Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11-23

AUTHORS

J Avruch, D Zhou, J Fitamant, N Bardeesy

ABSTRACT

The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its original mass after partial surgical resection. Recent studies using genetically engineered mouse strains have shed new light on this problem; the Hippo signalling pathway, first elucidated as a regulator of organ size in Drosophila, has been identified as dominant determinant of liver growth. Defects in this pathway in mouse liver lead to sustained liver overgrowth and the eventual development of both major types of liver cancer, hepatocellular carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo signalling in liver biology and the contribution of this pathway to liver cancer in humans. More... »

PAGES

24-32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6606011

DOI

http://dx.doi.org/10.1038/sj.bjc.6606011

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030871206

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21102585


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