Thalidomide salvage therapy following allogeneic stem cell transplantation for multiple myeloma: a retrospective study from the Intergroupe Francophone du Myélome ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11-08

AUTHORS

M Mohty, M Attal, G Marit, C E Bulabois, F Garban, N Gratecos, B Rio, J P Vernant, J J Sotto, J Y Cahn, D Blaise, J P Jouet, T Facon, I Yakoub-Agha

ABSTRACT

Summary:Thalidomide is effective in multiple myeloma (MM), even in patients who have relapsed after high-dose therapy. A potent graft-versus-myeloma (GVM) effect can be induced against MM after allogeneic stem cell transplantation (allo-SCT). In all, 31 MM patients received thalidomide as a salvage therapy after progression following allo-SCT. The median maximum daily dose of thalidomide was 200 mg (range, 50–600). Thalidomide had to be discontinued in six patients (19%) because of toxicity. In all, nine patients (29%; 95% CI, 13–45) achieved an objective response with thalidomide therapy (six partial and three very good partial responses, VGPR). Five patients developed graft-versus-host disease (GVHD) after thalidomide therapy, including the three patients achieving a VGPR. These data demonstrate that thalidomide is potentially effective in MM patients failing allo-SCT. More... »

PAGES

165-169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1704756

DOI

http://dx.doi.org/10.1038/sj.bmt.1704756

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006339769

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15531895


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