A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-02

AUTHORS

MJ Välimäki, K Kinnunen, L Volin, R Tähtelä, E Löyttyniemi, K Laitinen, P Mäkelä, P Keto, T Ruutu

ABSTRACT

Transplantation of solid organs including heart, kidney, and liver is associated with rapid bone loss and increased rate of fracture; data on bone marrow transplantation recipients (BMT) are scarce. The purpose of the present study was to examine the magnitude, timing, and mechanism of bone loss following allogeneic BMT, and to study whether bone loss can be prevented by calcium with or without calcitonin. Sixty-nine patients undergoing allogeneic BMT for malignant blood diseases were enrolled into the study. Forty-four (22 women, 22 men) completed 6 months, and 36 patients 1 year follow-up. They were randomized to receive either no additional treatment (n = 22), or oral calcium 1 g twice daily for 12 months (n = 12) or the same dose of calcium plus intranasal calcitonin 400 IU/day for the first month and then 200 IU/day for 11 months (n = 10). Bone mineral density (BMD) at the lumbar spine and three femoral sites (femoral neck, trochanter, Ward's triangle) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was followed with markers of bone formation and resorption (serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal (PICP) and aminoterminal propeptide (PINP), serum type I collagen carboxyterminal telopeptide (ICTP)). Serum testosterone was assayed in men. Calcium with or without calcitonin had no effect on bone loss or bone markers; consequently the three study groups were combined. During the first 6 post-transplant months BMD decreased by 5.7% in the lumbar spine and by 6.9% to 8.7% in the three femoral sites (P < 0.0001 for all); no significant further decline occured between 6 and 12 months. Four out of 25 assessable patients experienced vertebral compression fractures. Markers of bone formation reduced: B-ALP by 20% at 3 weeks (P = 0.027), PICP by 40% (P < 0.0001) and PINP by 63% at 6 weeks (P < 0.0001), with a return to baseline by 6 months. The marker of bone resorption, serum ICTP was above normal throughout the whole observation period, with a peak at 6 weeks (77% above baseline, P < 0.0001). In male patients serum testosterone decreased reaching a nadir (57% below baseline) at 6 weeks (P = 0.0003). In conclusion, significant bone loss occurs after BMT. It results from imbalance between reduced bone formation and increased bone resorption; hypogonadism may be a contributing factor in men. Bone loss can not be prevented by calcium with or without calcitonin. More... »

PAGES

1701586

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701586

DOI

http://dx.doi.org/10.1038/sj.bmt.1701586

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007706326

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10100579


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Inhalation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Remodeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Resorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcitonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "United Medix Laboratories (Finland)", 
          "id": "https://www.grid.ac/institutes/grid.438998.7", 
          "name": [
            "Department of Medicine, University of Helsinki, Finland", 
            "United Laboratories, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00e4lim\u00e4ki", 
        "givenName": "MJ", 
        "id": "sg:person.012301146260.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012301146260.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinnunen", 
        "givenName": "K", 
        "id": "sg:person.01313515604.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313515604.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Volin", 
        "givenName": "L", 
        "id": "sg:person.07531174677.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531174677.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United Medix Laboratories (Finland)", 
          "id": "https://www.grid.ac/institutes/grid.438998.7", 
          "name": [
            "United Laboratories, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "T\u00e4htel\u00e4", 
        "givenName": "R", 
        "id": "sg:person.01107001725.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107001725.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Statistics, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f6yttyniemi", 
        "givenName": "E", 
        "id": "sg:person.0627434550.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627434550.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laitinen", 
        "givenName": "K", 
        "id": "sg:person.01107734224.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107734224.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Radiology, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e4kel\u00e4", 
        "givenName": "P", 
        "id": "sg:person.01201507637.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201507637.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Radiology, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keto", 
        "givenName": "P", 
        "id": "sg:person.01321543224.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321543224.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruutu", 
        "givenName": "T", 
        "id": "sg:person.01370647451.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370647451.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jbmr.5650070202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000504524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650070202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000504524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199306173282404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009198565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000186373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012106375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00298552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024080235", 
          "https://doi.org/10.1007/bf00298552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199011000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025389720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199011000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025389720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)91862-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030188779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)91862-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030188779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02556148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032670081", 
          "https://doi.org/10.1007/bf02556148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02556148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032670081", 
          "https://doi.org/10.1007/bf02556148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650090802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034966333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650090802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034966333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039227423", 
          "https://doi.org/10.1007/s002239900240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-2760(94)90015-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039434337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042176146", 
          "https://doi.org/10.1007/s002239900206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00298990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048345161", 
          "https://doi.org/10.1007/bf00298990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(80)90380-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048876793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197504242921706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052170577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-123-5-2571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064261916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.82.5.1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064299607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.81.5.8626827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064320236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-104-5-648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073690936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-112-5-352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073694548"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-02", 
    "datePublishedReg": "1999-02-01", 
    "description": "Transplantation of solid organs including heart, kidney, and liver is associated with rapid bone loss and increased rate of fracture; data on bone marrow transplantation recipients (BMT) are scarce. The purpose of the present study was to examine the magnitude, timing, and mechanism of bone loss following allogeneic BMT, and to study whether bone loss can be prevented by calcium with or without calcitonin. Sixty-nine patients undergoing allogeneic BMT for malignant blood diseases were enrolled into the study. Forty-four (22 women, 22 men) completed 6 months, and 36 patients 1 year follow-up. They were randomized to receive either no additional treatment (n = 22), or oral calcium 1 g twice daily for 12 months (n = 12) or the same dose of calcium plus intranasal calcitonin 400 IU/day for the first month and then 200 IU/day for 11 months (n = 10). Bone mineral density (BMD) at the lumbar spine and three femoral sites (femoral neck, trochanter, Ward's triangle) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was followed with markers of bone formation and resorption (serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal (PICP) and aminoterminal propeptide (PINP), serum type I collagen carboxyterminal telopeptide (ICTP)). Serum testosterone was assayed in men. Calcium with or without calcitonin had no effect on bone loss or bone markers; consequently the three study groups were combined. During the first 6 post-transplant months BMD decreased by 5.7% in the lumbar spine and by 6.9% to 8.7% in the three femoral sites (P < 0.0001 for all); no significant further decline occured between 6 and 12 months. Four out of 25 assessable patients experienced vertebral compression fractures. Markers of bone formation reduced: B-ALP by 20% at 3 weeks (P = 0.027), PICP by 40% (P < 0.0001) and PINP by 63% at 6 weeks (P < 0.0001), with a return to baseline by 6 months. The marker of bone resorption, serum ICTP was above normal throughout the whole observation period, with a peak at 6 weeks (77% above baseline, P < 0.0001). In male patients serum testosterone decreased reaching a nadir (57% below baseline) at 6 weeks (P = 0.0003). In conclusion, significant bone loss occurs after BMT. It results from imbalance between reduced bone formation and increased bone resorption; hypogonadism may be a contributing factor in men. Bone loss can not be prevented by calcium with or without calcitonin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bmt.1701586", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin", 
    "pagination": "1701586", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "24b524c1118cda1604cb8f741e6aee210cc6cc50162ba6eb40d96885b0072daa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10100579"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1701586"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007706326"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1701586", 
      "https://app.dimensions.ai/details/publication/pub.1007706326"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29182_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1701586"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701586'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701586'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701586'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701586'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      21 PREDICATES      63 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1701586 schema:about N19e21b3265094080bc2891646a2e7191
2 N2ab2fa58d6ec4b1daf4a2a13a0b7e289
3 N2ce6a813e25e4a269d9f831346e1c70b
4 N3232eaebab7a494e97448506aada616e
5 N41eeb7c06d6e4e64b43f9f55e347e773
6 N463e2a600398462ca5eb40d765220b8f
7 N48bb2daf8e7d40bba15c26b797e6899e
8 N4ac13350c9f14666be012ad2fbd08c73
9 N5c35f2ad60f9438585c0adb3658d7553
10 N6ebd60b4eb404f0e988204fa31af691e
11 N737c535de3c74518abbf7faa93910018
12 N80412f9ecb804e3589f84dec768c70d7
13 N93005915002c4f4b92fb8b3f0295ea75
14 N9d06270811924c8caba0e40134df4c17
15 Na3c7abb0693d4e26ac8d2e5b75343482
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N4094d9e328484f2c943b3479aec12441
19 schema:citation sg:pub.10.1007/bf00298552
20 sg:pub.10.1007/bf00298990
21 sg:pub.10.1007/bf02556148
22 sg:pub.10.1007/s002239900206
23 sg:pub.10.1007/s002239900240
24 https://doi.org/10.1002/jbmr.5650070202
25 https://doi.org/10.1002/jbmr.5650090802
26 https://doi.org/10.1016/0002-9343(80)90380-0
27 https://doi.org/10.1016/1043-2760(94)90015-9
28 https://doi.org/10.1016/s0140-6736(88)91862-4
29 https://doi.org/10.1056/nejm197504242921706
30 https://doi.org/10.1056/nejm199306173282404
31 https://doi.org/10.1097/00007890-199011000-00028
32 https://doi.org/10.1159/000186373
33 https://doi.org/10.1210/endo-123-5-2571
34 https://doi.org/10.1210/jc.82.5.1497
35 https://doi.org/10.1210/jcem.81.5.8626827
36 https://doi.org/10.7326/0003-4819-104-5-648
37 https://doi.org/10.7326/0003-4819-112-5-352
38 schema:datePublished 1999-02
39 schema:datePublishedReg 1999-02-01
40 schema:description Transplantation of solid organs including heart, kidney, and liver is associated with rapid bone loss and increased rate of fracture; data on bone marrow transplantation recipients (BMT) are scarce. The purpose of the present study was to examine the magnitude, timing, and mechanism of bone loss following allogeneic BMT, and to study whether bone loss can be prevented by calcium with or without calcitonin. Sixty-nine patients undergoing allogeneic BMT for malignant blood diseases were enrolled into the study. Forty-four (22 women, 22 men) completed 6 months, and 36 patients 1 year follow-up. They were randomized to receive either no additional treatment (n = 22), or oral calcium 1 g twice daily for 12 months (n = 12) or the same dose of calcium plus intranasal calcitonin 400 IU/day for the first month and then 200 IU/day for 11 months (n = 10). Bone mineral density (BMD) at the lumbar spine and three femoral sites (femoral neck, trochanter, Ward's triangle) was measured by dual-energy X-ray absorptiometry (DXA). Bone turnover rate was followed with markers of bone formation and resorption (serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal (PICP) and aminoterminal propeptide (PINP), serum type I collagen carboxyterminal telopeptide (ICTP)). Serum testosterone was assayed in men. Calcium with or without calcitonin had no effect on bone loss or bone markers; consequently the three study groups were combined. During the first 6 post-transplant months BMD decreased by 5.7% in the lumbar spine and by 6.9% to 8.7% in the three femoral sites (P < 0.0001 for all); no significant further decline occured between 6 and 12 months. Four out of 25 assessable patients experienced vertebral compression fractures. Markers of bone formation reduced: B-ALP by 20% at 3 weeks (P = 0.027), PICP by 40% (P < 0.0001) and PINP by 63% at 6 weeks (P < 0.0001), with a return to baseline by 6 months. The marker of bone resorption, serum ICTP was above normal throughout the whole observation period, with a peak at 6 weeks (77% above baseline, P < 0.0001). In male patients serum testosterone decreased reaching a nadir (57% below baseline) at 6 weeks (P = 0.0003). In conclusion, significant bone loss occurs after BMT. It results from imbalance between reduced bone formation and increased bone resorption; hypogonadism may be a contributing factor in men. Bone loss can not be prevented by calcium with or without calcitonin.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N2ff9ce49767c4adc9957d84bdfd8ce92
45 Nfbdf0c94f0c4422dba12119856c7f968
46 sg:journal.1096890
47 schema:name A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin
48 schema:pagination 1701586
49 schema:productId N366721cd1ee94151b9d045366d45686b
50 N42668ca529fb49c09dfcc352ac0459a6
51 N43a3bb64153949cd8f909f3ec9b690ac
52 N70e4b7ab91424769abf5d09addbdf855
53 Nc24f6ad9e66d41a7b8749e476284afce
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007706326
55 https://doi.org/10.1038/sj.bmt.1701586
56 schema:sdDatePublished 2019-04-11T11:50
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N9392d7f755794520b8a31d3172689661
59 schema:url http://www.nature.com/articles/1701586
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0503de107cd74269a32729db08cb1e2f rdf:first sg:person.01107734224.37
64 rdf:rest N650713f026e44b3fbd7979383938668d
65 N0e0a0b60a58741edbc4b100b45f3522f rdf:first sg:person.07531174677.79
66 rdf:rest N914c9e5944ac4070ad20e2b02f906730
67 N19e21b3265094080bc2891646a2e7191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Hematologic Neoplasms
69 rdf:type schema:DefinedTerm
70 N2ab2fa58d6ec4b1daf4a2a13a0b7e289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Male
72 rdf:type schema:DefinedTerm
73 N2ce6a813e25e4a269d9f831346e1c70b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Adult
75 rdf:type schema:DefinedTerm
76 N2ff9ce49767c4adc9957d84bdfd8ce92 schema:issueNumber 4
77 rdf:type schema:PublicationIssue
78 N3232eaebab7a494e97448506aada616e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Bone Resorption
80 rdf:type schema:DefinedTerm
81 N354134abf0634dc7867faf215e8fdb82 rdf:first sg:person.01321543224.74
82 rdf:rest N861ccc18e962462688ff3f8aff8eff8d
83 N366721cd1ee94151b9d045366d45686b schema:name dimensions_id
84 schema:value pub.1007706326
85 rdf:type schema:PropertyValue
86 N39de90182a044f1398133c6ef2f38a20 rdf:first sg:person.0627434550.98
87 rdf:rest N0503de107cd74269a32729db08cb1e2f
88 N4094d9e328484f2c943b3479aec12441 rdf:first sg:person.012301146260.41
89 rdf:rest N9ab58255b7bf4b2e887d18724393514e
90 N41eeb7c06d6e4e64b43f9f55e347e773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Administration, Oral
92 rdf:type schema:DefinedTerm
93 N42668ca529fb49c09dfcc352ac0459a6 schema:name readcube_id
94 schema:value 24b524c1118cda1604cb8f741e6aee210cc6cc50162ba6eb40d96885b0072daa
95 rdf:type schema:PropertyValue
96 N43a3bb64153949cd8f909f3ec9b690ac schema:name nlm_unique_id
97 schema:value 8702459
98 rdf:type schema:PropertyValue
99 N463e2a600398462ca5eb40d765220b8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Calcium
101 rdf:type schema:DefinedTerm
102 N48bb2daf8e7d40bba15c26b797e6899e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Bone Marrow Transplantation
104 rdf:type schema:DefinedTerm
105 N4ac13350c9f14666be012ad2fbd08c73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Middle Aged
107 rdf:type schema:DefinedTerm
108 N5c35f2ad60f9438585c0adb3658d7553 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Bone Remodeling
110 rdf:type schema:DefinedTerm
111 N650713f026e44b3fbd7979383938668d rdf:first sg:person.01201507637.41
112 rdf:rest N354134abf0634dc7867faf215e8fdb82
113 N6ebd60b4eb404f0e988204fa31af691e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Prospective Studies
115 rdf:type schema:DefinedTerm
116 N70e4b7ab91424769abf5d09addbdf855 schema:name doi
117 schema:value 10.1038/sj.bmt.1701586
118 rdf:type schema:PropertyValue
119 N737c535de3c74518abbf7faa93910018 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N80412f9ecb804e3589f84dec768c70d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Calcitonin
124 rdf:type schema:DefinedTerm
125 N861ccc18e962462688ff3f8aff8eff8d rdf:first sg:person.01370647451.25
126 rdf:rest rdf:nil
127 N914c9e5944ac4070ad20e2b02f906730 rdf:first sg:person.01107001725.69
128 rdf:rest N39de90182a044f1398133c6ef2f38a20
129 N93005915002c4f4b92fb8b3f0295ea75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Administration, Inhalation
131 rdf:type schema:DefinedTerm
132 N9392d7f755794520b8a31d3172689661 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N9ab58255b7bf4b2e887d18724393514e rdf:first sg:person.01313515604.54
135 rdf:rest N0e0a0b60a58741edbc4b100b45f3522f
136 N9d06270811924c8caba0e40134df4c17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 Na3c7abb0693d4e26ac8d2e5b75343482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Transplantation, Homologous
141 rdf:type schema:DefinedTerm
142 Nc24f6ad9e66d41a7b8749e476284afce schema:name pubmed_id
143 schema:value 10100579
144 rdf:type schema:PropertyValue
145 Nfbdf0c94f0c4422dba12119856c7f968 schema:volumeNumber 23
146 rdf:type schema:PublicationVolume
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1096890 schema:issn 0268-3369
154 1476-5365
155 schema:name Bone Marrow Transplantation
156 rdf:type schema:Periodical
157 sg:person.01107001725.69 schema:affiliation https://www.grid.ac/institutes/grid.438998.7
158 schema:familyName Tähtelä
159 schema:givenName R
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107001725.69
161 rdf:type schema:Person
162 sg:person.01107734224.37 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
163 schema:familyName Laitinen
164 schema:givenName K
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107734224.37
166 rdf:type schema:Person
167 sg:person.01201507637.41 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
168 schema:familyName Mäkelä
169 schema:givenName P
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201507637.41
171 rdf:type schema:Person
172 sg:person.012301146260.41 schema:affiliation https://www.grid.ac/institutes/grid.438998.7
173 schema:familyName Välimäki
174 schema:givenName MJ
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012301146260.41
176 rdf:type schema:Person
177 sg:person.01313515604.54 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
178 schema:familyName Kinnunen
179 schema:givenName K
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313515604.54
181 rdf:type schema:Person
182 sg:person.01321543224.74 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
183 schema:familyName Keto
184 schema:givenName P
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321543224.74
186 rdf:type schema:Person
187 sg:person.01370647451.25 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
188 schema:familyName Ruutu
189 schema:givenName T
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370647451.25
191 rdf:type schema:Person
192 sg:person.0627434550.98 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
193 schema:familyName Löyttyniemi
194 schema:givenName E
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627434550.98
196 rdf:type schema:Person
197 sg:person.07531174677.79 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
198 schema:familyName Volin
199 schema:givenName L
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531174677.79
201 rdf:type schema:Person
202 sg:pub.10.1007/bf00298552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024080235
203 https://doi.org/10.1007/bf00298552
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00298990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048345161
206 https://doi.org/10.1007/bf00298990
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf02556148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032670081
209 https://doi.org/10.1007/bf02556148
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s002239900206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042176146
212 https://doi.org/10.1007/s002239900206
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/s002239900240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039227423
215 https://doi.org/10.1007/s002239900240
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/jbmr.5650070202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000504524
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/jbmr.5650090802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034966333
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0002-9343(80)90380-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048876793
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/1043-2760(94)90015-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039434337
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0140-6736(88)91862-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030188779
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1056/nejm197504242921706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052170577
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1056/nejm199306173282404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009198565
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/00007890-199011000-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025389720
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1159/000186373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012106375
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1210/endo-123-5-2571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064261916
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1210/jc.82.5.1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064299607
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1210/jcem.81.5.8626827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064320236
240 rdf:type schema:CreativeWork
241 https://doi.org/10.7326/0003-4819-104-5-648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690936
242 rdf:type schema:CreativeWork
243 https://doi.org/10.7326/0003-4819-112-5-352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073694548
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
246 schema:name Department of Statistics, University of Turku, Turku, Finland
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.438998.7 schema:alternateName United Medix Laboratories (Finland)
249 schema:name Department of Medicine, University of Helsinki, Finland
250 United Laboratories, Helsinki, Finland
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
253 schema:name Department of Medicine, University of Helsinki, Finland
254 Department of Radiology, University of Helsinki, Finland
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...