Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05-24

AUTHORS

S Y Ma, W Y Au, A K W Lie, I OL Ng, A Y H Leung, E W Tse, R H Liang, G K Lau, Y L Kwong

ABSTRACT

Summary:Graft-versus-host disease (GVHD) is the commonest complication after donor lymphocyte infusion (DLI). In 19 patients undergoing DLI for relapses of hematologic malignancies post hematopoietic stem cell transplantation (HSCT), 11 developed GVHD, of whom nine had isolated liver involvement, and two had liver and skin involvement. The clinical diagnosis of liver GVHD was hepatitic in six patients (55%) and classical in five patients (45%). Patients with GVHD post-DLI showed a different clinical pattern when compared to a cohort of 106 cases of GVHD post-HSCT, in having significantly more isolated liver involvement (9/11 vs 17/106, P<0.001), and less skin (2/11 vs 80/106, P<0.001) and gut (0/11 vs 28/106, P<0.001) involvement. However, liver GVHD post-DLI and post-HSCT had comparable patient characteristics, underlying diseases, clinical subtypes (classical and hepatitic) and response to treatment. More... »

PAGES

57-61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1704522

DOI

http://dx.doi.org/10.1038/sj.bmt.1704522

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027822497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15156162


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