Do minitransplants have minicosts? A cost comparison between myeloablative and nonmyeloablative allogeneic stem cell transplant in patients with acute myeloid ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07-25

AUTHORS

C Cordonnier, S Maury, H Esperou, C Pautas, J Beaune, M Rodet, J-L Lagrange, H Rouard, J-L Beaumont, F Bassompierre, E Glückman, M Kuentz, I Durand-Zaleski

ABSTRACT

Summary:Allogeneic hematopoietic stem cell transplantation (SCT) is a widely used, cost-intensive procedure. Although pretransplant nonmyeloablative (NMA) or reduced-intensity conditioning regimens appear very promising, prospective studies comparing this approach with the conventional myeloablative (MA) approach in specific hematologic diseases are necessary, especially in patients in whom the conventional approach is not contraindicated. Cost may be an important factor in the decision-making process. We compared the costs of MA and NMA transplants in patients with acute myeloid leukemia (AML). We estimated 1-year resource utilization in 12 consecutive MA patients (median age: 39 years) and in 11 consecutive NMA patients (median age: 58 years) who underwent HLA-identical sibling SCT for AML. Resources care expenses were valued using the average daily rate for personnel costs, supplies, and room costs. Other data were directly collected from the patients' charts. Despite a trend for lower costs in NMA patients during the first 6 months, costs during the 6–12-month period were significantly higher after NMA due to late complications and readmissions (P=0.03). Finally, mean 1-year costs were not different in MA and NMA patients (P=0.75). Prospective studies comparing conventional and NMA approaches in homogeneous populations should include economic items. More... »

PAGES

649-654

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109

DOI

http://dx.doi.org/10.1038/sj.bmt.1705109

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047659513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16044135


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatic Veno-Occlusive Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cordonnier", 
        "givenName": "C", 
        "id": "sg:person.01334421535.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334421535.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maury", 
        "givenName": "S", 
        "id": "sg:person.0762115262.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762115262.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de Greffe de Mo\u00eblle, H\u00f4pital Saint-Louis (AP/HP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Unit\u00e9 de Greffe de Mo\u00eblle, H\u00f4pital Saint-Louis (AP/HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Esperou", 
        "givenName": "H", 
        "id": "sg:person.0706141501.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706141501.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pautas", 
        "givenName": "C", 
        "id": "sg:person.01324451673.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324451673.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaune", 
        "givenName": "J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Etablissement Fran\u00e7ais du Sang (EFS), Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.443947.9", 
          "name": [
            "Etablissement Fran\u00e7ais du Sang (EFS), Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodet", 
        "givenName": "M", 
        "id": "sg:person.01241335620.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241335620.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Radioth\u00e9rapie, H\u00f4pital Henri Mondor (AP/HP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service de Radioth\u00e9rapie, H\u00f4pital Henri Mondor (AP/HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lagrange", 
        "givenName": "J-L", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Th\u00e9rapie Cellulaire, EFS, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.443947.9", 
          "name": [
            "Laboratoire de Th\u00e9rapie Cellulaire, EFS, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rouard", 
        "givenName": "H", 
        "id": "sg:person.01050634721.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050634721.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Etablissement Fran\u00e7ais du Sang (EFS), Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.443947.9", 
          "name": [
            "Etablissement Fran\u00e7ais du Sang (EFS), Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaumont", 
        "givenName": "J-L", 
        "id": "sg:person.0575533353.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575533353.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation \u00e0 la Recherche Clinique (AP/HP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "D\u00e9l\u00e9gation \u00e0 la Recherche Clinique (AP/HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bassompierre", 
        "givenName": "F", 
        "id": "sg:person.01156030023.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156030023.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de Greffe de Mo\u00eblle, H\u00f4pital Saint-Louis (AP/HP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Unit\u00e9 de Greffe de Mo\u00eblle, H\u00f4pital Saint-Louis (AP/HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gl\u00fcckman", 
        "givenName": "E", 
        "id": "sg:person.01344451445.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344451445.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Service d'H\u00e9matologie clinique, CHU Henri Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP/HP) and University Paris 12, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuentz", 
        "givenName": "M", 
        "id": "sg:person.01315410752.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315410752.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9partement de Sant\u00e9 Publique, H\u00f4pital Henri Mondor (AP/HP), Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "D\u00e9partement de Sant\u00e9 Publique, H\u00f4pital Henri Mondor (AP/HP), Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durand-Zaleski", 
        "givenName": "I", 
        "id": "sg:person.01327533357.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327533357.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1701160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000480077", 
          "https://doi.org/10.1038/sj.bmt.1701160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042711185", 
          "https://doi.org/10.1038/sj.bmt.1703641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1701065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042541997", 
          "https://doi.org/10.1038/sj.bmt.1701065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1701945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045285424", 
          "https://doi.org/10.1038/sj.bmt.1701945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-003-0654-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033556973", 
          "https://doi.org/10.1007/s00277-003-0654-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035035689", 
          "https://doi.org/10.1038/sj.bmt.1703310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016624462", 
          "https://doi.org/10.1038/sj.bmt.1703150"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-07-25", 
    "datePublishedReg": "2005-07-25", 
    "description": "Summary:Allogeneic hematopoietic stem cell transplantation (SCT) is a widely used, cost-intensive procedure. Although pretransplant nonmyeloablative (NMA) or reduced-intensity conditioning regimens appear very promising, prospective studies comparing this approach with the conventional myeloablative (MA) approach in specific hematologic diseases are necessary, especially in patients in whom the conventional approach is not contraindicated. Cost may be an important factor in the decision-making process. We compared the costs of MA and NMA transplants in patients with acute myeloid leukemia (AML). We estimated 1-year resource utilization in 12 consecutive MA patients (median age: 39 years) and in 11 consecutive NMA patients (median age: 58 years) who underwent HLA-identical sibling SCT for AML. Resources care expenses were valued using the average daily rate for personnel costs, supplies, and room costs. Other data were directly collected from the patients' charts. Despite a trend for lower costs in NMA patients during the first 6 months, costs during the 6\u201312-month period were significantly higher after NMA due to late complications and readmissions (P=0.03). Finally, mean 1-year costs were not different in MA and NMA patients (P=0.75). Prospective studies comparing conventional and NMA approaches in homogeneous populations should include economic items.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.bmt.1705109", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "keywords": [
      "acute myeloid leukemia", 
      "stem cell transplantation", 
      "NMA patients", 
      "prospective study", 
      "myeloid leukemia", 
      "HLA-Identical Sibling Stem Cell Transplantation", 
      "nonmyeloablative allogeneic stem cell transplant", 
      "reduced-intensity conditioning regimens", 
      "allogeneic stem cell transplant", 
      "hematopoietic stem cell transplantation", 
      "stem cell transplant", 
      "conditioning regimens", 
      "late complications", 
      "patient charts", 
      "cell transplant", 
      "cell transplantation", 
      "MA patients", 
      "hematologic diseases", 
      "myeloablative approaches", 
      "patients", 
      "room costs", 
      "care expenses", 
      "transplant", 
      "leukemia", 
      "homogeneous population", 
      "NMA approach", 
      "cost-intensive procedure", 
      "minitransplants", 
      "readmission", 
      "regimens", 
      "complications", 
      "transplantation", 
      "disease", 
      "personnel costs", 
      "months", 
      "charts", 
      "NMA", 
      "cost comparison", 
      "study", 
      "daily rate", 
      "resource utilization", 
      "important factor", 
      "population", 
      "decision-making process", 
      "period", 
      "factors", 
      "rate", 
      "procedure", 
      "average daily rate", 
      "items", 
      "data", 
      "utilization", 
      "approach", 
      "comparison", 
      "cost", 
      "trends", 
      "economic items", 
      "expense", 
      "conventional approaches", 
      "supply", 
      "low cost", 
      "process", 
      "Ma"
    ], 
    "name": "Do minitransplants have minicosts? A cost comparison between myeloablative and nonmyeloablative allogeneic stem cell transplant in patients with acute myeloid leukemia", 
    "pagination": "649-654", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047659513"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1705109"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16044135"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1705109", 
      "https://app.dimensions.ai/details/publication/pub.1047659513"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_405.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.bmt.1705109"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      112 URIs      97 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1705109 schema:about N04f87a0febf14ee393b73ba9d3a72b4a
2 N0852d7c3a36941cbb2097d9e1adb217d
3 N466788f1af8b4bcf9cce2421bd6908c1
4 N6bfe3c2121c440dbb7c84501154ea9d1
5 N6c76b909c6604ad2b46d4a6a92e3b828
6 N76a40d19eb074a53a518acf4a78b1fbc
7 N9c025b4f64d74f28a471995cacd5ead6
8 Na1797f8f94154d0d9b50b73311f9ce87
9 Na639c270e944485b8d89eecf2ca8887b
10 Na9ad3d7b966b4047909168bea95cc420
11 Naf18df8fa4cb4957a3c6334fa58fd5f1
12 Naf266b3677e74fc592aa9eb209755685
13 Nb041b7f326184848b036e154e5caaf6c
14 Nb227074aec35462c814985184ddd7dfa
15 Nb5e125f4062b4d73a753f33eec7b87e3
16 Ndbad0cc4d3aa4418afd170846288dc7c
17 Nf6f9d5c498a146879fae9e15d338bcaf
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N11dd66ac85a54f259f3ec814edbb7371
21 schema:citation sg:pub.10.1007/s00277-003-0654-9
22 sg:pub.10.1038/sj.bmt.1701065
23 sg:pub.10.1038/sj.bmt.1701160
24 sg:pub.10.1038/sj.bmt.1701945
25 sg:pub.10.1038/sj.bmt.1703150
26 sg:pub.10.1038/sj.bmt.1703310
27 sg:pub.10.1038/sj.bmt.1703641
28 schema:datePublished 2005-07-25
29 schema:datePublishedReg 2005-07-25
30 schema:description Summary:Allogeneic hematopoietic stem cell transplantation (SCT) is a widely used, cost-intensive procedure. Although pretransplant nonmyeloablative (NMA) or reduced-intensity conditioning regimens appear very promising, prospective studies comparing this approach with the conventional myeloablative (MA) approach in specific hematologic diseases are necessary, especially in patients in whom the conventional approach is not contraindicated. Cost may be an important factor in the decision-making process. We compared the costs of MA and NMA transplants in patients with acute myeloid leukemia (AML). We estimated 1-year resource utilization in 12 consecutive MA patients (median age: 39 years) and in 11 consecutive NMA patients (median age: 58 years) who underwent HLA-identical sibling SCT for AML. Resources care expenses were valued using the average daily rate for personnel costs, supplies, and room costs. Other data were directly collected from the patients' charts. Despite a trend for lower costs in NMA patients during the first 6 months, costs during the 6–12-month period were significantly higher after NMA due to late complications and readmissions (P=0.03). Finally, mean 1-year costs were not different in MA and NMA patients (P=0.75). Prospective studies comparing conventional and NMA approaches in homogeneous populations should include economic items.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf Nac21ed64f4b544fbaa93cb50c6306826
34 Nda05d1d02378493d929a8b4e83ace663
35 sg:journal.1096890
36 schema:keywords HLA-Identical Sibling Stem Cell Transplantation
37 MA patients
38 Ma
39 NMA
40 NMA approach
41 NMA patients
42 acute myeloid leukemia
43 allogeneic stem cell transplant
44 approach
45 average daily rate
46 care expenses
47 cell transplant
48 cell transplantation
49 charts
50 comparison
51 complications
52 conditioning regimens
53 conventional approaches
54 cost
55 cost comparison
56 cost-intensive procedure
57 daily rate
58 data
59 decision-making process
60 disease
61 economic items
62 expense
63 factors
64 hematologic diseases
65 hematopoietic stem cell transplantation
66 homogeneous population
67 important factor
68 items
69 late complications
70 leukemia
71 low cost
72 minitransplants
73 months
74 myeloablative approaches
75 myeloid leukemia
76 nonmyeloablative allogeneic stem cell transplant
77 patient charts
78 patients
79 period
80 personnel costs
81 population
82 procedure
83 process
84 prospective study
85 rate
86 readmission
87 reduced-intensity conditioning regimens
88 regimens
89 resource utilization
90 room costs
91 stem cell transplant
92 stem cell transplantation
93 study
94 supply
95 transplant
96 transplantation
97 trends
98 utilization
99 schema:name Do minitransplants have minicosts? A cost comparison between myeloablative and nonmyeloablative allogeneic stem cell transplant in patients with acute myeloid leukemia
100 schema:pagination 649-654
101 schema:productId N46171f0d123c4ff5b8e53b0cc7d19829
102 Nc165ecfdaa9f4802b6ec6cfb5304afec
103 Nfe8d221277f74401a9da157f72d9af21
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047659513
105 https://doi.org/10.1038/sj.bmt.1705109
106 schema:sdDatePublished 2022-12-01T06:25
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N935032de6ac34d1cbf77b2cbd3df66f5
109 schema:url https://doi.org/10.1038/sj.bmt.1705109
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N04f87a0febf14ee393b73ba9d3a72b4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cohort Studies
115 rdf:type schema:DefinedTerm
116 N0852d7c3a36941cbb2097d9e1adb217d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Female
118 rdf:type schema:DefinedTerm
119 N11dd66ac85a54f259f3ec814edbb7371 rdf:first sg:person.01334421535.45
120 rdf:rest Nbcdc490633f54968be8985d4ccf885ce
121 N411b9a099c6049f8a01219f82ec414e9 rdf:first sg:person.0575533353.36
122 rdf:rest N6aa1a3df5044400fb80f732c374aa88e
123 N4124b88bbd584e84aef652b613a76c86 rdf:first sg:person.01241335620.17
124 rdf:rest N4e62e5572648405ab0a60d776464f7cc
125 N46171f0d123c4ff5b8e53b0cc7d19829 schema:name pubmed_id
126 schema:value 16044135
127 rdf:type schema:PropertyValue
128 N466788f1af8b4bcf9cce2421bd6908c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Prospective Studies
130 rdf:type schema:DefinedTerm
131 N4e62e5572648405ab0a60d776464f7cc rdf:first N8f8326a95a2446cba92943cd4be13c31
132 rdf:rest Nd7ad415566754351b95838721e2c385b
133 N5ee5e349b80142389881feccedb511d3 rdf:first sg:person.0706141501.47
134 rdf:rest Nfcda7e919cb34dcb949dc1d18fb85beb
135 N6aa1a3df5044400fb80f732c374aa88e rdf:first sg:person.01156030023.96
136 rdf:rest Nda1ab010f6f74cf8a195ee8653adedb1
137 N6bfe3c2121c440dbb7c84501154ea9d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Leukemia, Myeloid, Acute
139 rdf:type schema:DefinedTerm
140 N6c76b909c6604ad2b46d4a6a92e3b828 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Hepatic Veno-Occlusive Disease
142 rdf:type schema:DefinedTerm
143 N76a40d19eb074a53a518acf4a78b1fbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Adult
145 rdf:type schema:DefinedTerm
146 N8f8326a95a2446cba92943cd4be13c31 schema:affiliation grid-institutes:grid.412116.1
147 schema:familyName Lagrange
148 schema:givenName J-L
149 rdf:type schema:Person
150 N935032de6ac34d1cbf77b2cbd3df66f5 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N9a0494d924c14aff9ad7e000d49c2fc3 rdf:first Ncddf20481b2b409ba84037c6cc43200e
153 rdf:rest N4124b88bbd584e84aef652b613a76c86
154 N9c025b4f64d74f28a471995cacd5ead6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Time Factors
156 rdf:type schema:DefinedTerm
157 Na1797f8f94154d0d9b50b73311f9ce87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Hematopoietic Stem Cell Transplantation
159 rdf:type schema:DefinedTerm
160 Na639c270e944485b8d89eecf2ca8887b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Recurrence
162 rdf:type schema:DefinedTerm
163 Na9ad3d7b966b4047909168bea95cc420 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Remission Induction
165 rdf:type schema:DefinedTerm
166 Nac21ed64f4b544fbaa93cb50c6306826 schema:issueNumber 7
167 rdf:type schema:PublicationIssue
168 Naf18df8fa4cb4957a3c6334fa58fd5f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 Naf266b3677e74fc592aa9eb209755685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aged
173 rdf:type schema:DefinedTerm
174 Naf69368cf9eb41a9b3e28d484f8a2487 rdf:first sg:person.01315410752.03
175 rdf:rest Nc75771e9137a47d7adf6eb8499b8ef63
176 Nb041b7f326184848b036e154e5caaf6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Transplantation, Homologous
178 rdf:type schema:DefinedTerm
179 Nb227074aec35462c814985184ddd7dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Middle Aged
181 rdf:type schema:DefinedTerm
182 Nb5e125f4062b4d73a753f33eec7b87e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Transplantation Conditioning
184 rdf:type schema:DefinedTerm
185 Nbcdc490633f54968be8985d4ccf885ce rdf:first sg:person.0762115262.49
186 rdf:rest N5ee5e349b80142389881feccedb511d3
187 Nc165ecfdaa9f4802b6ec6cfb5304afec schema:name dimensions_id
188 schema:value pub.1047659513
189 rdf:type schema:PropertyValue
190 Nc75771e9137a47d7adf6eb8499b8ef63 rdf:first sg:person.01327533357.46
191 rdf:rest rdf:nil
192 Ncddf20481b2b409ba84037c6cc43200e schema:affiliation grid-institutes:grid.412116.1
193 schema:familyName Beaune
194 schema:givenName J
195 rdf:type schema:Person
196 Nd7ad415566754351b95838721e2c385b rdf:first sg:person.01050634721.15
197 rdf:rest N411b9a099c6049f8a01219f82ec414e9
198 Nda05d1d02378493d929a8b4e83ace663 schema:volumeNumber 36
199 rdf:type schema:PublicationVolume
200 Nda1ab010f6f74cf8a195ee8653adedb1 rdf:first sg:person.01344451445.17
201 rdf:rest Naf69368cf9eb41a9b3e28d484f8a2487
202 Ndbad0cc4d3aa4418afd170846288dc7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Stem Cell Transplantation
204 rdf:type schema:DefinedTerm
205 Nf6f9d5c498a146879fae9e15d338bcaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Humans
207 rdf:type schema:DefinedTerm
208 Nfcda7e919cb34dcb949dc1d18fb85beb rdf:first sg:person.01324451673.29
209 rdf:rest N9a0494d924c14aff9ad7e000d49c2fc3
210 Nfe8d221277f74401a9da157f72d9af21 schema:name doi
211 schema:value 10.1038/sj.bmt.1705109
212 rdf:type schema:PropertyValue
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 sg:journal.1096890 schema:issn 0268-3369
220 1476-5365
221 schema:name Bone Marrow Transplantation
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01050634721.15 schema:affiliation grid-institutes:grid.443947.9
225 schema:familyName Rouard
226 schema:givenName H
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050634721.15
228 rdf:type schema:Person
229 sg:person.01156030023.96 schema:affiliation grid-institutes:grid.50550.35
230 schema:familyName Bassompierre
231 schema:givenName F
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156030023.96
233 rdf:type schema:Person
234 sg:person.01241335620.17 schema:affiliation grid-institutes:grid.443947.9
235 schema:familyName Rodet
236 schema:givenName M
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241335620.17
238 rdf:type schema:Person
239 sg:person.01315410752.03 schema:affiliation grid-institutes:grid.412116.1
240 schema:familyName Kuentz
241 schema:givenName M
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315410752.03
243 rdf:type schema:Person
244 sg:person.01324451673.29 schema:affiliation grid-institutes:grid.412116.1
245 schema:familyName Pautas
246 schema:givenName C
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324451673.29
248 rdf:type schema:Person
249 sg:person.01327533357.46 schema:affiliation grid-institutes:grid.412116.1
250 schema:familyName Durand-Zaleski
251 schema:givenName I
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327533357.46
253 rdf:type schema:Person
254 sg:person.01334421535.45 schema:affiliation grid-institutes:grid.412116.1
255 schema:familyName Cordonnier
256 schema:givenName C
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334421535.45
258 rdf:type schema:Person
259 sg:person.01344451445.17 schema:affiliation grid-institutes:grid.413328.f
260 schema:familyName Glückman
261 schema:givenName E
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344451445.17
263 rdf:type schema:Person
264 sg:person.0575533353.36 schema:affiliation grid-institutes:grid.443947.9
265 schema:familyName Beaumont
266 schema:givenName J-L
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575533353.36
268 rdf:type schema:Person
269 sg:person.0706141501.47 schema:affiliation grid-institutes:grid.413328.f
270 schema:familyName Esperou
271 schema:givenName H
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706141501.47
273 rdf:type schema:Person
274 sg:person.0762115262.49 schema:affiliation grid-institutes:grid.412116.1
275 schema:familyName Maury
276 schema:givenName S
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762115262.49
278 rdf:type schema:Person
279 sg:pub.10.1007/s00277-003-0654-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033556973
280 https://doi.org/10.1007/s00277-003-0654-9
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/sj.bmt.1701065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042541997
283 https://doi.org/10.1038/sj.bmt.1701065
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/sj.bmt.1701160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000480077
286 https://doi.org/10.1038/sj.bmt.1701160
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/sj.bmt.1701945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045285424
289 https://doi.org/10.1038/sj.bmt.1701945
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.bmt.1703150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016624462
292 https://doi.org/10.1038/sj.bmt.1703150
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/sj.bmt.1703310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035035689
295 https://doi.org/10.1038/sj.bmt.1703310
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/sj.bmt.1703641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042711185
298 https://doi.org/10.1038/sj.bmt.1703641
299 rdf:type schema:CreativeWork
300 grid-institutes:grid.412116.1 schema:alternateName Département de Santé Publique, Hôpital Henri Mondor (AP/HP), Créteil, France
301 Service d'Hématologie clinique, CHU Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP/HP) and University Paris 12, Créteil, France
302 Service de Radiothérapie, Hôpital Henri Mondor (AP/HP), Paris, France
303 schema:name Département de Santé Publique, Hôpital Henri Mondor (AP/HP), Créteil, France
304 Service d'Hématologie clinique, CHU Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP/HP) and University Paris 12, Créteil, France
305 Service de Radiothérapie, Hôpital Henri Mondor (AP/HP), Paris, France
306 rdf:type schema:Organization
307 grid-institutes:grid.413328.f schema:alternateName Unité de Greffe de Moëlle, Hôpital Saint-Louis (AP/HP), Paris, France
308 schema:name Unité de Greffe de Moëlle, Hôpital Saint-Louis (AP/HP), Paris, France
309 rdf:type schema:Organization
310 grid-institutes:grid.443947.9 schema:alternateName Etablissement Français du Sang (EFS), Créteil, France
311 Laboratoire de Thérapie Cellulaire, EFS, Créteil, France
312 schema:name Etablissement Français du Sang (EFS), Créteil, France
313 Laboratoire de Thérapie Cellulaire, EFS, Créteil, France
314 rdf:type schema:Organization
315 grid-institutes:grid.50550.35 schema:alternateName Délégation à la Recherche Clinique (AP/HP), Paris, France
316 schema:name Délégation à la Recherche Clinique (AP/HP), Paris, France
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...