Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case–control study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07

AUTHORS

N L Henry, D Pchejetski, R A'Hern, A T Nguyen, P Charles, J Waxman, L Li, A M Storniolo, D F Hayes, D A Flockhart, V Stearns, J Stebbing

ABSTRACT

BACKGROUND: The aromatase inhibitor (AI)-associated musculoskeletal syndrome (AIMSS) occurs in approximately 50% of AI-treated patients. Inflammatory mediators are associated with oestrogen signalling and may change with oestrogen depletion. We hypothesised that AIMSS may be associated with changes in circulating inflammatory markers. METHODS: Patients with breast cancer were enrolled in a trial of adjuvant AI therapy. Changes in pain and function during therapy were assessed prospectively. We selected 30 cases with AIMSS and 22 controls without AIMSS, matched for demographics and prior therapy. Serum samples collected at baseline and during treatment were assayed for multiple inflammatory cytokines and lipid mediators using multiplex assays. RESULTS: Before AI therapy, mean serum concentrations of 6 of 36 assayed factors were statistically significantly lower in cases than controls (all P<0.003). No statistically significant changes during AI therapy relative to pre-treatment were observed between cases and controls for any of the inflammatory markers tested. CONCLUSION: AIMSS is probably not associated with a systemic inflammatory response. Pre-treatment cytokine levels may predict for development of AIMSS. More... »

PAGES

291

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605768

DOI

http://dx.doi.org/10.1038/sj.bjc.6605768

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001874366

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20606683


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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