Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

F R Lamont, D C Tomlinson, P A Cooper, S D Shnyder, J D Chester, M A Knowles

ABSTRACT

BACKGROUND: Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are common in both superficial and invasive UC. METHODS: The effects of inhibition of receptor activity by three small molecule inhibitors (PD173074, TKI-258 and SU5402) were investigated in a panel of bladder tumour cell lines with known FGFR expression levels and FGFR3 mutation status. RESULTS: All inhibitors prevented activation of FGFR3, and inhibited downstream MAPK pathway signalling. Response was related to FGFR3 and/or FGFR1 expression levels. Cell lines with the highest levels of FGFR expression showed the greatest response and little or no effect was measured in normal human urothelial cells or in UC cell lines with activating RAS gene mutations. In sensitive cell lines, the drugs induced cell cycle arrest and/or apoptosis. IC(50) values for PD173074 and TKI-258 were in the nanomolar concentration range compared with micromolar concentrations for SU5402. PD173074 showed the greatest effects in vitro and in vivo significantly delayed the growth of subcutaneous bladder tumour xenografts. CONCLUSION: These results indicate that inhibition of FGFR1 and wild-type or mutant FGFR3 may represent a useful therapeutic approach in patients with both non-muscle invasive and muscle invasive UC. More... »

PAGES

75

References to SciGraph publications

  • 1999-11. Making biological sense of genome-wide expression data in NATURE GENETICS
  • 2001-07. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours in ONCOGENE
  • 2005-12. FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies in ONCOGENE
  • 2001-07. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs in GENOME BIOLOGY
  • 2004-05. Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074 in LEUKEMIA
  • 2005-09. Urothelial tumorigenesis: a tale of divergent pathways in NATURE REVIEWS CANCER
  • 2001-02. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma in ONCOGENE
  • 2001-03. Fibroblast growth factors in GENOME BIOLOGY
  • 1999-09. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas in NATURE GENETICS
  • 2005-08. FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma in ONCOGENE
  • 2007-08. Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer in ONCOGENE
  • 2006-08. Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway in ONCOGENE
  • 2009-12. Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner in ONCOGENE
  • 1997-07. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 in NATURE GENETICS
  • 1998-01. Oxaliplatin (L-OHP): a new reality in colorectal cancer in BRITISH JOURNAL OF CANCER
  • 1998-01. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition) in BRITISH JOURNAL OF CANCER
  • Journal

    TITLE

    British Journal of Cancer

    ISSUE

    1

    VOLUME

    104

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bjc.6606016

    DOI

    http://dx.doi.org/10.1038/sj.bjc.6606016

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032012679

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21119661


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