Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-06

AUTHORS

E Vellenga, WLJ van Putten, MA Boogaerts, GJ Daenen, GEG Verhoef, A Hagenbeek, AR Jonkhoff, PC Huijgens, LF Verdonck, J van der Lelie, HC Schouten, J Gmür, P Wijermans, A Gratwohl, U Hess, MF Fey, B Löwenberg

ABSTRACT

The clinical use of autologous marrow transplantation in acute myeloid leukemia (AML) has been hampered by the inability to collect adequate numbers of cells after remission induction chemotherapy and the notably delayed hematopoietic regeneration following autograft reinfusion. Here we present a study in which the feasibility of mobilizing stem cells was investigated in newly diagnosed AML. Among 96 AML patients, 76 patients (79%) entered complete remission. Mobilization was undertaken with low dose and high dose schedules of G-CSF in 63 patients, and 54 patients (87%) were leukapheresed. A median of 2.0 x 10(6) CD34+ cells/kg (range 0.1-72.0) was obtained in a median of three leukaphereses following a low dose G-CSF schedule (150 microg/m2) during an average of 20 days. Higher dose regimens of G-CSF (450 microg/m2 and 600 microg/m2) given during an average of 11 days resulted in 28 patients in a yield of 3.6 x 10(6) CD34+ cells/kg (range 0-60.3) also obtained following three leukaphereses. The low dose and high dose schedules of G-CSF permitted the collection of 2 x 10(6) CD34-positive cells in 46% and 79% of cases respectively (P = 0.01). Twenty-eight patients were transplanted with a peripheral blood stem cell (PBSC) graft and hemopoietic repopulation was compared with the results of a previous study with autologous bone marrow. Recovery of granulocytes (>0.5 x 10(9)/l, 17 vs 37 days) and platelets (>20 x 10(9)/l; 26 vs 96 days) was significantly faster after peripheral stem cell transplantation compared to autologous bone marrow transplantation. These results demonstrate the feasibility of PBSCT in the majority of cases with AML and the potential advantage of this approach with respect to hemopoietic recovery. More... »

PAGES

1701799

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701799

DOI

http://dx.doi.org/10.1038/sj.bmt.1701799

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015125876

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10414916


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD34", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Busulfan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocyte Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Mobilization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Autologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "University Hospital Groningen, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vellenga", 
        "givenName": "E", 
        "id": "sg:person.01150664247.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150664247.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hovon", 
          "id": "https://www.grid.ac/institutes/grid.476265.4", 
          "name": [
            "HOVON Data Center, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Putten", 
        "givenName": "WLJ", 
        "id": "sg:person.01304576273.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304576273.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "University Hospital Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boogaerts", 
        "givenName": "MA", 
        "id": "sg:person.014504473454.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504473454.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "University Hospital Groningen, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daenen", 
        "givenName": "GJ", 
        "id": "sg:person.016024430307.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016024430307.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "University Hospital Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verhoef", 
        "givenName": "GEG", 
        "id": "sg:person.014363667734.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014363667734.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "University Hospital Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagenbeek", 
        "givenName": "A", 
        "id": "sg:person.0706224144.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706224144.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "University Hospital, Vrije Universiteit, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jonkhoff", 
        "givenName": "AR", 
        "id": "sg:person.015571455154.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015571455154.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "University Hospital, Vrije Universiteit, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huijgens", 
        "givenName": "PC", 
        "id": "sg:person.015432427064.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015432427064.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "University Hospital Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verdonck", 
        "givenName": "LF", 
        "id": "sg:person.015031150617.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015031150617.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "University Hospital Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Lelie", 
        "givenName": "J", 
        "id": "sg:person.01357676132.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357676132.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maastricht University Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "University Hospital Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schouten", 
        "givenName": "HC", 
        "id": "sg:person.016047372244.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016047372244.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.412004.3", 
          "name": [
            "Universit\u00e4tsspital Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gm\u00fcr", 
        "givenName": "J", 
        "id": "sg:person.074606427.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074606427.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Leijenburg Hospital, The Hague, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wijermans", 
        "givenName": "P", 
        "id": "sg:person.014651007704.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014651007704.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Kantonsspital Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gratwohl", 
        "givenName": "A", 
        "id": "sg:person.01021337771.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021337771.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kantonsspital St. Gallen", 
          "id": "https://www.grid.ac/institutes/grid.413349.8", 
          "name": [
            "Kantonsspital St Gallen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hess", 
        "givenName": "U", 
        "id": "sg:person.0715271415.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715271415.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Bern", 
          "id": "https://www.grid.ac/institutes/grid.411656.1", 
          "name": [
            "University Hospital Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fey", 
        "givenName": "MF", 
        "id": "sg:person.01333347274.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333347274.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK): Daniel den Hoed Cancer Center Rotterdam, University Hospital Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f6wenberg", 
        "givenName": "B", 
        "id": "sg:person.0744563071.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744563071.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)90536-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007053081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199501263320403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007194631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)09214-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020730183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199501263320411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025097348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199410063311402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026923022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1984.00521.x-i1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036553812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1998.00614.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049350014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.12.3496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083183847"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "The clinical use of autologous marrow transplantation in acute myeloid leukemia (AML) has been hampered by the inability to collect adequate numbers of cells after remission induction chemotherapy and the notably delayed hematopoietic regeneration following autograft reinfusion. Here we present a study in which the feasibility of mobilizing stem cells was investigated in newly diagnosed AML. Among 96 AML patients, 76 patients (79%) entered complete remission. Mobilization was undertaken with low dose and high dose schedules of G-CSF in 63 patients, and 54 patients (87%) were leukapheresed. A median of 2.0 x 10(6) CD34+ cells/kg (range 0.1-72.0) was obtained in a median of three leukaphereses following a low dose G-CSF schedule (150 microg/m2) during an average of 20 days. Higher dose regimens of G-CSF (450 microg/m2 and 600 microg/m2) given during an average of 11 days resulted in 28 patients in a yield of 3.6 x 10(6) CD34+ cells/kg (range 0-60.3) also obtained following three leukaphereses. The low dose and high dose schedules of G-CSF permitted the collection of 2 x 10(6) CD34-positive cells in 46% and 79% of cases respectively (P = 0.01). Twenty-eight patients were transplanted with a peripheral blood stem cell (PBSC) graft and hemopoietic repopulation was compared with the results of a previous study with autologous bone marrow. Recovery of granulocytes (>0.5 x 10(9)/l, 17 vs 37 days) and platelets (>20 x 10(9)/l; 26 vs 96 days) was significantly faster after peripheral stem cell transplantation compared to autologous bone marrow transplantation. These results demonstrate the feasibility of PBSCT in the majority of cases with AML and the potential advantage of this approach with respect to hemopoietic recovery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bmt.1701799", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?", 
    "pagination": "1701799", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4810be2f1e53423d1bf6991838aff764ba7ecc6b51ccb815c02d879220327ee5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10414916"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1701799"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015125876"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1701799", 
      "https://app.dimensions.ai/details/publication/pub.1015125876"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29204_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1701799"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701799'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701799'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701799'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701799'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      56 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1701799 schema:about N161855f0f80a4cf1a0d6bd90e96a8960
2 N2faebc6b01564582800eed33e89b66b2
3 N31d758231f6144ea8477fc87a06959b9
4 N58de3e234b8643a9a16365c8e793bcfe
5 N5981a23511eb470bbda76a10c26c5a20
6 N5a723011286c4ce4ae823b2b47da0d2c
7 N5d3fb4f55297493d8512bb4bba0e85e4
8 N7a43ba14631f40eca0a7a0d0562b943a
9 Na169d89de65c4d058c73ef4fbef45a59
10 Na17450d4ecb645e481e09b1bf50204de
11 Nc4964f12a8f24d9e89fd56b334aa47ee
12 Ndb2d19f2dc9a4886a00c48ef4d997885
13 Ne2fd72d68a0e4c9a9ca1bcbd2c8e0041
14 Ne373f9f788d042df87aa06730db2f07e
15 Ne6e9d62da51e4102ac42f06c8a346428
16 Neaeaec6adf9e4835a02e4ee09f0a2ab6
17 Nf0829aa217eb4b5a8c5aa9cb035b433d
18 Nf17acf750c974a6cbe0246e287010c2e
19 Nfe5591b24ca746a4ac1cfa4eabaed95e
20 anzsrc-for:11
21 anzsrc-for:1102
22 schema:author Na17edce36f3c4fcfa6cd08bb4b737cfa
23 schema:citation https://doi.org/10.1016/s0140-6736(96)90536-x
24 https://doi.org/10.1016/s0140-6736(97)09214-3
25 https://doi.org/10.1046/j.1365-2141.1998.00614.x
26 https://doi.org/10.1056/nejm199410063311402
27 https://doi.org/10.1056/nejm199501263320403
28 https://doi.org/10.1056/nejm199501263320411
29 https://doi.org/10.1111/j.1365-2141.1984.00521.x-i1
30 https://doi.org/10.1200/jco.1997.15.12.3496
31 schema:datePublished 1999-06
32 schema:datePublishedReg 1999-06-01
33 schema:description The clinical use of autologous marrow transplantation in acute myeloid leukemia (AML) has been hampered by the inability to collect adequate numbers of cells after remission induction chemotherapy and the notably delayed hematopoietic regeneration following autograft reinfusion. Here we present a study in which the feasibility of mobilizing stem cells was investigated in newly diagnosed AML. Among 96 AML patients, 76 patients (79%) entered complete remission. Mobilization was undertaken with low dose and high dose schedules of G-CSF in 63 patients, and 54 patients (87%) were leukapheresed. A median of 2.0 x 10(6) CD34+ cells/kg (range 0.1-72.0) was obtained in a median of three leukaphereses following a low dose G-CSF schedule (150 microg/m2) during an average of 20 days. Higher dose regimens of G-CSF (450 microg/m2 and 600 microg/m2) given during an average of 11 days resulted in 28 patients in a yield of 3.6 x 10(6) CD34+ cells/kg (range 0-60.3) also obtained following three leukaphereses. The low dose and high dose schedules of G-CSF permitted the collection of 2 x 10(6) CD34-positive cells in 46% and 79% of cases respectively (P = 0.01). Twenty-eight patients were transplanted with a peripheral blood stem cell (PBSC) graft and hemopoietic repopulation was compared with the results of a previous study with autologous bone marrow. Recovery of granulocytes (>0.5 x 10(9)/l, 17 vs 37 days) and platelets (>20 x 10(9)/l; 26 vs 96 days) was significantly faster after peripheral stem cell transplantation compared to autologous bone marrow transplantation. These results demonstrate the feasibility of PBSCT in the majority of cases with AML and the potential advantage of this approach with respect to hemopoietic recovery.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N297c36a2d2bd48c0b519c338d0e5d6b7
38 N7cd951b7d27a478fab4031583d26b9e5
39 sg:journal.1096890
40 schema:name Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?
41 schema:pagination 1701799
42 schema:productId N0b5ada2a27d34e46974c1a8ff24e2669
43 N213a7f4d30624426bb6b7338cf4d22f9
44 N653247b17356481ea5bdf3f26dbae16c
45 N6f75292063e64d7abd0a3cde9a5dc59a
46 Na635b695c7c24303aa0174b841f3bd05
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015125876
48 https://doi.org/10.1038/sj.bmt.1701799
49 schema:sdDatePublished 2019-04-11T11:54
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N9c9d6dd110d6426c98b027eb11eb290b
52 schema:url http://www.nature.com/articles/1701799
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N00b2caf0105d438db6501ad8cef06d50 rdf:first sg:person.074606427.57
57 rdf:rest N127dbec44e1343b4bef67b43477e2311
58 N083c1e33a88440b0a208dbabdc8c0db2 rdf:first sg:person.016047372244.65
59 rdf:rest N00b2caf0105d438db6501ad8cef06d50
60 N0b5ada2a27d34e46974c1a8ff24e2669 schema:name pubmed_id
61 schema:value 10414916
62 rdf:type schema:PropertyValue
63 N127dbec44e1343b4bef67b43477e2311 rdf:first sg:person.014651007704.81
64 rdf:rest N39076085833849bea67304f4359fe40b
65 N161855f0f80a4cf1a0d6bd90e96a8960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Aged
67 rdf:type schema:DefinedTerm
68 N213a7f4d30624426bb6b7338cf4d22f9 schema:name doi
69 schema:value 10.1038/sj.bmt.1701799
70 rdf:type schema:PropertyValue
71 N23a4b9af3dce4a44872e248638c0b387 rdf:first sg:person.01304576273.35
72 rdf:rest N8a4e59378cd048b286276f71afc5440a
73 N23c8f1556e44457ea298a56d414623da rdf:first sg:person.014363667734.25
74 rdf:rest N498099d128e34c88831bde8bfa0f930a
75 N297c36a2d2bd48c0b519c338d0e5d6b7 schema:volumeNumber 23
76 rdf:type schema:PublicationVolume
77 N2a754238fc2042959a6d92638766582a rdf:first sg:person.0715271415.09
78 rdf:rest Ncab4294bcdf448d09a0a582970307d4a
79 N2faebc6b01564582800eed33e89b66b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Antineoplastic Agents, Alkylating
81 rdf:type schema:DefinedTerm
82 N31d758231f6144ea8477fc87a06959b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Busulfan
84 rdf:type schema:DefinedTerm
85 N39076085833849bea67304f4359fe40b rdf:first sg:person.01021337771.37
86 rdf:rest N2a754238fc2042959a6d92638766582a
87 N498099d128e34c88831bde8bfa0f930a rdf:first sg:person.0706224144.85
88 rdf:rest Nbaa7311acf2b462f92d75f463ee0fb6f
89 N512afd5a92a5461da78d59902188c173 rdf:first sg:person.015031150617.23
90 rdf:rest N5a7f02a5f96148b091ee1b38da7df6db
91 N58de3e234b8643a9a16365c8e793bcfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cyclophosphamide
93 rdf:type schema:DefinedTerm
94 N5981a23511eb470bbda76a10c26c5a20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N5a723011286c4ce4ae823b2b47da0d2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Acute Disease
99 rdf:type schema:DefinedTerm
100 N5a7f02a5f96148b091ee1b38da7df6db rdf:first sg:person.01357676132.83
101 rdf:rest N083c1e33a88440b0a208dbabdc8c0db2
102 N5d3fb4f55297493d8512bb4bba0e85e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N653247b17356481ea5bdf3f26dbae16c schema:name dimensions_id
106 schema:value pub.1015125876
107 rdf:type schema:PropertyValue
108 N6f75292063e64d7abd0a3cde9a5dc59a schema:name readcube_id
109 schema:value 4810be2f1e53423d1bf6991838aff764ba7ecc6b51ccb815c02d879220327ee5
110 rdf:type schema:PropertyValue
111 N7a43ba14631f40eca0a7a0d0562b943a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Hematopoietic Stem Cell Transplantation
113 rdf:type schema:DefinedTerm
114 N7cd951b7d27a478fab4031583d26b9e5 schema:issueNumber 12
115 rdf:type schema:PublicationIssue
116 N883de8e689144994ad06da2049473a0e rdf:first sg:person.0744563071.84
117 rdf:rest rdf:nil
118 N8a4e59378cd048b286276f71afc5440a rdf:first sg:person.014504473454.48
119 rdf:rest Nb428daf0a65e4ff098ad0f5cdc8efece
120 N94b6433b6b0b48d1b302322f2654b5dc rdf:first sg:person.015432427064.41
121 rdf:rest N512afd5a92a5461da78d59902188c173
122 N9c9d6dd110d6426c98b027eb11eb290b schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 Na169d89de65c4d058c73ef4fbef45a59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Granulocyte Colony-Stimulating Factor
126 rdf:type schema:DefinedTerm
127 Na17450d4ecb645e481e09b1bf50204de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Leukemia, Myeloid
129 rdf:type schema:DefinedTerm
130 Na17edce36f3c4fcfa6cd08bb4b737cfa rdf:first sg:person.01150664247.53
131 rdf:rest N23a4b9af3dce4a44872e248638c0b387
132 Na635b695c7c24303aa0174b841f3bd05 schema:name nlm_unique_id
133 schema:value 8702459
134 rdf:type schema:PropertyValue
135 Nb428daf0a65e4ff098ad0f5cdc8efece rdf:first sg:person.016024430307.47
136 rdf:rest N23c8f1556e44457ea298a56d414623da
137 Nbaa7311acf2b462f92d75f463ee0fb6f rdf:first sg:person.015571455154.68
138 rdf:rest N94b6433b6b0b48d1b302322f2654b5dc
139 Nc4964f12a8f24d9e89fd56b334aa47ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Transplantation, Autologous
141 rdf:type schema:DefinedTerm
142 Ncab4294bcdf448d09a0a582970307d4a rdf:first sg:person.01333347274.81
143 rdf:rest N883de8e689144994ad06da2049473a0e
144 Ndb2d19f2dc9a4886a00c48ef4d997885 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adolescent
146 rdf:type schema:DefinedTerm
147 Ne2fd72d68a0e4c9a9ca1bcbd2c8e0041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adult
149 rdf:type schema:DefinedTerm
150 Ne373f9f788d042df87aa06730db2f07e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Transplantation Conditioning
152 rdf:type schema:DefinedTerm
153 Ne6e9d62da51e4102ac42f06c8a346428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Hematopoietic Stem Cell Mobilization
155 rdf:type schema:DefinedTerm
156 Neaeaec6adf9e4835a02e4ee09f0a2ab6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Bone Marrow Transplantation
158 rdf:type schema:DefinedTerm
159 Nf0829aa217eb4b5a8c5aa9cb035b433d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Male
161 rdf:type schema:DefinedTerm
162 Nf171640c4f204d93a08e552e5a4e2fc5 schema:name Leijenburg Hospital, The Hague, The Netherlands
163 rdf:type schema:Organization
164 Nf17acf750c974a6cbe0246e287010c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Middle Aged
166 rdf:type schema:DefinedTerm
167 Nfe5591b24ca746a4ac1cfa4eabaed95e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Antigens, CD34
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
174 schema:name Cardiorespiratory Medicine and Haematology
175 rdf:type schema:DefinedTerm
176 sg:journal.1096890 schema:issn 0268-3369
177 1476-5365
178 schema:name Bone Marrow Transplantation
179 rdf:type schema:Periodical
180 sg:person.01021337771.37 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
181 schema:familyName Gratwohl
182 schema:givenName A
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021337771.37
184 rdf:type schema:Person
185 sg:person.01150664247.53 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
186 schema:familyName Vellenga
187 schema:givenName E
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150664247.53
189 rdf:type schema:Person
190 sg:person.01304576273.35 schema:affiliation https://www.grid.ac/institutes/grid.476265.4
191 schema:familyName van Putten
192 schema:givenName WLJ
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304576273.35
194 rdf:type schema:Person
195 sg:person.01333347274.81 schema:affiliation https://www.grid.ac/institutes/grid.411656.1
196 schema:familyName Fey
197 schema:givenName MF
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333347274.81
199 rdf:type schema:Person
200 sg:person.01357676132.83 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
201 schema:familyName van der Lelie
202 schema:givenName J
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357676132.83
204 rdf:type schema:Person
205 sg:person.014363667734.25 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
206 schema:familyName Verhoef
207 schema:givenName GEG
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014363667734.25
209 rdf:type schema:Person
210 sg:person.014504473454.48 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
211 schema:familyName Boogaerts
212 schema:givenName MA
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504473454.48
214 rdf:type schema:Person
215 sg:person.014651007704.81 schema:affiliation Nf171640c4f204d93a08e552e5a4e2fc5
216 schema:familyName Wijermans
217 schema:givenName P
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014651007704.81
219 rdf:type schema:Person
220 sg:person.015031150617.23 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
221 schema:familyName Verdonck
222 schema:givenName LF
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015031150617.23
224 rdf:type schema:Person
225 sg:person.015432427064.41 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
226 schema:familyName Huijgens
227 schema:givenName PC
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015432427064.41
229 rdf:type schema:Person
230 sg:person.015571455154.68 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
231 schema:familyName Jonkhoff
232 schema:givenName AR
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015571455154.68
234 rdf:type schema:Person
235 sg:person.016024430307.47 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
236 schema:familyName Daenen
237 schema:givenName GJ
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016024430307.47
239 rdf:type schema:Person
240 sg:person.016047372244.65 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
241 schema:familyName Schouten
242 schema:givenName HC
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016047372244.65
244 rdf:type schema:Person
245 sg:person.0706224144.85 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
246 schema:familyName Hagenbeek
247 schema:givenName A
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706224144.85
249 rdf:type schema:Person
250 sg:person.0715271415.09 schema:affiliation https://www.grid.ac/institutes/grid.413349.8
251 schema:familyName Hess
252 schema:givenName U
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715271415.09
254 rdf:type schema:Person
255 sg:person.0744563071.84 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
256 schema:familyName Löwenberg
257 schema:givenName B
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744563071.84
259 rdf:type schema:Person
260 sg:person.074606427.57 schema:affiliation https://www.grid.ac/institutes/grid.412004.3
261 schema:familyName Gmür
262 schema:givenName J
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074606427.57
264 rdf:type schema:Person
265 https://doi.org/10.1016/s0140-6736(96)90536-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007053081
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0140-6736(97)09214-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020730183
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1046/j.1365-2141.1998.00614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049350014
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1056/nejm199410063311402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026923022
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1056/nejm199501263320403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007194631
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1056/nejm199501263320411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025097348
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1365-2141.1984.00521.x-i1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036553812
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1200/jco.1997.15.12.3496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083183847
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
282 schema:name University Hospital Amsterdam, The Netherlands
283 University Hospital, Vrije Universiteit, Amsterdam, The Netherlands
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
286 schema:name Kantonsspital Basel, Switzerland
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.410569.f schema:alternateName Universitaire Ziekenhuizen Leuven
289 schema:name University Hospital Leuven, Belgium
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.411656.1 schema:alternateName University Hospital of Bern
292 schema:name University Hospital Bern, Switzerland
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.412004.3 schema:alternateName University Hospital of Zurich
295 schema:name Universitätsspital Zürich, Switzerland
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
298 schema:name University Hospital Maastricht, The Netherlands
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.413349.8 schema:alternateName Kantonsspital St. Gallen
301 schema:name Kantonsspital St Gallen, Switzerland
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
304 schema:name University Hospital Groningen, Amsterdam, The Netherlands
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.476265.4 schema:alternateName Hovon
307 schema:name HOVON Data Center, Rotterdam, The Netherlands
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
310 schema:name Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK): Daniel den Hoed Cancer Center Rotterdam, University Hospital Rotterdam, The Netherlands
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
313 schema:name University Hospital Utrecht, The Netherlands
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...