miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03

AUTHORS

T Chiyomaru, H Enokida, S Tatarano, K Kawahara, Y Uchida, K Nishiyama, L Fujimura, N Kikkawa, N Seki, M Nakagawa

ABSTRACT

BACKGROUND: We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC. METHODS: We focused on fascin homologue 1 (FSCN1) from the gene expression profile in miR-145 transfectant. The luciferase assay was used to confirm the actual binding sites of FSCN1 mRNA. Cell viability was evaluated by cell growth, wound-healing, and matrigel invasion assays. BC specimens were subjected to immunohistochemistry of FSCN1 and in situ hybridisation of miR-145. RESULTS: The miR-133a as well as miR-145 had the target sequence of FSCN1 mRNA by the database search, and both microRNAs repressed the mRNA and protein expression of FSCN1. The luciferase assay revealed that miR-145 and miR-133a were directly bound to FSCN1 mRNA. Cell viability was significantly inhibited in miR-145, miR-133a, and si-FSCN1 transfectants. In situ hybridisation revealed that miR-145 expression was markedly repressed in the tumour lesion in which FSCN1 was strongly stained. The immunohistochemical score of FSCN1 in invasive BC (n=46) was significantly higher than in non-invasive BC (n=20) (P=0.0055). CONCLUSION: Tumour suppressive miR-145 and miR-133a directly control oncogenic FSCN1 in BC. More... »

PAGES

883

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605570

DOI

http://dx.doi.org/10.1038/sj.bjc.6605570

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022937267

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20160723


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