Life-threatening carboplatin hypersensitivity during conditioning for autologous PBSC transplantation: successful rechallenge after desensitization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-04

AUTHORS

H Kook, K M Kim, S H Choi, B S Choi, H J Kim, S Y Chung, S J Choi, T J Hwang

ABSTRACT

Carboplatin hypersensitivity has rarely been reported in patients receiving repeated cycles of therapy, but has not been reported in transplant settings. We report a case of carboplatin hypersensitivity during conditioning for autologous PBSC transplantation. The patient suddenly developed chest tightness, hemoptysis, hypoxia and hypotension, resulting in a transient myocardial ischemia. The pathophysiologic mechanism for the event seemed to be non-immune-mediated direct histamine release given the lack of prior exposure to platinum. Contrary to advice not to continue further treatment with carboplatin by some authors, we successfully desensitized the patient and subsequently gave more carboplatin as a part of conditioning. Awareness of carboplatin as one of the causes of hypersensitivity may help avoid further problems either by substitution or desensitization, along with premedications. More... »

PAGES

1701161

References to SciGraph publications

  • 1979-09. Anaphylactoid reaction to mannitol in JOURNAL CANADIEN D'ANESTHÉSIE
  • 1995-07. Hypersensitivity and cross-reactivity to cisplatin and analogues in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bmt.1701161

    DOI

    http://dx.doi.org/10.1038/sj.bmt.1701161

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005680735

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9578315


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