Do minitransplants have minicosts? A cost comparison between myeloablative and nonmyeloablative allogeneic stem cell transplant in patients with acute myeloid ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07-25

AUTHORS

C Cordonnier, S Maury, H Esperou, C Pautas, J Beaune, M Rodet, J-L Lagrange, H Rouard, J-L Beaumont, F Bassompierre, E Glückman, M Kuentz, I Durand-Zaleski

ABSTRACT

Summary:Allogeneic hematopoietic stem cell transplantation (SCT) is a widely used, cost-intensive procedure. Although pretransplant nonmyeloablative (NMA) or reduced-intensity conditioning regimens appear very promising, prospective studies comparing this approach with the conventional myeloablative (MA) approach in specific hematologic diseases are necessary, especially in patients in whom the conventional approach is not contraindicated. Cost may be an important factor in the decision-making process. We compared the costs of MA and NMA transplants in patients with acute myeloid leukemia (AML). We estimated 1-year resource utilization in 12 consecutive MA patients (median age: 39 years) and in 11 consecutive NMA patients (median age: 58 years) who underwent HLA-identical sibling SCT for AML. Resources care expenses were valued using the average daily rate for personnel costs, supplies, and room costs. Other data were directly collected from the patients' charts. Despite a trend for lower costs in NMA patients during the first 6 months, costs during the 6–12-month period were significantly higher after NMA due to late complications and readmissions (P=0.03). Finally, mean 1-year costs were not different in MA and NMA patients (P=0.75). Prospective studies comparing conventional and NMA approaches in homogeneous populations should include economic items. More... »

PAGES

649-654

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1705109

DOI

http://dx.doi.org/10.1038/sj.bmt.1705109

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047659513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16044135


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30 schema:description Summary:Allogeneic hematopoietic stem cell transplantation (SCT) is a widely used, cost-intensive procedure. Although pretransplant nonmyeloablative (NMA) or reduced-intensity conditioning regimens appear very promising, prospective studies comparing this approach with the conventional myeloablative (MA) approach in specific hematologic diseases are necessary, especially in patients in whom the conventional approach is not contraindicated. Cost may be an important factor in the decision-making process. We compared the costs of MA and NMA transplants in patients with acute myeloid leukemia (AML). We estimated 1-year resource utilization in 12 consecutive MA patients (median age: 39 years) and in 11 consecutive NMA patients (median age: 58 years) who underwent HLA-identical sibling SCT for AML. Resources care expenses were valued using the average daily rate for personnel costs, supplies, and room costs. Other data were directly collected from the patients' charts. Despite a trend for lower costs in NMA patients during the first 6 months, costs during the 6–12-month period were significantly higher after NMA due to late complications and readmissions (P=0.03). Finally, mean 1-year costs were not different in MA and NMA patients (P=0.75). Prospective studies comparing conventional and NMA approaches in homogeneous populations should include economic items.
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37 MA patients
38 Ma
39 NMA
40 NMA approach
41 NMA patients
42 acute myeloid leukemia
43 allogeneic stem cell transplant
44 approach
45 average daily rate
46 care expenses
47 cell transplant
48 cell transplantation
49 charts
50 comparison
51 complications
52 conditioning regimens
53 conventional approaches
54 cost
55 cost comparison
56 cost-intensive procedure
57 daily rate
58 data
59 decision-making process
60 disease
61 economic items
62 expense
63 factors
64 hematologic diseases
65 hematopoietic stem cell transplantation
66 homogeneous population
67 important factor
68 items
69 late complications
70 leukemia
71 low cost
72 minitransplants
73 months
74 myeloablative approaches
75 myeloid leukemia
76 nonmyeloablative allogeneic stem cell transplant
77 patient charts
78 patients
79 period
80 personnel costs
81 population
82 procedure
83 process
84 prospective study
85 rate
86 readmission
87 reduced-intensity conditioning regimens
88 regimens
89 resource utilization
90 room costs
91 stem cell transplant
92 stem cell transplantation
93 study
94 supply
95 transplant
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97 trends
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