Identical twin marrow transplantation for venous thrombosis in paroxysmal nocturnal hemoglobinuria; long-term complete remission as assessed by flow cytometry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-10

AUTHORS

MA Doukas, D Fleming, D Jennings

ABSTRACT

Paroxysmal nocturnal hemoglobinuria (PNH), an acquired clonal hematopoietic disorder characterized by protean clinical manifestations, is associated with significant morbidity and mortality. We report a 24-year-old patient with PNH complicated by deep vein thrombosis who underwent syngeneic bone marrow transplantation. No clinical symptomatology or stigmata of disease have recurred. Immunophenotyping of this patient over 12 years after her procedure revealed all peripheral circulating cells to express normal levels of CD59. Histocompatible marrow transplantation remains the definitive method of treatment for PNH with modern immunophenotyping capable of sensitive follow-up post-transplant. More... »

PAGES

717

References to SciGraph publications

  • 1992. Paroxysmal Nocturnal Hemoglobinuria in MEMBRANE DEFENSES AGAINST ATTACK BY COMPLEMENT AND PERFORINS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701345

    DOI

    http://dx.doi.org/10.1038/sj.bmt.1701345

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040498558

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9818702


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemoglobinuria, Paroxysmal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histocompatibility Testing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Homologous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Twins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Venous Thrombosis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Lexington VA Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.413837.a", 
              "name": [
                "Veterans Affairs Medical Center, Hematology/Oncology Section (111-E), Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doukas", 
            "givenName": "MA", 
            "id": "sg:person.01321251667.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321251667.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Louisville", 
              "id": "https://www.grid.ac/institutes/grid.266623.5", 
              "name": [
                "University of Louisville, James Graham Brown Cancer Center, Louisville, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fleming", 
            "givenName": "D", 
            "id": "sg:person.0612537366.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612537366.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Albert B. Chandler Hospital", 
              "id": "https://www.grid.ac/institutes/grid.461341.5", 
              "name": [
                "Department of Pathology, University of Kentucky Medical Center, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jennings", 
            "givenName": "D", 
            "id": "sg:person.0673303322.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673303322.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90250-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016316087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-77014-2_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017363941", 
              "https://doi.org/10.1007/978-3-642-77014-2_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)90068-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051731831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)90068-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051731831"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1998-10", 
        "datePublishedReg": "1998-10-01", 
        "description": "Paroxysmal nocturnal hemoglobinuria (PNH), an acquired clonal hematopoietic disorder characterized by protean clinical manifestations, is associated with significant morbidity and mortality. We report a 24-year-old patient with PNH complicated by deep vein thrombosis who underwent syngeneic bone marrow transplantation. No clinical symptomatology or stigmata of disease have recurred. Immunophenotyping of this patient over 12 years after her procedure revealed all peripheral circulating cells to express normal levels of CD59. Histocompatible marrow transplantation remains the definitive method of treatment for PNH with modern immunophenotyping capable of sensitive follow-up post-transplant.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.bmt.1701345", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "Identical twin marrow transplantation for venous thrombosis in paroxysmal nocturnal hemoglobinuria; long-term complete remission as assessed by flow cytometry", 
        "pagination": "717", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c0eb51051db30206621a0d3f1e1934212e21ab6ce47570cf7297d1c4a21d1728"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "9818702"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8702459"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.bmt.1701345"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1040498558"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.bmt.1701345", 
          "https://app.dimensions.ai/details/publication/pub.1040498558"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:15", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54015_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/1701345"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701345'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701345'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701345'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1701345'


     

    This table displays all metadata directly associated to this object as RDF triples.

    147 TRIPLES      21 PREDICATES      44 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.bmt.1701345 schema:about N0485424fa9f84149b50598fba09696df
    2 N098f659f30a64bc7b5f830468bb2ed62
    3 N3a73dd8cc91f4ab7b2410cea65330200
    4 N3ef0d58d79ee4fc49b440ab5a68a5327
    5 N4f633fc140754f989792155e5936d028
    6 Na4bb1d30a2b947d4b1c8a31010ce0003
    7 Nb7193694823b40dcbbed9f99dbf809df
    8 Nb756e02fd9b14694b2d8de932aab6e37
    9 Nba62613b8da94955a1098bf64e810038
    10 Nc196ac8f9499416fa8dce69bb5fb3423
    11 Ne10c806017204ebe88c9cee6562807fb
    12 Ne245e24b10f44507a9831e8aec68b0e1
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 schema:author N3ef932793ed0414cbec65052530a66d7
    16 schema:citation sg:pub.10.1007/978-3-642-77014-2_10
    17 https://doi.org/10.1016/0092-8674(93)90250-t
    18 https://doi.org/10.1016/s0140-6736(94)90068-x
    19 schema:datePublished 1998-10
    20 schema:datePublishedReg 1998-10-01
    21 schema:description Paroxysmal nocturnal hemoglobinuria (PNH), an acquired clonal hematopoietic disorder characterized by protean clinical manifestations, is associated with significant morbidity and mortality. We report a 24-year-old patient with PNH complicated by deep vein thrombosis who underwent syngeneic bone marrow transplantation. No clinical symptomatology or stigmata of disease have recurred. Immunophenotyping of this patient over 12 years after her procedure revealed all peripheral circulating cells to express normal levels of CD59. Histocompatible marrow transplantation remains the definitive method of treatment for PNH with modern immunophenotyping capable of sensitive follow-up post-transplant.
    22 schema:genre research_article
    23 schema:inLanguage en
    24 schema:isAccessibleForFree true
    25 schema:isPartOf N4aa65e58127040508503bb8ecc37ca70
    26 Nd6c4940393c44ae590b9c84b7e95802a
    27 sg:journal.1096890
    28 schema:name Identical twin marrow transplantation for venous thrombosis in paroxysmal nocturnal hemoglobinuria; long-term complete remission as assessed by flow cytometry
    29 schema:pagination 717
    30 schema:productId N101d093824b14de9ab5e7d945c90f601
    31 N4c959ba20f1d4f6bbd9fe3cfcd66dd48
    32 N577bba1921344bc7bf0d63f702de8f0f
    33 N73269f1c343d4e7f82d623475b37f757
    34 N85328f119adb408087d2cf30142ac817
    35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040498558
    36 https://doi.org/10.1038/sj.bmt.1701345
    37 schema:sdDatePublished 2019-04-11T12:15
    38 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    39 schema:sdPublisher N92501d4e90b54548a86f40443a326ae9
    40 schema:url https://www.nature.com/articles/1701345
    41 sgo:license sg:explorer/license/
    42 sgo:sdDataset articles
    43 rdf:type schema:ScholarlyArticle
    44 N0485424fa9f84149b50598fba09696df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    45 schema:name Venous Thrombosis
    46 rdf:type schema:DefinedTerm
    47 N098f659f30a64bc7b5f830468bb2ed62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    48 schema:name Twins
    49 rdf:type schema:DefinedTerm
    50 N0cd89061e58f4e9f8c9967037e9ca004 rdf:first sg:person.0612537366.28
    51 rdf:rest N76c7ee15b50a497f8f066f19e0eaf6e2
    52 N101d093824b14de9ab5e7d945c90f601 schema:name doi
    53 schema:value 10.1038/sj.bmt.1701345
    54 rdf:type schema:PropertyValue
    55 N3a73dd8cc91f4ab7b2410cea65330200 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    56 schema:name Histocompatibility Testing
    57 rdf:type schema:DefinedTerm
    58 N3ef0d58d79ee4fc49b440ab5a68a5327 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    59 schema:name Humans
    60 rdf:type schema:DefinedTerm
    61 N3ef932793ed0414cbec65052530a66d7 rdf:first sg:person.01321251667.39
    62 rdf:rest N0cd89061e58f4e9f8c9967037e9ca004
    63 N4aa65e58127040508503bb8ecc37ca70 schema:volumeNumber 22
    64 rdf:type schema:PublicationVolume
    65 N4c959ba20f1d4f6bbd9fe3cfcd66dd48 schema:name nlm_unique_id
    66 schema:value 8702459
    67 rdf:type schema:PropertyValue
    68 N4f633fc140754f989792155e5936d028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Bone Marrow Transplantation
    70 rdf:type schema:DefinedTerm
    71 N577bba1921344bc7bf0d63f702de8f0f schema:name readcube_id
    72 schema:value c0eb51051db30206621a0d3f1e1934212e21ab6ce47570cf7297d1c4a21d1728
    73 rdf:type schema:PropertyValue
    74 N73269f1c343d4e7f82d623475b37f757 schema:name pubmed_id
    75 schema:value 9818702
    76 rdf:type schema:PropertyValue
    77 N76c7ee15b50a497f8f066f19e0eaf6e2 rdf:first sg:person.0673303322.91
    78 rdf:rest rdf:nil
    79 N85328f119adb408087d2cf30142ac817 schema:name dimensions_id
    80 schema:value pub.1040498558
    81 rdf:type schema:PropertyValue
    82 N92501d4e90b54548a86f40443a326ae9 schema:name Springer Nature - SN SciGraph project
    83 rdf:type schema:Organization
    84 Na4bb1d30a2b947d4b1c8a31010ce0003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Transplantation, Homologous
    86 rdf:type schema:DefinedTerm
    87 Nb7193694823b40dcbbed9f99dbf809df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Remission Induction
    89 rdf:type schema:DefinedTerm
    90 Nb756e02fd9b14694b2d8de932aab6e37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Adult
    92 rdf:type schema:DefinedTerm
    93 Nba62613b8da94955a1098bf64e810038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Female
    95 rdf:type schema:DefinedTerm
    96 Nc196ac8f9499416fa8dce69bb5fb3423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Time Factors
    98 rdf:type schema:DefinedTerm
    99 Nd6c4940393c44ae590b9c84b7e95802a schema:issueNumber 7
    100 rdf:type schema:PublicationIssue
    101 Ne10c806017204ebe88c9cee6562807fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Hemoglobinuria, Paroxysmal
    103 rdf:type schema:DefinedTerm
    104 Ne245e24b10f44507a9831e8aec68b0e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Flow Cytometry
    106 rdf:type schema:DefinedTerm
    107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    108 schema:name Medical and Health Sciences
    109 rdf:type schema:DefinedTerm
    110 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    111 schema:name Clinical Sciences
    112 rdf:type schema:DefinedTerm
    113 sg:journal.1096890 schema:issn 0268-3369
    114 1476-5365
    115 schema:name Bone Marrow Transplantation
    116 rdf:type schema:Periodical
    117 sg:person.01321251667.39 schema:affiliation https://www.grid.ac/institutes/grid.413837.a
    118 schema:familyName Doukas
    119 schema:givenName MA
    120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321251667.39
    121 rdf:type schema:Person
    122 sg:person.0612537366.28 schema:affiliation https://www.grid.ac/institutes/grid.266623.5
    123 schema:familyName Fleming
    124 schema:givenName D
    125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612537366.28
    126 rdf:type schema:Person
    127 sg:person.0673303322.91 schema:affiliation https://www.grid.ac/institutes/grid.461341.5
    128 schema:familyName Jennings
    129 schema:givenName D
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673303322.91
    131 rdf:type schema:Person
    132 sg:pub.10.1007/978-3-642-77014-2_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017363941
    133 https://doi.org/10.1007/978-3-642-77014-2_10
    134 rdf:type schema:CreativeWork
    135 https://doi.org/10.1016/0092-8674(93)90250-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1016316087
    136 rdf:type schema:CreativeWork
    137 https://doi.org/10.1016/s0140-6736(94)90068-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051731831
    138 rdf:type schema:CreativeWork
    139 https://www.grid.ac/institutes/grid.266623.5 schema:alternateName University of Louisville
    140 schema:name University of Louisville, James Graham Brown Cancer Center, Louisville, KY, USA
    141 rdf:type schema:Organization
    142 https://www.grid.ac/institutes/grid.413837.a schema:alternateName Lexington VA Medical Center
    143 schema:name Veterans Affairs Medical Center, Hematology/Oncology Section (111-E), Lexington, KY, USA
    144 rdf:type schema:Organization
    145 https://www.grid.ac/institutes/grid.461341.5 schema:alternateName Albert B. Chandler Hospital
    146 schema:name Department of Pathology, University of Kentucky Medical Center, Lexington, KY, USA
    147 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...