Pathological complete response and survival according to the level of HER-2 amplification after trastuzumab-based neoadjuvant therapy for breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10

AUTHORS

S Guiu, M Gauthier, B Coudert, F Bonnetain, L Favier, S Ladoire, H Tixier, B Guiu, F Penault-Llorca, F Ettore, P Fumoleau, L Arnould

ABSTRACT

BACKGROUND: We analysed whether the level of human epidermal growth factor receptor-2 (HER-2) amplification significantly influenced either pathological complete response (pCR) or recurrence-free survival (RFS) and overall survival (OS) after trastuzumab-based neoadjuvant therapy. METHODS: In all, 99 patients with an HER-2-amplified breast tumour treated with trastuzumab-based neoadjuvant therapy were included. Tumours were classified as low amplified (LA; 6-10 signals per nuclei) or highly amplified (HA; >10 signals). Pathological response was assessed according to Chevallier's classification (pCR was defined as grade 1 or 2). Median follow-up lasted 46 months (6-83). Cox uni- and multivariate analyses were performed. RESULTS: In all, 33 tumour samples were LA and 66 were HA. The pCR in HA tumours was significantly higher than in LA tumours (55% vs 24%, P=0.005), whereas no association was found between the pCR rate and tumour stage, grade or hormone receptor status. In multivariate analysis, the pathological nodal status (P=0.005) and adjuvant trastuzumab (P=0.037) were independently associated with RFS, whereas the level of HER-2 amplification nearly reached statistical significance (P=0.057). There was no significant difference between LA and HA tumours for OS (P=0.22, log-rank). CONCLUSION: The level of HER-2 gene amplification significantly influenced pCR but not RFS or OS in non-metastatic breast cancer treated with trastuzumab-based neoadjuvant therapy. However, RFS in patients with HA tumours tended to be shorter. More... »

PAGES

1335

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605939

DOI

http://dx.doi.org/10.1038/sj.bjc.6605939

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042181882

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20978512


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Amplification", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, erbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trastuzumab", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guiu", 
        "givenName": "S", 
        "id": "sg:person.01340757636.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340757636.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Biostatistics Unit, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France", 
            "EA 4184 School of Medicine, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gauthier", 
        "givenName": "M", 
        "id": "sg:person.01257672243.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257672243.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coudert", 
        "givenName": "B", 
        "id": "sg:person.0727212634.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727212634.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Biostatistics Unit, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France", 
            "EA 4184 School of Medicine, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonnetain", 
        "givenName": "F", 
        "id": "sg:person.01252021215.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252021215.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Favier", 
        "givenName": "L", 
        "id": "sg:person.0771464734.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771464734.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ladoire", 
        "givenName": "S", 
        "id": "sg:person.01055441045.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055441045.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tixier", 
        "givenName": "H", 
        "id": "sg:person.01254515001.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254515001.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Regional Universitaire De Dijon", 
          "id": "https://www.grid.ac/institutes/grid.31151.37", 
          "name": [
            "Department of Radiology, CHU (University Hospital), F-21079 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guiu", 
        "givenName": "B", 
        "id": "sg:person.01250400145.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250400145.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Jean Perrin Cancer Center, F-63011 Clermont-Ferrand, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Penault-Llorca", 
        "givenName": "F", 
        "id": "sg:person.0643603315.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643603315.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Antoine-Lacassagne Cancer Center, F-06189 Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ettore", 
        "givenName": "F", 
        "id": "sg:person.01164511300.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164511300.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fumoleau", 
        "givenName": "P", 
        "id": "sg:person.01101667531.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101667531.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Georges-Fran\u00e7ois Leclerc Cancer Center, F-21000 Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arnould", 
        "givenName": "L", 
        "id": "sg:person.01121675220.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121675220.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/annonc/mdj096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000995155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2005.n.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001198940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60028-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002898249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003035955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003769138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007014320", 
          "https://doi.org/10.1038/modpathol.2008.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2003.n.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009640058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.11.852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010730561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.8886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011847416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014471058", 
          "https://doi.org/10.1038/modpathol.2008.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014791751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.11.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015062444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.8197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015199418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-008-9155-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016696899", 
          "https://doi.org/10.1007/s10637-008-9155-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-008-9155-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016696899", 
          "https://doi.org/10.1007/s10637-008-9155-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-3022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021783047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022644824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9887-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023598351", 
          "https://doi.org/10.1007/s10549-007-9887-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9887-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023598351", 
          "https://doi.org/10.1007/s10549-007-9887-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.6187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026719751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200103153441101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.4577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036202282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.9994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036230219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa053028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043831613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyp052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044940285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyp052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044940285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.7939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045310505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.6914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045440787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910490504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049237181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3798106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.sabcs-09-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063217684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.12.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.2.460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074265640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.8.2334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.8.2894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083129505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.8.2672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083305985"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10", 
    "datePublishedReg": "2010-10-01", 
    "description": "BACKGROUND: We analysed whether the level of human epidermal growth factor receptor-2 (HER-2) amplification significantly influenced either pathological complete response (pCR) or recurrence-free survival (RFS) and overall survival (OS) after trastuzumab-based neoadjuvant therapy.\nMETHODS: In all, 99 patients with an HER-2-amplified breast tumour treated with trastuzumab-based neoadjuvant therapy were included. Tumours were classified as low amplified (LA; 6-10 signals per nuclei) or highly amplified (HA; >10 signals). Pathological response was assessed according to Chevallier's classification (pCR was defined as grade 1 or 2). Median follow-up lasted 46 months (6-83). Cox uni- and multivariate analyses were performed.\nRESULTS: In all, 33 tumour samples were LA and 66 were HA. The pCR in HA tumours was significantly higher than in LA tumours (55% vs 24%, P=0.005), whereas no association was found between the pCR rate and tumour stage, grade or hormone receptor status. In multivariate analysis, the pathological nodal status (P=0.005) and adjuvant trastuzumab (P=0.037) were independently associated with RFS, whereas the level of HER-2 amplification nearly reached statistical significance (P=0.057). There was no significant difference between LA and HA tumours for OS (P=0.22, log-rank).\nCONCLUSION: The level of HER-2 gene amplification significantly influenced pCR but not RFS or OS in non-metastatic breast cancer treated with trastuzumab-based neoadjuvant therapy. However, RFS in patients with HA tumours tended to be shorter.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6605939", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "103"
      }
    ], 
    "name": "Pathological complete response and survival according to the level of HER-2 amplification after trastuzumab-based neoadjuvant therapy for breast cancer", 
    "pagination": "1335", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c8ef19c9377a2e35db1738ed88711df707ed21939c9534e869fcd4575d5f8cfb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20978512"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6605939"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042181882"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6605939", 
      "https://app.dimensions.ai/details/publication/pub.1042181882"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000351_0000000351/records_43256_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6605939"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605939'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605939'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605939'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605939'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      79 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6605939 schema:about N10b71ac1b2414d60a0ef91b5e7eedd53
2 N11b47af1da784088b1f5944e47515c05
3 N179abda5ce2d49948c37dffd30a38f67
4 N28d2f265a7014bd68948d3c2e5f659d4
5 N372ca468c3694945b05a0a6ba1ca988e
6 N6124af57621e4825885c1968cb0dc388
7 N6ae14847ee984ad8b1b00b86cc964307
8 N7ae7894b9e2a434cb782b724ec14ac4d
9 N8b5d42099cc440f582f31c032f63c72a
10 Na147500a48bd4bae8e6cab4281066c85
11 Nc52182dbd2c64081b6aecb67b693d5e8
12 Nc6748cc01d374b7bad46000305f6d29e
13 Nd17a628079a74dd98cddb7e10460ee9a
14 Necee79e89ddb4a5b8fe57b0960f53579
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N2ffb92a7631547978686ae3b7af9d508
18 schema:citation sg:pub.10.1007/s10549-007-9887-y
19 sg:pub.10.1007/s10637-008-9155-y
20 sg:pub.10.1038/modpathol.2008.34
21 sg:pub.10.1038/modpathol.2008.83
22 https://doi.org/10.1002/ijc.2910490504
23 https://doi.org/10.1016/j.ejca.2006.11.019
24 https://doi.org/10.1016/s0140-6736(07)60028-2
25 https://doi.org/10.1056/nejm200103153441101
26 https://doi.org/10.1056/nejmoa052122
27 https://doi.org/10.1056/nejmoa052306
28 https://doi.org/10.1056/nejmoa053028
29 https://doi.org/10.1093/annonc/mdj096
30 https://doi.org/10.1093/jjco/hyp052
31 https://doi.org/10.1093/jnci/94.11.852
32 https://doi.org/10.1093/jnci/94.11.855
33 https://doi.org/10.1126/science.3798106
34 https://doi.org/10.1158/0008-5472.sabcs-09-62
35 https://doi.org/10.1158/1078-0432.ccr-06-1345
36 https://doi.org/10.1158/1078-0432.ccr-06-3022
37 https://doi.org/10.1200/jco.1997.15.8.2894
38 https://doi.org/10.1200/jco.1998.16.8.2672
39 https://doi.org/10.1200/jco.1999.17.2.460
40 https://doi.org/10.1200/jco.2001.19.8.2334
41 https://doi.org/10.1200/jco.2003.12.109
42 https://doi.org/10.1200/jco.2005.02.6187
43 https://doi.org/10.1200/jco.2005.02.6914
44 https://doi.org/10.1200/jco.2005.02.8886
45 https://doi.org/10.1200/jco.2005.04.173
46 https://doi.org/10.1200/jco.2005.07.032
47 https://doi.org/10.1200/jco.2006.09.2775
48 https://doi.org/10.1200/jco.2006.09.9994
49 https://doi.org/10.1200/jco.2007.14.8197
50 https://doi.org/10.1200/jco.2008.19.7939
51 https://doi.org/10.1200/jco.2008.21.4577
52 https://doi.org/10.3816/cbc.2003.n.040
53 https://doi.org/10.3816/cbc.2005.n.026
54 schema:datePublished 2010-10
55 schema:datePublishedReg 2010-10-01
56 schema:description BACKGROUND: We analysed whether the level of human epidermal growth factor receptor-2 (HER-2) amplification significantly influenced either pathological complete response (pCR) or recurrence-free survival (RFS) and overall survival (OS) after trastuzumab-based neoadjuvant therapy. METHODS: In all, 99 patients with an HER-2-amplified breast tumour treated with trastuzumab-based neoadjuvant therapy were included. Tumours were classified as low amplified (LA; 6-10 signals per nuclei) or highly amplified (HA; >10 signals). Pathological response was assessed according to Chevallier's classification (pCR was defined as grade 1 or 2). Median follow-up lasted 46 months (6-83). Cox uni- and multivariate analyses were performed. RESULTS: In all, 33 tumour samples were LA and 66 were HA. The pCR in HA tumours was significantly higher than in LA tumours (55% vs 24%, P=0.005), whereas no association was found between the pCR rate and tumour stage, grade or hormone receptor status. In multivariate analysis, the pathological nodal status (P=0.005) and adjuvant trastuzumab (P=0.037) were independently associated with RFS, whereas the level of HER-2 amplification nearly reached statistical significance (P=0.057). There was no significant difference between LA and HA tumours for OS (P=0.22, log-rank). CONCLUSION: The level of HER-2 gene amplification significantly influenced pCR but not RFS or OS in non-metastatic breast cancer treated with trastuzumab-based neoadjuvant therapy. However, RFS in patients with HA tumours tended to be shorter.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N2cd967ad36564282b88318cd87334d48
61 N325a3a32661a4844b367456c6e8dd607
62 sg:journal.1017082
63 schema:name Pathological complete response and survival according to the level of HER-2 amplification after trastuzumab-based neoadjuvant therapy for breast cancer
64 schema:pagination 1335
65 schema:productId N18cf8a5ca5bd449b93bdd0c685d5568b
66 N41f3f725827049a6bb3d568e39b98777
67 N635929e2f822407394e3f1ae0480d5bb
68 Ne210170f46b842e5ac2c4e20d1d2eff3
69 Ne46a5de0d0f64956937d2bd004b2acca
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042181882
71 https://doi.org/10.1038/sj.bjc.6605939
72 schema:sdDatePublished 2019-04-11T10:54
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nabcfa29ca1ce4ac2af641686430510c1
75 schema:url https://www.nature.com/articles/6605939
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N009ca26c56d640ab8b9e6f7df3f68452 rdf:first sg:person.0643603315.57
80 rdf:rest N672c79eafa9940e7803b32018f051e3e
81 N10b71ac1b2414d60a0ef91b5e7eedd53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Middle Aged
83 rdf:type schema:DefinedTerm
84 N11b47af1da784088b1f5944e47515c05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Remission Induction
86 rdf:type schema:DefinedTerm
87 N1227f4977b964f0a8d5a921d8741b0c7 rdf:first sg:person.01101667531.56
88 rdf:rest N2fa435fd123f43be999827aea51a7bbd
89 N168aa47ac0364f90be51a72afcce20d3 rdf:first sg:person.0727212634.00
90 rdf:rest N92c2cd90813648b08ba9e9468496cc19
91 N179abda5ce2d49948c37dffd30a38f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Gene Amplification
93 rdf:type schema:DefinedTerm
94 N18cf8a5ca5bd449b93bdd0c685d5568b schema:name nlm_unique_id
95 schema:value 0370635
96 rdf:type schema:PropertyValue
97 N1ad02e4ecef6429a86bece1fee299c74 schema:name Biostatistics Unit, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
98 EA 4184 School of Medicine, F-21000 Dijon, France
99 rdf:type schema:Organization
100 N1dacbda556544e2eadcdf6bcc54bc855 schema:name Department of Oncology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
101 rdf:type schema:Organization
102 N20b86bd712664d9cb3815934b31d432d schema:name Department of Oncology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
103 rdf:type schema:Organization
104 N28d2f265a7014bd68948d3c2e5f659d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Trastuzumab
106 rdf:type schema:DefinedTerm
107 N2cd967ad36564282b88318cd87334d48 schema:issueNumber 9
108 rdf:type schema:PublicationIssue
109 N2fa435fd123f43be999827aea51a7bbd rdf:first sg:person.01121675220.27
110 rdf:rest rdf:nil
111 N2ffb92a7631547978686ae3b7af9d508 rdf:first sg:person.01340757636.16
112 rdf:rest N9f7785bb50a2427e82f5d944c66252c5
113 N308fc9cad84644be988d1a9dbce2178b schema:name Biostatistics Unit, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
114 EA 4184 School of Medicine, F-21000 Dijon, France
115 rdf:type schema:Organization
116 N325a3a32661a4844b367456c6e8dd607 schema:volumeNumber 103
117 rdf:type schema:PublicationVolume
118 N372ca468c3694945b05a0a6ba1ca988e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adult
120 rdf:type schema:DefinedTerm
121 N41f3f725827049a6bb3d568e39b98777 schema:name doi
122 schema:value 10.1038/sj.bjc.6605939
123 rdf:type schema:PropertyValue
124 N5021b1cc3f97471f9d73c47da7f23452 schema:name Department of Surgery, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
125 rdf:type schema:Organization
126 N6124af57621e4825885c1968cb0dc388 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Disease-Free Survival
128 rdf:type schema:DefinedTerm
129 N635929e2f822407394e3f1ae0480d5bb schema:name dimensions_id
130 schema:value pub.1042181882
131 rdf:type schema:PropertyValue
132 N672c79eafa9940e7803b32018f051e3e rdf:first sg:person.01164511300.52
133 rdf:rest N1227f4977b964f0a8d5a921d8741b0c7
134 N6ae14847ee984ad8b1b00b86cc964307 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genes, erbB-2
136 rdf:type schema:DefinedTerm
137 N76b75c39418745248bcf5afbc832e25b schema:name Department of Pathology, Antoine-Lacassagne Cancer Center, F-06189 Nice, France
138 rdf:type schema:Organization
139 N7ae7894b9e2a434cb782b724ec14ac4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Neoadjuvant Therapy
141 rdf:type schema:DefinedTerm
142 N86ebf954742c48978d92c03e2361713f schema:name Department of Pathology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
143 rdf:type schema:Organization
144 N893ebbb6e4c341d7944bbedd220f1e6f rdf:first sg:person.01254515001.65
145 rdf:rest Nf85d0c45f2874c6b986970dbb2cbb9f9
146 N8b5d42099cc440f582f31c032f63c72a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Breast Neoplasms
148 rdf:type schema:DefinedTerm
149 N92c2cd90813648b08ba9e9468496cc19 rdf:first sg:person.01252021215.22
150 rdf:rest Nd8033b195f054a53b6b4d2645445213f
151 N9369383b724b4a68a524eeb43aad146d schema:name Department of Pathology, Jean Perrin Cancer Center, F-63011 Clermont-Ferrand, France
152 rdf:type schema:Organization
153 N9f7785bb50a2427e82f5d944c66252c5 rdf:first sg:person.01257672243.78
154 rdf:rest N168aa47ac0364f90be51a72afcce20d3
155 Na147500a48bd4bae8e6cab4281066c85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Antibodies, Monoclonal, Humanized
157 rdf:type schema:DefinedTerm
158 Nab6ff6c8b10c411f954c83656ac5bc3a schema:name Department of Oncology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
159 rdf:type schema:Organization
160 Nabcfa29ca1ce4ac2af641686430510c1 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Nb0db6d71af044ddc91764404d5ccc36a rdf:first sg:person.01055441045.63
163 rdf:rest N893ebbb6e4c341d7944bbedd220f1e6f
164 Nc52182dbd2c64081b6aecb67b693d5e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Nc6748cc01d374b7bad46000305f6d29e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Aged
169 rdf:type schema:DefinedTerm
170 Nd125833e775b40a6a48ea1a860145883 schema:name Department of Oncology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
171 rdf:type schema:Organization
172 Nd17a628079a74dd98cddb7e10460ee9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antibodies, Monoclonal
174 rdf:type schema:DefinedTerm
175 Nd8033b195f054a53b6b4d2645445213f rdf:first sg:person.0771464734.13
176 rdf:rest Nb0db6d71af044ddc91764404d5ccc36a
177 Ndf8b7f59a7974b29ba83ed7f0490c362 schema:name Department of Oncology, Georges-François Leclerc Cancer Center, F-21000 Dijon, France
178 rdf:type schema:Organization
179 Ne210170f46b842e5ac2c4e20d1d2eff3 schema:name pubmed_id
180 schema:value 20978512
181 rdf:type schema:PropertyValue
182 Ne46a5de0d0f64956937d2bd004b2acca schema:name readcube_id
183 schema:value c8ef19c9377a2e35db1738ed88711df707ed21939c9534e869fcd4575d5f8cfb
184 rdf:type schema:PropertyValue
185 Necee79e89ddb4a5b8fe57b0960f53579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Female
187 rdf:type schema:DefinedTerm
188 Nf85d0c45f2874c6b986970dbb2cbb9f9 rdf:first sg:person.01250400145.41
189 rdf:rest N009ca26c56d640ab8b9e6f7df3f68452
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
194 schema:name Oncology and Carcinogenesis
195 rdf:type schema:DefinedTerm
196 sg:journal.1017082 schema:issn 0007-0920
197 1532-1827
198 schema:name British Journal of Cancer
199 rdf:type schema:Periodical
200 sg:person.01055441045.63 schema:affiliation Nab6ff6c8b10c411f954c83656ac5bc3a
201 schema:familyName Ladoire
202 schema:givenName S
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055441045.63
204 rdf:type schema:Person
205 sg:person.01101667531.56 schema:affiliation N1dacbda556544e2eadcdf6bcc54bc855
206 schema:familyName Fumoleau
207 schema:givenName P
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101667531.56
209 rdf:type schema:Person
210 sg:person.01121675220.27 schema:affiliation N86ebf954742c48978d92c03e2361713f
211 schema:familyName Arnould
212 schema:givenName L
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121675220.27
214 rdf:type schema:Person
215 sg:person.01164511300.52 schema:affiliation N76b75c39418745248bcf5afbc832e25b
216 schema:familyName Ettore
217 schema:givenName F
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164511300.52
219 rdf:type schema:Person
220 sg:person.01250400145.41 schema:affiliation https://www.grid.ac/institutes/grid.31151.37
221 schema:familyName Guiu
222 schema:givenName B
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250400145.41
224 rdf:type schema:Person
225 sg:person.01252021215.22 schema:affiliation N308fc9cad84644be988d1a9dbce2178b
226 schema:familyName Bonnetain
227 schema:givenName F
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252021215.22
229 rdf:type schema:Person
230 sg:person.01254515001.65 schema:affiliation N5021b1cc3f97471f9d73c47da7f23452
231 schema:familyName Tixier
232 schema:givenName H
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254515001.65
234 rdf:type schema:Person
235 sg:person.01257672243.78 schema:affiliation N1ad02e4ecef6429a86bece1fee299c74
236 schema:familyName Gauthier
237 schema:givenName M
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257672243.78
239 rdf:type schema:Person
240 sg:person.01340757636.16 schema:affiliation N20b86bd712664d9cb3815934b31d432d
241 schema:familyName Guiu
242 schema:givenName S
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340757636.16
244 rdf:type schema:Person
245 sg:person.0643603315.57 schema:affiliation N9369383b724b4a68a524eeb43aad146d
246 schema:familyName Penault-Llorca
247 schema:givenName F
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643603315.57
249 rdf:type schema:Person
250 sg:person.0727212634.00 schema:affiliation Ndf8b7f59a7974b29ba83ed7f0490c362
251 schema:familyName Coudert
252 schema:givenName B
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727212634.00
254 rdf:type schema:Person
255 sg:person.0771464734.13 schema:affiliation Nd125833e775b40a6a48ea1a860145883
256 schema:familyName Favier
257 schema:givenName L
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771464734.13
259 rdf:type schema:Person
260 sg:pub.10.1007/s10549-007-9887-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1023598351
261 https://doi.org/10.1007/s10549-007-9887-y
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s10637-008-9155-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1016696899
264 https://doi.org/10.1007/s10637-008-9155-y
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/modpathol.2008.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007014320
267 https://doi.org/10.1038/modpathol.2008.34
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/modpathol.2008.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014471058
270 https://doi.org/10.1038/modpathol.2008.83
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/ijc.2910490504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049237181
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.ejca.2006.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022644824
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0140-6736(07)60028-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002898249
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1056/nejm200103153441101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768583
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejmoa052122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035589584
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1056/nejmoa052306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014794593
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1056/nejmoa053028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043831613
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/annonc/mdj096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000995155
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/jjco/hyp052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044940285
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/jnci/94.11.852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010730561
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/jnci/94.11.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015062444
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.3798106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621480
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1158/0008-5472.sabcs-09-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063217684
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1158/1078-0432.ccr-06-1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003769138
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1158/1078-0432.ccr-06-3022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021783047
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1200/jco.1997.15.8.2894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083129505
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1200/jco.1998.16.8.2672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083305985
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1200/jco.1999.17.2.460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074265640
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1200/jco.2001.19.8.2334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800023
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1200/jco.2003.12.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204022
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1200/jco.2005.02.6187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025932563
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1200/jco.2005.02.6914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045440787
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1200/jco.2005.02.8886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011847416
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1200/jco.2005.04.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003035955
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1200/jco.2005.07.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014791751
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1200/jco.2006.09.9994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036230219
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1200/jco.2007.14.8197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015199418
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1200/jco.2008.19.7939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045310505
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1200/jco.2008.21.4577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036202282
331 rdf:type schema:CreativeWork
332 https://doi.org/10.3816/cbc.2003.n.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009640058
333 rdf:type schema:CreativeWork
334 https://doi.org/10.3816/cbc.2005.n.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001198940
335 rdf:type schema:CreativeWork
336 https://www.grid.ac/institutes/grid.31151.37 schema:alternateName Centre Hospitalier Regional Universitaire De Dijon
337 schema:name Department of Radiology, CHU (University Hospital), F-21079 Dijon, France
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...