Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-11

AUTHORS

P R Fallen, L McGreavey, J A Madrigal, M Potter, M Ethell, H G Prentice, A Guimarães, P J Travers

ABSTRACT

The factors affecting T cell reconstitution post haematopoietic cell transplantation (HCT) are not well characterised. We carried out a longitudinal analysis of T cell reconstitution in 32 HCT recipients during the first 12 months post transplant. We analysed reconstitution of naïve, memory and effector T cells, their diversity and monitored thymic output using TCR rearrangement excision circles (TRECs). Thymic-independent pathways were responsible for the rapid reconstitution of memory and effector T cells less than 6 months post HCT. Thymic-dependent pathways were activated between 6 and 12 months in the majority of patients with naïve T cell numbers increasing in parallel with TREC levels. Increasing patient age, chronic GVHD and T cell depletion (with or without pretransplant Campath-1H) predicted low TREC levels and slow naïve T cell recovery. Furthermore, increasing patient age also predicted high memory and effector T cell numbers. The effects of post HCT immunosuppression, total body irradiation, donor leucocyte infusions, T cell dose and post HCT infections on T cell recovery were also analysed. However, no effects of these single variables across a variety of different age, GVHD and T cell depletion groups were apparent. This study suggests that future analysis of the factors affecting T cell reconstitution and studies aimed at reactivating the thymus through therapeutic intervention should be analysed in age-, GVHD- and TCD-matched patient groups. More... »

PAGES

1704235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1704235

DOI

http://dx.doi.org/10.1038/sj.bmt.1704235

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031583638

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14595388


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft vs Host Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Depletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Anthony Nolan", 
          "id": "https://www.grid.ac/institutes/grid.426412.7", 
          "name": [
            "Anthony Nolan Research Institute, Fleet Road, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fallen", 
        "givenName": "P R", 
        "id": "sg:person.01307115021.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307115021.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Anthony Nolan", 
          "id": "https://www.grid.ac/institutes/grid.426412.7", 
          "name": [
            "Anthony Nolan Research Institute, Fleet Road, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGreavey", 
        "givenName": "L", 
        "id": "sg:person.01021626010.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021626010.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Anthony Nolan Research Institute, Fleet Road, London, UK", 
            "Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madrigal", 
        "givenName": "J A", 
        "id": "sg:person.07465546124.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07465546124.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potter", 
        "givenName": "M", 
        "id": "sg:person.016310433302.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016310433302.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ethell", 
        "givenName": "M", 
        "id": "sg:person.01053700261.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053700261.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prentice", 
        "givenName": "H G", 
        "id": "sg:person.0631425377.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631425377.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Portuguese Oncology Institute", 
          "id": "https://www.grid.ac/institutes/grid.418711.a", 
          "name": [
            "Unidade de Transplante de Medula \u00d3ssea, Instituto Portugu\u00eas de Oncologia, Centro de Lisboa, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guimar\u00e3es", 
        "givenName": "A", 
        "id": "sg:person.01327015700.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327015700.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Anthony Nolan Research Institute, Fleet Road, London, UK", 
            "Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Travers", 
        "givenName": "P J", 
        "id": "sg:person.01242344565.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242344565.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood.v97.2.383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000592189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mlc.2003.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002502803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mlc.2003.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002502803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0597-533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002856145", 
          "https://doi.org/10.1038/nm0597-533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.8.1329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003477249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003740181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.7.803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004612832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.8.2352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004798171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1996.d01-1834.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005952095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199501193320303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006006309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03601.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006541307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199804023381405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006602107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199303043280901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009054172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/clin.1994.1023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010865753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(00)01714-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012643056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199806)28:06<1886::aid-immu1886>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016673599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2001.02900.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017385747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cimm.2001.1761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022778127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci6762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023927725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1997.tb00974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024413674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.4.1116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025525454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.58.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028451491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1995.tb44479.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028746131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02293-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029625189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1986.tb07574.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030659473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.1985.tb01916.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031105099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780380912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031109074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1997.tb00980.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031303250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0192-0561(98)00034-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032099733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006611518223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032158393", 
          "https://doi.org/10.1023/a:1006611518223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1997.tb01030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032386180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.16.6301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032996822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(00)00655-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033966050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.8.2851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035020111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.5.1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035083560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000054630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035462267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)03098-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035515366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.5.1458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035536986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-5769(00)00006-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035634625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(79)90825-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035816551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(79)90825-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035816551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198208000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036523118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198208000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036523118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)08086-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.10.2900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038120288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1702400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039922183", 
          "https://doi.org/10.1038/sj.bmt.1702400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-2478(97)02713-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041564189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.5.1601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042306738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043842213", 
          "https://doi.org/10.1038/sj.bmt.1703118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045631673", 
          "https://doi.org/10.1038/25374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045631673", 
          "https://doi.org/10.1038/25374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199103073241005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048916015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(96)80543-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049591790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000237091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049799656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)92848-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053026354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)92848-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053026354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.9.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/7.1.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059712234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200002150-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200002150-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200002150-00026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064243698", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.139.2.5729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-119-3-199308010-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073697618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074488265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074666193", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074696652", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074718151", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.3.1524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074751357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.14.3340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074849835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075114483", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077702013", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078833599", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079648037", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079678857", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079807585", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079808064", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081620610", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081669760", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081758498", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082220993", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082421979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082442979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466630", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082560049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082564938", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082600665", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082707235", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082723588", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082790779", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082800607", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082892883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082953149", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.2.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083054548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083134073", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083354417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083358629", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083373197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083379027", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-11", 
    "datePublishedReg": "2003-11-01", 
    "description": "The factors affecting T cell reconstitution post haematopoietic cell transplantation (HCT) are not well characterised. We carried out a longitudinal analysis of T cell reconstitution in 32 HCT recipients during the first 12 months post transplant. We analysed reconstitution of na\u00efve, memory and effector T cells, their diversity and monitored thymic output using TCR rearrangement excision circles (TRECs). Thymic-independent pathways were responsible for the rapid reconstitution of memory and effector T cells less than 6 months post HCT. Thymic-dependent pathways were activated between 6 and 12 months in the majority of patients with na\u00efve T cell numbers increasing in parallel with TREC levels. Increasing patient age, chronic GVHD and T cell depletion (with or without pretransplant Campath-1H) predicted low TREC levels and slow na\u00efve T cell recovery. Furthermore, increasing patient age also predicted high memory and effector T cell numbers. The effects of post HCT immunosuppression, total body irradiation, donor leucocyte infusions, T cell dose and post HCT infections on T cell recovery were also analysed. However, no effects of these single variables across a variety of different age, GVHD and T cell depletion groups were apparent. This study suggests that future analysis of the factors affecting T cell reconstitution and studies aimed at reactivating the thymus through therapeutic intervention should be analysed in age-, GVHD- and TCD-matched patient groups.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bmt.1704235", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients", 
    "pagination": "1704235", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9675323ce3a4ab1efa995389e5d89f943b2ea8002ed5cc7ecc693cde50280a1e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14595388"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1704235"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031583638"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1704235", 
      "https://app.dimensions.ai/details/publication/pub.1031583638"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1704235"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1704235'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1704235'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1704235'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1704235'


 

This table displays all metadata directly associated to this object as RDF triples.

449 TRIPLES      21 PREDICATES      140 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1704235 schema:about N20d5c1f040e246f79a23e1bef1adcbf3
2 N36dc3cccc2504b9fad0dab3fdc5d1611
3 N378381da9f544e23b9612227e61a4bcf
4 N4f2941ecd576453d96c0fc471297bc46
5 N66ace34751654470b268c17cc4be5a64
6 N69a3c66efb5b463c88babb82ac970ed9
7 N7238125eb3fb432fb8c735f72fcf745c
8 N8dd2702e9a0a4235af98582d1d29a4f8
9 Na26eff8c06374b97a8f5a47d3e0ae37d
10 Naa604f4ab8474b51992c7172066c5650
11 Nae730cc13dc94f238c8e776a78ce0835
12 Nbef6f7e8664843ae9e5a71751abc7f81
13 Nbf111bb50b8444f9810edec81ba9b483
14 Nc67bf01f2c35445ca3a2809621da2f4b
15 Nc793727a208846869f59c5ca9a40862b
16 Ncf0b138826f74e3688aa651bf608e39e
17 Nf9bd03c2d25f46dbb1f141a150dfa7fb
18 Nfc8a93c597d64c7d9cc0818fce191690
19 Nffcc298b7d4242799714ededafa855d6
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N3e53252cf2ed4c1bb88d1130e29ba171
23 schema:citation sg:pub.10.1023/a:1006611518223
24 sg:pub.10.1038/25374
25 sg:pub.10.1038/nm0597-533
26 sg:pub.10.1038/sj.bmt.1702400
27 sg:pub.10.1038/sj.bmt.1703118
28 https://app.dimensions.ai/details/publication/pub.1064243698
29 https://app.dimensions.ai/details/publication/pub.1074488265
30 https://app.dimensions.ai/details/publication/pub.1074666193
31 https://app.dimensions.ai/details/publication/pub.1074696652
32 https://app.dimensions.ai/details/publication/pub.1074718151
33 https://app.dimensions.ai/details/publication/pub.1075114483
34 https://app.dimensions.ai/details/publication/pub.1077702013
35 https://app.dimensions.ai/details/publication/pub.1078833599
36 https://app.dimensions.ai/details/publication/pub.1079648037
37 https://app.dimensions.ai/details/publication/pub.1079678857
38 https://app.dimensions.ai/details/publication/pub.1079807585
39 https://app.dimensions.ai/details/publication/pub.1079808064
40 https://app.dimensions.ai/details/publication/pub.1081620610
41 https://app.dimensions.ai/details/publication/pub.1081669760
42 https://app.dimensions.ai/details/publication/pub.1081758498
43 https://app.dimensions.ai/details/publication/pub.1082220993
44 https://app.dimensions.ai/details/publication/pub.1082421979
45 https://app.dimensions.ai/details/publication/pub.1082442979
46 https://app.dimensions.ai/details/publication/pub.1082466630
47 https://app.dimensions.ai/details/publication/pub.1082560049
48 https://app.dimensions.ai/details/publication/pub.1082564938
49 https://app.dimensions.ai/details/publication/pub.1082600665
50 https://app.dimensions.ai/details/publication/pub.1082707235
51 https://app.dimensions.ai/details/publication/pub.1082723588
52 https://app.dimensions.ai/details/publication/pub.1082790779
53 https://app.dimensions.ai/details/publication/pub.1082800607
54 https://app.dimensions.ai/details/publication/pub.1082892883
55 https://app.dimensions.ai/details/publication/pub.1082953149
56 https://app.dimensions.ai/details/publication/pub.1083134073
57 https://app.dimensions.ai/details/publication/pub.1083354417
58 https://app.dimensions.ai/details/publication/pub.1083358629
59 https://app.dimensions.ai/details/publication/pub.1083373197
60 https://app.dimensions.ai/details/publication/pub.1083379027
61 https://doi.org/10.1001/archneur.58.1.91
62 https://doi.org/10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y
63 https://doi.org/10.1002/(sici)1521-4141(199806)28:06<1886::aid-immu1886>3.0.co;2-m
64 https://doi.org/10.1002/art.1780380912
65 https://doi.org/10.1006/cimm.2001.1761
66 https://doi.org/10.1006/clin.1994.1023
67 https://doi.org/10.1016/0167-5699(96)80543-3
68 https://doi.org/10.1016/s0140-6736(00)02293-5
69 https://doi.org/10.1016/s0140-6736(79)90825-0
70 https://doi.org/10.1016/s0140-6736(84)92848-4
71 https://doi.org/10.1016/s0140-6736(96)08086-5
72 https://doi.org/10.1016/s0140-6736(97)03098-5
73 https://doi.org/10.1016/s0165-2478(97)02713-2
74 https://doi.org/10.1016/s0167-5699(00)01714-x
75 https://doi.org/10.1016/s0192-0561(98)00034-4
76 https://doi.org/10.1016/s0301-472x(00)00655-x
77 https://doi.org/10.1016/s1567-5769(00)00006-0
78 https://doi.org/10.1046/j.1365-2141.1996.d01-1834.x
79 https://doi.org/10.1046/j.1365-2141.2001.02900.x
80 https://doi.org/10.1056/nejm199103073241005
81 https://doi.org/10.1056/nejm199303043280901
82 https://doi.org/10.1056/nejm199501193320303
83 https://doi.org/10.1056/nejm199804023381405
84 https://doi.org/10.1067/mlc.2003.5
85 https://doi.org/10.1073/pnas.87.16.6301
86 https://doi.org/10.1084/jem.186.9.1407
87 https://doi.org/10.1084/jem.189.8.1329
88 https://doi.org/10.1084/jem.193.7.803
89 https://doi.org/10.1093/intimm/7.1.97
90 https://doi.org/10.1097/00007890-198208000-00007
91 https://doi.org/10.1097/00007890-200002150-00026
92 https://doi.org/10.1111/j.1365-2141.1986.tb07574.x
93 https://doi.org/10.1111/j.1365-3083.1985.tb01916.x
94 https://doi.org/10.1111/j.1600-065x.1997.tb00974.x
95 https://doi.org/10.1111/j.1600-065x.1997.tb00980.x
96 https://doi.org/10.1111/j.1600-065x.1997.tb01030.x
97 https://doi.org/10.1111/j.1749-6632.1995.tb44479.x
98 https://doi.org/10.1111/j.1749-6632.2001.tb03601.x
99 https://doi.org/10.1159/000054630
100 https://doi.org/10.1159/000237091
101 https://doi.org/10.1172/jci6762
102 https://doi.org/10.1182/blood.v97.2.383
103 https://doi.org/10.1182/blood.v97.5.1458
104 https://doi.org/10.1182/blood.v97.5.1491
105 https://doi.org/10.1182/blood.v98.10.2900
106 https://doi.org/10.1182/blood.v98.4.1116
107 https://doi.org/10.1182/blood.v98.5.1601
108 https://doi.org/10.1182/blood.v98.8.2352
109 https://doi.org/10.1182/blood.v99.8.2851
110 https://doi.org/10.1200/jco.1997.15.2.557
111 https://doi.org/10.1200/jco.2001.19.14.3340
112 https://doi.org/10.1210/endo.139.2.5729
113 https://doi.org/10.4049/jimmunol.166.3.1524
114 https://doi.org/10.7326/0003-4819-119-3-199308010-00005
115 schema:datePublished 2003-11
116 schema:datePublishedReg 2003-11-01
117 schema:description The factors affecting T cell reconstitution post haematopoietic cell transplantation (HCT) are not well characterised. We carried out a longitudinal analysis of T cell reconstitution in 32 HCT recipients during the first 12 months post transplant. We analysed reconstitution of naïve, memory and effector T cells, their diversity and monitored thymic output using TCR rearrangement excision circles (TRECs). Thymic-independent pathways were responsible for the rapid reconstitution of memory and effector T cells less than 6 months post HCT. Thymic-dependent pathways were activated between 6 and 12 months in the majority of patients with naïve T cell numbers increasing in parallel with TREC levels. Increasing patient age, chronic GVHD and T cell depletion (with or without pretransplant Campath-1H) predicted low TREC levels and slow naïve T cell recovery. Furthermore, increasing patient age also predicted high memory and effector T cell numbers. The effects of post HCT immunosuppression, total body irradiation, donor leucocyte infusions, T cell dose and post HCT infections on T cell recovery were also analysed. However, no effects of these single variables across a variety of different age, GVHD and T cell depletion groups were apparent. This study suggests that future analysis of the factors affecting T cell reconstitution and studies aimed at reactivating the thymus through therapeutic intervention should be analysed in age-, GVHD- and TCD-matched patient groups.
118 schema:genre research_article
119 schema:inLanguage en
120 schema:isAccessibleForFree true
121 schema:isPartOf N8734d3dca7ab49c2bf287d460bedcccb
122 Ne620b4740ef14af0969dff3d0d4cb259
123 sg:journal.1096890
124 schema:name Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients
125 schema:pagination 1704235
126 schema:productId N1bc8dd6d24a0430a8524a54c3554c3c2
127 N821088eacaec4efc8e61f1651e472bd4
128 N95e2af8f3eb84458bde0ab411246b375
129 Nd1755bdbced446d2b1cf129e1f312bb2
130 Nd27f1bb3693f4595935966a4476c2a5c
131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031583638
132 https://doi.org/10.1038/sj.bmt.1704235
133 schema:sdDatePublished 2019-04-10T21:24
134 schema:sdLicense https://scigraph.springernature.com/explorer/license/
135 schema:sdPublisher N62f1a0ef98a04823a4762401bc3ad851
136 schema:url http://www.nature.com/articles/1704235
137 sgo:license sg:explorer/license/
138 sgo:sdDataset articles
139 rdf:type schema:ScholarlyArticle
140 N118d902078374936830230c0d758d8ec rdf:first sg:person.01242344565.16
141 rdf:rest rdf:nil
142 N1744833816b140d3ae77df0db86261db rdf:first sg:person.07465546124.13
143 rdf:rest Nf2ef3386fdd340009dd431b05ff9ccb7
144 N1bc8dd6d24a0430a8524a54c3554c3c2 schema:name pubmed_id
145 schema:value 14595388
146 rdf:type schema:PropertyValue
147 N20d5c1f040e246f79a23e1bef1adcbf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 N36dc3cccc2504b9fad0dab3fdc5d1611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Middle Aged
152 rdf:type schema:DefinedTerm
153 N378381da9f544e23b9612227e61a4bcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Lymphocyte Depletion
155 rdf:type schema:DefinedTerm
156 N3e53252cf2ed4c1bb88d1130e29ba171 rdf:first sg:person.01307115021.27
157 rdf:rest N40e3d2fa8ca7463cb9843cd9f847769e
158 N40e3d2fa8ca7463cb9843cd9f847769e rdf:first sg:person.01021626010.51
159 rdf:rest N1744833816b140d3ae77df0db86261db
160 N4f2941ecd576453d96c0fc471297bc46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Thymus Gland
162 rdf:type schema:DefinedTerm
163 N62f1a0ef98a04823a4762401bc3ad851 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N66ace34751654470b268c17cc4be5a64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Regeneration
167 rdf:type schema:DefinedTerm
168 N69a3c66efb5b463c88babb82ac970ed9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name T-Lymphocyte Subsets
170 rdf:type schema:DefinedTerm
171 N7238125eb3fb432fb8c735f72fcf745c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Lymphocyte Count
173 rdf:type schema:DefinedTerm
174 N7791f5385efa4c4d82d1420ca02d71fc rdf:first sg:person.01053700261.59
175 rdf:rest Nf66d22d96a994f9bae9cd4ff918905f0
176 N821088eacaec4efc8e61f1651e472bd4 schema:name readcube_id
177 schema:value 9675323ce3a4ab1efa995389e5d89f943b2ea8002ed5cc7ecc693cde50280a1e
178 rdf:type schema:PropertyValue
179 N8734d3dca7ab49c2bf287d460bedcccb schema:issueNumber 10
180 rdf:type schema:PublicationIssue
181 N8dd2702e9a0a4235af98582d1d29a4f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Adult
183 rdf:type schema:DefinedTerm
184 N95e2af8f3eb84458bde0ab411246b375 schema:name dimensions_id
185 schema:value pub.1031583638
186 rdf:type schema:PropertyValue
187 Na26eff8c06374b97a8f5a47d3e0ae37d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Hematopoietic Stem Cell Transplantation
189 rdf:type schema:DefinedTerm
190 Naa604f4ab8474b51992c7172066c5650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Transplantation, Homologous
192 rdf:type schema:DefinedTerm
193 Nae730cc13dc94f238c8e776a78ce0835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Longitudinal Studies
195 rdf:type schema:DefinedTerm
196 Nbef6f7e8664843ae9e5a71751abc7f81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name T-Lymphocytes
198 rdf:type schema:DefinedTerm
199 Nbf111bb50b8444f9810edec81ba9b483 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Lymphopoiesis
201 rdf:type schema:DefinedTerm
202 Nc5d5e281f9bc4a7688193ce1659dda22 rdf:first sg:person.01327015700.66
203 rdf:rest N118d902078374936830230c0d758d8ec
204 Nc67bf01f2c35445ca3a2809621da2f4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Adolescent
206 rdf:type schema:DefinedTerm
207 Nc793727a208846869f59c5ca9a40862b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Receptors, Antigen, T-Cell
209 rdf:type schema:DefinedTerm
210 Ncf0b138826f74e3688aa651bf608e39e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Child
212 rdf:type schema:DefinedTerm
213 Nd1755bdbced446d2b1cf129e1f312bb2 schema:name nlm_unique_id
214 schema:value 8702459
215 rdf:type schema:PropertyValue
216 Nd27f1bb3693f4595935966a4476c2a5c schema:name doi
217 schema:value 10.1038/sj.bmt.1704235
218 rdf:type schema:PropertyValue
219 Ne620b4740ef14af0969dff3d0d4cb259 schema:volumeNumber 32
220 rdf:type schema:PublicationVolume
221 Nf2ef3386fdd340009dd431b05ff9ccb7 rdf:first sg:person.016310433302.65
222 rdf:rest N7791f5385efa4c4d82d1420ca02d71fc
223 Nf66d22d96a994f9bae9cd4ff918905f0 rdf:first sg:person.0631425377.33
224 rdf:rest Nc5d5e281f9bc4a7688193ce1659dda22
225 Nf9bd03c2d25f46dbb1f141a150dfa7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Blood Cells
227 rdf:type schema:DefinedTerm
228 Nfc8a93c597d64c7d9cc0818fce191690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Age Factors
230 rdf:type schema:DefinedTerm
231 Nffcc298b7d4242799714ededafa855d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Graft vs Host Disease
233 rdf:type schema:DefinedTerm
234 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
235 schema:name Medical and Health Sciences
236 rdf:type schema:DefinedTerm
237 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
238 schema:name Clinical Sciences
239 rdf:type schema:DefinedTerm
240 sg:journal.1096890 schema:issn 0268-3369
241 1476-5365
242 schema:name Bone Marrow Transplantation
243 rdf:type schema:Periodical
244 sg:person.01021626010.51 schema:affiliation https://www.grid.ac/institutes/grid.426412.7
245 schema:familyName McGreavey
246 schema:givenName L
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021626010.51
248 rdf:type schema:Person
249 sg:person.01053700261.59 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
250 schema:familyName Ethell
251 schema:givenName M
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053700261.59
253 rdf:type schema:Person
254 sg:person.01242344565.16 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
255 schema:familyName Travers
256 schema:givenName P J
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242344565.16
258 rdf:type schema:Person
259 sg:person.01307115021.27 schema:affiliation https://www.grid.ac/institutes/grid.426412.7
260 schema:familyName Fallen
261 schema:givenName P R
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307115021.27
263 rdf:type schema:Person
264 sg:person.01327015700.66 schema:affiliation https://www.grid.ac/institutes/grid.418711.a
265 schema:familyName Guimarães
266 schema:givenName A
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327015700.66
268 rdf:type schema:Person
269 sg:person.016310433302.65 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
270 schema:familyName Potter
271 schema:givenName M
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016310433302.65
273 rdf:type schema:Person
274 sg:person.0631425377.33 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
275 schema:familyName Prentice
276 schema:givenName H G
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631425377.33
278 rdf:type schema:Person
279 sg:person.07465546124.13 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
280 schema:familyName Madrigal
281 schema:givenName J A
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07465546124.13
283 rdf:type schema:Person
284 sg:pub.10.1023/a:1006611518223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032158393
285 https://doi.org/10.1023/a:1006611518223
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/25374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045631673
288 https://doi.org/10.1038/25374
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nm0597-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002856145
291 https://doi.org/10.1038/nm0597-533
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.bmt.1702400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039922183
294 https://doi.org/10.1038/sj.bmt.1702400
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/sj.bmt.1703118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043842213
297 https://doi.org/10.1038/sj.bmt.1703118
298 rdf:type schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1064243698 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1074488265 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1074666193 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1074696652 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1074718151 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1075114483 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1077702013 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1078833599 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1079648037 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1079678857 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1079807585 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1079808064 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1081620610 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1081669760 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1081758498 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1082220993 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1082421979 schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1082442979 schema:CreativeWork
317 https://app.dimensions.ai/details/publication/pub.1082466630 schema:CreativeWork
318 https://app.dimensions.ai/details/publication/pub.1082560049 schema:CreativeWork
319 https://app.dimensions.ai/details/publication/pub.1082564938 schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1082600665 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1082707235 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1082723588 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1082790779 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1082800607 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1082892883 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1082953149 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1083134073 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1083354417 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1083358629 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1083373197 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1083379027 schema:CreativeWork
332 https://doi.org/10.1001/archneur.58.1.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028451491
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1003740181
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1002/(sici)1521-4141(199806)28:06<1886::aid-immu1886>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1016673599
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1002/art.1780380912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031109074
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1006/cimm.2001.1761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022778127
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1006/clin.1994.1023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010865753
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/0167-5699(96)80543-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049591790
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/s0140-6736(00)02293-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029625189
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/s0140-6736(79)90825-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035816551
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0140-6736(84)92848-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053026354
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0140-6736(96)08086-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037658881
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0140-6736(97)03098-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035515366
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s0165-2478(97)02713-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041564189
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0167-5699(00)01714-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012643056
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0192-0561(98)00034-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032099733
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0301-472x(00)00655-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033966050
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s1567-5769(00)00006-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035634625
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1046/j.1365-2141.1996.d01-1834.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005952095
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1046/j.1365-2141.2001.02900.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017385747
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1056/nejm199103073241005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048916015
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1056/nejm199303043280901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009054172
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1056/nejm199501193320303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006006309
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1056/nejm199804023381405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006602107
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1067/mlc.2003.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002502803
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1073/pnas.87.16.6301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032996822
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1084/jem.186.9.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438620
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1084/jem.189.8.1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003477249
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1084/jem.193.7.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004612832
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/intimm/7.1.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059712234
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1097/00007890-198208000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036523118
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1097/00007890-200002150-00026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060281794
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1111/j.1365-2141.1986.tb07574.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030659473
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1111/j.1365-3083.1985.tb01916.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031105099
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1111/j.1600-065x.1997.tb00974.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024413674
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1111/j.1600-065x.1997.tb00980.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031303250
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1111/j.1600-065x.1997.tb01030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032386180
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1111/j.1749-6632.1995.tb44479.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028746131
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1111/j.1749-6632.2001.tb03601.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541307
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1159/000054630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035462267
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1159/000237091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049799656
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1172/jci6762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023927725
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1182/blood.v97.2.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000592189
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1182/blood.v97.5.1458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035536986
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1182/blood.v97.5.1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035083560
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1182/blood.v98.10.2900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038120288
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1182/blood.v98.4.1116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025525454
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1182/blood.v98.5.1601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042306738
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1182/blood.v98.8.2352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004798171
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1182/blood.v99.8.2851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035020111
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1200/jco.1997.15.2.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083054548
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1200/jco.2001.19.14.3340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074849835
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1210/endo.139.2.5729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282150
435 rdf:type schema:CreativeWork
436 https://doi.org/10.4049/jimmunol.166.3.1524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074751357
437 rdf:type schema:CreativeWork
438 https://doi.org/10.7326/0003-4819-119-3-199308010-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073697618
439 rdf:type schema:CreativeWork
440 https://www.grid.ac/institutes/grid.418711.a schema:alternateName Portuguese Oncology Institute
441 schema:name Unidade de Transplante de Medula Óssea, Instituto Português de Oncologia, Centro de Lisboa, Portugal
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.426412.7 schema:alternateName Anthony Nolan
444 schema:name Anthony Nolan Research Institute, Fleet Road, London, UK
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
447 schema:name Anthony Nolan Research Institute, Fleet Road, London, UK
448 Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, London, UK
449 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...