Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

C H Lee, C J Chang, Y J Lin, C N Yeh, M F Chen, S Y Hsieh

ABSTRACT

Bile duct cells and hepatocytes differentiate from the same hepatic progenitor cells. To investigate the possible association of viral hepatitis B and C with intrahepatic cholangiocarcinoma (ICC), we conducted a retrospective case-control study using univariate and multivariate logistic analyses to identify risk factors for ICC. Besides hepatic lithiasis (25.6%; P<0.001), seropositivity for hepatitis B surface antigen (37.5% of all ICC patients; odds ratio (OR) =4.985, P<0.001) and seropositivity for hepatitis C antibodies (13.1%; OR=2.709; P=0.021) are the primary independent risk factors for ICC. Cirrhosis exerted synergic effects on the development of ICC. We compared the age distributions of viral-hepatitis associated ICC to that of viral hepatitis-associated hepatocellular carcinoma (HCC). The mean age of ICC patients with viral hepatitis B (56.4+/-11.1 years) were 9 years younger than that of ICC patients with viral hepatitis C (65.6+/-9.17 years), similar to that observed in HCC. The incidence ratio of HCC : ICC : CHC (combined hepatocellular cholangiocarcinoma) in our population was 233 : 17 : 1 consistent with the theoretic ratio of hepatocyte number to cholangiocyte number in the liver. Our findings indicated that both viral hepatitis-associated ICC and HCC shared common disease process for carcinogenesis and, possibly, both arose from the hepatic progenitor cells. More... »

PAGES

6605063

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6605063

DOI

http://dx.doi.org/10.1038/sj.bjc.6605063

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030328242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19436294


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholangiocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Cirrhosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of General and Geriatric Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "C H", 
        "id": "sg:person.01004206355.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004206355.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Resource Center for Clinical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "C J", 
        "id": "sg:person.016571157240.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016571157240.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Resource Center for Clinical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Y J", 
        "id": "sg:person.01170556434.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170556434.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yeh", 
        "givenName": "C N", 
        "id": "sg:person.0773114302.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773114302.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan", 
            "Chang Gung University School of Medicine, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "M F", 
        "id": "sg:person.01113204002.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113204002.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Chang Gung University School of Medicine, Taoyuan, Taiwan", 
            "Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsieh", 
        "givenName": "S Y", 
        "id": "sg:person.01025077426.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025077426.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.04.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002106742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prp.2005.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006060857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006159098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2006.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006942919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e328224b935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009546408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e328224b935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009546408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m607712200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011704959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.09.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013843939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017757146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028943887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0603499103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032807474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033300720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2007.02929.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033803772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1140485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034305158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.060798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034940462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035359747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035508050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.2005.00354.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036315531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.2005.00354.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036315531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038634263", 
          "https://doi.org/10.1038/sj.onc.1210648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ijgc:37:1:27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041759668", 
          "https://doi.org/10.1385/ijgc:37:1:27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042243364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2008.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042849494", 
          "https://doi.org/10.1038/cr.2008.40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cld.2007.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043157198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.04.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043463959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044121035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.8.3048-3059.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045405628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2006.12.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046315996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2007.01104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050052215", 
          "https://doi.org/10.1111/j.1572-0241.2007.01104.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051714789", 
          "https://doi.org/10.1038/sj.onc.1209558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051714789", 
          "https://doi.org/10.1038/sj.onc.1209558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2004-815564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057429926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.13.6478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.14.632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i39.6261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071365090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077026121", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077327769", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v13.i48.6478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092703694"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-06", 
    "datePublishedReg": "2009-06-01", 
    "description": "Bile duct cells and hepatocytes differentiate from the same hepatic progenitor cells. To investigate the possible association of viral hepatitis B and C with intrahepatic cholangiocarcinoma (ICC), we conducted a retrospective case-control study using univariate and multivariate logistic analyses to identify risk factors for ICC. Besides hepatic lithiasis (25.6%; P<0.001), seropositivity for hepatitis B surface antigen (37.5% of all ICC patients; odds ratio (OR) =4.985, P<0.001) and seropositivity for hepatitis C antibodies (13.1%; OR=2.709; P=0.021) are the primary independent risk factors for ICC. Cirrhosis exerted synergic effects on the development of ICC. We compared the age distributions of viral-hepatitis associated ICC to that of viral hepatitis-associated hepatocellular carcinoma (HCC). The mean age of ICC patients with viral hepatitis B (56.4+/-11.1 years) were 9 years younger than that of ICC patients with viral hepatitis C (65.6+/-9.17 years), similar to that observed in HCC. The incidence ratio of HCC : ICC : CHC (combined hepatocellular cholangiocarcinoma) in our population was 233 : 17 : 1 consistent with the theoretic ratio of hepatocyte number to cholangiocyte number in the liver. Our findings indicated that both viral hepatitis-associated ICC and HCC shared common disease process for carcinogenesis and, possibly, both arose from the hepatic progenitor cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6605063", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "100"
      }
    ], 
    "name": "Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma", 
    "pagination": "6605063", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "907a2af9f3f37714084e28945f26440bd5de6b698a77deade7547e25f35c4bc1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19436294"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6605063"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030328242"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6605063", 
      "https://app.dimensions.ai/details/publication/pub.1030328242"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000339_0000000339/records_109518_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/6605063"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605063'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605063'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605063'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605063'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      77 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6605063 schema:about N07faa4b7a71c4bef8dc116403572eed3
2 N12f3ecc6f73a412aa4e8574dcd7089fc
3 N265f1dd878a64e7dbb4e5fe4e3bc634e
4 N29117ac6ad1e4075a915e909d8625b63
5 N625ff3b2c71e44b89da3416a93279671
6 N7424a476fc924d37a077569937bef43f
7 N79a6b448d22e439d9f5c6078a07eeb4a
8 N83ad280f5a024078be5700ef8120b9ea
9 N89ffa3ffbf3d4d558a8383f8a34b3d21
10 Ncb0364a7560d46f29dfa7eeed709b570
11 Nd2a0723cafa34bd4a15dbfe2ef125d55
12 Nf2990da22fd241c480c384ea12a3fc9e
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N00f0bc717b59426d9b77394271e36e7f
16 schema:citation sg:pub.10.1038/cr.2008.40
17 sg:pub.10.1038/sj.onc.1209558
18 sg:pub.10.1038/sj.onc.1210648
19 sg:pub.10.1111/j.1572-0241.2007.01104.x
20 sg:pub.10.1385/ijgc:37:1:27
21 https://app.dimensions.ai/details/publication/pub.1077026121
22 https://app.dimensions.ai/details/publication/pub.1077327769
23 https://doi.org/10.1002/hep.22125
24 https://doi.org/10.1002/hep.22310
25 https://doi.org/10.1002/hep.22606
26 https://doi.org/10.1002/ijc.22283
27 https://doi.org/10.1002/ijc.23251
28 https://doi.org/10.1016/j.bbrc.2007.09.106
29 https://doi.org/10.1016/j.ccr.2006.12.016
30 https://doi.org/10.1016/j.ccr.2008.01.013
31 https://doi.org/10.1016/j.cell.2005.04.014
32 https://doi.org/10.1016/j.cld.2007.11.003
33 https://doi.org/10.1016/j.humpath.2006.04.012
34 https://doi.org/10.1016/j.prp.2005.10.011
35 https://doi.org/10.1053/j.gastro.2004.09.011
36 https://doi.org/10.1053/j.gastro.2007.04.025
37 https://doi.org/10.1053/j.gastro.2007.04.061
38 https://doi.org/10.1055/s-2004-815564
39 https://doi.org/10.1073/pnas.0603499103
40 https://doi.org/10.1074/jbc.m607712200
41 https://doi.org/10.1097/meg.0b013e328224b935
42 https://doi.org/10.1111/j.1365-2184.2005.00354.x
43 https://doi.org/10.1111/j.1365-2559.2007.02929.x
44 https://doi.org/10.1126/science.1140485
45 https://doi.org/10.1128/mcb.26.8.3048-3059.2006
46 https://doi.org/10.1158/0008-5472.can-07-0908
47 https://doi.org/10.2353/ajpath.2007.060798
48 https://doi.org/10.3748/wjg.13.6478
49 https://doi.org/10.3748/wjg.14.632
50 https://doi.org/10.3748/wjg.v12.i39.6261
51 https://doi.org/10.3748/wjg.v13.i48.6478
52 schema:datePublished 2009-06
53 schema:datePublishedReg 2009-06-01
54 schema:description Bile duct cells and hepatocytes differentiate from the same hepatic progenitor cells. To investigate the possible association of viral hepatitis B and C with intrahepatic cholangiocarcinoma (ICC), we conducted a retrospective case-control study using univariate and multivariate logistic analyses to identify risk factors for ICC. Besides hepatic lithiasis (25.6%; P<0.001), seropositivity for hepatitis B surface antigen (37.5% of all ICC patients; odds ratio (OR) =4.985, P<0.001) and seropositivity for hepatitis C antibodies (13.1%; OR=2.709; P=0.021) are the primary independent risk factors for ICC. Cirrhosis exerted synergic effects on the development of ICC. We compared the age distributions of viral-hepatitis associated ICC to that of viral hepatitis-associated hepatocellular carcinoma (HCC). The mean age of ICC patients with viral hepatitis B (56.4+/-11.1 years) were 9 years younger than that of ICC patients with viral hepatitis C (65.6+/-9.17 years), similar to that observed in HCC. The incidence ratio of HCC : ICC : CHC (combined hepatocellular cholangiocarcinoma) in our population was 233 : 17 : 1 consistent with the theoretic ratio of hepatocyte number to cholangiocyte number in the liver. Our findings indicated that both viral hepatitis-associated ICC and HCC shared common disease process for carcinogenesis and, possibly, both arose from the hepatic progenitor cells.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N3bd74cd4c08743dcb9a9ada2b14c8abd
59 Ne9579fcd9b0c4a3b9cc4582b1ee7e62f
60 sg:journal.1017082
61 schema:name Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma
62 schema:pagination 6605063
63 schema:productId N2a868e4a2a2e4d7d9340688e026a6c26
64 N69a0a015168a4a3885166a01c3ba9376
65 N79e7fba13c304f629bb4a09e79d30a1e
66 Nd414f62166724803a01ddb0f8085c519
67 Nd47f3884c8924164bbc22127975839bc
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030328242
69 https://doi.org/10.1038/sj.bjc.6605063
70 schema:sdDatePublished 2019-04-11T09:20
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Naf4f96d5526b425e8f1e23cf1ba0c519
73 schema:url http://www.nature.com/articles/6605063
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N00f0bc717b59426d9b77394271e36e7f rdf:first sg:person.01004206355.56
78 rdf:rest Nc0fadc61899e43f7913c1995fcda7b73
79 N06868a71494e46df9f89a37decbe6763 schema:name Resource Center for Clinical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
80 rdf:type schema:Organization
81 N07faa4b7a71c4bef8dc116403572eed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Risk Factors
83 rdf:type schema:DefinedTerm
84 N12f3ecc6f73a412aa4e8574dcd7089fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Liver Cirrhosis
86 rdf:type schema:DefinedTerm
87 N265f1dd878a64e7dbb4e5fe4e3bc634e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Female
89 rdf:type schema:DefinedTerm
90 N29117ac6ad1e4075a915e909d8625b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Humans
92 rdf:type schema:DefinedTerm
93 N2a868e4a2a2e4d7d9340688e026a6c26 schema:name nlm_unique_id
94 schema:value 0370635
95 rdf:type schema:PropertyValue
96 N3bd74cd4c08743dcb9a9ada2b14c8abd schema:issueNumber 11
97 rdf:type schema:PublicationIssue
98 N625ff3b2c71e44b89da3416a93279671 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Male
100 rdf:type schema:DefinedTerm
101 N69a0a015168a4a3885166a01c3ba9376 schema:name dimensions_id
102 schema:value pub.1030328242
103 rdf:type schema:PropertyValue
104 N7424a476fc924d37a077569937bef43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Hepatitis B
106 rdf:type schema:DefinedTerm
107 N79a6b448d22e439d9f5c6078a07eeb4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N79e7fba13c304f629bb4a09e79d30a1e schema:name readcube_id
111 schema:value 907a2af9f3f37714084e28945f26440bd5de6b698a77deade7547e25f35c4bc1
112 rdf:type schema:PropertyValue
113 N83ad280f5a024078be5700ef8120b9ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Middle Aged
115 rdf:type schema:DefinedTerm
116 N89ffa3ffbf3d4d558a8383f8a34b3d21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Hepatitis C
118 rdf:type schema:DefinedTerm
119 N8a1a05a728fa4bbd82cd47e698e33948 schema:name Division of General and Geriatric Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
120 rdf:type schema:Organization
121 N99327df91281446e83435233ad387e38 schema:name Resource Center for Clinical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
122 rdf:type schema:Organization
123 Naf4f96d5526b425e8f1e23cf1ba0c519 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 Nb8d779f2b9244a2da378f3907198b41f schema:name Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
126 rdf:type schema:Organization
127 Nc0fadc61899e43f7913c1995fcda7b73 rdf:first sg:person.016571157240.35
128 rdf:rest Nd57c699e5c084d14b76c8f2858d7cafc
129 Ncb0364a7560d46f29dfa7eeed709b570 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Carcinoma, Hepatocellular
131 rdf:type schema:DefinedTerm
132 Nd2a0723cafa34bd4a15dbfe2ef125d55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cholangiocarcinoma
134 rdf:type schema:DefinedTerm
135 Nd414f62166724803a01ddb0f8085c519 schema:name doi
136 schema:value 10.1038/sj.bjc.6605063
137 rdf:type schema:PropertyValue
138 Nd47f3884c8924164bbc22127975839bc schema:name pubmed_id
139 schema:value 19436294
140 rdf:type schema:PropertyValue
141 Nd57c699e5c084d14b76c8f2858d7cafc rdf:first sg:person.01170556434.41
142 rdf:rest Nea0c587793064682beac54ad67a71196
143 Ne06d4251a5b140e08ca898e6798e765e rdf:first sg:person.01113204002.44
144 rdf:rest Ne60e0a232a6d4260ac8d8547e9043096
145 Ne60e0a232a6d4260ac8d8547e9043096 rdf:first sg:person.01025077426.98
146 rdf:rest rdf:nil
147 Ne9579fcd9b0c4a3b9cc4582b1ee7e62f schema:volumeNumber 100
148 rdf:type schema:PublicationVolume
149 Nea0c587793064682beac54ad67a71196 rdf:first sg:person.0773114302.82
150 rdf:rest Ne06d4251a5b140e08ca898e6798e765e
151 Nf2990da22fd241c480c384ea12a3fc9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Liver Neoplasms
153 rdf:type schema:DefinedTerm
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
158 schema:name Clinical Sciences
159 rdf:type schema:DefinedTerm
160 sg:journal.1017082 schema:issn 0007-0920
161 1532-1827
162 schema:name British Journal of Cancer
163 rdf:type schema:Periodical
164 sg:person.01004206355.56 schema:affiliation N8a1a05a728fa4bbd82cd47e698e33948
165 schema:familyName Lee
166 schema:givenName C H
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004206355.56
168 rdf:type schema:Person
169 sg:person.01025077426.98 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
170 schema:familyName Hsieh
171 schema:givenName S Y
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025077426.98
173 rdf:type schema:Person
174 sg:person.01113204002.44 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
175 schema:familyName Chen
176 schema:givenName M F
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113204002.44
178 rdf:type schema:Person
179 sg:person.01170556434.41 schema:affiliation N99327df91281446e83435233ad387e38
180 schema:familyName Lin
181 schema:givenName Y J
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170556434.41
183 rdf:type schema:Person
184 sg:person.016571157240.35 schema:affiliation N06868a71494e46df9f89a37decbe6763
185 schema:familyName Chang
186 schema:givenName C J
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016571157240.35
188 rdf:type schema:Person
189 sg:person.0773114302.82 schema:affiliation Nb8d779f2b9244a2da378f3907198b41f
190 schema:familyName Yeh
191 schema:givenName C N
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773114302.82
193 rdf:type schema:Person
194 sg:pub.10.1038/cr.2008.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042849494
195 https://doi.org/10.1038/cr.2008.40
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/sj.onc.1209558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051714789
198 https://doi.org/10.1038/sj.onc.1209558
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/sj.onc.1210648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038634263
201 https://doi.org/10.1038/sj.onc.1210648
202 rdf:type schema:CreativeWork
203 sg:pub.10.1111/j.1572-0241.2007.01104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050052215
204 https://doi.org/10.1111/j.1572-0241.2007.01104.x
205 rdf:type schema:CreativeWork
206 sg:pub.10.1385/ijgc:37:1:27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041759668
207 https://doi.org/10.1385/ijgc:37:1:27
208 rdf:type schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1077026121 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1077327769 schema:CreativeWork
211 https://doi.org/10.1002/hep.22125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017757146
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/hep.22310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006159098
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/hep.22606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033300720
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/ijc.22283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035508050
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/ijc.23251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044121035
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.bbrc.2007.09.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013843939
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ccr.2006.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046315996
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ccr.2008.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042243364
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.cell.2005.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038939615
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.cld.2007.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043157198
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.humpath.2006.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006942919
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.prp.2005.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006060857
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1053/j.gastro.2004.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035359747
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1053/j.gastro.2007.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002106742
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1053/j.gastro.2007.04.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043463959
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1055/s-2004-815564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057429926
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.0603499103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032807474
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.m607712200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011704959
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/meg.0b013e328224b935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009546408
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1365-2184.2005.00354.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036315531
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1365-2559.2007.02929.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033803772
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.1140485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034305158
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1128/mcb.26.8.3048-3059.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045405628
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1158/0008-5472.can-07-0908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028943887
258 rdf:type schema:CreativeWork
259 https://doi.org/10.2353/ajpath.2007.060798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034940462
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3748/wjg.13.6478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360018
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3748/wjg.14.632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360988
264 rdf:type schema:CreativeWork
265 https://doi.org/10.3748/wjg.v12.i39.6261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071365090
266 rdf:type schema:CreativeWork
267 https://doi.org/10.3748/wjg.v13.i48.6478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092703694
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.145695.a schema:alternateName Chang Gung University
270 schema:name Chang Gung University School of Medicine, Taoyuan, Taiwan
271 Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
272 Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, Taiwan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...