Cyclosporine short infusion and C2 monitoring in haematopoietic stem cell transplant recipients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09-18

AUTHORS

M P Hendriks, N M A Blijlevens, A V M B Schattenberg, D M Burger, J P Donnelly

ABSTRACT

Blood concentrations of cyclosporine A (CsA) ⩾800 μg/l measured 2 h post-dosing, the C2 concentration, is necessary to obtain a maximal pharmacological effect and correlates well with transplant-related complications such as transplant rejection and toxicity. In an open crossover study CsA blood levels were measured during 24 h to generate a pharmacokinetic profile on days 1, 8 and 15 after starting CsA infusion in 21 haematopoietic allogeneic stem cell transplant recipients who were receiving intravenously CsA 3 mg/kg/day either by continuous infusion or by 2 h infusion given every 12 h. C2 levels after the 2 h infusion correlated better than C1 or C3 levels with the area under the concentration-time curve from 0 to 4 h (r2=0.62). C2 levels ⩾800 μg/l were also achieved for 20 out of 24 (83%) of cases after the 2 h infusion of CsA without any increase of CsA-related toxicity but for only three of the 23 patients (13%) after continuous infusion. Therefore, we recommend CsA infusions in 2 h during transplant and perform C2 monitoring to obtain therapeutic C2 levels ⩾800 μg/l. More... »

PAGES

521-525

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705481

DOI

http://dx.doi.org/10.1038/sj.bmt.1705481

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050679665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16981000


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194 Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
195 rdf:type schema:Organization
 




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