High-dose busulfan, melphalan and thiotepa followed by autologous peripheral blood stem cell (PBSC) rescue in patients with advanced stage III/IV ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-10

AUTHORS

A Jacobs, CD Buckner, FR Appelbaum, G Goodman, G Harrer, J Klarnet, LA Holmberg, N Zuckerman, P Montgomery, P Weiden, R Gersh, R Goldberg, R Maziarz, R McCloskey, S Rivkin, S Rowley, T Demirer, W Nichols, WI Bensinger

ABSTRACT

The purpose of this study was to evaluate the efficacy of high-dose chemotherapy (HDC) with busulfan, melphalan and thiotepa (BUMELTT) followed by autologous PBSC infusion in treating patients with advanced ovarian cancer. Thirty-one patients, 18 with stage III/IIIc and 13 with stage IV ovarian cancer, were treated with BU (12 mg/kg), MEL (100 mg/m2) and TT (500 mg/m2) and autologous PBSC rescue. Fifteen patients were in clinical complete remission (CR) at treatment; 11 had platinum-sensitive disease. Sixteen patients were not in CR; two had platinum-sensitive disease. The probabilities of overall survival (OS), event-free survival (EFS) and relapse (R) for all patients at 18 months were 0.57, 0.30 and 0.63; for patients in CR, the rates were 0.87, 0.44 and 0.49 and for patients not in CR, 0.38, 0.13 and 0.81. Two patients (6.5%) died of treatment-related causes. Among the 13 patients with platinum-sensitive disease, all are still alive, with seven having relapsed 129-1021 days after PBSC infusion. OS, EFS and R were 1.00, 0.52 and 0.48. Of the 18 patients with platinum-resistant disease, four remain alive (two in remission). Six patients did not respond and eight relapsed from days 104-429. The OS, EFS and R were 0.33, 0.11 and 0.78. We conclude that BUMELTT is well tolerated in patients with advanced ovarian cancer and results are equivalent to other published HDC regimens. More... »

PAGES

1701398

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701398

DOI

http://dx.doi.org/10.1038/sj.bmt.1701398

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9818692


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