Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm View Full Text


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Article Info

DATE

2005-09-26

AUTHORS

A Y H Leung, K-Y Yuen, Y-L Kwong

ABSTRACT

Summary:Haemorrhagic cystitis (HC) is a distinct clinical disorder of multiple aetiologies. It is characterized by painful haematuria due to haemorrhagic inflammation of the urinary bladder mucosa. In allogeneic haematopoietic stem cell transplantation (HSCT), HC occurring before engraftment is mostly transient and self-limiting, whereas that after engraftment is severe and sometimes life-threatening. Pre- and post-engraftment HC represent distinct disorders with different aetiologies and treatment implications. Recent data suggest that reactivation of the polyoma BK virus (BKV) plays a pivotal role in post-engraftment HC. Urotoxicity of the conditioning regimen and alloimmune reaction accompanying graft-versus-host disease (GVHD) upon engraftment are also important pathogenetic factors. Based on data from BKV studies, we propose that HC may be divided into three phases. In the first phase, the conditioning regimen damages uroepithelial cells, providing a milieu for BKV replication. In the second phase, unchecked uroepithelial BKV replication leads to BK viruria. In the last phase after engraftment, alloimmunity against BKV-infected uroepithelial cells leads to HC. The quinolone antibiotics suppress BKV replication in vivo and in vitro, suggesting that their prophylactic use may prevent the occurrence of HC. More... »

PAGES

929-937

References to SciGraph publications

  • 2003-10-16. Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: a survey from the Italian association of pediatric hematology oncology–bone marrow transplantation group in BONE MARROW TRANSPLANTATION
  • 2003-11-18. Late hemorrhagic cystitis after reduced-intensity hematopoietic stem cell transplantation (RIST) in BONE MARROW TRANSPLANTATION
  • 2005-01-24. Successful treatment of severe hemorrhagic cystitis with selective vesical artery embolization in BONE MARROW TRANSPLANTATION
  • 2003-08-11. Oncogenic transformation by BK virus and association with human tumors in ONCOGENE
  • 2000-02. Imaging findings of hemorrhagic cystitis in pediatric oncology patients in PEDIATRIC RADIOLOGY
  • 2003-10-16. Multivariate analysis of risk factors for hemorrhagic cystitis after hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2002-03-01. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2005-01-17. Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2005-06-06. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report in BONE MARROW TRANSPLANTATION
  • 2003-05-01. Successful treatment of severe hemorrhagic cystitis after hemopoietic cell transplantation by selective embolization of the vesical arteries in BONE MARROW TRANSPLANTATION
  • 2000-04-26. Encouraging results in the treatment of haemorrhagic cystitis with estrogen – report of 10 cases and review of the literature in BONE MARROW TRANSPLANTATION
  • 2001-08-01. Off-label use of recombinant factor VIIa in patients following bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2005-04-04. Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 1998-12-22. Risk factors for severe hemorrhagic cystitis following BMT in BONE MARROW TRANSPLANTATION
  • 2004-09-13. Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients in BONE MARROW TRANSPLANTATION
  • 2000-07-28. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir in BONE MARROW TRANSPLANTATION
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    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705139

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    http://dx.doi.org/10.1038/sj.bmt.1705139

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015815952

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16184185


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