Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04-01

AUTHORS

D Soligo, A Ibatici, E Berti, P Morandi, E Longhi, L Venegoni, M Corbellino, C Annaloro, L Robbiolo, A Della Volpe, E Alessi, G Lambertenghi Deliliers

ABSTRACT

Summary:Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling. More... »

PAGES

663-666

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1703872

DOI

http://dx.doi.org/10.1038/sj.bmt.1703872

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015789209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12692606


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