells may reduce rejection and graft versus host disease (GvHD) after allogeneic stem cell transplantation (SCT), but can increase the risks of viral infection. Here, we report human herpes virus-6 (HHV-6) encephalitis despite antiviral prophylaxis in 5 of 43 (11.6%) patients receiving alemtuzumab supported conditioning. Encephalitis occurred at 41-103 days (median 60 days) presenting with confusion in all patients, combined with amnesia (n=3) or seizures (n=2). MRI revealed non-specific white matter changes in two and a non-enhancing medial temporal lobe lesion in three patients. Cerebrospinal fluid (CSF) PCR amplification for HHV-6 was positive in all five patients, (600-2 25 000 (median 4700) copies/ml CSF), while analysis of peripheral blood revealed 100-22 500 (median 1200) viral copies/ml plasma. CSF protein was elevated in four patients, with minimal CSF pleocytosis. Intravenous foscarnet produced neurological improvement at 8-13 (median 11) days and negative plasma PCR at 30-66 (median 50) days. Four patients had complete neurological recovery, but one patient with persistent viral DNA in the CSF succumbed to progressive encephalopathy. Given this high incidence of HHV-6 and the possibility of successful outcome with prompt treatment, a high index of suspicion of this disorder is required in recipients of monoclonal antibody supported allografts. More... »
PAGES1705666
http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705666
DOIhttp://dx.doi.org/10.1038/sj.bmt.1705666
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031763683
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17401392
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alemtuzumab",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal, Humanized",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cerebrospinal Fluid Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Encephalitis, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematologic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Herpesvirus 6, Human",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymerase Chain Reaction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Roseolovirus Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Conditioning",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation, Homologous",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Vu",
"givenName": "T",
"id": "sg:person.01066715025.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066715025.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Carrum",
"givenName": "G",
"id": "sg:person.0760502111.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760502111.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Hutton",
"givenName": "G",
"id": "sg:person.0611155412.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611155412.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Heslop",
"givenName": "H E",
"id": "sg:person.01014446240.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014446240.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Brenner",
"givenName": "M K",
"id": "sg:person.011106571652.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011106571652.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Kamble",
"givenName": "R",
"id": "sg:person.014651273444.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014651273444.21"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1080/00365540050165857",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000043853"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/338044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000802181"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-03-0701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002588296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa042207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007823447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/428060",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012766374"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/498531",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015395448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-197410000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017240382"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-197410000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017240382"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-197410000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017240382"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2006.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025886042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199405123301905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032642484"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.1251",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032923781"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/314581",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033722973"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-3062.2002.040101.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033859867"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2006.09.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037208369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jcm.44.4.1571-1574.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039290786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/339411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040486176"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2005.04.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042681249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2005.04.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042681249"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bmt.1703423",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053649070",
"https://doi.org/10.1038/sj.bmt.1703423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/515142",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058789532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-200006270-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060282217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-200006270-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060282217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-200006270-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060282217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-200006270-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060282217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.50.5.1441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064376217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.50.5.1441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064376217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.50.5.1441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064376217"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075005007",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076881056",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082895253",
"type": "CreativeWork"
}
],
"datePublished": "2007-06",
"datePublishedReg": "2007-06-01",
"description": "Immunosuppressive monoclonal antibodies directed to immune system cells may reduce rejection and graft versus host disease (GvHD) after allogeneic stem cell transplantation (SCT), but can increase the risks of viral infection. Here, we report human herpes virus-6 (HHV-6) encephalitis despite antiviral prophylaxis in 5 of 43 (11.6%) patients receiving alemtuzumab supported conditioning. Encephalitis occurred at 41-103 days (median 60 days) presenting with confusion in all patients, combined with amnesia (n=3) or seizures (n=2). MRI revealed non-specific white matter changes in two and a non-enhancing medial temporal lobe lesion in three patients. Cerebrospinal fluid (CSF) PCR amplification for HHV-6 was positive in all five patients, (600-2 25 000 (median 4700) copies/ml CSF), while analysis of peripheral blood revealed 100-22 500 (median 1200) viral copies/ml plasma. CSF protein was elevated in four patients, with minimal CSF pleocytosis. Intravenous foscarnet produced neurological improvement at 8-13 (median 11) days and negative plasma PCR at 30-66 (median 50) days. Four patients had complete neurological recovery, but one patient with persistent viral DNA in the CSF succumbed to progressive encephalopathy. Given this high incidence of HHV-6 and the possibility of successful outcome with prompt treatment, a high index of suspicion of this disorder is required in recipients of monoclonal antibody supported allografts.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.bmt.1705666",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1096890",
"issn": [
"0268-3369",
"1476-5365"
],
"name": "Bone Marrow Transplantation",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "39"
}
],
"name": "Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation",
"pagination": "1705666",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9750da027a3c71100c429cbddd7cc06e472943be0d98d0d891c87b54a2883477"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"17401392"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8702459"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bmt.1705666"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031763683"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bmt.1705666",
"https://app.dimensions.ai/details/publication/pub.1031763683"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71673_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/1705666"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705666'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705666'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705666'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705666'
This table displays all metadata directly associated to this object as RDF triples.
259 TRIPLES
21 PREDICATES
74 URIs
43 LITERALS
31 BLANK NODES