Guidelines for the welfare and use of animals in cancer research View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05-25

AUTHORS

P Workman, E O Aboagye, F Balkwill, A Balmain, G Bruder, D J Chaplin, J A Double, J Everitt, D A H Farningham, M J Glennie, L R Kelland, V Robinson, I J Stratford, G M Tozer, S Watson, S R Wedge, S A Eccles

ABSTRACT

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice. More... »

PAGES

1555-1577

References to SciGraph publications

  • 2006-12. New approaches to molecular cancer therapeutics in NATURE CHEMICAL BIOLOGY
  • 2009-08-31. Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death in ONCOGENE
  • 2007-05-24. Eradication of cross-contaminated cell lines: A call for action in CELL BIOLOGY AND TOXICOLOGY
  • 2005-10. The multiple uses of fluorescent proteins to visualize cancer in vivo in NATURE REVIEWS CANCER
  • 2008-08-17. Modelling Myc inhibition as a cancer therapy in NATURE
  • 2006-03-20. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model in ONCOGENE
  • 2006-02. Essential role for gene profiling analysis in the authentication of human cell lines in HUMAN CELL
  • 2004-06. Reconstructing immunity after allogeneic transplantation in IMMUNOLOGIC RESEARCH
  • 2007-02-07. Small Animal Absorbed Radiation Dose from Serial Micro-Computed Tomography Imaging in MOLECULAR IMAGING AND BIOLOGY
  • 2001-09. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice in NATURE
  • 2009-04. Metastasis: from dissemination to organ-specific colonization in NATURE REVIEWS CANCER
  • 2008-04-02. Imaging in the era of molecular oncology in NATURE
  • 2009-04. The cancer genome in NATURE
  • 2000-09. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects in NATURE GENETICS
  • 2001-07. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy in NATURE MEDICINE
  • 2002-11-12. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-10-04. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis in NATURE
  • 2005-05-29. Temporal dissection of p53 function in vitro and in vivo in NATURE GENETICS
  • 2009-02-04. Intravital microscopy of tumor angiogenesis and regression in the dorsal skin fold chamber: mechanistic insights and preclinical testing of therapeutic strategies in CLINICAL & EXPERIMENTAL METASTASIS
  • 1993-11. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts in BRITISH JOURNAL OF CANCER
  • 1991-07. Growth and metastasis of human bladder cancer xenografts in the bladder of nude rats in UROLITHIASIS
  • 2001-11-05. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer in NATURE GENETICS
  • 1999-05. Matrilysin as a target for chemotherapy for colon cancer: use of antisense oligonucleotides as antimetastatic agents in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2004-07-30. Cancer genes and the pathways they control in NATURE MEDICINE
  • 2000-08. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice in NATURE
  • 1988-07. UKCCCR guidelines for the welfare of animals in experimental neoplasia in BRITISH JOURNAL OF CANCER
  • 2006-09-09. Carcinogenesis related to intense pulsed light and UV exposure: an experimental animal study in LASERS IN MEDICAL SCIENCE
  • 2008-02-05. Interactions between microenvironment and cancer cells in two animal models of bone metastasis in BRITISH JOURNAL OF CANCER
  • 2005-05. Tumor infiltration by myeloid suppressor cells in response to T cell activation in rat gliomas in JOURNAL OF NEURO-ONCOLOGY
  • 2006-08-18. The mighty mouse: genetically engineered mouse models in cancer drug development in NATURE REVIEWS DRUG DISCOVERY
  • 2001-04-26. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice in NATURE
  • 2008-07-26. Mouse Modifier Genes in Mammary Tumorigenesis and Metastasis in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2008-07-24. Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2005-07-01. Dual-color, whole-body imaging in mice in NATURE BIOTECHNOLOGY
  • 2004-11-19. Effects of Rapamycin in the Eker Rat Model of Tuberous Sclerosis Complex in PEDIATRIC RESEARCH
  • 2004-11-17. Targeted cancer therapy in NATURE
  • 2003-12. Intravital imaging of cell movement in tumours in NATURE REVIEWS CANCER
  • 1999-02. Relationship Between Drug Delivery and the Intra-arterial Infusion Rate of SarCNU in C6 Rat Brain Tumor Model in JOURNAL OF NEURO-ONCOLOGY
  • 2006-09-06. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression in NATURE
  • 2006-08-16. Off by a whisker in NATURE
  • 2007-09. Maximizing mouse cancer models in NATURE REVIEWS CANCER
  • 1999-03-26. Radioimmunotherapy of micrometastases in lung with vascular targeted213Bi in BRITISH JOURNAL OF CANCER
  • 2010-02. Signatures of mutation and selection in the cancer genome in NATURE
  • 2004-06-04. Both soluble and membrane-bound forms of Flt3 ligand enhance tumor immunity following “suicide” gene therapy in a murine colon carcinoma model in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1996-02. Mammary tumors induced by polyomavirus in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-02. New approaches for imaging tumour responses to treatment in NATURE REVIEWS CANCER
  • 2005-11. Effect of Asymptomatic Natural Infections due to Common Mouse Pathogens on the Metastatic Progression of B16 Murine Melanoma in C57BL/6 Mice in CLINICAL & EXPERIMENTAL METASTASIS
  • 2006. RAPID DETECTION OF MYCOPLASMA CONTAMINATION IN CELL CULTURES USING SYBR GREEN-BASED REAL-TIME POLYMERASE CHAIN REACTION in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • 1998-01. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition) in BRITISH JOURNAL OF CANCER
  • 1999-05. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation in NATURE GENETICS
  • 2010-01. A census of amplified and overexpressed human cancer genes in NATURE REVIEWS CANCER
  • Journal

    TITLE

    British Journal of Cancer

    ISSUE

    11

    VOLUME

    102

    Author Affiliations

  • Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK
  • Comprehensive Cancer Imaging Centre, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, W12 ONN, London, UK
  • Centre for Cancer & Inflammation, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, EC1M 6BQ, London, UK
  • Helen Diller Family Comprehensive Cancer Center, University of California San Francisco 1450 3rd Street, 94158, San Francisco, CA, USA
  • Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK
  • OXiGENE Inc., 701 Gateway Boulevard, 94080, San Francisco, CA, USA
  • University of Bradford, Richmond Road, BD7 1DP, Bradford, UK
  • GlaxoSmithkline Pharmaceutical R&D, PO Box 13398, Five Moore Drive, N2.2210.2B, 27709-3398, Research Triangle Park, NC, USA
  • Current address: Medical Research Council, 20 Park Crescent London W1B 1AL, UK
  • Cancer Sciences Division, Tenovus Laboratory, Southampton University School of Medicine, General Hospital, SO16 6YD, Southampton, UK
  • Cancer Research Technology Development Laboratories, Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT, London, UK
  • National Centre for the Replacement, Refinement and Reduction of Animals in Research 20, Park Crescent, W1B 1AL, London, UK
  • School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK
  • Department of Oncology, K Floor, School of Medicine, University of Sheffield, Beech Hill Road, S10 2RX, Sheffield, UK
  • Division of Pre-Clinical Oncology & PRECOS, D Floor West Block, Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK
  • Cancer Bioscience, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
  • Related Patents

  • Compositions Comprising Bacterial Strains
  • A Sirp1-Alpha-4-1bbl Fusion Protein And Methods Of Use Thereof
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • A Sirp1 Alpha-41bbl Fusion Protein And Methods Of Use Thereof
  • Compositions Comprising Bacterial Strains
  • Combination Of Opioids And Anticancer Drugs For Cancer Treatment
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Labelled Carboxylic Acids And Their Uses In Molecular Imaging
  • Compositions Comprising Bacterial Strains
  • Control Of Tumour Growth And Gut Bleeding By Biosurfactants
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Composition Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Combination Of Opioids And Anticancer Drugs For Cancer Treatment
  • Compositions Comprising Bacterial Strains
  • Brush-Arm Star Polymer Imaging Agents And Uses Thereof
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Bacterium For Use As A Probiotic For Nutritional And Medical Applications
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Deuterated N-(5-(2,3-Dihydrobenzo[B][1,4]Dioxine-6-Carboxamido)-2-Fluorophenyl)-2-((4-Ethylpiperazin-1 -Yl)Methyl)Quinoline-6-Carboxamide
  • Labelled Carboxylic Acids And Their Uses In Molecular Imaging
  • Composition Of Bacteroides Thetaiotaomicron For Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Isotopic Carbon Choline Analogs
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • A Method For The Identification Of Immunotherapy-Drug Combinations Using A Network Approach
  • Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising A Bacterial Strain Of The Genus Megasphera And Uses Thereof
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Mammary Fat Pad (Mfp) Tumor Cell Inoculation To Avoid Tumor Ulceration
  • A Method For The Identification Of Immunotherapy-Drug Combinations Using A Network Approach
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strain
  • Lactic Acid Bacterial Strains
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605642

    DOI

    http://dx.doi.org/10.1038/sj.bjc.6605642

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034513961

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20502460


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Algorithms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animal Experimentation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animal Welfare", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Pharmacological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomedical Research", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Transformed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnostic Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Practice Guidelines as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK", 
              "id": "http://www.grid.ac/institutes/grid.18886.3f", 
              "name": [
                "Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Workman", 
            "givenName": "P", 
            "id": "sg:person.01264301660.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301660.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Cancer Imaging Centre, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, W12 ONN, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Comprehensive Cancer Imaging Centre, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, W12 ONN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aboagye", 
            "givenName": "E O", 
            "id": "sg:person.01000053751.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000053751.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Cancer & Inflammation, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, EC1M 6BQ, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "Centre for Cancer & Inflammation, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, EC1M 6BQ, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balkwill", 
            "givenName": "F", 
            "id": "sg:person.016530027317.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530027317.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helen Diller Family Comprehensive Cancer Center, University of California San Francisco 1450 3rd Street, 94158, San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.511215.3", 
              "name": [
                "Helen Diller Family Comprehensive Cancer Center, University of California San Francisco 1450 3rd Street, 94158, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balmain", 
            "givenName": "A", 
            "id": "sg:person.01124651751.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124651751.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK", 
              "id": "http://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruder", 
            "givenName": "G", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "OXiGENE Inc., 701 Gateway Boulevard, 94080, San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.487337.c", 
              "name": [
                "OXiGENE Inc., 701 Gateway Boulevard, 94080, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chaplin", 
            "givenName": "D J", 
            "id": "sg:person.0745300522.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745300522.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bradford, Richmond Road, BD7 1DP, Bradford, UK", 
              "id": "http://www.grid.ac/institutes/grid.6268.a", 
              "name": [
                "University of Bradford, Richmond Road, BD7 1DP, Bradford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Double", 
            "givenName": "J A", 
            "id": "sg:person.01363601633.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363601633.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithkline Pharmaceutical R&D, PO Box 13398, Five Moore Drive, N2.2210.2B, 27709-3398, Research Triangle Park, NC, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "GlaxoSmithkline Pharmaceutical R&D, PO Box 13398, Five Moore Drive, N2.2210.2B, 27709-3398, Research Triangle Park, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Everitt", 
            "givenName": "J", 
            "id": "sg:person.014213714737.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014213714737.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Current address: Medical Research Council, 20 Park Crescent London W1B 1AL, UK", 
              "id": "http://www.grid.ac/institutes/grid.14105.31", 
              "name": [
                "Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Herts, UK", 
                "Current address: Medical Research Council, 20 Park Crescent London W1B 1AL, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Farningham", 
            "givenName": "D A H", 
            "id": "sg:person.014650767650.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014650767650.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Sciences Division, Tenovus Laboratory, Southampton University School of Medicine, General Hospital, SO16 6YD, Southampton, UK", 
              "id": "http://www.grid.ac/institutes/grid.123047.3", 
              "name": [
                "Cancer Sciences Division, Tenovus Laboratory, Southampton University School of Medicine, General Hospital, SO16 6YD, Southampton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glennie", 
            "givenName": "M J", 
            "id": "sg:person.01152654306.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152654306.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Technology Development Laboratories, Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Cancer Research Technology Development Laboratories, Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kelland", 
            "givenName": "L R", 
            "id": "sg:person.01205306746.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205306746.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Centre for the Replacement, Refinement and Reduction of Animals in Research 20, Park Crescent, W1B 1AL, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.453088.2", 
              "name": [
                "National Centre for the Replacement, Refinement and Reduction of Animals in Research 20, Park Crescent, W1B 1AL, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robinson", 
            "givenName": "V", 
            "id": "sg:person.01074357476.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074357476.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK", 
              "id": "http://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stratford", 
            "givenName": "I J", 
            "id": "sg:person.0734743640.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734743640.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology, K Floor, School of Medicine, University of Sheffield, Beech Hill Road, S10 2RX, Sheffield, UK", 
              "id": "http://www.grid.ac/institutes/grid.11835.3e", 
              "name": [
                "Department of Oncology, K Floor, School of Medicine, University of Sheffield, Beech Hill Road, S10 2RX, Sheffield, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tozer", 
            "givenName": "G M", 
            "id": "sg:person.0736063251.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736063251.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Pre-Clinical Oncology & PRECOS, D Floor West Block, Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK", 
              "id": "http://www.grid.ac/institutes/grid.415598.4", 
              "name": [
                "Division of Pre-Clinical Oncology & PRECOS, D Floor West Block, Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watson", 
            "givenName": "S", 
            "id": "sg:person.014546474002.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014546474002.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Bioscience, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK", 
              "id": "http://www.grid.ac/institutes/grid.417815.e", 
              "name": [
                "Cancer Bioscience, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wedge", 
            "givenName": "S R", 
            "id": "sg:person.01266520760.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266520760.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK", 
              "id": "http://www.grid.ac/institutes/grid.18886.3f", 
              "name": [
                "Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eccles", 
            "givenName": "S A", 
            "id": "sg:person.010756561124.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010756561124.88"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/35020592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017226982", 
              "https://doi.org/10.1038/35020592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1290/0505035.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001865169", 
              "https://doi.org/10.1290/0505035.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050920222", 
              "https://doi.org/10.1038/sj.onc.1209482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041030245", 
              "https://doi.org/10.1038/ng747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002735811", 
              "https://doi.org/10.1038/nature08768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10911-008-9089-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022027718", 
              "https://doi.org/10.1007/s10911-008-9089-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034282407", 
              "https://doi.org/10.1038/nrc2192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018861713", 
              "https://doi.org/10.1038/sj.bjc.6604238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014428392", 
              "https://doi.org/10.1038/nrc1717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10911-008-9087-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008584064", 
              "https://doi.org/10.1007/s10911-008-9087-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020705083", 
              "https://doi.org/10.1038/nature06917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016113160", 
              "https://doi.org/10.1038/nature05077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1988.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021666755", 
              "https://doi.org/10.1038/bjc.1988.174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002368480", 
              "https://doi.org/10.1038/nrc1231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-005-5261-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014656033", 
              "https://doi.org/10.1007/s10585-005-5261-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1749-0774.2005.00007.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052099031", 
              "https://doi.org/10.1111/j.1749-0774.2005.00007.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00305296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053382879", 
              "https://doi.org/10.1007/bf00305296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-002-0529-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006440096", 
              "https://doi.org/10.1007/s00280-002-0529-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024563444", 
              "https://doi.org/10.1038/nrc2289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020158834", 
              "https://doi.org/10.1038/nrc2622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046474258", 
              "https://doi.org/10.1038/bjc.1998.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/442739a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010269938", 
              "https://doi.org/10.1038/442739a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10103-006-0395-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045360072", 
              "https://doi.org/10.1007/s10103-006-0395-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0705-790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005460227", 
              "https://doi.org/10.1038/nbt0705-790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002800051098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049327216", 
              "https://doi.org/10.1007/s002800051098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006104220315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024964176", 
              "https://doi.org/10.1023/a:1006104220315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021879419", 
              "https://doi.org/10.1038/bjc.1993.453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/8743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022713663", 
              "https://doi.org/10.1038/8743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6690337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042217225", 
              "https://doi.org/10.1038/sj.bjc.6690337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-007-9442-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005859834", 
              "https://doi.org/10.1007/s11060-007-9442-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046203017", 
              "https://doi.org/10.1038/nature06188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015354678", 
              "https://doi.org/10.1038/89997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-008-9234-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051136537", 
              "https://doi.org/10.1007/s10585-008-9234-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01806077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045369194", 
              "https://doi.org/10.1007/bf01806077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10565-007-9019-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052595435", 
              "https://doi.org/10.1007/s10565-007-9019-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000147727.78571.07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036965717", 
              "https://doi.org/10.1203/01.pdr.0000147727.78571.07"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029567400", 
              "https://doi.org/10.1038/nrc2771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760692", 
              "https://doi.org/10.1038/nrd2110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-007-0080-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021982578", 
              "https://doi.org/10.1007/s11307-007-0080-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026059473", 
              "https://doi.org/10.1038/nm1087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010000533", 
              "https://doi.org/10.1038/nature03095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050584708", 
              "https://doi.org/10.1038/nchembio840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/ir:29:1-3:269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035513849", 
              "https://doi.org/10.1385/ir:29:1-3:269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829095", 
              "https://doi.org/10.1038/nature07943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046768621", 
              "https://doi.org/10.1038/ng1572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021789508", 
              "https://doi.org/10.1038/79075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35092584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014622173", 
              "https://doi.org/10.1038/35092584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002917648", 
              "https://doi.org/10.1038/nature07260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35074129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005772949", 
              "https://doi.org/10.1038/35074129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-004-0553-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008163498", 
              "https://doi.org/10.1007/s00262-004-0553-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017598156", 
              "https://doi.org/10.1038/onc.2009.250"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-05-25", 
        "datePublishedReg": "2010-05-25", 
        "description": "Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/sj.bjc.6605642", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4057491", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2768922", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "102"
          }
        ], 
        "keywords": [
          "cancer research", 
          "high-quality cancer research", 
          "tumor model", 
          "study design", 
          "animal experiments", 
          "pilot study", 
          "humane endpoints", 
          "animal care", 
          "use of animals", 
          "animals", 
          "guidelines", 
          "malignancy", 
          "therapy", 
          "cancer", 
          "endpoint", 
          "care", 
          "excellent standard", 
          "best practices", 
          "use", 
          "replacement", 
          "recommendations", 
          "study", 
          "reduction", 
          "fundamental mechanisms", 
          "mechanism", 
          "research", 
          "practice", 
          "publications", 
          "standards", 
          "choice", 
          "animal welfare", 
          "statistics", 
          "aspects", 
          "conduct", 
          "method", 
          "welfare", 
          "model", 
          "experiments", 
          "design", 
          "refinement"
        ], 
        "name": "Guidelines for the welfare and use of animals in cancer research", 
        "pagination": "1555-1577", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1034513961"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.bjc.6605642"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20502460"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.bjc.6605642", 
          "https://app.dimensions.ai/details/publication/pub.1034513961"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_505.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/sj.bjc.6605642"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605642'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605642'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605642'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605642'


     

    This table displays all metadata directly associated to this object as RDF triples.

    537 TRIPLES      21 PREDICATES      134 URIs      75 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.bjc.6605642 schema:about N0f7fe44027bb4a8a92c95fb9ac1cec79
    2 N11c0a164a594405f9a3abc036d83ad33
    3 N1aeeaceab93f4302b5f0eae64b5b1389
    4 N309462001baf4c988dbbca3a6e360146
    5 N4d1685e4595a4e79976fcb1c107e0642
    6 N59eda7c9403f4347af52a416a318f5da
    7 N5bb790dd7d7a44b591934f689c1b13cd
    8 N68634c84302b44858ef1a55424fc1ea0
    9 N8204bcf7f0b04d699e1d284593991177
    10 N8c633d406d5d432cbd5147aad164cfd6
    11 N90296fbc09364ee7a4e25a223f37a9b4
    12 N9954aee300b7465e85f4aafcd66ca941
    13 Nb0a7c23cf7c94e2fa7a43ccfed25469f
    14 Nba0d563f92bf42df999ce8f53585286a
    15 Nbdb8448599c64fb9aaa8c452d6496b8f
    16 Ncc8f945a4a004c20b82915f388dea8c9
    17 Nce965f261524466bb82f8435c86439bb
    18 Ne0baa53f680f4ea3a89d5f65167e3852
    19 anzsrc-for:11
    20 anzsrc-for:1112
    21 schema:author N538c28c44c48463695fde86d65493982
    22 schema:citation sg:pub.10.1007/bf00305296
    23 sg:pub.10.1007/bf01806077
    24 sg:pub.10.1007/s00262-004-0553-5
    25 sg:pub.10.1007/s00280-002-0529-0
    26 sg:pub.10.1007/s002800051098
    27 sg:pub.10.1007/s10103-006-0395-9
    28 sg:pub.10.1007/s10565-007-9019-9
    29 sg:pub.10.1007/s10585-005-5261-9
    30 sg:pub.10.1007/s10585-008-9234-7
    31 sg:pub.10.1007/s10911-008-9087-3
    32 sg:pub.10.1007/s10911-008-9089-1
    33 sg:pub.10.1007/s11060-007-9442-z
    34 sg:pub.10.1007/s11307-007-0080-9
    35 sg:pub.10.1023/a:1006104220315
    36 sg:pub.10.1038/35020592
    37 sg:pub.10.1038/35074129
    38 sg:pub.10.1038/35092584
    39 sg:pub.10.1038/442739a
    40 sg:pub.10.1038/79075
    41 sg:pub.10.1038/8743
    42 sg:pub.10.1038/89997
    43 sg:pub.10.1038/bjc.1988.174
    44 sg:pub.10.1038/bjc.1993.453
    45 sg:pub.10.1038/bjc.1998.1
    46 sg:pub.10.1038/nature03095
    47 sg:pub.10.1038/nature05077
    48 sg:pub.10.1038/nature06188
    49 sg:pub.10.1038/nature06917
    50 sg:pub.10.1038/nature07260
    51 sg:pub.10.1038/nature07943
    52 sg:pub.10.1038/nature08768
    53 sg:pub.10.1038/nbt0705-790
    54 sg:pub.10.1038/nchembio840
    55 sg:pub.10.1038/ng1572
    56 sg:pub.10.1038/ng747
    57 sg:pub.10.1038/nm1087
    58 sg:pub.10.1038/nrc1231
    59 sg:pub.10.1038/nrc1717
    60 sg:pub.10.1038/nrc2192
    61 sg:pub.10.1038/nrc2289
    62 sg:pub.10.1038/nrc2622
    63 sg:pub.10.1038/nrc2771
    64 sg:pub.10.1038/nrd2110
    65 sg:pub.10.1038/onc.2009.250
    66 sg:pub.10.1038/sj.bjc.6604238
    67 sg:pub.10.1038/sj.bjc.6690337
    68 sg:pub.10.1038/sj.onc.1209482
    69 sg:pub.10.1111/j.1749-0774.2005.00007.x
    70 sg:pub.10.1203/01.pdr.0000147727.78571.07
    71 sg:pub.10.1290/0505035.1
    72 sg:pub.10.1385/ir:29:1-3:269
    73 schema:datePublished 2010-05-25
    74 schema:datePublishedReg 2010-05-25
    75 schema:description Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
    76 schema:genre article
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N0c43cfffb22d4661810b7831dc04b09d
    79 N2dc46022ce5e4a81bcaa2d33444e587f
    80 sg:journal.1017082
    81 schema:keywords animal care
    82 animal experiments
    83 animal welfare
    84 animals
    85 aspects
    86 best practices
    87 cancer
    88 cancer research
    89 care
    90 choice
    91 conduct
    92 design
    93 endpoint
    94 excellent standard
    95 experiments
    96 fundamental mechanisms
    97 guidelines
    98 high-quality cancer research
    99 humane endpoints
    100 malignancy
    101 mechanism
    102 method
    103 model
    104 pilot study
    105 practice
    106 publications
    107 recommendations
    108 reduction
    109 refinement
    110 replacement
    111 research
    112 standards
    113 statistics
    114 study
    115 study design
    116 therapy
    117 tumor model
    118 use
    119 use of animals
    120 welfare
    121 schema:name Guidelines for the welfare and use of animals in cancer research
    122 schema:pagination 1555-1577
    123 schema:productId N2df674d10d1f459b90776ce0116a0e4c
    124 N50669da482e340b493502d92daa73c1d
    125 N7ec7425d20d34c6182103a82c0991c46
    126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034513961
    127 https://doi.org/10.1038/sj.bjc.6605642
    128 schema:sdDatePublished 2022-12-01T06:28
    129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    130 schema:sdPublisher Nc4b947f5077f45deb7264668e5eb78b8
    131 schema:url https://doi.org/10.1038/sj.bjc.6605642
    132 sgo:license sg:explorer/license/
    133 sgo:sdDataset articles
    134 rdf:type schema:ScholarlyArticle
    135 N000f94b176e44fa7a0cca21b3676c4fd rdf:first sg:person.0745300522.28
    136 rdf:rest Nc73d1d9e5b744dbbadcb1cf612eb6848
    137 N071d454a6cb64b598e6a74ee6397d7a4 rdf:first sg:person.01152654306.21
    138 rdf:rest Nde03dc7670e34010b43c9d84fb4fdf8a
    139 N0af7af8535e44bbaa1f5783cdcc4b7c0 rdf:first sg:person.010756561124.88
    140 rdf:rest rdf:nil
    141 N0c43cfffb22d4661810b7831dc04b09d schema:volumeNumber 102
    142 rdf:type schema:PublicationVolume
    143 N0f7fe44027bb4a8a92c95fb9ac1cec79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Xenograft Model Antitumor Assays
    145 rdf:type schema:DefinedTerm
    146 N11c0a164a594405f9a3abc036d83ad33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Mice
    148 rdf:type schema:DefinedTerm
    149 N1aeeaceab93f4302b5f0eae64b5b1389 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Animal Experimentation
    151 rdf:type schema:DefinedTerm
    152 N2dc46022ce5e4a81bcaa2d33444e587f schema:issueNumber 11
    153 rdf:type schema:PublicationIssue
    154 N2df674d10d1f459b90776ce0116a0e4c schema:name dimensions_id
    155 schema:value pub.1034513961
    156 rdf:type schema:PropertyValue
    157 N2f9907b6f1e74943a1c9fbcb088e57d1 rdf:first sg:person.01266520760.40
    158 rdf:rest N0af7af8535e44bbaa1f5783cdcc4b7c0
    159 N309462001baf4c988dbbca3a6e360146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Diagnostic Imaging
    161 rdf:type schema:DefinedTerm
    162 N34a771fb0b854e6aaef82b612a73204f rdf:first sg:person.014213714737.56
    163 rdf:rest N6bbaf0b217644cfeaeedcd36f47e69a9
    164 N363005de425541d2be843e0996842cd9 schema:affiliation grid-institutes:grid.5379.8
    165 schema:familyName Bruder
    166 schema:givenName G
    167 rdf:type schema:Person
    168 N4d1685e4595a4e79976fcb1c107e0642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Animal Welfare
    170 rdf:type schema:DefinedTerm
    171 N50669da482e340b493502d92daa73c1d schema:name pubmed_id
    172 schema:value 20502460
    173 rdf:type schema:PropertyValue
    174 N538c28c44c48463695fde86d65493982 rdf:first sg:person.01264301660.41
    175 rdf:rest N653e249f647c4785ab458bc642c68d38
    176 N59eda7c9403f4347af52a416a318f5da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Treatment Outcome
    178 rdf:type schema:DefinedTerm
    179 N5bb790dd7d7a44b591934f689c1b13cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Disease Models, Animal
    181 rdf:type schema:DefinedTerm
    182 N5c006c82d0ef4f31bb60e0193f1c147e rdf:first sg:person.0734743640.85
    183 rdf:rest N7d4025e849704598835d1f9a11acc311
    184 N653e249f647c4785ab458bc642c68d38 rdf:first sg:person.01000053751.67
    185 rdf:rest N8512ca5cc9c84026b630ca893ae1f6c5
    186 N68634c84302b44858ef1a55424fc1ea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Biomarkers, Pharmacological
    188 rdf:type schema:DefinedTerm
    189 N6bbaf0b217644cfeaeedcd36f47e69a9 rdf:first sg:person.014650767650.38
    190 rdf:rest N071d454a6cb64b598e6a74ee6397d7a4
    191 N7d4025e849704598835d1f9a11acc311 rdf:first sg:person.0736063251.63
    192 rdf:rest N8b0d1a8bdb494697aceb7978da688bad
    193 N7ec7425d20d34c6182103a82c0991c46 schema:name doi
    194 schema:value 10.1038/sj.bjc.6605642
    195 rdf:type schema:PropertyValue
    196 N7f70735b2f1d4cd6a50c359fb41bafea rdf:first sg:person.01074357476.41
    197 rdf:rest N5c006c82d0ef4f31bb60e0193f1c147e
    198 N8204bcf7f0b04d699e1d284593991177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Animals
    200 rdf:type schema:DefinedTerm
    201 N8512ca5cc9c84026b630ca893ae1f6c5 rdf:first sg:person.016530027317.07
    202 rdf:rest Neaa9bdd3574844ffb6affd25bbc09335
    203 N8b0d1a8bdb494697aceb7978da688bad rdf:first sg:person.014546474002.44
    204 rdf:rest N2f9907b6f1e74943a1c9fbcb088e57d1
    205 N8c633d406d5d432cbd5147aad164cfd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Algorithms
    207 rdf:type schema:DefinedTerm
    208 N90296fbc09364ee7a4e25a223f37a9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Biomedical Research
    210 rdf:type schema:DefinedTerm
    211 N97a0f37cba16414098eed375b2f6e8f2 rdf:first N363005de425541d2be843e0996842cd9
    212 rdf:rest N000f94b176e44fa7a0cca21b3676c4fd
    213 N9954aee300b7465e85f4aafcd66ca941 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Humans
    215 rdf:type schema:DefinedTerm
    216 Nb0a7c23cf7c94e2fa7a43ccfed25469f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Practice Guidelines as Topic
    218 rdf:type schema:DefinedTerm
    219 Nba0d563f92bf42df999ce8f53585286a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Female
    221 rdf:type schema:DefinedTerm
    222 Nbdb8448599c64fb9aaa8c452d6496b8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Male
    224 rdf:type schema:DefinedTerm
    225 Nc4b947f5077f45deb7264668e5eb78b8 schema:name Springer Nature - SN SciGraph project
    226 rdf:type schema:Organization
    227 Nc73d1d9e5b744dbbadcb1cf612eb6848 rdf:first sg:person.01363601633.38
    228 rdf:rest N34a771fb0b854e6aaef82b612a73204f
    229 Ncc8f945a4a004c20b82915f388dea8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Cell Line, Transformed
    231 rdf:type schema:DefinedTerm
    232 Nce965f261524466bb82f8435c86439bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Neoplasms
    234 rdf:type schema:DefinedTerm
    235 Nde03dc7670e34010b43c9d84fb4fdf8a rdf:first sg:person.01205306746.50
    236 rdf:rest N7f70735b2f1d4cd6a50c359fb41bafea
    237 Ne0baa53f680f4ea3a89d5f65167e3852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Neoplasm Transplantation
    239 rdf:type schema:DefinedTerm
    240 Neaa9bdd3574844ffb6affd25bbc09335 rdf:first sg:person.01124651751.58
    241 rdf:rest N97a0f37cba16414098eed375b2f6e8f2
    242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Medical and Health Sciences
    244 rdf:type schema:DefinedTerm
    245 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    246 schema:name Oncology and Carcinogenesis
    247 rdf:type schema:DefinedTerm
    248 sg:grant.2768922 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.bjc.6605642
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.4057491 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.bjc.6605642
    251 rdf:type schema:MonetaryGrant
    252 sg:journal.1017082 schema:issn 0007-0920
    253 1532-1827
    254 schema:name British Journal of Cancer
    255 schema:publisher Springer Nature
    256 rdf:type schema:Periodical
    257 sg:person.01000053751.67 schema:affiliation grid-institutes:grid.7445.2
    258 schema:familyName Aboagye
    259 schema:givenName E O
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000053751.67
    261 rdf:type schema:Person
    262 sg:person.01074357476.41 schema:affiliation grid-institutes:grid.453088.2
    263 schema:familyName Robinson
    264 schema:givenName V
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074357476.41
    266 rdf:type schema:Person
    267 sg:person.010756561124.88 schema:affiliation grid-institutes:grid.18886.3f
    268 schema:familyName Eccles
    269 schema:givenName S A
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010756561124.88
    271 rdf:type schema:Person
    272 sg:person.01124651751.58 schema:affiliation grid-institutes:grid.511215.3
    273 schema:familyName Balmain
    274 schema:givenName A
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124651751.58
    276 rdf:type schema:Person
    277 sg:person.01152654306.21 schema:affiliation grid-institutes:grid.123047.3
    278 schema:familyName Glennie
    279 schema:givenName M J
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152654306.21
    281 rdf:type schema:Person
    282 sg:person.01205306746.50 schema:affiliation grid-institutes:grid.83440.3b
    283 schema:familyName Kelland
    284 schema:givenName L R
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205306746.50
    286 rdf:type schema:Person
    287 sg:person.01264301660.41 schema:affiliation grid-institutes:grid.18886.3f
    288 schema:familyName Workman
    289 schema:givenName P
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301660.41
    291 rdf:type schema:Person
    292 sg:person.01266520760.40 schema:affiliation grid-institutes:grid.417815.e
    293 schema:familyName Wedge
    294 schema:givenName S R
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266520760.40
    296 rdf:type schema:Person
    297 sg:person.01363601633.38 schema:affiliation grid-institutes:grid.6268.a
    298 schema:familyName Double
    299 schema:givenName J A
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363601633.38
    301 rdf:type schema:Person
    302 sg:person.014213714737.56 schema:affiliation grid-institutes:None
    303 schema:familyName Everitt
    304 schema:givenName J
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014213714737.56
    306 rdf:type schema:Person
    307 sg:person.014546474002.44 schema:affiliation grid-institutes:grid.415598.4
    308 schema:familyName Watson
    309 schema:givenName S
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014546474002.44
    311 rdf:type schema:Person
    312 sg:person.014650767650.38 schema:affiliation grid-institutes:grid.14105.31
    313 schema:familyName Farningham
    314 schema:givenName D A H
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014650767650.38
    316 rdf:type schema:Person
    317 sg:person.016530027317.07 schema:affiliation grid-institutes:grid.4868.2
    318 schema:familyName Balkwill
    319 schema:givenName F
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530027317.07
    321 rdf:type schema:Person
    322 sg:person.0734743640.85 schema:affiliation grid-institutes:grid.5379.8
    323 schema:familyName Stratford
    324 schema:givenName I J
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734743640.85
    326 rdf:type schema:Person
    327 sg:person.0736063251.63 schema:affiliation grid-institutes:grid.11835.3e
    328 schema:familyName Tozer
    329 schema:givenName G M
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736063251.63
    331 rdf:type schema:Person
    332 sg:person.0745300522.28 schema:affiliation grid-institutes:grid.487337.c
    333 schema:familyName Chaplin
    334 schema:givenName D J
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745300522.28
    336 rdf:type schema:Person
    337 sg:pub.10.1007/bf00305296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053382879
    338 https://doi.org/10.1007/bf00305296
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1007/bf01806077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045369194
    341 https://doi.org/10.1007/bf01806077
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1007/s00262-004-0553-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008163498
    344 https://doi.org/10.1007/s00262-004-0553-5
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1007/s00280-002-0529-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006440096
    347 https://doi.org/10.1007/s00280-002-0529-0
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1007/s002800051098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049327216
    350 https://doi.org/10.1007/s002800051098
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1007/s10103-006-0395-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045360072
    353 https://doi.org/10.1007/s10103-006-0395-9
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1007/s10565-007-9019-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052595435
    356 https://doi.org/10.1007/s10565-007-9019-9
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1007/s10585-005-5261-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014656033
    359 https://doi.org/10.1007/s10585-005-5261-9
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1007/s10585-008-9234-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051136537
    362 https://doi.org/10.1007/s10585-008-9234-7
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1007/s10911-008-9087-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008584064
    365 https://doi.org/10.1007/s10911-008-9087-3
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1007/s10911-008-9089-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022027718
    368 https://doi.org/10.1007/s10911-008-9089-1
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1007/s11060-007-9442-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005859834
    371 https://doi.org/10.1007/s11060-007-9442-z
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1007/s11307-007-0080-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021982578
    374 https://doi.org/10.1007/s11307-007-0080-9
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1023/a:1006104220315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024964176
    377 https://doi.org/10.1023/a:1006104220315
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/35020592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017226982
    380 https://doi.org/10.1038/35020592
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/35074129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005772949
    383 https://doi.org/10.1038/35074129
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/35092584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014622173
    386 https://doi.org/10.1038/35092584
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/442739a schema:sameAs https://app.dimensions.ai/details/publication/pub.1010269938
    389 https://doi.org/10.1038/442739a
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/79075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021789508
    392 https://doi.org/10.1038/79075
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/8743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022713663
    395 https://doi.org/10.1038/8743
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/89997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015354678
    398 https://doi.org/10.1038/89997
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/bjc.1988.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021666755
    401 https://doi.org/10.1038/bjc.1988.174
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/bjc.1993.453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021879419
    404 https://doi.org/10.1038/bjc.1993.453
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/bjc.1998.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046474258
    407 https://doi.org/10.1038/bjc.1998.1
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/nature03095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010000533
    410 https://doi.org/10.1038/nature03095
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/nature05077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016113160
    413 https://doi.org/10.1038/nature05077
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nature06188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046203017
    416 https://doi.org/10.1038/nature06188
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/nature06917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020705083
    419 https://doi.org/10.1038/nature06917
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nature07260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002917648
    422 https://doi.org/10.1038/nature07260
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nature07943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004829095
    425 https://doi.org/10.1038/nature07943
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/nature08768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002735811
    428 https://doi.org/10.1038/nature08768
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/nbt0705-790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005460227
    431 https://doi.org/10.1038/nbt0705-790
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/nchembio840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050584708
    434 https://doi.org/10.1038/nchembio840
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/ng1572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046768621
    437 https://doi.org/10.1038/ng1572
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/ng747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041030245
    440 https://doi.org/10.1038/ng747
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nm1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026059473
    443 https://doi.org/10.1038/nm1087
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/nrc1231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002368480
    446 https://doi.org/10.1038/nrc1231
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/nrc1717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014428392
    449 https://doi.org/10.1038/nrc1717
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/nrc2192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034282407
    452 https://doi.org/10.1038/nrc2192
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/nrc2289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024563444
    455 https://doi.org/10.1038/nrc2289
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1038/nrc2622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020158834
    458 https://doi.org/10.1038/nrc2622
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/nrc2771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029567400
    461 https://doi.org/10.1038/nrc2771
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1038/nrd2110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760692
    464 https://doi.org/10.1038/nrd2110
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1038/onc.2009.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017598156
    467 https://doi.org/10.1038/onc.2009.250
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/sj.bjc.6604238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018861713
    470 https://doi.org/10.1038/sj.bjc.6604238
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1038/sj.bjc.6690337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042217225
    473 https://doi.org/10.1038/sj.bjc.6690337
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1038/sj.onc.1209482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050920222
    476 https://doi.org/10.1038/sj.onc.1209482
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1111/j.1749-0774.2005.00007.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052099031
    479 https://doi.org/10.1111/j.1749-0774.2005.00007.x
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1203/01.pdr.0000147727.78571.07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036965717
    482 https://doi.org/10.1203/01.pdr.0000147727.78571.07
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1290/0505035.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001865169
    485 https://doi.org/10.1290/0505035.1
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1385/ir:29:1-3:269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035513849
    488 https://doi.org/10.1385/ir:29:1-3:269
    489 rdf:type schema:CreativeWork
    490 grid-institutes:None schema:alternateName GlaxoSmithkline Pharmaceutical R&D, PO Box 13398, Five Moore Drive, N2.2210.2B, 27709-3398, Research Triangle Park, NC, USA
    491 schema:name GlaxoSmithkline Pharmaceutical R&D, PO Box 13398, Five Moore Drive, N2.2210.2B, 27709-3398, Research Triangle Park, NC, USA
    492 rdf:type schema:Organization
    493 grid-institutes:grid.11835.3e schema:alternateName Department of Oncology, K Floor, School of Medicine, University of Sheffield, Beech Hill Road, S10 2RX, Sheffield, UK
    494 schema:name Department of Oncology, K Floor, School of Medicine, University of Sheffield, Beech Hill Road, S10 2RX, Sheffield, UK
    495 rdf:type schema:Organization
    496 grid-institutes:grid.123047.3 schema:alternateName Cancer Sciences Division, Tenovus Laboratory, Southampton University School of Medicine, General Hospital, SO16 6YD, Southampton, UK
    497 schema:name Cancer Sciences Division, Tenovus Laboratory, Southampton University School of Medicine, General Hospital, SO16 6YD, Southampton, UK
    498 rdf:type schema:Organization
    499 grid-institutes:grid.14105.31 schema:alternateName Current address: Medical Research Council, 20 Park Crescent London W1B 1AL, UK
    500 schema:name Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Herts, UK
    501 Current address: Medical Research Council, 20 Park Crescent London W1B 1AL, UK
    502 rdf:type schema:Organization
    503 grid-institutes:grid.18886.3f schema:alternateName Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK
    504 schema:name Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, SM2 5NG, Sutton, Surrey, UK
    505 rdf:type schema:Organization
    506 grid-institutes:grid.415598.4 schema:alternateName Division of Pre-Clinical Oncology & PRECOS, D Floor West Block, Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK
    507 schema:name Division of Pre-Clinical Oncology & PRECOS, D Floor West Block, Queen's Medical Centre, University Hospital, NG7 2UH, Nottingham, UK
    508 rdf:type schema:Organization
    509 grid-institutes:grid.417815.e schema:alternateName Cancer Bioscience, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
    510 schema:name Cancer Bioscience, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
    511 rdf:type schema:Organization
    512 grid-institutes:grid.453088.2 schema:alternateName National Centre for the Replacement, Refinement and Reduction of Animals in Research 20, Park Crescent, W1B 1AL, London, UK
    513 schema:name National Centre for the Replacement, Refinement and Reduction of Animals in Research 20, Park Crescent, W1B 1AL, London, UK
    514 rdf:type schema:Organization
    515 grid-institutes:grid.4868.2 schema:alternateName Centre for Cancer & Inflammation, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, EC1M 6BQ, London, UK
    516 schema:name Centre for Cancer & Inflammation, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, EC1M 6BQ, London, UK
    517 rdf:type schema:Organization
    518 grid-institutes:grid.487337.c schema:alternateName OXiGENE Inc., 701 Gateway Boulevard, 94080, San Francisco, CA, USA
    519 schema:name OXiGENE Inc., 701 Gateway Boulevard, 94080, San Francisco, CA, USA
    520 rdf:type schema:Organization
    521 grid-institutes:grid.511215.3 schema:alternateName Helen Diller Family Comprehensive Cancer Center, University of California San Francisco 1450 3rd Street, 94158, San Francisco, CA, USA
    522 schema:name Helen Diller Family Comprehensive Cancer Center, University of California San Francisco 1450 3rd Street, 94158, San Francisco, CA, USA
    523 rdf:type schema:Organization
    524 grid-institutes:grid.5379.8 schema:alternateName Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK
    525 School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    526 schema:name Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK
    527 School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    528 rdf:type schema:Organization
    529 grid-institutes:grid.6268.a schema:alternateName University of Bradford, Richmond Road, BD7 1DP, Bradford, UK
    530 schema:name University of Bradford, Richmond Road, BD7 1DP, Bradford, UK
    531 rdf:type schema:Organization
    532 grid-institutes:grid.7445.2 schema:alternateName Comprehensive Cancer Imaging Centre, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, W12 ONN, London, UK
    533 schema:name Comprehensive Cancer Imaging Centre, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, W12 ONN, London, UK
    534 rdf:type schema:Organization
    535 grid-institutes:grid.83440.3b schema:alternateName Cancer Research Technology Development Laboratories, Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT, London, UK
    536 schema:name Cancer Research Technology Development Laboratories, Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT, London, UK
    537 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...