Long-term event-free survivors after high-dose therapy and autologous stem-cell transplantation for low-grade follicular lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-10-03

AUTHORS

C Andreadis, S J Schuster, E A Chong, J Svoboda, S M Luger, D L Porter, D E Tsai, S D Nasta, R L Elstrom, S C Goldstein, L H Downs, P A Mangan, K A Cunningham, K A Hummel, P A Gimotty, D L Siegel, E Glatstein, E A Stadtmauer

ABSTRACT

Summary:Although follicular lymphoma (FL) is generally responsive to conventional-dose chemotherapy, improved survival in patients with this disease has been difficult to demonstrate. High-dose chemo/radiotherapy followed by autologous stem-cell transplantation (ASCT) can improve response rates, although its effects on survival remain controversial. Between 1990 and 2003, we transplanted 49 patients with low-grade FL at our institution. Twenty-two patients (45%) had undergone histologic transformation at the time of ASCT. In all, 44 patients (90%) had relapsed disease and five patients (10%) were resistant to chemotherapy at the time of transplantation. After ASCT, 30 patients (61%) were in complete remission (CR). The median overall survival (OS) has not been reached, while the median event-free survival (EFS) is 2.4 years. At a median follow-up of 5.5 years (longest 12.4 years), a plateau has been reached with 56% of patients remaining alive, and 35% event-free. ASCT was well tolerated except for two (4%) treatment-related deaths. In multivariable analysis, CR after ASCT and age less than 60 years are the best predictors of EFS and OS. ASCT is thus a safe therapeutic approach in FL, resulting in long-term EFS and OS for some patients, even with transformed disease. More... »

PAGES

955-961

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705178

DOI

http://dx.doi.org/10.1038/sj.bmt.1705178

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043995852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16205727


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Turtle is a human-readable linked data format.

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