Fatal obstructive lung disease after haploidentical sibling cord blood transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-05

AUTHORS

K Ohnuma, Y Toyoda, Y Ishida, K Honda, T Nagao, R Ijiri, Y Tanaka, K Goto, K Hiroki, H Kigasawa, H Nishihira

ABSTRACT

We report the case of a patient with fatal obstructive lung disease after an HLA-haploidentical sibling cord blood transplant (CBT), with severe acute GVHD. A 2-year-old girl developed expiratory air trapping gradually with acute and chronic GVHD after CBT for the treatment of ALL. Anti-CMV and immunosuppressive therapy were ineffective, and the patient died of progressive respiratory acidosis. Necropsy of the lung revealed severe bronchiolitis obliterans with cytomegalic inclusion cells in the granulation tissues of the bronchiolitis. Thus, immunologic and GVHD problems can occur even in CBT. More... »

PAGES

939

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701214

DOI

http://dx.doi.org/10.1038/sj.bmt.1701214

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051850633

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9613788


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