Early allogeneic transplantation favorably influences the outcome of adult patients suffering from acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-05-01

AUTHORS

E Jourdan, D Maraninchi, J Reiffers, E Gluckman, B Rio, JP Jouet, M Michallet, L Molina, E Archimbaud, JL Harousseau, N Ifrah, M Attal, F Guilhot, M Kuentz, D Guyotat, JL Pico, C Dauriac, M Legros, F Dreyfus, P Bordigoni, V Leblond, N Gratecos, B Varet, C Auzanneau, H Tilly, E Vilmer, VJ Bardou, D Blaise

ABSTRACT

Allogeneic BMT for patients with acute myeloid leukemia (AML) is presently a reference therapy. The indications for this therapy mainly rely upon prognostic factors, and their importance is constantly reassessed. To examine the impact of time from diagnosis to transplant on survival and leukemia-free survival (LFS), we analyzed 109 patients from the database of the SFGM comprising patients who had all received an HLA-identical allogeneic BMT for a diagnosis of AML in first complete remission (CR1) between January 1987 and December 1992. All patients were conditioned with cyclophosphamide (CY) and total body irradiation (TBI) (CY-TBI), and methotrexate (MTX) + cyclosporin A (CsA) were used as graft-versus-host disease (GVHD) prophylaxis. Patient characteristics were: age = 33 ± 9, M/F = 64/45, white blood cell count (WBC) at diagnosis = 27 ± 42 × 109/l, FAB distribution: M1 and M2 = 55; M3 = 15, M4 and M5 = 33, M0, M6 and M7 = 6. Karyotyping was carried out for 64 patients: 32 had a normal karyotype, 16 had good prognosis abnormalities (t(8;21), t(15;17), inv 16) and 16 patients had other abnormalities. Eleven patients needed two courses of induction to achieve CR. Time between diagnosis and BMT was 120 (64–287) days. Forty-nine patients developed grade ⩾2 acute GVHD (actuarial probability = 46%). With a median follow-up of 50 months (27–100), the 5-year probabilities for transplant-related mortality (TRM), relapse, overall survival and LFS are respectively 25%, 26%, 59% and 55%. A multivariate analysis showed that survival is adversely influenced by three independent factors: time to transplant (>120 days vs ⩽120 days), acute GVHD (grade 2–4 vs grade 0–1) and age (>33 vs ⩽33). LFS is only influenced by the first two of these factors. The favorable impact of a shorter time from diagnosis to transplant should lead to performing the transplant as early as possible. Practically speaking, this means that when such therapy is chosen for a patient with CR1 AML, the search for an allogeneic donor should begin immediately and transplant be performed as soon as possible. More... »

PAGES

875-881

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bmt.1700761

DOI

http://dx.doi.org/10.1038/sj.bmt.1700761

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044210116

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9156260


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "BMT Units:, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jourdan", 
        "givenName": "E", 
        "id": "sg:person.01125636763.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125636763.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maraninchi", 
        "givenName": "D", 
        "id": "sg:person.01364057057.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364057057.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reiffers", 
        "givenName": "J", 
        "id": "sg:person.01230203137.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230203137.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "H\u00f4pital Saint-Louis, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gluckman", 
        "givenName": "E", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4tel-Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "H\u00f4tel-Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rio", 
        "givenName": "B", 
        "id": "sg:person.01245127334.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245127334.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Lille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jouet", 
        "givenName": "JP", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michallet", 
        "givenName": "M", 
        "id": "sg:person.01264301106.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301106.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Molina", 
        "givenName": "L", 
        "id": "sg:person.01315134524.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315134524.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Archimbaud", 
        "givenName": "E", 
        "id": "sg:person.01074473410.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074473410.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Nantes, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harousseau", 
        "givenName": "JL", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Angers, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Angers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ifrah", 
        "givenName": "N", 
        "id": "sg:person.0772462561.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772462561.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Toulouse, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Attal", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Poitiers, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guilhot", 
        "givenName": "F", 
        "id": "sg:person.0766311767.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766311767.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Henri Mondor, Cr\u00e9teil, France", 
          "id": "http://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "H\u00f4pital Henri Mondor, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuentz", 
        "givenName": "M", 
        "id": "sg:person.01315410752.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315410752.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Saint-Etienne, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Saint-Etienne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guyotat", 
        "givenName": "D", 
        "id": "sg:person.0655776276.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655776276.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy, Villejuif, France", 
          "id": "http://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Institut Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pico", 
        "givenName": "JL", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Rennes, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dauriac", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Clermont-Ferrand, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Clermont-Ferrand, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legros", 
        "givenName": "M", 
        "id": "sg:person.01352470515.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352470515.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dreyfus", 
        "givenName": "F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Nancy, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Nancy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bordigoni", 
        "givenName": "P", 
        "id": "sg:person.01261125776.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261125776.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leblond", 
        "givenName": "V", 
        "id": "sg:person.01342065164.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342065164.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Nice, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gratecos", 
        "givenName": "N", 
        "id": "sg:person.0764162542.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764162542.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Necker adultes, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "H\u00f4pital Necker adultes, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varet", 
        "givenName": "B", 
        "id": "sg:person.01030342604.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030342604.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Val-de-Grace, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414014.4", 
          "name": [
            "H\u00f4pital Val-de-Grace, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auzanneau", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Rouen, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Rouen, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tilly", 
        "givenName": "H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "H\u00f4pital Robert Debr\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vilmer", 
        "givenName": "E", 
        "id": "sg:person.01164751365.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164751365.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistical Unit of Institut Paoli Calmettes, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Biostatistical Unit of Institut Paoli Calmettes, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bardou", 
        "givenName": "VJ", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BMT Units:, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BMT Units:, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blaise", 
        "givenName": "D", 
        "id": "sg:person.0644473065.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644473065.59"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997-05-01", 
    "datePublishedReg": "1997-05-01", 
    "description": "Allogeneic BMT for patients with acute myeloid leukemia (AML) is presently a reference therapy. The indications for this therapy mainly rely upon prognostic factors, and their importance is constantly reassessed. To examine the impact of time from diagnosis to transplant on survival and leukemia-free survival (LFS), we analyzed 109 patients from the database of the SFGM comprising patients who had all received an HLA-identical allogeneic BMT for a diagnosis of AML in first complete remission (CR1) between January 1987 and December 1992. All patients were conditioned with cyclophosphamide (CY) and total body irradiation (TBI) (CY-TBI), and methotrexate (MTX) + cyclosporin A (CsA) were used as graft-versus-host disease (GVHD) prophylaxis. Patient characteristics were: age = 33 \u00b1 9, M/F = 64/45, white blood cell count (WBC) at diagnosis = 27 \u00b1 42 \u00d7 109/l, FAB distribution: M1 and M2 = 55; M3 = 15, M4 and M5 = 33, M0, M6 and M7 = 6. Karyotyping was carried out for 64 patients: 32 had a normal karyotype, 16 had good prognosis abnormalities (t(8;21), t(15;17), inv 16) and 16 patients had other abnormalities. Eleven patients needed two courses of induction to achieve CR. Time between diagnosis and BMT was 120 (64\u2013287) days. Forty-nine patients developed grade \u2a7e2 acute GVHD (actuarial probability = 46%). With a median follow-up of 50 months (27\u2013100), the 5-year probabilities for transplant-related mortality (TRM), relapse, overall survival and LFS are respectively 25%, 26%, 59% and 55%. A multivariate analysis showed that survival is adversely influenced by three independent factors: time to transplant (>120 days vs \u2a7d120 days), acute GVHD (grade 2\u20134 vs grade 0\u20131) and age (>33 vs \u2a7d33). LFS is only influenced by the first two of these factors. The favorable impact of a shorter time from diagnosis to transplant should lead to performing the transplant as early as possible. Practically speaking, this means that when such therapy is chosen for a patient with CR1 AML, the search for an allogeneic donor should begin immediately and transplant be performed as soon as possible.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.bmt.1700761", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "leukemia-free survival", 
      "acute myeloid leukemia", 
      "white blood cell count", 
      "transplant-related mortality", 
      "total body irradiation", 
      "acute GVHD", 
      "allogeneic BMT", 
      "myeloid leukemia", 
      "diagnosis of AML", 
      "HLA-identical allogeneic BMT", 
      "host disease (GVHD) prophylaxis", 
      "early allogeneic transplantation", 
      "first complete remission", 
      "blood cell count", 
      "complete remission", 
      "reference therapy", 
      "patient characteristics", 
      "course of induction", 
      "overall survival", 
      "adult patients", 
      "prognostic factors", 
      "disease prophylaxis", 
      "allogeneic transplantation", 
      "body irradiation", 
      "allogeneic donors", 
      "such therapy", 
      "patients", 
      "independent factors", 
      "cell count", 
      "FAB distribution", 
      "multivariate analysis", 
      "transplant", 
      "cyclosporin A", 
      "diagnosis", 
      "therapy", 
      "BMT", 
      "normal karyotype", 
      "GVHD", 
      "survival", 
      "cyclophosphamide", 
      "favorable impact", 
      "leukemia", 
      "abnormalities", 
      "impact of time", 
      "age", 
      "remission", 
      "prophylaxis", 
      "relapse", 
      "transplantation", 
      "graft", 
      "mortality", 
      "factors", 
      "months", 
      "outcomes", 
      "induction", 
      "indications", 
      "count", 
      "days", 
      "karyotyping", 
      "M1", 
      "grade", 
      "karyotype", 
      "donors", 
      "M6", 
      "course", 
      "time", 
      "M4", 
      "short time", 
      "M5", 
      "database", 
      "M0", 
      "impact", 
      "m2", 
      "M7", 
      "search", 
      "importance", 
      "irradiation", 
      "analysis", 
      "characteristics", 
      "probability", 
      "m3", 
      "Cr", 
      "distribution"
    ], 
    "name": "Early allogeneic transplantation favorably influences the outcome of adult patients suffering from acute myeloid leukemia", 
    "pagination": "875-881", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044210116"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bmt.1700761"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9156260"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bmt.1700761", 
      "https://app.dimensions.ai/details/publication/pub.1044210116"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_292.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.bmt.1700761"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1700761'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1700761'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1700761'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bmt.1700761'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      20 PREDICATES      120 URIs      112 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bmt.1700761 schema:about N133e5df714174c20ad9eaf2b593a7932
2 N178dd4c77aae46cd8d568f5c88a19b16
3 N3e6bb33bba5d4b60ad40d9cdff97f014
4 N4581ed13991f4572a7cbceb881bbc4b1
5 N549f3d2df5654c95ac954dd13390d7d1
6 N58765e4eb6754076b3207e027c6dc3f8
7 N820684acad9f470497ae2d3381893621
8 N8ef77b0444524bb8b59fcea53386f4ea
9 Na8c25aac04cf49968e06cc402797d361
10 Nc1c206f351034862b156200255c5dffb
11 Ndf913675aa6547748e4461cafee55265
12 Nf8b64d5b5b17428a953136d0c1ad881d
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Na0edb372e5124cefa963e53355e90015
16 schema:datePublished 1997-05-01
17 schema:datePublishedReg 1997-05-01
18 schema:description Allogeneic BMT for patients with acute myeloid leukemia (AML) is presently a reference therapy. The indications for this therapy mainly rely upon prognostic factors, and their importance is constantly reassessed. To examine the impact of time from diagnosis to transplant on survival and leukemia-free survival (LFS), we analyzed 109 patients from the database of the SFGM comprising patients who had all received an HLA-identical allogeneic BMT for a diagnosis of AML in first complete remission (CR1) between January 1987 and December 1992. All patients were conditioned with cyclophosphamide (CY) and total body irradiation (TBI) (CY-TBI), and methotrexate (MTX) + cyclosporin A (CsA) were used as graft-versus-host disease (GVHD) prophylaxis. Patient characteristics were: age = 33 ± 9, M/F = 64/45, white blood cell count (WBC) at diagnosis = 27 ± 42 × 109/l, FAB distribution: M1 and M2 = 55; M3 = 15, M4 and M5 = 33, M0, M6 and M7 = 6. Karyotyping was carried out for 64 patients: 32 had a normal karyotype, 16 had good prognosis abnormalities (t(8;21), t(15;17), inv 16) and 16 patients had other abnormalities. Eleven patients needed two courses of induction to achieve CR. Time between diagnosis and BMT was 120 (64–287) days. Forty-nine patients developed grade ⩾2 acute GVHD (actuarial probability = 46%). With a median follow-up of 50 months (27–100), the 5-year probabilities for transplant-related mortality (TRM), relapse, overall survival and LFS are respectively 25%, 26%, 59% and 55%. A multivariate analysis showed that survival is adversely influenced by three independent factors: time to transplant (>120 days vs ⩽120 days), acute GVHD (grade 2–4 vs grade 0–1) and age (>33 vs ⩽33). LFS is only influenced by the first two of these factors. The favorable impact of a shorter time from diagnosis to transplant should lead to performing the transplant as early as possible. Practically speaking, this means that when such therapy is chosen for a patient with CR1 AML, the search for an allogeneic donor should begin immediately and transplant be performed as soon as possible.
19 schema:genre article
20 schema:isAccessibleForFree false
21 schema:isPartOf N8f7cc81eecbd4d6ea8441d152ecd7229
22 Nf7e1abb288fa48b9bd62ae23b078a1ec
23 sg:journal.1096890
24 schema:keywords BMT
25 Cr
26 FAB distribution
27 GVHD
28 HLA-identical allogeneic BMT
29 M0
30 M1
31 M4
32 M5
33 M6
34 M7
35 abnormalities
36 acute GVHD
37 acute myeloid leukemia
38 adult patients
39 age
40 allogeneic BMT
41 allogeneic donors
42 allogeneic transplantation
43 analysis
44 blood cell count
45 body irradiation
46 cell count
47 characteristics
48 complete remission
49 count
50 course
51 course of induction
52 cyclophosphamide
53 cyclosporin A
54 database
55 days
56 diagnosis
57 diagnosis of AML
58 disease prophylaxis
59 distribution
60 donors
61 early allogeneic transplantation
62 factors
63 favorable impact
64 first complete remission
65 grade
66 graft
67 host disease (GVHD) prophylaxis
68 impact
69 impact of time
70 importance
71 independent factors
72 indications
73 induction
74 irradiation
75 karyotype
76 karyotyping
77 leukemia
78 leukemia-free survival
79 m2
80 m3
81 months
82 mortality
83 multivariate analysis
84 myeloid leukemia
85 normal karyotype
86 outcomes
87 overall survival
88 patient characteristics
89 patients
90 probability
91 prognostic factors
92 prophylaxis
93 reference therapy
94 relapse
95 remission
96 search
97 short time
98 such therapy
99 survival
100 therapy
101 time
102 total body irradiation
103 transplant
104 transplant-related mortality
105 transplantation
106 white blood cell count
107 schema:name Early allogeneic transplantation favorably influences the outcome of adult patients suffering from acute myeloid leukemia
108 schema:pagination 875-881
109 schema:productId N0cbba5015aaa41ee89f4f674c4832d28
110 N505e73a362a74b4c83a6232e163c0a28
111 Nfda47ebd37694a7793a2b5caa82bf28c
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044210116
113 https://doi.org/10.1038/sj.bmt.1700761
114 schema:sdDatePublished 2022-09-02T15:49
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Nd088ac2f105f4508b175f67793f14065
117 schema:url https://doi.org/10.1038/sj.bmt.1700761
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N005df189bfce445b936a82bbd357bc60 rdf:first sg:person.01245127334.86
122 rdf:rest N55dde6a851da4415a33eed5b33f024b3
123 N01e255d8cfcd4c069e76136340ada3c5 rdf:first N15f149a63f114ab2ae6e205e362eaad6
124 rdf:rest N4e48409259ed4c438d5ac8366642696a
125 N098e9ac55fe84a77a94e4f22c3f76eef schema:affiliation grid-institutes:grid.411784.f
126 schema:familyName Dreyfus
127 schema:givenName F
128 rdf:type schema:Person
129 N0cbba5015aaa41ee89f4f674c4832d28 schema:name pubmed_id
130 schema:value 9156260
131 rdf:type schema:PropertyValue
132 N129f39b5c063460794606aac724665c1 rdf:first Nd410a7d77c6944de8fdc45bce0615460
133 rdf:rest N84af4d84fced440981b3749a8f9c22e6
134 N133e5df714174c20ad9eaf2b593a7932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Acute Disease
136 rdf:type schema:DefinedTerm
137 N15f149a63f114ab2ae6e205e362eaad6 schema:affiliation grid-institutes:grid.418443.e
138 schema:familyName Bardou
139 schema:givenName VJ
140 rdf:type schema:Person
141 N178dd4c77aae46cd8d568f5c88a19b16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 N1bc2be0d330a470297413f96c9e23f51 schema:affiliation grid-institutes:None
145 schema:familyName Dauriac
146 schema:givenName C
147 rdf:type schema:Person
148 N1e03d674ab5042f98a82cd210c170075 rdf:first sg:person.01352470515.30
149 rdf:rest N2fbc1f9bb5ba4efd9e8acbab9e8a3a91
150 N2faf0ec2f338468db2534bbff77d30fa rdf:first sg:person.01230203137.18
151 rdf:rest Nfa20b22f861e43998e34f9672b9eea61
152 N2fbc1f9bb5ba4efd9e8acbab9e8a3a91 rdf:first N098e9ac55fe84a77a94e4f22c3f76eef
153 rdf:rest Nb2320436bcd34e389d0a7ceb671c9229
154 N37bc4378d8624c54a99c18e6d3a998ed rdf:first sg:person.01315410752.03
155 rdf:rest N9ff9b337a9a8486ca472358785e1f65f
156 N3e6bb33bba5d4b60ad40d9cdff97f014 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Transplantation, Homologous
158 rdf:type schema:DefinedTerm
159 N4581ed13991f4572a7cbceb881bbc4b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Female
161 rdf:type schema:DefinedTerm
162 N4dcd8eb19c6a413293911735b88a0493 schema:affiliation grid-institutes:None
163 schema:familyName Jouet
164 schema:givenName JP
165 rdf:type schema:Person
166 N4e48409259ed4c438d5ac8366642696a rdf:first sg:person.0644473065.59
167 rdf:rest rdf:nil
168 N505e73a362a74b4c83a6232e163c0a28 schema:name doi
169 schema:value 10.1038/sj.bmt.1700761
170 rdf:type schema:PropertyValue
171 N549f3d2df5654c95ac954dd13390d7d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 N55dde6a851da4415a33eed5b33f024b3 rdf:first N4dcd8eb19c6a413293911735b88a0493
175 rdf:rest Nbaeec25f9f6d4c2b9776c72721f6b5e2
176 N58765e4eb6754076b3207e027c6dc3f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Adolescent
178 rdf:type schema:DefinedTerm
179 N5df358b1e12141f883551fb0aa6f1559 schema:affiliation grid-institutes:grid.413328.f
180 schema:familyName Gluckman
181 schema:givenName E
182 rdf:type schema:Person
183 N7ce524f319b94cee86685c416fde487a rdf:first N1bc2be0d330a470297413f96c9e23f51
184 rdf:rest N1e03d674ab5042f98a82cd210c170075
185 N7f8472352a414d34b6af991e849bc292 rdf:first sg:person.0764162542.29
186 rdf:rest Nffc1a9fb809a40c982b9d63e09553a84
187 N820684acad9f470497ae2d3381893621 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Recurrence
189 rdf:type schema:DefinedTerm
190 N84af4d84fced440981b3749a8f9c22e6 rdf:first Ne351dcc644694334b3fb590abd996547
191 rdf:rest Nd4128f5ddf5544fb9182bbdd532748e3
192 N8ef77b0444524bb8b59fcea53386f4ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Treatment Outcome
194 rdf:type schema:DefinedTerm
195 N8f7cc81eecbd4d6ea8441d152ecd7229 schema:issueNumber 9
196 rdf:type schema:PublicationIssue
197 N9ff9b337a9a8486ca472358785e1f65f rdf:first sg:person.0655776276.35
198 rdf:rest Na161a720fad240569f5a88080a82cc03
199 Na0edb372e5124cefa963e53355e90015 rdf:first sg:person.01125636763.43
200 rdf:rest Nccd8c1b71dff40dd84c81a0b942db715
201 Na161a720fad240569f5a88080a82cc03 rdf:first Nb73aa43274f34a01ac41ab2fca07a392
202 rdf:rest N7ce524f319b94cee86685c416fde487a
203 Na53bf8bb11c1443d86c51a339a636615 rdf:first sg:person.0766311767.93
204 rdf:rest N37bc4378d8624c54a99c18e6d3a998ed
205 Na81b394725844c2bbe19bdccec89383a rdf:first Ncd762f7ec374418a9290344fa3ee8ce6
206 rdf:rest Ne3c0bd2bc0ab4d3580364eba91cb846d
207 Na82a15598d894db8a7bf8738e4c5087d rdf:first Nb956fd1989c44b66b051d8b6528c54f5
208 rdf:rest Na53bf8bb11c1443d86c51a339a636615
209 Na8c25aac04cf49968e06cc402797d361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Adult
211 rdf:type schema:DefinedTerm
212 Nb2320436bcd34e389d0a7ceb671c9229 rdf:first sg:person.01261125776.69
213 rdf:rest Neab74d33b67340d0a70de1a1e3fdd6af
214 Nb354e5cd04d84161a0cdcabc7549e952 rdf:first sg:person.01315134524.05
215 rdf:rest Nf2891263b49f48a7bc3ddb614c2c131b
216 Nb73aa43274f34a01ac41ab2fca07a392 schema:affiliation grid-institutes:grid.14925.3b
217 schema:familyName Pico
218 schema:givenName JL
219 rdf:type schema:Person
220 Nb956fd1989c44b66b051d8b6528c54f5 schema:affiliation grid-institutes:None
221 schema:familyName Attal
222 schema:givenName M
223 rdf:type schema:Person
224 Nbaeec25f9f6d4c2b9776c72721f6b5e2 rdf:first sg:person.01264301106.83
225 rdf:rest Nb354e5cd04d84161a0cdcabc7549e952
226 Nc1c206f351034862b156200255c5dffb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Leukemia, Myeloid
228 rdf:type schema:DefinedTerm
229 Nccd8c1b71dff40dd84c81a0b942db715 rdf:first sg:person.01364057057.31
230 rdf:rest N2faf0ec2f338468db2534bbff77d30fa
231 Ncd762f7ec374418a9290344fa3ee8ce6 schema:affiliation grid-institutes:None
232 schema:familyName Harousseau
233 schema:givenName JL
234 rdf:type schema:Person
235 Nd088ac2f105f4508b175f67793f14065 schema:name Springer Nature - SN SciGraph project
236 rdf:type schema:Organization
237 Nd410a7d77c6944de8fdc45bce0615460 schema:affiliation grid-institutes:grid.414014.4
238 schema:familyName Auzanneau
239 schema:givenName C
240 rdf:type schema:Person
241 Nd4128f5ddf5544fb9182bbdd532748e3 rdf:first sg:person.01164751365.30
242 rdf:rest N01e255d8cfcd4c069e76136340ada3c5
243 Ndf913675aa6547748e4461cafee55265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name Middle Aged
245 rdf:type schema:DefinedTerm
246 Ne351dcc644694334b3fb590abd996547 schema:affiliation grid-institutes:None
247 schema:familyName Tilly
248 schema:givenName H
249 rdf:type schema:Person
250 Ne3c0bd2bc0ab4d3580364eba91cb846d rdf:first sg:person.0772462561.54
251 rdf:rest Na82a15598d894db8a7bf8738e4c5087d
252 Neab74d33b67340d0a70de1a1e3fdd6af rdf:first sg:person.01342065164.04
253 rdf:rest N7f8472352a414d34b6af991e849bc292
254 Nf2891263b49f48a7bc3ddb614c2c131b rdf:first sg:person.01074473410.46
255 rdf:rest Na81b394725844c2bbe19bdccec89383a
256 Nf7e1abb288fa48b9bd62ae23b078a1ec schema:volumeNumber 19
257 rdf:type schema:PublicationVolume
258 Nf8b64d5b5b17428a953136d0c1ad881d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Bone Marrow Transplantation
260 rdf:type schema:DefinedTerm
261 Nfa20b22f861e43998e34f9672b9eea61 rdf:first N5df358b1e12141f883551fb0aa6f1559
262 rdf:rest N005df189bfce445b936a82bbd357bc60
263 Nfda47ebd37694a7793a2b5caa82bf28c schema:name dimensions_id
264 schema:value pub.1044210116
265 rdf:type schema:PropertyValue
266 Nffc1a9fb809a40c982b9d63e09553a84 rdf:first sg:person.01030342604.06
267 rdf:rest N129f39b5c063460794606aac724665c1
268 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
269 schema:name Medical and Health Sciences
270 rdf:type schema:DefinedTerm
271 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
272 schema:name Cardiorespiratory Medicine and Haematology
273 rdf:type schema:DefinedTerm
274 sg:journal.1096890 schema:issn 0268-3369
275 1476-5365
276 schema:name Bone Marrow Transplantation
277 schema:publisher Springer Nature
278 rdf:type schema:Periodical
279 sg:person.01030342604.06 schema:affiliation grid-institutes:grid.412134.1
280 schema:familyName Varet
281 schema:givenName B
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030342604.06
283 rdf:type schema:Person
284 sg:person.01074473410.46 schema:affiliation grid-institutes:None
285 schema:familyName Archimbaud
286 schema:givenName E
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074473410.46
288 rdf:type schema:Person
289 sg:person.01125636763.43 schema:affiliation grid-institutes:None
290 schema:familyName Jourdan
291 schema:givenName E
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125636763.43
293 rdf:type schema:Person
294 sg:person.01164751365.30 schema:affiliation grid-institutes:grid.413235.2
295 schema:familyName Vilmer
296 schema:givenName E
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164751365.30
298 rdf:type schema:Person
299 sg:person.01230203137.18 schema:affiliation grid-institutes:None
300 schema:familyName Reiffers
301 schema:givenName J
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230203137.18
303 rdf:type schema:Person
304 sg:person.01245127334.86 schema:affiliation grid-institutes:grid.411394.a
305 schema:familyName Rio
306 schema:givenName B
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245127334.86
308 rdf:type schema:Person
309 sg:person.01261125776.69 schema:affiliation grid-institutes:None
310 schema:familyName Bordigoni
311 schema:givenName P
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261125776.69
313 rdf:type schema:Person
314 sg:person.01264301106.83 schema:affiliation grid-institutes:None
315 schema:familyName Michallet
316 schema:givenName M
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301106.83
318 rdf:type schema:Person
319 sg:person.01315134524.05 schema:affiliation grid-institutes:None
320 schema:familyName Molina
321 schema:givenName L
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315134524.05
323 rdf:type schema:Person
324 sg:person.01315410752.03 schema:affiliation grid-institutes:grid.412116.1
325 schema:familyName Kuentz
326 schema:givenName M
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315410752.03
328 rdf:type schema:Person
329 sg:person.01342065164.04 schema:affiliation grid-institutes:grid.411439.a
330 schema:familyName Leblond
331 schema:givenName V
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342065164.04
333 rdf:type schema:Person
334 sg:person.01352470515.30 schema:affiliation grid-institutes:None
335 schema:familyName Legros
336 schema:givenName M
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352470515.30
338 rdf:type schema:Person
339 sg:person.01364057057.31 schema:affiliation grid-institutes:None
340 schema:familyName Maraninchi
341 schema:givenName D
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364057057.31
343 rdf:type schema:Person
344 sg:person.0644473065.59 schema:affiliation grid-institutes:None
345 schema:familyName Blaise
346 schema:givenName D
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644473065.59
348 rdf:type schema:Person
349 sg:person.0655776276.35 schema:affiliation grid-institutes:None
350 schema:familyName Guyotat
351 schema:givenName D
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655776276.35
353 rdf:type schema:Person
354 sg:person.0764162542.29 schema:affiliation grid-institutes:None
355 schema:familyName Gratecos
356 schema:givenName N
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764162542.29
358 rdf:type schema:Person
359 sg:person.0766311767.93 schema:affiliation grid-institutes:None
360 schema:familyName Guilhot
361 schema:givenName F
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766311767.93
363 rdf:type schema:Person
364 sg:person.0772462561.54 schema:affiliation grid-institutes:None
365 schema:familyName Ifrah
366 schema:givenName N
367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772462561.54
368 rdf:type schema:Person
369 grid-institutes:None schema:alternateName BMT Units:, Angers, France
370 BMT Units:, Bordeaux, France
371 BMT Units:, Clermont-Ferrand, France
372 BMT Units:, Grenoble, France
373 BMT Units:, Lille, France
374 BMT Units:, Lyon, France
375 BMT Units:, Marseille, France
376 BMT Units:, Nancy, France
377 BMT Units:, Nantes, France
378 BMT Units:, Nice, France
379 BMT Units:, Poitiers, France
380 BMT Units:, Rennes, France
381 BMT Units:, Rouen, France
382 BMT Units:, Saint-Etienne, France
383 BMT Units:, Toulouse, France
384 schema:name BMT Units:, Angers, France
385 BMT Units:, Bordeaux, France
386 BMT Units:, Clermont-Ferrand, France
387 BMT Units:, Grenoble, France
388 BMT Units:, Lille, France
389 BMT Units:, Lyon, France
390 BMT Units:, Marseille, France
391 BMT Units:, Nancy, France
392 BMT Units:, Nantes, France
393 BMT Units:, Nice, France
394 BMT Units:, Poitiers, France
395 BMT Units:, Rennes, France
396 BMT Units:, Rouen, France
397 BMT Units:, Saint-Etienne, France
398 BMT Units:, Toulouse, France
399 rdf:type schema:Organization
400 grid-institutes:grid.14925.3b schema:alternateName Institut Gustave Roussy, Villejuif, France
401 schema:name Institut Gustave Roussy, Villejuif, France
402 rdf:type schema:Organization
403 grid-institutes:grid.411394.a schema:alternateName Hôtel-Dieu, Paris, France
404 schema:name Hôtel-Dieu, Paris, France
405 rdf:type schema:Organization
406 grid-institutes:grid.411439.a schema:alternateName Hôpital Pitié-Salpétrière, Paris, France
407 schema:name Hôpital Pitié-Salpétrière, Paris, France
408 rdf:type schema:Organization
409 grid-institutes:grid.411784.f schema:alternateName Hôpital Cochin, Paris, France
410 schema:name Hôpital Cochin, Paris, France
411 rdf:type schema:Organization
412 grid-institutes:grid.412116.1 schema:alternateName Hôpital Henri Mondor, Créteil, France
413 schema:name Hôpital Henri Mondor, Créteil, France
414 rdf:type schema:Organization
415 grid-institutes:grid.412134.1 schema:alternateName Hôpital Necker adultes, Paris, France
416 schema:name Hôpital Necker adultes, Paris, France
417 rdf:type schema:Organization
418 grid-institutes:grid.413235.2 schema:alternateName Hôpital Robert Debré, Paris, France
419 schema:name Hôpital Robert Debré, Paris, France
420 rdf:type schema:Organization
421 grid-institutes:grid.413328.f schema:alternateName Hôpital Saint-Louis, Paris, France
422 schema:name Hôpital Saint-Louis, Paris, France
423 rdf:type schema:Organization
424 grid-institutes:grid.414014.4 schema:alternateName Hôpital Val-de-Grace, Paris, France
425 schema:name Hôpital Val-de-Grace, Paris, France
426 rdf:type schema:Organization
427 grid-institutes:grid.418443.e schema:alternateName Biostatistical Unit of Institut Paoli Calmettes, Marseille, France
428 schema:name Biostatistical Unit of Institut Paoli Calmettes, Marseille, France
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...