Concurrent presence of both patient and donor t(14;18) in a follicular lymphoma patient after undergoing allogeneic BMT: implications for minimal ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-05

AUTHORS

M D Rosenblum, W R Drobyski, C Keever-Taylor, C-C Chang

ABSTRACT

We report the case of a t(14:18)(+) follicular lymphoma (FL) patient in long-term clinical remission after undergoing an allogeneic bone marrow transplantation (allo-BMT) from a human leukocyte antigen (HLA)-identical sibling donor who was the normal healthy carrier of a t(14:18)(+) B cell clone. Using real-time quantitative PCR (RQ-PCR) and gel electrophoresis, we document the temporal disappearance of the patient's t(14:18)(+) clone early post-transplant with the concomitant emergence and long-term persistence of the donor's t(14:18)(+) clone in the patient's peripheral blood. This report indicates that the use of PCR-based techniques to measure minimal residual disease in FL patients post-alloBMT should incorporate pretransplant screening of the donor for t(14;18). Furthermore, it suggests that healthy individuals with t(14:18) need not be excluded as donors for FL patients treated with allo-BMT. More... »

PAGES

947

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1704039

DOI

http://dx.doi.org/10.1038/sj.bmt.1704039

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034055077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12748676


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