Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-02

AUTHORS

X Mao, T A Jones, I Tomlinson, A J Rowan, L I Fedorova, A V Zelenin, J-I Mao, N J Gutowski, M Noble, D Sheer

ABSTRACT

We have examined the genetic aberrations in two near-diploid glioblastoma multiforme cell lines that appear to have arisen from different glial lineages. One cell line, Hu-O-2A/Gb1, expresses antigens and metabolic profiles characteristic of the oligodendrocyte-type-2 astrocyte (0-2A) lineage of the rat central nervous system. This line generates, in vitro, cells with characteristics of 0-2A progenitor cells, oligodendrocytes and astrocytes. The second cell line, IN1434, is derived from an astrocyte or a precursor cell restricted to astrocytic differentiation. In Hu-O-2A/Gb1 the sole homologue of chromosome 10 is disrupted at band 10p11-12.1 by translocation with chromosomes X and 15. The translocation breakpoint is localized between genetic markers D10S2103 and [D10S637, D10S1962, D10S355]. Other aberrations include a 5;14 translocation, deletion of the long and short arms of chromosome 16 and loss of one copy of the CDKN2 gene. IN1434 cells share some cytogenetic abnormalities with Hu-O-2A/Gb1 cells, despite their apparent derivation from a different biological origin, but also have translocations involving the long and short arms of chromosome 1 and the long arm of chromosome 7, and deletion of chromosome 13 at bands 13q12-21. More... »

PAGES

724

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6690116

DOI

http://dx.doi.org/10.1038/sj.bjc.6690116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048620595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10070860


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