Peripheral blood stem cell transplantation for POEMS syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-09

AUTHORS

KS Peggs, S Paneesha, PD Kottaridis, RK Chakraverty, G Tobias, M Reilly, P Mahendra, K Yong

ABSTRACT

In common with other plasma cell dyscrasias in which a small tumour burden is associated with severe clinical symptoms (notably systemic AL amyloidosis) the possible benefits of dose intensification are yet to be fully explored in POEMS syndrome. One important issue is whether the toxicity of the procedure is significantly increased in this group. We report two cases of POEMS syndrome with solitary asymptomatic bone lesions treated with high-dose melphalan (200 mg/m(2)) and peripheral blood stem cell (PBSC) rescue. In both cases there was minimal peri-transplant morbidity and a subsequent substantial and maintained improvement in the peripheral neuropathy. More... »

PAGES

401

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1703670

DOI

http://dx.doi.org/10.1038/sj.bmt.1703670

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039658525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12235526


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