Richter's syndrome after allogeneic stem cell transplantation for chronic lymphocytic leukaemia successfully treated by withdrawal of immunosuppression, and donor lymphocyte ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-02

AUTHORS

I Español, T Büchler, C Ferrá, D Gallardo, P Reyes, J Sarrá, A Domingo, V Romagosa, A Grañena

ABSTRACT

Development of high-grade non-Hodgkin's lymphoma is a possible complication of chronic lymphocytic leukaemia/small lymphocytic lymphoma, known as Richter's syndrome (RS). Treatment for RS includes systemic chemotherapy and, recently, allogeneic stem cell transplantation (SCT). We describe a patient with B-chronic lymphocytic leukaemia who developed RS 4 months after allogeneic SCT from an HLA-identical sibling. The RS presented with systemic symptoms, lymphadenopathy, pancytopenia and serum lactate dehydrogenase elevation. The patient was treated with immunosuppressive drug withdrawal and a donor lymphocyte infusion (DLI) of 1 x 10(7) CD3/kg, leading to the disappearance of all symptoms and the attainment of complete donor chimerism. After 18 months of the therapeutic DLI, the patient continues in complete remission. More... »

PAGES

1703788

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1703788

DOI

http://dx.doi.org/10.1038/sj.bmt.1703788

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026172065

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12621484


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