Ontology type: schema:ScholarlyArticle Open Access: True
2010-04
AUTHORSN Penel, S Clisant, E Dansin, C Desauw, M Dégardin, L Mortier, M Vanhuyse, F Bonodeau, C Fournier, J-L Cazin, A Adenis
ABSTRACTBACKGROUND: To evaluate the antitumour activity and safety of metronomic cyclophosphamide vs megestrol acetate in progressive and advanced cancer patients having exhausted all effective therapies under standard care. METHODS: Patients were randomly assigned to receive orally metronomic cyclophosphamide (50 mg b.i.d) or megestrol acetate (160 mg only daily) until intolerance or progression (RECIST 1.0). The primary efficacy end point was a 2-month progression-free rate (PFR(2m)). According to Optimal Simon's design and the following assumptions, namely, P0=5%, P1=20%, alpha=beta=10%, the treatment is considered as effective if atleast 5 out of 44 patients achieved PFR(2m). RESULTS: Between September 2006 and January 2009, 88 patients were enrolled. Two patients experienced grade 3-4 toxicities in each arm (4%). One toxic death occurred in the megestrol acetate arm as a consequence of thrombosis. The metronomic cyclophosphamide arm reached the predefined level of efficacy with a PFR(2m) rate of 9 out of 44 and a PFR(4m) rate of 5 out of 44. The MA arm failed to achieve the level of efficacy with a PFR(2m) of 4 out of 44 and a PFR(4m) of 1 out of 44. The median overall survival was 195 and 144 days in the metronomic cyclophosphamide arm and megestrol acetate arm, respectively. CONCLUSION: Metronomic cyclophosphamide is well tolerated and provides stable disease in such vulnerable and poor-prognosis cancer patients. This regimen warrants further evaluations. More... »
PAGES1207
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605623
DOIhttp://dx.doi.org/10.1038/sj.bjc.6605623
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1045585023
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20354522
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Alkylating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Hormonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclophosphamide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Progression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Administration Schedule",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Evaluation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Megestrol Acetate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Palliative Care",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Centre Oscar Lambret, Lille, France",
"Equipe d\u2019Accueil 2694: Sant\u00e9 Publique, Epid\u00e9miologie et mod\u00e9lisation des maladies chroniques, Lille University, Lille, France"
],
"type": "Organization"
},
"familyName": "Penel",
"givenName": "N",
"id": "sg:person.0677574257.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574257.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Clisant",
"givenName": "S",
"id": "sg:person.0762650444.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762650444.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Dansin",
"givenName": "E",
"id": "sg:person.0676160054.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676160054.72"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"H\u00f4pital Saint-Vincent, Lille, France"
],
"type": "Organization"
},
"familyName": "Desauw",
"givenName": "C",
"id": "sg:person.0630453244.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630453244.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "D\u00e9gardin",
"givenName": "M",
"id": "sg:person.0711726650.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711726650.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Regional et Universitaire de Lille",
"id": "https://www.grid.ac/institutes/grid.410463.4",
"name": [
"University Hospital, Lille, France"
],
"type": "Organization"
},
"familyName": "Mortier",
"givenName": "L",
"id": "sg:person.0771215027.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771215027.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Vanhuyse",
"givenName": "M",
"id": "sg:person.0653463064.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653463064.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Bonodeau",
"givenName": "F",
"id": "sg:person.0655661501.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655661501.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Fournier",
"givenName": "C",
"id": "sg:person.0652247341.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652247341.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Cazin",
"givenName": "J-L",
"id": "sg:person.011452071077.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011452071077.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Oscar Lambret",
"id": "https://www.grid.ac/institutes/grid.452351.4",
"name": [
"Centre Oscar Lambret, Lille, France"
],
"type": "Organization"
},
"familyName": "Adenis",
"givenName": "A",
"id": "sg:person.01303404424.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303404424.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/bjc.1996.297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000022523",
"https://doi.org/10.1038/bjc.1996.297"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1996.297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000022523",
"https://doi.org/10.1038/bjc.1996.297"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/theoncologist.12-1-99",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000327133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000243657.64056.c3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001670387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000243657.64056.c3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001670387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2007.01.143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003981947"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd004310.pub2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005148883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd004310.pub2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005148883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)00219-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007068725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.12.1939",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007277658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.07.093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008723372"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdi101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013672736"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000192148.90120.15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014521465"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000192148.90120.15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014521465"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000192148.90120.15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014521465"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-007-9088-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015314449",
"https://doi.org/10.1007/s10637-007-9088-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdj066",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015926177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.5029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016013473"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.20544",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017646228"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.23.1811",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018649793"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd004310",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018862594"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1369",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019159796",
"https://doi.org/10.1038/nrc1369"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1369",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019159796",
"https://doi.org/10.1038/nrc1369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdh384",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019279502"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdm548",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021926589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-0621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022489746"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0163-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026409148",
"https://doi.org/10.1007/s00280-005-0163-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0163-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026409148",
"https://doi.org/10.1007/s00280-005-0163-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.17.4789",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030653254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/92.3.205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032301848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.11713",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038670473"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039960660"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039960660"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039960660"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)00398-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041121456"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(01)00398-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041730636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.2135406100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050157278"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.19.5081",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051958990"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2005.08.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052903491"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2005.08.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052903491"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/85.5.365",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059818446"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.01.8010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064204190"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1999.17.10.3299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074528576"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074623639",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074645170",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1996.14.1.135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082858543"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083277514",
"type": "CreativeWork"
}
],
"datePublished": "2010-04",
"datePublishedReg": "2010-04-01",
"description": "BACKGROUND: To evaluate the antitumour activity and safety of metronomic cyclophosphamide vs megestrol acetate in progressive and advanced cancer patients having exhausted all effective therapies under standard care.\nMETHODS: Patients were randomly assigned to receive orally metronomic cyclophosphamide (50 mg b.i.d) or megestrol acetate (160 mg only daily) until intolerance or progression (RECIST 1.0). The primary efficacy end point was a 2-month progression-free rate (PFR(2m)). According to Optimal Simon's design and the following assumptions, namely, P0=5%, P1=20%, alpha=beta=10%, the treatment is considered as effective if atleast 5 out of 44 patients achieved PFR(2m).\nRESULTS: Between September 2006 and January 2009, 88 patients were enrolled. Two patients experienced grade 3-4 toxicities in each arm (4%). One toxic death occurred in the megestrol acetate arm as a consequence of thrombosis. The metronomic cyclophosphamide arm reached the predefined level of efficacy with a PFR(2m) rate of 9 out of 44 and a PFR(4m) rate of 5 out of 44. The MA arm failed to achieve the level of efficacy with a PFR(2m) of 4 out of 44 and a PFR(4m) of 1 out of 44. The median overall survival was 195 and 144 days in the metronomic cyclophosphamide arm and megestrol acetate arm, respectively.\nCONCLUSION: Metronomic cyclophosphamide is well tolerated and provides stable disease in such vulnerable and poor-prognosis cancer patients. This regimen warrants further evaluations.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.bjc.6605623",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "102"
}
],
"name": "Megestrol acetate versus metronomic cyclophosphamide in patients having exhausted all effective therapies under standard care",
"pagination": "1207",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"d924573ac85d7720c79a39411cb75599db7727bf86f7c42358dc61dcfe3d2042"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20354522"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6605623"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1045585023"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6605623",
"https://app.dimensions.ai/details/publication/pub.1045585023"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54336_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/6605623"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605623'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605623'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605623'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605623'
This table displays all metadata directly associated to this object as RDF triples.
320 TRIPLES
21 PREDICATES
81 URIs
36 LITERALS
24 BLANK NODES