Pure red cell aplasia after allogeneic stem cell transplantation with reduced conditioning View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10-01

AUTHORS

H Veelken, R Wäsch, D Behringer, H Bertz, J Finke

ABSTRACT

Conditioning regimens with reduced intensity are used increasingly for allogeneic stem cell transplantation in elderly or extensively pretreated patients. Two cases of pure red cell aplasia after fludarabine-based conditioning and during immunosuppression with cyclosporin are described. Both patients received AB0-mismatched stem cells and had anti-donor isoagglutinins. Red cell recovery occurred after extended immunosuppression when isoagglutinins had disappeared. Colony assays indicated serologic suppression of the erythrocyte lineage in one patient. Since reduced conditioning permits donor cell engraftment primarily by suppression of host T cells, antibody-mediated immunological complications may occur more frequently than after ‘classical’ conditioning. Bone Marrow Transplantation (2000) 26, 911–915. More... »

PAGES

911-915

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1702629

DOI

http://dx.doi.org/10.1038/sj.bmt.1702629

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001197168

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11081395


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