Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-06-15

AUTHORS

S Takano, K Sogawa, H Yoshitomi, T Shida, K Mogushi, F Kimura, H Shimizu, H Yoshidome, M Ohtsuka, A Kato, T Ishihara, H Tanaka, O Yokosuka, F Nomura, M Miyazaki

ABSTRACT

Background:Intracellular phosphoprotein activation significantly regulates cancer progression. However, the significance of circulating phosphoproteins in the blood remains unknown. We investigated the serum phosphoprotein profile involved in pancreatic cancer (PaCa) by a novel approach that comprehensively measured serum phosphoproteins levels, and clinically applied this method to the detection of PaCa.Methods:We analysed the serum phosphoproteins that comprised cancer cellular signal pathways by comparing sera from PaCa patients and benign controls including healthy volunteers (HVs) and pancreatitis patients.Results:Hierarchical clustering analysis between PaCa patients and HVs revealed differential pathway-specific profiles. In particular, the components of the extracellular signal-regulated kinase (ERK) signalling pathway were significantly increased in the sera of PaCa patients compared with HVs. The positive rate of p-ERK1/2 (82%) was found to be superior to that of CA19-9 (53%) for early stage PaCa. For the combination of these serum levels, the area under the receiver-operator characteristics curves was showing significant ability to distinguish between the two populations in independent validation set, and between cancer and non-cancer populations in another validation set.Conclusion:The comprehensive measurement of serum cell signal phosphoproteins is useful for the detection of PaCa. Further investigations will lead to the implementation of tailor-made molecular-targeted therapeutics. More... »

PAGES

223-231

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605734

DOI

http://dx.doi.org/10.1038/sj.bjc.6605734

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034112670

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20551957


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