Effects of cyclosporin A on hepatitis C virus infection in bone marrow transplant patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-12

AUTHORS

H Akiyama, H Yoshinaga, T Tanaka, K Hiruma, S Tanikawa, H Sakamaki, Y Onozawa, T Wakita, M Kohara

ABSTRACT

The hepatitis C virus (HCV) infection has, in general, been considered not to affect liver function severely during the course of bone marrow transplantation (BMT) except for late hepatitis which coincided with a decrease in immunosuppressive therapy. We examined serial sera of two patients with positive HCV antibody who underwent allogeneic BMT and found that while the dose of cyclosporin A tapered off, the serum concentration of HCV core protein increased before the occurrence of hepatitis. This suggests that viral reactivation and growth might be one of the important mechanisms of hepatitis after BMT in patients with positive HCV antibody. More... »

PAGES

1700996

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1700996

DOI

http://dx.doi.org/10.1038/sj.bmt.1700996

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014803958

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9422481


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