Chromosomal transformation in donor cells following allogeneic bone marrow transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-05-17

AUTHORS

Z Lang, P Dinndorf, S Ladisch, E Bayever, G Reaman

ABSTRACT

Summary:We report here a monosomy 7 transformation of donor cells following matched-unrelated, same sex, allogeneic bone marrow transplantation in a patient with severe congenital aplastic anemia. A PCR technique was employed to amplify microsatellite markers on chromosome 7 to confirm donor/recipient identity. We found that the transformation of monosomy 7 occurred in previously genetically normal donor cells. This study suggests that the microenvironment of the bone marrow of our patient with severe congenital aplastic anemia may have played a critical role in the development of monosomy 7 of normal donor cells and we conclude that chromosomal microsatellite marker analysis can be a valuable tool for precise donor/recipient differentiation in engraftment monitoring. More... »

PAGES

1253-1256

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1704450

DOI

http://dx.doi.org/10.1038/sj.bmt.1704450

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007219250

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15146169


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