Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03

AUTHORS

N C Turner, S J Strauss, D Sarker, R Gillmore, A Kirkwood, A Hackshaw, A Papadopoulou, J Bell, I Kayani, C Toumpanakis, F Grillo, A Mayer, D Hochhauser, R H Begent, M E Caplin, T Meyer

ABSTRACT

BACKGROUND: The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD: We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cisplatin (70 mg m(-2)) and streptozocin (1000 mg m(-2)) (FCiSt) administered three weekly for up to six cycles. Patients were assessed for radiological response, toxicity and survival. RESULTS: In the 79 patients assessable for response, treatment with FCiSt was associated with an overall response rate of 33% (38% for pancreatic primary sites and 25% for non-pancreatic primary sites). Stable disease occurred in a further 51%, with progression in 16%. The median time to progression was 9.1 months and median overall survival was 31.5 months. The most common grade 3-4 toxicity was neutropaenia (28% patients) but grade 3-4 infection was rare (7%). The most frequent non-haematological grade 3-4 toxicity was nausea and vomiting (17%). Prognostic factors included Ki-67, mitotic index, grade and chromogranin A, whereas response to chemotherapy was predicted by mitotic index, grade and alpha-fetoprotein. CONCLUSIONS: FCiSt is an effective regimen for neuroendocrine tumours with an acceptable toxicity profile. Grade and mitotic index are the best predictors of response. More... »

PAGES

1106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605618

DOI

http://dx.doi.org/10.1038/sj.bjc.6605618

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005779365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20234360


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroendocrine Tumors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptozocin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "N C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strauss", 
        "givenName": "S J", 
        "id": "sg:person.01142646030.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142646030.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarker", 
        "givenName": "D", 
        "id": "sg:person.01116143235.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116143235.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gillmore", 
        "givenName": "R", 
        "id": "sg:person.01346321334.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346321334.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Research UK and UCL Cancer Trials Centre, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirkwood", 
        "givenName": "A", 
        "id": "sg:person.0731715270.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731715270.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Research UK and UCL Cancer Trials Centre, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hackshaw", 
        "givenName": "A", 
        "id": "sg:person.016330343704.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016330343704.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Free Hospital", 
          "id": "https://www.grid.ac/institutes/grid.426108.9", 
          "name": [
            "Department of Radiology, Royal Free Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papadopoulou", 
        "givenName": "A", 
        "id": "sg:person.01114213067.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114213067.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Free Hospital", 
          "id": "https://www.grid.ac/institutes/grid.426108.9", 
          "name": [
            "Department of Radiology, Royal Free Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bell", 
        "givenName": "J", 
        "id": "sg:person.01152135317.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152135317.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.439749.4", 
          "name": [
            "Department of Radiology, University College Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kayani", 
        "givenName": "I", 
        "id": "sg:person.01014444731.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014444731.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Free Hospital", 
          "id": "https://www.grid.ac/institutes/grid.426108.9", 
          "name": [
            "Department of Gastroenterology, Royal Free Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toumpanakis", 
        "givenName": "C", 
        "id": "sg:person.0721457666.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721457666.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Pathology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grillo", 
        "givenName": "F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "A", 
        "id": "sg:person.0665427104.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665427104.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK", 
            "Department of Oncology, UCL Cancer Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hochhauser", 
        "givenName": "D", 
        "id": "sg:person.01062062554.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062062554.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK", 
            "Department of Oncology, UCL Cancer Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Begent", 
        "givenName": "R H", 
        "id": "sg:person.013552066274.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013552066274.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Free Hospital", 
          "id": "https://www.grid.ac/institutes/grid.426108.9", 
          "name": [
            "Department of Gastroenterology, Royal Free Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caplin", 
        "givenName": "M E", 
        "id": "sg:person.01123015105.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123015105.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Oncology, UCL Medical School, Royal Free Campus, London, UK", 
            "Department of Oncology, UCL Cancer Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyer", 
        "givenName": "T", 
        "id": "sg:person.01133336225.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133336225.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002414313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010901)92:5<1101::aid-cncr1426>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005512554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<944::aid-cncr8>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006556218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007577414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.6046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010536433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820650902>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013267408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199202203260804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017495638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-006-0250-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017988295", 
          "https://doi.org/10.1007/s00428-006-0250-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022459045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beem.2007.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022578563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc-06-0074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023350278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026002664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc-08-0017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027013209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198011203032101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032615173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010415)91:8<1543::aid-cncr1163>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032717641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033288252", 
          "https://doi.org/10.1038/sj.bjc.6690325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033288252", 
          "https://doi.org/10.1038/sj.bjc.6690325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036454965", 
          "https://doi.org/10.1038/sj.bjc.6604428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.4377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037736197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039950836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19871215)60:12<2891::aid-cncr2820601207>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039951183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19910715)68:2<227::aid-cncr2820680202>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053464505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1984.2.11.1255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081637788"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-03", 
    "datePublishedReg": "2010-03-01", 
    "description": "BACKGROUND: The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen.\nMETHOD: We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cisplatin (70 mg m(-2)) and streptozocin (1000 mg m(-2)) (FCiSt) administered three weekly for up to six cycles. Patients were assessed for radiological response, toxicity and survival.\nRESULTS: In the 79 patients assessable for response, treatment with FCiSt was associated with an overall response rate of 33% (38% for pancreatic primary sites and 25% for non-pancreatic primary sites). Stable disease occurred in a further 51%, with progression in 16%. The median time to progression was 9.1 months and median overall survival was 31.5 months. The most common grade 3-4 toxicity was neutropaenia (28% patients) but grade 3-4 infection was rare (7%). The most frequent non-haematological grade 3-4 toxicity was nausea and vomiting (17%). Prognostic factors included Ki-67, mitotic index, grade and chromogranin A, whereas response to chemotherapy was predicted by mitotic index, grade and alpha-fetoprotein.\nCONCLUSIONS: FCiSt is an effective regimen for neuroendocrine tumours with an acceptable toxicity profile. Grade and mitotic index are the best predictors of response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6605618", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "102"
      }
    ], 
    "name": "Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours", 
    "pagination": "1106", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b88cc3dc40e47f90e2155192487e7d0cf623055118940f93b42cf18d7762d6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20234360"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6605618"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005779365"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6605618", 
      "https://app.dimensions.ai/details/publication/pub.1005779365"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54298_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6605618"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605618'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605618'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605618'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605618'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      66 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6605618 schema:about N0cdd99b0a24f4b2e805ad8d60692a093
2 N0cff45c9d7cb4d2a9b1d5e745128b195
3 N257eb7de582847319edfc6fb5fb359ee
4 N3dd78d5270594bf3b29f2c71a406fda5
5 N4184fc949d6e4bc3913b848c07353a99
6 N7635fe89549b436ea34e357a2a888962
7 N7c75990cf4c44407970d0e9c49563574
8 N7ee5be8c1c604a95901b66ead62b41d2
9 N939f8e87f43a41729b017e304cf0e375
10 Naf10a548a76d4893b28147b65556a871
11 Nb3e8f544af304ed4957f415dd107bc53
12 Nc61f2403d99d4ec6a69626b2bd10e47d
13 Ndfb4739eaa7a43ad9447491bc4f56d9c
14 Ne73936a0170e4dc8a01551b02cf3a555
15 Nf02c38abf1a246d9bf8c45f54433240e
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N3835965729634927a9fedfd9fa6a3804
19 schema:citation sg:pub.10.1007/s00428-006-0250-1
20 sg:pub.10.1038/sj.bjc.6604428
21 sg:pub.10.1038/sj.bjc.6690325
22 https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<944::aid-cncr8>3.0.co;2-p
23 https://doi.org/10.1002/1097-0142(19871215)60:12<2891::aid-cncr2820601207>3.0.co;2-6
24 https://doi.org/10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820650902>3.0.co;2-3
25 https://doi.org/10.1002/1097-0142(19910715)68:2<227::aid-cncr2820680202>3.0.co;2-i
26 https://doi.org/10.1002/1097-0142(20010415)91:8<1543::aid-cncr1163>3.0.co;2-n
27 https://doi.org/10.1002/1097-0142(20010901)92:5<1101::aid-cncr1426>3.0.co;2-v
28 https://doi.org/10.1002/cncr.20466
29 https://doi.org/10.1002/cncr.23549
30 https://doi.org/10.1016/j.beem.2007.01.005
31 https://doi.org/10.1056/nejm198011203032101
32 https://doi.org/10.1056/nejm199202203260804
33 https://doi.org/10.1158/1078-0432.ccr-06-2053
34 https://doi.org/10.1200/jco.1984.2.11.1255
35 https://doi.org/10.1200/jco.2004.04.024
36 https://doi.org/10.1200/jco.2005.03.6046
37 https://doi.org/10.1200/jco.2005.03.616
38 https://doi.org/10.1200/jco.2007.15.4377
39 https://doi.org/10.1677/erc-06-0074
40 https://doi.org/10.1677/erc-08-0017
41 schema:datePublished 2010-03
42 schema:datePublishedReg 2010-03-01
43 schema:description BACKGROUND: The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD: We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cisplatin (70 mg m(-2)) and streptozocin (1000 mg m(-2)) (FCiSt) administered three weekly for up to six cycles. Patients were assessed for radiological response, toxicity and survival. RESULTS: In the 79 patients assessable for response, treatment with FCiSt was associated with an overall response rate of 33% (38% for pancreatic primary sites and 25% for non-pancreatic primary sites). Stable disease occurred in a further 51%, with progression in 16%. The median time to progression was 9.1 months and median overall survival was 31.5 months. The most common grade 3-4 toxicity was neutropaenia (28% patients) but grade 3-4 infection was rare (7%). The most frequent non-haematological grade 3-4 toxicity was nausea and vomiting (17%). Prognostic factors included Ki-67, mitotic index, grade and chromogranin A, whereas response to chemotherapy was predicted by mitotic index, grade and alpha-fetoprotein. CONCLUSIONS: FCiSt is an effective regimen for neuroendocrine tumours with an acceptable toxicity profile. Grade and mitotic index are the best predictors of response.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N89b0a091db074088a281072c30cdce3e
48 N9b4b4795a53d49bea13a371972481810
49 sg:journal.1017082
50 schema:name Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours
51 schema:pagination 1106
52 schema:productId N164b2dccb7b34c9da4995c6c366ad1bb
53 N1bfc163691fc49cb9a1fb6280abdf814
54 N9c9a26e1a4f342a6b3c41bae93710078
55 Na27df09b4a1c4774ab61f4f3fb188d5e
56 Nd6374913a64246a990e7d6bf7198f07e
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005779365
58 https://doi.org/10.1038/sj.bjc.6605618
59 schema:sdDatePublished 2019-04-11T10:15
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Nd01a18ffa4e046f0a6b9eece045b3b78
62 schema:url https://www.nature.com/articles/6605618
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0cdd99b0a24f4b2e805ad8d60692a093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Fluorouracil
68 rdf:type schema:DefinedTerm
69 N0cff45c9d7cb4d2a9b1d5e745128b195 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Aged, 80 and over
71 rdf:type schema:DefinedTerm
72 N164b2dccb7b34c9da4995c6c366ad1bb schema:name readcube_id
73 schema:value 1b88cc3dc40e47f90e2155192487e7d0cf623055118940f93b42cf18d7762d6d
74 rdf:type schema:PropertyValue
75 N1bfc163691fc49cb9a1fb6280abdf814 schema:name pubmed_id
76 schema:value 20234360
77 rdf:type schema:PropertyValue
78 N20fc3edee22a40a3bdc7b53a5d0e2d24 rdf:first N9692217c859a4ac2b1d12552790e0e1c
79 rdf:rest N2d0ade46874f45e5977482eb0d8c11b8
80 N257eb7de582847319edfc6fb5fb359ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Adult
82 rdf:type schema:DefinedTerm
83 N2d0ade46874f45e5977482eb0d8c11b8 rdf:first sg:person.0665427104.66
84 rdf:rest Nbd97fbc3a5304f03abe1222bac5ca5e6
85 N310ee70186a2479e88b4f2afe0ca5669 rdf:first sg:person.01116143235.44
86 rdf:rest Ndf3c1edbeb694a5996a1ffbb64250b46
87 N333b249ebfec4118b83740a74c465da8 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
88 schema:familyName Turner
89 schema:givenName N C
90 rdf:type schema:Person
91 N3835965729634927a9fedfd9fa6a3804 rdf:first N333b249ebfec4118b83740a74c465da8
92 rdf:rest Nbfa165cf33004934be808661408bc942
93 N3dd78d5270594bf3b29f2c71a406fda5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Survival Analysis
95 rdf:type schema:DefinedTerm
96 N4184fc949d6e4bc3913b848c07353a99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Male
98 rdf:type schema:DefinedTerm
99 N4834d59c67e44111b21d22a1a1d59787 rdf:first sg:person.01114213067.18
100 rdf:rest N690355cff8ec4c07972d8afd1284f322
101 N570443fa6b324e68a3ca24b8d2947903 rdf:first sg:person.016330343704.49
102 rdf:rest N4834d59c67e44111b21d22a1a1d59787
103 N690355cff8ec4c07972d8afd1284f322 rdf:first sg:person.01152135317.05
104 rdf:rest Nb76582d6336b423880c8cb9ff4d5a305
105 N6e2eb9028c35486c87730971d0dd971c rdf:first sg:person.01123015105.00
106 rdf:rest Nf2866e1b59a542b0951c391504772638
107 N7635fe89549b436ea34e357a2a888962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N7c75990cf4c44407970d0e9c49563574 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Middle Aged
112 rdf:type schema:DefinedTerm
113 N7ee5be8c1c604a95901b66ead62b41d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Antineoplastic Combined Chemotherapy Protocols
115 rdf:type schema:DefinedTerm
116 N89b0a091db074088a281072c30cdce3e schema:volumeNumber 102
117 rdf:type schema:PublicationVolume
118 N8dee4c4d215e44c49ec495ad520180c9 rdf:first sg:person.0721457666.52
119 rdf:rest N20fc3edee22a40a3bdc7b53a5d0e2d24
120 N939f8e87f43a41729b017e304cf0e375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Aged
122 rdf:type schema:DefinedTerm
123 N9692217c859a4ac2b1d12552790e0e1c schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
124 schema:familyName Grillo
125 schema:givenName F
126 rdf:type schema:Person
127 N9b4b4795a53d49bea13a371972481810 schema:issueNumber 7
128 rdf:type schema:PublicationIssue
129 N9c9a26e1a4f342a6b3c41bae93710078 schema:name dimensions_id
130 schema:value pub.1005779365
131 rdf:type schema:PropertyValue
132 Na27df09b4a1c4774ab61f4f3fb188d5e schema:name doi
133 schema:value 10.1038/sj.bjc.6605618
134 rdf:type schema:PropertyValue
135 Naf10a548a76d4893b28147b65556a871 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 Nb3e8f544af304ed4957f415dd107bc53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Neuroendocrine Tumors
140 rdf:type schema:DefinedTerm
141 Nb76582d6336b423880c8cb9ff4d5a305 rdf:first sg:person.01014444731.20
142 rdf:rest N8dee4c4d215e44c49ec495ad520180c9
143 Nbd97fbc3a5304f03abe1222bac5ca5e6 rdf:first sg:person.01062062554.16
144 rdf:rest Ncdce1e49fc9547f3a72b01aa8cd374bc
145 Nbfa165cf33004934be808661408bc942 rdf:first sg:person.01142646030.43
146 rdf:rest N310ee70186a2479e88b4f2afe0ca5669
147 Nc61f2403d99d4ec6a69626b2bd10e47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Streptozocin
149 rdf:type schema:DefinedTerm
150 Ncdce1e49fc9547f3a72b01aa8cd374bc rdf:first sg:person.013552066274.83
151 rdf:rest N6e2eb9028c35486c87730971d0dd971c
152 Nce4d2e40eb3f4ee19a12d94ed2a9a11b schema:name Cancer Research UK and UCL Cancer Trials Centre, London, UK
153 rdf:type schema:Organization
154 Nd01a18ffa4e046f0a6b9eece045b3b78 schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 Nd142f19286b34b809806134e9258a1df schema:name Cancer Research UK and UCL Cancer Trials Centre, London, UK
157 rdf:type schema:Organization
158 Nd6374913a64246a990e7d6bf7198f07e schema:name nlm_unique_id
159 schema:value 0370635
160 rdf:type schema:PropertyValue
161 Ndf3c1edbeb694a5996a1ffbb64250b46 rdf:first sg:person.01346321334.26
162 rdf:rest Nfa09c15c53d2484c9be6b66e7bf2a550
163 Ndfb4739eaa7a43ad9447491bc4f56d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cisplatin
165 rdf:type schema:DefinedTerm
166 Ne73936a0170e4dc8a01551b02cf3a555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Young Adult
168 rdf:type schema:DefinedTerm
169 Nf02c38abf1a246d9bf8c45f54433240e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Treatment Outcome
171 rdf:type schema:DefinedTerm
172 Nf2866e1b59a542b0951c391504772638 rdf:first sg:person.01133336225.77
173 rdf:rest rdf:nil
174 Nfa09c15c53d2484c9be6b66e7bf2a550 rdf:first sg:person.0731715270.77
175 rdf:rest N570443fa6b324e68a3ca24b8d2947903
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
180 schema:name Oncology and Carcinogenesis
181 rdf:type schema:DefinedTerm
182 sg:journal.1017082 schema:issn 0007-0920
183 1532-1827
184 schema:name British Journal of Cancer
185 rdf:type schema:Periodical
186 sg:person.01014444731.20 schema:affiliation https://www.grid.ac/institutes/grid.439749.4
187 schema:familyName Kayani
188 schema:givenName I
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014444731.20
190 rdf:type schema:Person
191 sg:person.01062062554.16 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
192 schema:familyName Hochhauser
193 schema:givenName D
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062062554.16
195 rdf:type schema:Person
196 sg:person.01114213067.18 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
197 schema:familyName Papadopoulou
198 schema:givenName A
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114213067.18
200 rdf:type schema:Person
201 sg:person.01116143235.44 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
202 schema:familyName Sarker
203 schema:givenName D
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116143235.44
205 rdf:type schema:Person
206 sg:person.01123015105.00 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
207 schema:familyName Caplin
208 schema:givenName M E
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123015105.00
210 rdf:type schema:Person
211 sg:person.01133336225.77 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
212 schema:familyName Meyer
213 schema:givenName T
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133336225.77
215 rdf:type schema:Person
216 sg:person.01142646030.43 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
217 schema:familyName Strauss
218 schema:givenName S J
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142646030.43
220 rdf:type schema:Person
221 sg:person.01152135317.05 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
222 schema:familyName Bell
223 schema:givenName J
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152135317.05
225 rdf:type schema:Person
226 sg:person.01346321334.26 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
227 schema:familyName Gillmore
228 schema:givenName R
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346321334.26
230 rdf:type schema:Person
231 sg:person.013552066274.83 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
232 schema:familyName Begent
233 schema:givenName R H
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013552066274.83
235 rdf:type schema:Person
236 sg:person.016330343704.49 schema:affiliation Nce4d2e40eb3f4ee19a12d94ed2a9a11b
237 schema:familyName Hackshaw
238 schema:givenName A
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016330343704.49
240 rdf:type schema:Person
241 sg:person.0665427104.66 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
242 schema:familyName Mayer
243 schema:givenName A
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665427104.66
245 rdf:type schema:Person
246 sg:person.0721457666.52 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
247 schema:familyName Toumpanakis
248 schema:givenName C
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721457666.52
250 rdf:type schema:Person
251 sg:person.0731715270.77 schema:affiliation Nd142f19286b34b809806134e9258a1df
252 schema:familyName Kirkwood
253 schema:givenName A
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731715270.77
255 rdf:type schema:Person
256 sg:pub.10.1007/s00428-006-0250-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017988295
257 https://doi.org/10.1007/s00428-006-0250-1
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/sj.bjc.6604428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036454965
260 https://doi.org/10.1038/sj.bjc.6604428
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.bjc.6690325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033288252
263 https://doi.org/10.1038/sj.bjc.6690325
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<944::aid-cncr8>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1006556218
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/1097-0142(19871215)60:12<2891::aid-cncr2820601207>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039951183
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820650902>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013267408
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/1097-0142(19910715)68:2<227::aid-cncr2820680202>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1053464505
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/1097-0142(20010415)91:8<1543::aid-cncr1163>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1032717641
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/1097-0142(20010901)92:5<1101::aid-cncr1426>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1005512554
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/cncr.20466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022459045
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/cncr.23549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039950836
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.beem.2007.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022578563
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejm198011203032101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032615173
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1056/nejm199202203260804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017495638
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1158/1078-0432.ccr-06-2053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002414313
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.1984.2.11.1255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081637788
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/jco.2004.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026002664
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1200/jco.2005.03.6046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010536433
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1200/jco.2005.03.616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007577414
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1200/jco.2007.15.4377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037736197
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1677/erc-06-0074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023350278
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1677/erc-08-0017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027013209
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.426108.9 schema:alternateName Royal Free Hospital
304 schema:name Department of Gastroenterology, Royal Free Hospital, London, UK
305 Department of Radiology, Royal Free Hospital, London, UK
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.439749.4 schema:alternateName University College Hospital
308 schema:name Department of Radiology, University College Hospital, London, UK
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
311 schema:name Department of Oncology, UCL Cancer Institute, London, UK
312 Department of Oncology, UCL Medical School, Royal Free Campus, London, UK
313 Department of Pathology, UCL Medical School, Royal Free Campus, London, UK
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...