Inhibition of renin–angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11

AUTHORS

Y Nakai, H Isayama, H Ijichi, T Sasaki, N Sasahira, K Hirano, H Kogure, K Kawakubo, H Yagioka, Y Yashima, S Mizuno, K Yamamoto, T Arizumi, O Togawa, S Matsubara, T Tsujino, K Tateishi, M Tada, M Omata, K Koike

ABSTRACT

BACKGROUND: The renin-angiotensin system (RAS) is thought to have a role in carcinogenesis, and RAS inhibition may prevent tumour growth. METHODS: We retrospectively investigated the impact of angiotensin I-converting enzyme inhibitors (ACEIs) and angiotensin II type-1 receptor blockers (ARBs) in 155 patients with pancreatic cancer receiving gemcitabine monotherapy. Patients were divided into three groups: the ACEI/ARB group (27 patients receiving an ACEI or ARB for hypertension (HT)), the non-ACEI/ARB with HT group (25 patients receiving antihypertensive drugs other than ACEIs or ARBs), and the non-HT group (103 patients receiving no antihypertensive drugs). RESULTS: Patient characteristics were not different, except for age and HT medications. Progression-free survival (PFS) was 8.7 months in the ACEI/ARB group, 4.5 months in the non-ACEI/ARB with HT group, and 3.6 months in the non-HT group. Overall survival (OS) was 15.1 months in the ACEI/ARB group, 8.9 months in the non-ACEI/ARB with HT group, and 9.5 months in the non-HT group. The use of ACEIs/ARBs was a significant prognostic factor for both PFS (P=0.032) and OS (P=0.014) in the multivariate analysis. CONCLUSIONS: The ACEIs/ARBs in combination with gemcitabine might improve clinical outcomes in patients with advanced pancreatic cancer. Prospective trials are needed to test this hypothesis. More... »

PAGES

1644

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605955

DOI

http://dx.doi.org/10.1038/sj.bjc.6605955

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007353268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20978506


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